MX2019005583A - Vinculantes de conjugacion, conjugados de molecula de union a celulas que contienen los vinculantes, metodos de creacion y usos de dichos conjugados con los vinculantes. - Google Patents

Vinculantes de conjugacion, conjugados de molecula de union a celulas que contienen los vinculantes, metodos de creacion y usos de dichos conjugados con los vinculantes.

Info

Publication number
MX2019005583A
MX2019005583A MX2019005583A MX2019005583A MX2019005583A MX 2019005583 A MX2019005583 A MX 2019005583A MX 2019005583 A MX2019005583 A MX 2019005583A MX 2019005583 A MX2019005583 A MX 2019005583A MX 2019005583 A MX2019005583 A MX 2019005583A
Authority
MX
Mexico
Prior art keywords
linkers
conjugates
binding molecule
likers
making
Prior art date
Application number
MX2019005583A
Other languages
English (en)
Inventor
Zhu Haifeng
Li Chen
Huang Yuanyuan
Yang Qingliang
GAI Shun
YE Hangbo
Yang Chengyu
Guo Huihui
ZHOU Xiaomai
Xie Hongsheng
Tong Qianqian
Cao Minjun
ZHAO Linyao
Jia Junxiang
Li Wenjun
Xu Yifang
Robert ZHAO Yongxin
Gao Shuihong
Guo Zhixiang
Bai Lu
Yang Yanlei
Wang Chunyan
Ye Zhichang
Original Assignee
Hangzhou Dac Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hangzhou Dac Biotech Co Ltd filed Critical Hangzhou Dac Biotech Co Ltd
Publication of MX2019005583A publication Critical patent/MX2019005583A/es

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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  • Health & Medical Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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Abstract

La presente invención se refiere a enlazadores que tienen un grupo de propiolilo, acrilo sustituido (acriloilo) o propanoilo disustituido, y al uso de tales enlazadores para la conjugación de compuestos, en particular, agentes citotóxicos a una molécula de unión celular.
MX2019005583A 2016-11-14 2016-11-14 Vinculantes de conjugacion, conjugados de molecula de union a celulas que contienen los vinculantes, metodos de creacion y usos de dichos conjugados con los vinculantes. MX2019005583A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/105799 WO2018086139A1 (en) 2016-11-14 2016-11-14 Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers

Publications (1)

Publication Number Publication Date
MX2019005583A true MX2019005583A (es) 2019-10-21

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MX2019005583A MX2019005583A (es) 2016-11-14 2016-11-14 Vinculantes de conjugacion, conjugados de molecula de union a celulas que contienen los vinculantes, metodos de creacion y usos de dichos conjugados con los vinculantes.

Country Status (11)

Country Link
US (6) US20210308277A1 (es)
EP (2) EP3538080A4 (es)
JP (2) JP7138350B2 (es)
KR (7) KR102345175B1 (es)
CN (2) CN110099682B (es)
AU (3) AU2016429272A1 (es)
CA (1) CA3042442C (es)
MX (1) MX2019005583A (es)
NZ (1) NZ752394A (es)
PH (1) PH12019501056A1 (es)
WO (1) WO2018086139A1 (es)

Families Citing this family (40)

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Publication number Priority date Publication date Assignee Title
US11873281B2 (en) 2012-07-12 2024-01-16 Hangzhou Dac Biotech Co., Ltd. Conjugates of cell binding molecules with cytotoxic agents
PL2872157T3 (pl) 2012-07-12 2020-07-13 Hangzhou Dac Biotech Co., Ltd Koniugaty wiążących komórkę cząsteczek ze środkami cytotoksycznymi
US10292961B2 (en) 2015-07-15 2019-05-21 Hangzhou Dac Biotech Co., Ltd. Disulfur bridge linkers for conjugation of a cell-binding molecule
EP3484518B1 (en) 2016-07-07 2024-08-14 The Board of Trustees of the Leland Stanford Junior University Antibody adjuvant conjugates
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