PL3334824T3 - Przeciwciała anty-pd-1 - Google Patents

Przeciwciała anty-pd-1

Info

Publication number
PL3334824T3
PL3334824T3 PL16834640T PL16834640T PL3334824T3 PL 3334824 T3 PL3334824 T3 PL 3334824T3 PL 16834640 T PL16834640 T PL 16834640T PL 16834640 T PL16834640 T PL 16834640T PL 3334824 T3 PL3334824 T3 PL 3334824T3
Authority
PL
Poland
Prior art keywords
antibodies
Prior art date
Application number
PL16834640T
Other languages
English (en)
Inventor
Hemanta Baruah
Cheng Chen
Xiaolin Liu
Andy TSUN
Dechao M. Yu
Original Assignee
Innovent Biologics (Suzhou) Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovent Biologics (Suzhou) Co., Ltd. filed Critical Innovent Biologics (Suzhou) Co., Ltd.
Publication of PL3334824T3 publication Critical patent/PL3334824T3/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
PL16834640T 2015-08-10 2016-08-09 Przeciwciała anty-pd-1 PL3334824T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2015/086494 WO2017024465A1 (en) 2015-08-10 2015-08-10 Pd-1 antibodies
PCT/CN2016/094122 WO2017025016A1 (en) 2015-08-10 2016-08-09 Pd-1 antibodies
EP16834640.1A EP3334824B1 (en) 2015-08-10 2016-08-09 Pd-1 antibodies

Publications (1)

Publication Number Publication Date
PL3334824T3 true PL3334824T3 (pl) 2022-03-28

Family

ID=57982889

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16834640T PL3334824T3 (pl) 2015-08-10 2016-08-09 Przeciwciała anty-pd-1

Country Status (27)

Country Link
US (1) US10316089B2 (pl)
EP (1) EP3334824B1 (pl)
JP (1) JP6513296B2 (pl)
KR (1) KR102132100B1 (pl)
CN (2) CN110003339B (pl)
AR (1) AR105489A1 (pl)
AU (1) AU2016307002B2 (pl)
BR (1) BR112018002274B1 (pl)
CA (1) CA2990492C (pl)
CY (1) CY1124955T1 (pl)
DK (1) DK3334824T3 (pl)
ES (1) ES2904586T3 (pl)
HK (1) HK1255195B (pl)
HR (1) HRP20220111T1 (pl)
HU (1) HUE058273T2 (pl)
IL (1) IL256844B (pl)
LT (1) LT3334824T (pl)
MX (1) MX365390B (pl)
MY (1) MY199019A (pl)
NZ (1) NZ738979A (pl)
PL (1) PL3334824T3 (pl)
PT (1) PT3334824T (pl)
RS (1) RS62897B1 (pl)
RU (1) RU2686612C1 (pl)
SI (1) SI3334824T1 (pl)
TW (1) TWI674275B (pl)
WO (2) WO2017024465A1 (pl)

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112552401B (zh) 2013-09-13 2023-08-25 广州百济神州生物制药有限公司 抗pd1抗体及其作为治疗剂与诊断剂的用途
US10544225B2 (en) 2014-07-03 2020-01-28 Beigene, Ltd. Anti-PD-L1 antibodies and their use as therapeutics and diagnostics
MX2017000985A (es) 2014-07-22 2018-03-08 Cb Therapeutics Inc Anticuerpos anti-pd-1.
CN107001463B (zh) 2014-08-05 2020-01-17 中美冠科生物技术(太仓)有限公司 抗pd-l1抗体
SG10201913303XA (en) 2015-07-13 2020-03-30 Cytomx Therapeutics Inc Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof
PE20181322A1 (es) 2015-09-01 2018-08-14 Agenus Inc Anticuerpo anti-pd1 y sus metodos de uso
AU2016332725A1 (en) 2015-09-29 2018-03-22 Celgene Corporation PD-1 binding proteins and methods of use thereof
BR112018008904A2 (pt) 2015-11-03 2018-11-27 Janssen Biotech Inc anticorpos que se ligam especificamente a tim-3 e seus usos
EP3471753A1 (en) 2016-06-20 2019-04-24 Kymab Limited Anti-pd-l1 and il-2 cytokines
WO2018007885A1 (en) 2016-07-05 2018-01-11 Beigene, Ltd. COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER
WO2018027524A1 (en) * 2016-08-09 2018-02-15 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibody formulation
WO2018033135A1 (en) 2016-08-19 2018-02-22 Beigene, Ltd. Use of a combination comprising a btk inhibitor for treating cancers
US10751414B2 (en) 2016-09-19 2020-08-25 Celgene Corporation Methods of treating psoriasis using PD-1 binding antibodies
US10766958B2 (en) 2016-09-19 2020-09-08 Celgene Corporation Methods of treating vitiligo using PD-1 binding antibodies
JP6967515B2 (ja) * 2016-10-15 2021-11-17 イノベント バイオロジックス (スウツォウ) カンパニー,リミテッド Pd−1抗体
WO2018081621A1 (en) 2016-10-28 2018-05-03 Bristol-Myers Squibb Company Methods of treating urothelial carcinoma using an anti-pd-1 antibody
KR20230141941A (ko) 2016-11-03 2023-10-10 브리스톨-마이어스 스큅 컴퍼니 활성화가능한 항-ctla-4 항체 및 그의 용도
JOP20190133A1 (ar) 2016-12-08 2019-06-02 Innovent Biologics Suzhou Co Ltd أجسام مضادة لـ Tim-3 لمزجها بأجسام مضادة لـ PD-1
US11512134B2 (en) 2017-08-01 2022-11-29 Eli Lilly And Company Anti-CD137 antibodies
CN117586401A (zh) 2017-01-20 2024-02-23 大有华夏生物医药集团有限公司 抗pd-1抗体及其用途
EP3573989A4 (en) 2017-01-25 2020-11-18 Beigene, Ltd. CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) -PIPERIDINE-4-YL) -2- (4-PHENOXYPHENYL) -4,5,6,7-TETRAHYDROPYRAZOLO [1,5-A ] PYRIMIDINE-3-CARBOXAMIDE, MANUFACTURING AND USES THEREOF
TWI674261B (zh) 2017-02-17 2019-10-11 美商英能腫瘤免疫股份有限公司 Nlrp3 調節劑
WO2018160540A1 (en) 2017-02-28 2018-09-07 Sanofi Therapeutic rna
WO2018183928A1 (en) 2017-03-31 2018-10-04 Bristol-Myers Squibb Company Methods of treating tumor
TWI788340B (zh) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 抗icos促效劑抗體及其用途
CA3065304A1 (en) 2017-05-30 2018-12-06 Bristol-Myers Squibb Company Compositions comprising an anti-lag-3 antibody or an anti-lag-3 antibody and an anti-pd-1 or anti-pd-l1 antibody
CA3060989A1 (en) 2017-05-30 2018-12-06 Bristol-Myers Squibb Company Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent
WO2018222718A1 (en) 2017-05-30 2018-12-06 Bristol-Myers Squibb Company Treatment of lag-3 positive tumors
WO2018223040A1 (en) 2017-06-01 2018-12-06 Bristol-Myers Squibb Company Methods of treating a tumor using an anti-pd-1 antibody
AU2018290532A1 (en) 2017-06-26 2019-11-21 Beigene, Ltd. Immunotherapy for hepatocellular carcinoma
AR112603A1 (es) 2017-07-10 2019-11-20 Lilly Co Eli Anticuerpos biespecíficos inhibidores de punto de control
BR112020000523A2 (pt) 2017-07-14 2020-07-14 Innate Tumor Immunity, Inc. moduladores de nlrp3
WO2019075468A1 (en) 2017-10-15 2019-04-18 Bristol-Myers Squibb Company TUMOR TREATMENT METHODS
CN111315397A (zh) 2017-11-06 2020-06-19 百时美施贵宝公司 治疗肿瘤的方法
US11786529B2 (en) 2017-11-29 2023-10-17 Beigene Switzerland Gmbh Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
WO2019129137A1 (zh) 2017-12-27 2019-07-04 信达生物制药(苏州)有限公司 抗lag-3抗体及其用途
CN109970856B (zh) 2017-12-27 2022-08-23 信达生物制药(苏州)有限公司 抗lag-3抗体及其用途
WO2019143607A1 (en) 2018-01-16 2019-07-25 Bristol-Myers Squibb Company Methods of treating cancer with antibodies against tim3
EP3743061A1 (en) 2018-01-22 2020-12-02 Pascal Biosciences Inc. Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells
KR20200112904A (ko) 2018-01-22 2020-10-05 브리스톨-마이어스 스큅 컴퍼니 암을 치료하는 조성물 및 방법
WO2019153200A1 (zh) 2018-02-08 2019-08-15 北京韩美药品有限公司 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备
KR20240017090A (ko) 2018-03-23 2024-02-06 일라이 릴리 앤드 캄파니 항-pd-1 항체와의 조합을 위한 항-cd137 항체
CN111886256A (zh) 2018-03-23 2020-11-03 百时美施贵宝公司 抗mica和/或micb抗体及其用途
CN111971306A (zh) 2018-03-30 2020-11-20 百时美施贵宝公司 治疗肿瘤的方法
US20210163581A1 (en) * 2018-04-02 2021-06-03 Alamab Therapeutics, Inc. Connexin 43 antibodies and use thereof
US20210155703A1 (en) 2018-04-04 2021-05-27 Bristol-Myers Squibb Company Anti-cd27 antibodies and uses thereof
US20210267964A1 (en) 2018-04-25 2021-09-02 Innate Tumor Immunity, Inc. Nlrp3 modulators
IL307925A (en) 2018-05-07 2023-12-01 Genmab As Combination of an antibody against 1-PD and conjugation of a drug with an antibody against TF for use in the treatment of cancer
JP2021523949A (ja) 2018-05-17 2021-09-09 ナンジン リーズ バイオラブズ カンパニー リミテッド Pd−1に結合する抗体及びその使用
EP3842070A4 (en) * 2018-07-18 2022-04-20 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. MEDICATED COMBINATION OF QUINOLINE DERIVATIVE AND ANTIBODY
CN112334488B (zh) * 2018-07-19 2023-12-08 伊莱利利公司 靶向免疫检查点的双特异性抗体
EP3823991A4 (en) * 2018-07-19 2022-08-03 Tayu Huaxia Biotech Medical Group Co., Ltd. ANTI-PD-1 ANTIBODIES, DOSAGES AND USES THEREOF
JP2021532058A (ja) 2018-07-25 2021-11-25 イノベント バイオロジックス (スウツォウ) カンパニー,リミテッド 抗tigit抗体及びその使用
EP3826660A1 (en) 2018-07-26 2021-06-02 Bristol-Myers Squibb Company Lag-3 combination therapy for the treatment of cancer
JP7433291B2 (ja) 2018-08-16 2024-02-19 イネイト・テューマー・イミュニティ・インコーポレイテッド イミダゾ[4,5-c]キノリン誘導体のNLRP3モジュレーター
JP7364663B2 (ja) 2018-08-16 2023-10-18 イネイト・テューマー・イミュニティ・インコーポレイテッド イミダゾ[4,5-c]キノリン誘導体のNLRP3モジュレーター
SG11202101486RA (en) 2018-08-16 2021-03-30 Innate Tumor Immunity Inc Substitued 4-amino-1h-imidazo[4,5-c]quinoline compounds and improved methods for their preparation
JP2022500002A (ja) 2018-09-21 2022-01-04 イノベント バイオロジックス (スウツォウ) カンパニー,リミテッド 新規インターロイキン2およびその使用
WO2020057645A1 (zh) 2018-09-21 2020-03-26 信达生物制药(苏州)有限公司 新型白介素2及其用途
CN111253486B (zh) * 2018-09-27 2023-09-29 再鼎医药(上海)有限公司 抗pd-1抗体及其用途
CN112839962A (zh) 2018-10-09 2021-05-25 百时美施贵宝公司 用于治疗癌症的抗mertk抗体
AU2019361124A1 (en) 2018-10-19 2021-06-03 Bristol-Myers Squibb Company Combination therapy for melanoma
EP3870609A1 (en) 2018-10-23 2021-09-01 Bristol-Myers Squibb Company Methods of treating tumor
CN111100846A (zh) * 2018-10-26 2020-05-05 上海元宋生物技术有限公司 表达pd-1结合蛋白的溶瘤病毒及其应用
JP2022509942A (ja) 2018-11-16 2022-01-25 ブリストル-マイヤーズ スクイブ カンパニー 抗nkg2a抗体およびその使用
KR20210098504A (ko) 2018-12-04 2021-08-10 브리스톨-마이어스 스큅 컴퍼니 다중 동위원소체 반응 모니터링에 의한 샘플내 보정 곡선을 사용한 분석 방법
EP3666905A1 (en) 2018-12-11 2020-06-17 Sanofi E. coli positive for pks island as marker of positive response to anti-pd1 therapy in colorectal cancer
EA202191763A1 (ru) 2018-12-21 2022-03-10 Озе Иммьюнотерапьютикс Бифункциональная молекула анти-pd-1/sirp
US20230071889A1 (en) 2018-12-21 2023-03-09 Ose Immunotherapeutics Bifunctional anti-pd-1/il-7 molecule
JP7340021B2 (ja) 2018-12-23 2023-09-06 エフ. ホフマン-ラ ロシュ アーゲー 予測腫瘍遺伝子変異量に基づいた腫瘍分類
CN111423510B (zh) 2019-01-10 2024-02-06 迈威(上海)生物科技股份有限公司 重组抗人pd-1抗体及其应用
KR20210102327A (ko) 2019-01-11 2021-08-19 일라이 릴리 앤드 캄파니 암 치료를 위한 tim-3 항체 및 다른 체크포인트 억제제와의 조합
WO2020150116A1 (en) 2019-01-14 2020-07-23 Innate Tumor Immunity, Inc. Nlrp3 modulators
US20220089572A1 (en) 2019-01-14 2022-03-24 Innate Tumor Immunity, Inc. Nlrp3 modulators
EP3911416A1 (en) 2019-01-14 2021-11-24 Innate Tumor Immunity, Inc. Substituted quinazolines as nlrp3 modulators, for use in the treatment of cancer
CN113301962A (zh) 2019-01-14 2021-08-24 先天肿瘤免疫公司 用于治疗癌症的杂环nlrp3调节剂
EP3914355A1 (en) 2019-01-21 2021-12-01 Sanofi Therapeutic rna and anti-pd1 antibodies for advanced stage solid tumor cancers
AU2020219112A1 (en) * 2019-02-04 2021-08-26 Alamab Therapeutics, Inc. Connexin 43 antibodies and use thereof
WO2020165374A1 (en) 2019-02-14 2020-08-20 Ose Immunotherapeutics Bifunctional molecule comprising il-15ra
KR20210146349A (ko) 2019-03-28 2021-12-03 브리스톨-마이어스 스큅 컴퍼니 종양을 치료하는 방법
EP3946625A1 (en) 2019-03-28 2022-02-09 Bristol-Myers Squibb Company Methods of treating tumor
AU2020281535A1 (en) 2019-05-24 2022-01-27 Merck Patent Gmbh Combination therapies using CDK inhibitors
JP2022534967A (ja) 2019-05-30 2022-08-04 ブリストル-マイヤーズ スクイブ カンパニー 多腫瘍遺伝子シグネチャーおよびその使用
CN114174537A (zh) 2019-05-30 2022-03-11 百时美施贵宝公司 细胞定位特征和组合疗法
JP2022534982A (ja) 2019-05-30 2022-08-04 ブリストル-マイヤーズ スクイブ カンパニー 細胞局在化シグネチャーおよびその使用
MX2021015054A (es) * 2019-06-05 2022-03-17 Anaptysbio Inc Agonista de pd-1 y metodo para usar el mismo.
JP6881658B2 (ja) 2019-07-05 2021-06-02 小野薬品工業株式会社 Pd−1/cd3二重特異性タンパク質による血液がん治療
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
EP4011918A4 (en) 2019-08-08 2023-08-23 ONO Pharmaceutical Co., Ltd. DUAL SPECIFIC PROTEIN
AU2020350795A1 (en) 2019-09-22 2022-03-31 Bristol-Myers Squibb Company Quantitative spatial profiling for LAG-3 antagonist therapy
KR20220066950A (ko) 2019-09-25 2022-05-24 브리스톨-마이어스 스큅 컴퍼니 암 요법을 위한 복합 바이오마커
CA3154522A1 (en) 2019-10-15 2021-04-22 Christopher Carl Frye Recombinantly engineered, lipase/esterase-deficient mammalian cell lines
WO2021088853A1 (zh) 2019-11-04 2021-05-14 正大天晴药业集团股份有限公司 喹啉衍生物与pd-1单抗的药物组合
JP2022553821A (ja) 2019-11-05 2022-12-26 ブリストル-マイヤーズ スクイブ カンパニー M-タンパク質アッセイおよびその使用
WO2021092221A1 (en) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
WO2021092220A1 (en) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
US20220411499A1 (en) 2019-11-08 2022-12-29 Bristol-Myers Squibb Company LAG-3 Antagonist Therapy for Melanoma
EP4058465A1 (en) 2019-11-14 2022-09-21 Cohbar Inc. Cxcr4 antagonist peptides
TWI820361B (zh) 2019-11-27 2023-11-01 南韓商Gi醫諾微新股份有限公司 包含含有il-2蛋白與cd80蛋白之融合蛋白及免疫檢查點抑制劑的用於治療癌症的藥學組成物
WO2021122866A1 (en) 2019-12-17 2021-06-24 Ose Immunotherapeutics Bifunctional molecules comprising an il-7 variant
CN115243721A (zh) 2019-12-19 2022-10-25 百时美施贵宝公司 Dgk抑制剂和检查点拮抗剂的组合
TW202128224A (zh) * 2019-12-23 2021-08-01 大陸商信達生物製藥(蘇州)有限公司 抗pd-1抗體和組蛋白去乙醯化酶抑制劑的藥物組合及其用途、使用方法
KR20220127848A (ko) 2020-01-10 2022-09-20 인네이트 튜머 이뮤니티, 인코포레이티드 Nlrp3 조정제
TW202128171A (zh) * 2020-01-13 2021-08-01 大陸商信達生物製藥(蘇州)有限公司 抗pd-1抗體和喹唑啉衍生物的藥物組合以及其用途、使用其的方法
WO2021152005A1 (en) 2020-01-28 2021-08-05 Universite De Strasbourg Antisense oligonucleotide targeting linc00518 for treating melanoma
BR112022014962A2 (pt) 2020-01-30 2022-09-20 Ona Therapeutics S L Terapia de combinação para tratamento de câncer e metástase de câncer
JP2023514152A (ja) 2020-02-06 2023-04-05 ブリストル-マイヤーズ スクイブ カンパニー Il-10およびその使用
US20230235073A1 (en) 2020-03-06 2023-07-27 Ona Therapeutics, S.L. Anti-cd36 antibodies and their use to treat cancer
BR112022017637A2 (pt) 2020-03-06 2022-11-08 Celgene Quanticel Res Inc Métodos de tratamento do câncer de pulmão de células pequenas e/ou câncer de pulmão de células não pequenas
TW202200191A (zh) 2020-03-18 2022-01-01 南韓商Gi醫諾微新股份有限公司 包含含有il-2蛋白與cd80蛋白之融合蛋白及抗癌藥物的用於治療癌症的藥學組成物
IL296673A (en) 2020-03-23 2022-11-01 Bristol Myers Squibb Co Anti-ccr8 antibodies for cancer treatment
CN115867808A (zh) * 2020-05-01 2023-03-28 瑞泽恩制药公司 用于治疗蛋白的中和抗体测定
EP4143229A1 (en) 2020-05-01 2023-03-08 NGM Biopharmaceuticals, Inc. Ilt-binding agents and methods of use thereof
CN115943312A (zh) 2020-05-07 2023-04-07 法国居里学院 免疫抑制性成纤维细胞群体的生物标志物antxr1及其在预测对免疫疗法的反应中的用途
WO2021228069A1 (zh) * 2020-05-12 2021-11-18 信达生物制药(苏州)有限公司 抗vegf抗体和抗pd-1抗体组合用于预防或治疗疾病的应用
AU2021306613A1 (en) 2020-07-07 2023-02-02 BioNTech SE Therapeutic RNA for HPV-positive cancer
BR112023003427A2 (pt) 2020-08-28 2023-03-21 Bristol Myers Squibb Co Terapia com antagonista de lag-3 para carcinoma hepatocelular
EP4204453A1 (en) 2020-08-31 2023-07-05 Bristol-Myers Squibb Company Cell localization signature and immunotherapy
KR20230080460A (ko) 2020-10-05 2023-06-07 브리스톨-마이어스 스큅 컴퍼니 단백질을 농축시키는 방법
US20230364127A1 (en) 2020-10-06 2023-11-16 Codiak Biosciences, Inc. Extracellular vesicle-aso constructs targeting stat6
EP4226377A1 (en) 2020-10-09 2023-08-16 Worldwide Innovative Network Novel prediction method and gene signatures for the treatment of cancer
CA3196496A1 (en) 2020-10-23 2022-04-28 Laurence David TOMS Lag-3 antagonist therapy for lung cancer
KR20230098279A (ko) 2020-10-28 2023-07-03 이케나 온콜로지, 인코포레이티드 Pdx 억제제 또는 독소루비신과 ahr 억제제의 조합
AU2021383611A1 (en) 2020-11-17 2023-06-29 Peter Maccallum Cancer Institute Methods of treating cancer with a combination of tucatinib and an anti-pd-1/anti-pd-l1 antibody
WO2022112198A1 (en) 2020-11-24 2022-06-02 Worldwide Innovative Network Method to select the optimal immune checkpoint therapies
WO2022118197A1 (en) 2020-12-02 2022-06-09 Pfizer Inc. Time to resolution of axitinib-related adverse events
WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
CN114601924A (zh) * 2020-12-09 2022-06-10 信达生物制药(苏州)有限公司 抗pd-1抗体或其抗原结合片段治疗鳞状非小细胞肺癌的方法
AU2021402065A1 (en) 2020-12-17 2023-06-29 Ose Immunotherapeutics Bifunctional anti-pd1/il-7 molecules
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性rna
WO2022146948A1 (en) 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Subcutaneous administration of pd1/pd-l1 antibodies
WO2022146947A1 (en) 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
US20240034795A1 (en) 2020-12-31 2024-02-01 Innovent Biologics (Suzhou) Co., Ltd. Protein containing heterodimer antibody fc, and preparation method therefor
WO2022148781A1 (en) 2021-01-05 2022-07-14 Institut Curie Combination of mcoln activators and immune checkpoint inhibitors
CN116761889A (zh) * 2021-01-29 2023-09-15 明慧医药(杭州)有限公司 抗原结合蛋白及其用途
TW202304506A (zh) 2021-03-25 2023-02-01 日商安斯泰來製藥公司 涉及抗claudin 18.2抗體的組合治療以治療癌症
EP4313127A1 (en) 2021-03-29 2024-02-07 Juno Therapeutics, Inc. Methods for dosing and treatment with a combination of a checkpoint inhibitor therapy and a car t cell therapy
JP2024514530A (ja) 2021-04-02 2024-04-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 切断型cdcp1に対する抗体およびその使用
EP4320156A1 (en) 2021-04-09 2024-02-14 Ose Immunotherapeutics Scaffold for bifunctioanl molecules comprising pd-1 or cd28 and sirp binding domains
KR20240005741A (ko) 2021-04-09 2024-01-12 오제 이뮈노테라프틱스 특성이 향상된 이작용성 분자용 신규한 스캐폴드
GB202107994D0 (en) 2021-06-04 2021-07-21 Kymab Ltd Treatment of cancer
AU2022312698A1 (en) 2021-07-13 2024-01-25 BioNTech SE Multispecific binding agents against cd40 and cd137 in combination therapy for cancer
WO2023007472A1 (en) 2021-07-30 2023-02-02 ONA Therapeutics S.L. Anti-cd36 antibodies and their use to treat cancer
CN113621066A (zh) * 2021-08-31 2021-11-09 安徽瀚海博兴生物技术有限公司 一种抗pd-1抗体及其晶体制备方法
WO2023040804A1 (zh) * 2021-09-14 2023-03-23 信达生物制药(苏州)有限公司 抗pd-1抗体和化疗药的药物组合及其使用方法
WO2023045977A1 (zh) * 2021-09-22 2023-03-30 信达生物制药(苏州)有限公司 白介素2突变体以及其融合蛋白
WO2023051926A1 (en) 2021-09-30 2023-04-06 BioNTech SE Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists
TW202327595A (zh) 2021-10-05 2023-07-16 美商輝瑞大藥廠 用於治療癌症之氮雜內醯胺化合物的組合
WO2023057534A1 (en) 2021-10-06 2023-04-13 Genmab A/S Multispecific binding agents against pd-l1 and cd137 in combination
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
WO2023077090A1 (en) 2021-10-29 2023-05-04 Bristol-Myers Squibb Company Lag-3 antagonist therapy for hematological cancer
WO2023079428A1 (en) 2021-11-03 2023-05-11 Pfizer Inc. Combination therapies using tlr7/8 agonist
WO2023083439A1 (en) 2021-11-09 2023-05-19 BioNTech SE Tlr7 agonist and combinations for cancer treatment
WO2023147371A1 (en) 2022-01-26 2023-08-03 Bristol-Myers Squibb Company Combination therapy for hepatocellular carcinoma
WO2023164638A1 (en) 2022-02-25 2023-08-31 Bristol-Myers Squibb Company Combination therapy for colorectal carcinoma
WO2023168404A1 (en) 2022-03-04 2023-09-07 Bristol-Myers Squibb Company Methods of treating a tumor
WO2023170606A1 (en) 2022-03-08 2023-09-14 Alentis Therapeutics Ag Use of anti-claudin-1 antibodies to increase t cell availability
WO2023178329A1 (en) 2022-03-18 2023-09-21 Bristol-Myers Squibb Company Methods of isolating polypeptides
WO2023196987A1 (en) 2022-04-07 2023-10-12 Bristol-Myers Squibb Company Methods of treating tumor
WO2023196964A1 (en) 2022-04-08 2023-10-12 Bristol-Myers Squibb Company Machine learning identification, classification, and quantification of tertiary lymphoid structures
WO2023211068A1 (ko) 2022-04-25 2023-11-02 웰마커바이오 주식회사 항-igsf1 항체 및 항-pd-1 항체를 포함하는 암 치료용 약학 조성물
WO2023218046A1 (en) 2022-05-12 2023-11-16 Genmab A/S Binding agents capable of binding to cd27 in combination therapy
WO2023235847A1 (en) 2022-06-02 2023-12-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
WO2024003360A1 (en) 2022-07-01 2024-01-04 Institut Curie Biomarkers and uses thereof for the treatment of neuroblastoma
EP4310197A1 (en) 2022-07-21 2024-01-24 Fundación para la Investigación Biomédica del Hospital Universitario Puerta de Hierro Majadahonda Method for identifying lung cancer patients for a combination treatment of immuno- and chemotherapy
WO2024023740A1 (en) 2022-07-27 2024-02-01 Astrazeneca Ab Combinations of recombinant virus expressing interleukin-12 with pd-1/pd-l1 inhibitors
WO2024028386A1 (en) 2022-08-02 2024-02-08 Ose Immunotherapeutics Multifunctional molecule directed against cd28
WO2024069009A1 (en) 2022-09-30 2024-04-04 Alentis Therapeutics Ag Treatment of drug-resistant hepatocellular carcinoma

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2539411T3 (es) 1999-08-23 2015-06-30 Dana-Farber Cancer Institute, Inc. PD-1, receptor para la B7-4 y su utilización
EP2388590A1 (en) 2001-04-02 2011-11-23 Dana Farber Cancer Institute PD-1, a receptor for B7-4, and uses thereof
ATE524495T1 (de) 2001-07-31 2011-09-15 Ono Pharmaceutical Co Pd-1-spezifische substanz
EP3287144A1 (en) 2002-07-03 2018-02-28 ONO Pharmaceutical Co., Ltd. Immunopotentiating compositions
CN101899114A (zh) * 2002-12-23 2010-12-01 惠氏公司 抗pd-1抗体及其用途
KR20050107399A (ko) 2003-01-23 2005-11-11 오노 야꾸힝 고교 가부시키가이샤 인간 pd-1에 대하여 특이성을 갖는 물질
GB0400440D0 (en) 2004-01-09 2004-02-11 Isis Innovation Receptor modulators
PT1810026T (pt) 2004-10-06 2018-06-11 Mayo Found Medical Education & Res B7-h1 e pd-1 no tratamento do carcinona de células renais
PL2439273T3 (pl) * 2005-05-09 2019-08-30 Ono Pharmaceutical Co., Ltd. Ludzkie przeciwciała monoklonalne przeciwko białku programowanej śmierci komórki 1(pd-1) oraz metody leczenia nowotworów z wykorzystaniem przeciwciał anty-pd-1 samodzielnie lub w połączeniu z innymi immunoterapeutykami
PL1907000T5 (pl) 2005-06-08 2020-11-16 Dana-Farber Cancer Institute Metody i kompozycje do leczenia infekcji przetrwałych
NZ600281A (en) * 2006-12-27 2013-03-28 Harvard College Compositions and methods for the treatment of infections and tumors
EP2170959B1 (en) 2007-06-18 2013-10-02 Merck Sharp & Dohme B.V. Antibodies to human programmed death receptor pd-1
AU2008329530A1 (en) 2007-11-28 2009-06-04 Universite De Montreal PD-1 modulation and uses thereof
EP2262837A4 (en) 2008-03-12 2011-04-06 Merck Sharp & Dohme PD-1 BINDING PROTEINS
EP2342228B1 (en) 2008-09-12 2017-09-06 Oxford University Innovation Limited Pd-1 specific antibodies and uses thereof
AU2009290544B2 (en) 2008-09-12 2015-07-16 Oxford University Innovation Limited PD-1 specific antibodies and uses thereof
AU2009296392B2 (en) * 2008-09-26 2016-06-02 Dana-Farber Cancer Institute, Inc. Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor
PT2691112T (pt) * 2011-03-31 2018-07-10 Merck Sharp & Dohme Formulações estáveis de anticorpos para o recetor pd-1 humano de morte programada e tratamentos relacionados
DK2699264T3 (en) 2011-04-20 2018-06-25 Medimmune Llc ANTIBODIES AND OTHER MOLECULES BINDING B7-H1 AND PD-1
AU2012290121B2 (en) * 2011-08-01 2015-11-26 Genentech, Inc. Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors
CN105209919B (zh) * 2013-03-15 2019-03-05 豪夫迈·罗氏有限公司 治疗pd-1和pd-l1相关疾患的生物标志物和方法
LT2992017T (lt) 2013-05-02 2021-02-25 Anaptysbio, Inc. Antikūnai nukreipti prieš programuotos žūties baltymą-1 (pd-1)
CN103242448B (zh) * 2013-05-27 2015-01-14 郑州大学 一种全人源化抗pd-1单克隆抗体及其制备方法和应用
WO2014194302A2 (en) 2013-05-31 2014-12-04 Sorrento Therapeutics, Inc. Antigen binding proteins that bind pd-1
CN104250302B (zh) * 2013-06-26 2017-11-14 上海君实生物医药科技股份有限公司 抗pd‑1抗体及其应用
US10077305B2 (en) 2013-09-10 2018-09-18 Medimmune Limited Antibodies against PD-1 and uses thereof
CN112552401B (zh) 2013-09-13 2023-08-25 广州百济神州生物制药有限公司 抗pd1抗体及其作为治疗剂与诊断剂的用途
ME03527B (me) * 2013-12-12 2020-04-20 Shanghai hengrui pharmaceutical co ltd Pd-1 antitijelo, njegov fragment koji se vezuje na antigen, i njegova medicinska primjena

Also Published As

Publication number Publication date
MX365390B (es) 2019-05-31
CN108473977A (zh) 2018-08-31
BR112018002274B1 (pt) 2021-12-07
EP3334824A1 (en) 2018-06-20
CA2990492C (en) 2021-11-23
TWI674275B (zh) 2019-10-11
BR112018002274A2 (pt) 2018-12-11
US20170044260A1 (en) 2017-02-16
AU2016307002B2 (en) 2019-07-11
CN108473977B (zh) 2019-03-26
HK1255195B (zh) 2020-04-09
LT3334824T (lt) 2022-02-25
WO2017024465A1 (en) 2017-02-16
RU2686612C1 (ru) 2019-04-29
IL256844A (en) 2018-03-29
ES2904586T3 (es) 2022-04-05
RS62897B1 (sr) 2022-03-31
WO2017025016A1 (en) 2017-02-16
NZ738979A (en) 2019-10-25
CA2990492A1 (en) 2017-02-16
IL256844B (en) 2022-08-01
EP3334824A4 (en) 2019-01-23
CN110003339B (zh) 2022-06-28
TW201713698A (en) 2017-04-16
PT3334824T (pt) 2022-02-08
SI3334824T1 (sl) 2022-04-29
AU2016307002A1 (en) 2018-02-01
HRP20220111T1 (hr) 2022-04-15
JP2018531986A (ja) 2018-11-01
MY199019A (en) 2023-10-09
EP3334824B1 (en) 2021-11-17
CY1124955T1 (el) 2023-01-05
KR20180030580A (ko) 2018-03-23
JP6513296B2 (ja) 2019-05-15
CN110003339A (zh) 2019-07-12
AR105489A1 (es) 2017-10-11
KR102132100B1 (ko) 2020-07-08
US10316089B2 (en) 2019-06-11
HUE058273T2 (hu) 2022-07-28
MX2018001671A (es) 2018-09-26
DK3334824T3 (da) 2022-02-07

Similar Documents

Publication Publication Date Title
HK1255195B (zh) Pd-1抗體
HK1253507A1 (zh) 抗 ror1 抗體
HK1254836A1 (zh) 抗-ror1抗體
HK1256116A1 (zh) 抗lag-3抗體
GB201521391D0 (en) Antibodies
GB201521393D0 (en) Antibodies
HK1246804A1 (zh) Tau結合抗體
GB201521382D0 (en) Antibodies
IL253633A0 (en) Anti-transthyretin antibodies
IL255323A0 (en) Anti-fcrn antibodies
HK1255056A1 (zh) 抗cd115抗體
PL3250593T3 (pl) Przeciwciała przeciwko transtyretynie
GB201509907D0 (en) Antibodies
GB201522394D0 (en) Antibodies
GB201503438D0 (en) Antibodies
ZA201800781B (en) Pd-1 antibodies
IL284022A (en) Anti-transthyretin antibodies
GB201518728D0 (en) Antibodies
GB201515570D0 (en) Anti-LAG-3 antibodies
GB201515572D0 (en) Anti-LAG-3 antibodies
GB201514425D0 (en) Antibodies
GB201508444D0 (en) Antibodies
GB201508437D0 (en) Antibodies
GB201507541D0 (en) Antibodies
GB201504858D0 (en) Antibodies