IT1317731B1 - Tassani semisintetici con attivita' antitumorale ed antiangiogenetica. - Google Patents

Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.

Info

Publication number
IT1317731B1
IT1317731B1 IT2000MI000056A ITMI20000056A IT1317731B1 IT 1317731 B1 IT1317731 B1 IT 1317731B1 IT 2000MI000056 A IT2000MI000056 A IT 2000MI000056A IT MI20000056 A ITMI20000056 A IT MI20000056A IT 1317731 B1 IT1317731 B1 IT 1317731B1
Authority
IT
Italy
Prior art keywords
del
ins
sup
delete
date
Prior art date
Application number
IT2000MI000056A
Other languages
English (en)
Inventor
Ezio Bombardelli
Alessandro Pontiroli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of ITMI20000056A0 publication Critical patent/ITMI20000056A0/it
Priority to IT2000MI000056A priority Critical patent/IT1317731B1/it
Priority to PCT/EP2001/000386 priority patent/WO2001053282A1/en
Priority to TR2004/01811T priority patent/TR200401811T4/xx
Priority to CA002397591A priority patent/CA2397591C/en
Priority to AU33694/01A priority patent/AU781650B2/en
Priority to CZ20022478A priority patent/CZ301251B6/cs
Priority to IL15078701A priority patent/IL150787A0/xx
Priority to PL356272A priority patent/PL202591B1/pl
Priority to ES01905668T priority patent/ES2223778T3/es
Priority to DE60104281T priority patent/DE60104281T2/de
Priority to SK1056-2002A priority patent/SK285683B6/sk
Priority to HU0204344A priority patent/HU229347B1/hu
Priority to PT01905668T priority patent/PT1248776E/pt
Priority to AT01905668T priority patent/ATE271044T1/de
Priority to SI200130147T priority patent/SI1248776T1/xx
Priority to EP01905668A priority patent/EP1248776B1/en
Priority to RU2002119060/04A priority patent/RU2259363C2/ru
Priority to DK01905668T priority patent/DK1248776T3/da
Priority to CNB018038344A priority patent/CN1176916C/zh
Priority to KR1020027009182A priority patent/KR100813704B1/ko
Priority to JP2001553757A priority patent/JP4986354B2/ja
Publication of ITMI20000056A1 publication Critical patent/ITMI20000056A1/it
Priority to US10/187,995 priority patent/US6589979B2/en
Priority to NO20023428A priority patent/NO329403B1/no
Priority to HK03102021.6A priority patent/HK1049998B/zh
Application granted granted Critical
Publication of IT1317731B1 publication Critical patent/IT1317731B1/it
Priority to US11/158,323 priority patent/USRE39723E1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
IT2000MI000056A 2000-01-18 2000-01-18 Tassani semisintetici con attivita' antitumorale ed antiangiogenetica. IT1317731B1 (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
IT2000MI000056A IT1317731B1 (it) 2000-01-18 2000-01-18 Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.
PT01905668T PT1248776E (pt) 2000-01-18 2001-01-15 Taxanos semi-sinteticos com actividades antitumor e anti-angiogeneticas
SI200130147T SI1248776T1 (en) 2000-01-18 2001-01-15 Semi-synthetic taxanes with antitumor and antiangiogenetic activities
CA002397591A CA2397591C (en) 2000-01-18 2001-01-15 Semi-synthetic taxanes with antitumor and antiangiogenetic activities
AU33694/01A AU781650B2 (en) 2000-01-18 2001-01-15 Semi-synthetic taxanes with antitumor and antiangiogenetic activities
CZ20022478A CZ301251B6 (cs) 2000-01-18 2001-01-15 Polosyntetické taxany s antitumorovými a antiangiogenními úcinky a jejich použití pro výrobu farmaceutického prostredku
IL15078701A IL150787A0 (en) 2000-01-18 2001-01-15 Semi-synthetic taxanes with antitumor and antiangiogenetic activities
PL356272A PL202591B1 (pl) 2000-01-18 2001-01-15 Związki stanowiace pochodne seco-bakkatyny, kompozycje farmaceutyczne zawierające te związki i zastosowanie tych związków do wytwarzania leków o działaniu przeciwnowotworowym i przeciwnaczyniotwórczym
ES01905668T ES2223778T3 (es) 2000-01-18 2001-01-15 Taxanos semisinteticos con actividad antitumoral y antiangiogenica.
DE60104281T DE60104281T2 (de) 2000-01-18 2001-01-15 Semi-synthetische taxane mit antitumor und antiangiogenetischer wirkung
SK1056-2002A SK285683B6 (sk) 2000-01-18 2001-01-15 Polosyntetické taxány, farmaceutický prostriedok s ich obsahom a ich použitie
HU0204344A HU229347B1 (hu) 2000-01-18 2001-01-15 Daganatellenes és érképzõdés-ellenes hatású félszintetikus taxánok, valamint ezeket tartalmazó gyógyászati készítmények
PCT/EP2001/000386 WO2001053282A1 (en) 2000-01-18 2001-01-15 Semi-synthetic taxanes with antitumor and antiangiogenetic activities
AT01905668T ATE271044T1 (de) 2000-01-18 2001-01-15 Semi-synthetische taxane mit antitumor und antiangiogenetischer wirkung
TR2004/01811T TR200401811T4 (tr) 2000-01-18 2001-01-15 Antitümör ve antianjiyogenetik etkinlikleri olan yarı-sentetik taksanlar.
EP01905668A EP1248776B1 (en) 2000-01-18 2001-01-15 Semi-synthetic taxanes with antitumor and antiangiogenetic activities
RU2002119060/04A RU2259363C2 (ru) 2000-01-18 2001-01-15 Полусинтетические таксаны и фармацевтические композиции на их основе
DK01905668T DK1248776T3 (da) 2000-01-18 2001-01-15 Semi-syntetiske taxaner med antitumor og antiangiogene aktiviteter
CNB018038344A CN1176916C (zh) 2000-01-18 2001-01-15 具有抗肿瘤和抗血管生成活性的半合成紫杉烷
KR1020027009182A KR100813704B1 (ko) 2000-01-18 2001-01-15 항암활성 및 혈관신생억제활성을 가진 반합성 탁산
JP2001553757A JP4986354B2 (ja) 2000-01-18 2001-01-15 抗腫瘍活性及び抗脈管形成活性を有する半合成タキサン類
US10/187,995 US6589979B2 (en) 2000-01-18 2002-07-03 Semi-synthetic taxanes with antitumor and antiangiogenetic activities
NO20023428A NO329403B1 (no) 2000-01-18 2002-07-17 Semisyntetiske taksaner med antitumor, antiangiogenetiske og anti-artrose aktiviteter, farmasoytiske sammensetninger inneholdende dem og anvendelse av forbindelsene
HK03102021.6A HK1049998B (zh) 2000-01-18 2003-03-19 具有抗腫瘤和抗血管生成活性的半合成紫杉烷
US11/158,323 USRE39723E1 (en) 2000-01-18 2005-06-20 Semi-synthetic taxanes with antitumor and antiangiogenetic activities

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI000056A IT1317731B1 (it) 2000-01-18 2000-01-18 Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.

Publications (3)

Publication Number Publication Date
ITMI20000056A0 ITMI20000056A0 (it) 2000-01-18
ITMI20000056A1 ITMI20000056A1 (it) 2001-07-18
IT1317731B1 true IT1317731B1 (it) 2003-07-15

Family

ID=11443708

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI000056A IT1317731B1 (it) 2000-01-18 2000-01-18 Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.

Country Status (24)

Country Link
US (2) US6589979B2 (it)
EP (1) EP1248776B1 (it)
JP (1) JP4986354B2 (it)
KR (1) KR100813704B1 (it)
CN (1) CN1176916C (it)
AT (1) ATE271044T1 (it)
AU (1) AU781650B2 (it)
CA (1) CA2397591C (it)
CZ (1) CZ301251B6 (it)
DE (1) DE60104281T2 (it)
DK (1) DK1248776T3 (it)
ES (1) ES2223778T3 (it)
HK (1) HK1049998B (it)
HU (1) HU229347B1 (it)
IL (1) IL150787A0 (it)
IT (1) IT1317731B1 (it)
NO (1) NO329403B1 (it)
PL (1) PL202591B1 (it)
PT (1) PT1248776E (it)
RU (1) RU2259363C2 (it)
SI (1) SI1248776T1 (it)
SK (1) SK285683B6 (it)
TR (1) TR200401811T4 (it)
WO (1) WO2001053282A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1688415A1 (en) * 2004-12-07 2006-08-09 Aventis Pharma S.A. Cytotoxic agents comprising new C-2 modified taxanes
ITMI20050415A1 (it) * 2005-03-15 2006-09-16 Indena Spa Derivati tassanici semi-sintetici ad attivita' antitumorale
CA2891280C (en) 2012-11-24 2018-03-20 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
ES2960619T3 (es) 2014-02-28 2024-03-05 Hangzhou Dac Biotech Co Ltd Enlazadores cargados y sus usos para la conjugación
WO2015151081A2 (en) 2015-07-12 2015-10-08 Suzhou M-Conj Biotech Co., Ltd Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
KR102459468B1 (ko) 2016-11-14 2022-10-26 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
CA2109861C (en) * 1992-12-04 1999-03-16 Shu-Hui Chen 6,7-modified paclitaxels
RO115875B1 (ro) * 1994-07-26 2000-07-28 Indena Spa Derivati de taxan, procedeu pentru prepararea acestora, intermediar pentru prepararea acestora si compozitie farmaceutica care ii contine

Also Published As

Publication number Publication date
CA2397591A1 (en) 2001-07-26
EP1248776B1 (en) 2004-07-14
PL202591B1 (pl) 2009-07-31
ES2223778T3 (es) 2005-03-01
KR20020068082A (ko) 2002-08-24
JP2003520792A (ja) 2003-07-08
NO20023428D0 (no) 2002-07-17
PL356272A1 (en) 2004-06-28
CZ301251B6 (cs) 2009-12-23
US20030028038A1 (en) 2003-02-06
IL150787A0 (en) 2003-02-12
DE60104281D1 (de) 2004-08-19
DK1248776T3 (da) 2004-11-22
CN1176916C (zh) 2004-11-24
AU781650B2 (en) 2005-06-02
NO20023428L (no) 2002-09-16
JP4986354B2 (ja) 2012-07-25
SK285683B6 (sk) 2007-06-07
KR100813704B1 (ko) 2008-03-13
HK1049998A1 (en) 2003-06-06
CZ20022478A3 (cs) 2002-10-16
RU2002119060A (ru) 2004-01-10
HUP0204344A2 (en) 2003-05-28
ITMI20000056A0 (it) 2000-01-18
PT1248776E (pt) 2004-10-29
SK10562002A3 (sk) 2002-11-06
USRE39723E1 (en) 2007-07-10
AU3369401A (en) 2001-07-31
HK1049998B (zh) 2005-04-01
RU2259363C2 (ru) 2005-08-27
TR200401811T4 (tr) 2004-09-21
SI1248776T1 (en) 2004-10-31
HUP0204344A3 (en) 2004-01-28
ITMI20000056A1 (it) 2001-07-18
CA2397591C (en) 2009-10-20
DE60104281T2 (de) 2005-08-18
EP1248776A1 (en) 2002-10-16
NO329403B1 (no) 2010-10-11
WO2001053282A1 (en) 2001-07-26
ATE271044T1 (de) 2004-07-15
CN1395571A (zh) 2003-02-05
HU229347B1 (hu) 2013-11-28
US6589979B2 (en) 2003-07-08

Similar Documents

Publication Publication Date Title
TR200200717T2 (tr) Terapötik kinazolin türevleri.
UY25679A1 (es) Derivados de quinolin-2-ona inhibidores de la farnesil proteína transferasa útiles como agentes contra el cáncer
BR0015911A (pt) Derivados de benzoimidazole úteis como agentes antiproliferativos
TR199900674T2 (xx) Kinazolin t�revleri ve bunlar� i�eren farmas�tik bile�imler.
BR0010746A (pt) Derivados heterocìclicos úteis com agentes anticâncer
DE69838070D1 (de) Substituierte pyridin-derivate als entzündungshemmende mittel
TR200201505T2 (tr) Terapötik maddeler olarak pirazolopirimidinler
BR9709959A (pt) Derivados tricìclicos de fenilamino substituìdo para o tratamento de doenças hiperproliferativas
BR0014378A (pt) Derivados de ácido indolil-3-glioxìlico tendo propriedades terapeuticamente valiosas
PT1212312E (pt) Novos derivados de flavonas xantonas e cumarinas
BR0108816A (pt) Derivados de quinolina como antagonistas alfa-2
BRPI0413438A (pt) derivados de pirimidilpirrol ativos como inibidores de cinase
ATE268174T1 (de) Sibutramin und orlistat enthaltende pharmazeutische zusammensetzungen
ATE233754T1 (de) Diphenyl-piperidin derivate
ATE238981T1 (de) Antitumorwirkstoffe
IT1317731B1 (it) Tassani semisintetici con attivita' antitumorale ed antiangiogenetica.
SE9902267D0 (sv) New compounds
TR200103457T2 (tr) 4-Fenil-Pirimidin Türevleri.
NO20031410D0 (no) Antitumorterapi innbefattende distamycinderivater
ES2188908T3 (es) Derivados de cis-3,4-cromano utiles para la prevencion o tratamiento de sindromes relacionados con el estrogenos.
MXPA01012936A (es) Composicion farmaceutica que contiene sibutramina y orlistat.
TR200200017T2 (tr) Benzofuran türevleri
HUP0202340A2 (hu) Hatóanyagként kondenzált heterociklusos vegyületeket tartalmazó gyógyszerkészítmények és alkalmazásuk
FR2786184B1 (fr) Nouveaux derives du benzofurane, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
ITFI990097A0 (it) Composizioni farmaceutiche contenenti inibitori dell'ormone della crescita o loro frammenti biologicamente attivi per il trattamento