MX2018001671A - Anticuerpos pd-1. - Google Patents

Anticuerpos pd-1.

Info

Publication number
MX2018001671A
MX2018001671A MX2018001671A MX2018001671A MX2018001671A MX 2018001671 A MX2018001671 A MX 2018001671A MX 2018001671 A MX2018001671 A MX 2018001671A MX 2018001671 A MX2018001671 A MX 2018001671A MX 2018001671 A MX2018001671 A MX 2018001671A
Authority
MX
Mexico
Prior art keywords
antibodies
chemotherapy
combination
cell death
programmed cell
Prior art date
Application number
MX2018001671A
Other languages
English (en)
Other versions
MX365390B (es
Inventor
Baruah Hemanta
Chen Cheng
Liu Xiaolin
Tsun Andy
M Yu Dechao
Original Assignee
Innovent Biologics Suzhou Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovent Biologics Suzhou Co Ltd filed Critical Innovent Biologics Suzhou Co Ltd
Publication of MX2018001671A publication Critical patent/MX2018001671A/es
Publication of MX365390B publication Critical patent/MX365390B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se proporcionan en la presente anticuerpos que se unen a la muerte celular programada humana 1 (PD-1) y a su uso para el tratamiento de cáncer solos o en combinación con quimioterapia y otros agentes terapéuticos contra el cáncer.
MX2018001671A 2015-08-10 2016-08-09 Anticuerpos pd-1. MX365390B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2015/086494 WO2017024465A1 (en) 2015-08-10 2015-08-10 Pd-1 antibodies
PCT/CN2016/094122 WO2017025016A1 (en) 2015-08-10 2016-08-09 Pd-1 antibodies

Publications (2)

Publication Number Publication Date
MX2018001671A true MX2018001671A (es) 2018-09-26
MX365390B MX365390B (es) 2019-05-31

Family

ID=57982889

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018001671A MX365390B (es) 2015-08-10 2016-08-09 Anticuerpos pd-1.

Country Status (27)

Country Link
US (1) US10316089B2 (es)
EP (1) EP3334824B1 (es)
JP (1) JP6513296B2 (es)
KR (1) KR102132100B1 (es)
CN (2) CN108473977B (es)
AR (1) AR105489A1 (es)
AU (1) AU2016307002B2 (es)
BR (1) BR112018002274B1 (es)
CA (1) CA2990492C (es)
CY (1) CY1124955T1 (es)
DK (1) DK3334824T3 (es)
ES (1) ES2904586T3 (es)
HK (1) HK1255195B (es)
HR (1) HRP20220111T1 (es)
HU (1) HUE058273T2 (es)
IL (1) IL256844B (es)
LT (1) LT3334824T (es)
MX (1) MX365390B (es)
MY (1) MY199019A (es)
NZ (1) NZ738979A (es)
PL (1) PL3334824T3 (es)
PT (1) PT3334824T (es)
RS (1) RS62897B1 (es)
RU (1) RU2686612C1 (es)
SI (1) SI3334824T1 (es)
TW (1) TWI674275B (es)
WO (2) WO2017024465A1 (es)

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