MX2015009986A - Agonistas del receptor de esfingosina-1-fosfato, metodos para prepararlos y composiciones farmaceuticas que contienen los mismos como un agente activo. - Google Patents
Agonistas del receptor de esfingosina-1-fosfato, metodos para prepararlos y composiciones farmaceuticas que contienen los mismos como un agente activo.Info
- Publication number
- MX2015009986A MX2015009986A MX2015009986A MX2015009986A MX2015009986A MX 2015009986 A MX2015009986 A MX 2015009986A MX 2015009986 A MX2015009986 A MX 2015009986A MX 2015009986 A MX2015009986 A MX 2015009986A MX 2015009986 A MX2015009986 A MX 2015009986A
- Authority
- MX
- Mexico
- Prior art keywords
- same
- sphingosine
- preparing
- receptor agonists
- phosphate receptor
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
La presente invención se relaciona a compuestos novedosos de la Fórmula 1 como agonistas del receptor de esfingosina-1-fosfato que se pueden utilizar efectivamente para el tratamiento de enfermedades autoinmunes, un método para prepararlos, y una composición farmacéutica que comprende los mismos como un componente activo. Los compuestos de acuerdo con la presente invención son efectivos en enfermedades autoinmunes extensivas y enfermedades inflamatorias crónicas que incluyen esclerosis múltiple remitente de recaída, y también se pueden utilizar para tratar o prevenir trastornos de inmunorregulación.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20130018293 | 2013-02-20 | ||
PCT/KR2014/001336 WO2014129796A1 (en) | 2013-02-20 | 2014-02-19 | Sphingosine-1-phosphate receptor agonists, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2015009986A true MX2015009986A (es) | 2015-10-05 |
MX370032B MX370032B (es) | 2019-11-28 |
Family
ID=51391525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015009986A MX370032B (es) | 2013-02-20 | 2014-02-19 | Agonistas del receptor de esfingosina-1-fosfato, metodos para prepararlos y composiciones farmaceuticas que contienen los mismos como un agente activo. |
Country Status (17)
Country | Link |
---|---|
US (1) | US9540362B2 (es) |
EP (1) | EP2958913B1 (es) |
JP (1) | JP6294359B2 (es) |
KR (1) | KR101939657B1 (es) |
CN (1) | CN105051037B (es) |
AU (1) | AU2014219575B2 (es) |
BR (1) | BR112015019794B1 (es) |
DK (1) | DK2958913T3 (es) |
ES (1) | ES2698359T3 (es) |
HU (1) | HUE039931T2 (es) |
MX (1) | MX370032B (es) |
PL (1) | PL2958913T3 (es) |
PT (1) | PT2958913T (es) |
RU (1) | RU2654483C2 (es) |
SI (1) | SI2958913T1 (es) |
TW (1) | TWI582073B (es) |
WO (1) | WO2014129796A1 (es) |
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TWI692469B (zh) * | 2012-11-09 | 2020-05-01 | 南韓商Lg化學股份有限公司 | Gpr40受體促效劑,製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物 |
KR102644587B1 (ko) * | 2015-12-24 | 2024-03-07 | (주)아모레퍼시픽 | 유사 세라마이드 화합물 및 그 제조방법 |
JP6950534B2 (ja) * | 2016-01-29 | 2021-10-13 | 小野薬品工業株式会社 | テトラヒドロナフタレン誘導体 |
US11192886B2 (en) * | 2016-07-22 | 2021-12-07 | Medshine Discovery Inc. | S1P1 agonist and application thereof |
EP3592739A1 (en) | 2017-03-07 | 2020-01-15 | H. Hoffnabb-La Roche Ag | Oxadiazole transient receptor potential channel inhibitors |
CN107382965A (zh) * | 2017-08-14 | 2017-11-24 | 河南科技大学第附属医院 | 具有抗肿瘤活性的新型s1p‑1受体激动剂药物分子的合成方法 |
KR101891051B1 (ko) * | 2018-01-29 | 2018-08-31 | 주식회사 세종바이오메드 | 스핑고신-1-포스페이트 유사체 및 이의 합성 방법 |
US10710994B2 (en) | 2018-03-19 | 2020-07-14 | Genentech, Inc. | Oxadiazole transient receptor potential channel inhibitors |
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CN110240537B (zh) * | 2019-05-22 | 2022-06-21 | 成都阿奇生物医药科技有限公司 | 一种茚氧乙酸类化合物及其制备方法和用途 |
JP7427314B2 (ja) * | 2019-12-03 | 2024-02-05 | エルジー・ケム・リミテッド | スフィンゴシン-1-リン酸受容体アゴニスト、その製造方法、およびそれを活性成分として含有する医薬組成物 |
KR20210073998A (ko) | 2019-12-11 | 2021-06-21 | 주식회사 엘지화학 | 다발성 경화증 예방 또는 치료용 약제학적 조성물 |
TW202220651A (zh) * | 2020-09-28 | 2022-06-01 | 南韓商Lg化學股份有限公司 | 神經鞘胺醇-1-磷酸受體促效劑的用途 |
TW202402285A (zh) | 2020-09-28 | 2024-01-16 | 南韓商Lg化學股份有限公司 | 神經鞘胺醇-1-磷酸受體促效劑的用途 |
WO2022080812A1 (ko) * | 2020-10-13 | 2022-04-21 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조 방법 |
EP4219443A4 (en) * | 2020-10-13 | 2024-04-17 | Lg Chemical Ltd | METHOD FOR PREPARING INTERMEDIATE FOR SYNTHESIS OF SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST |
CN117242057A (zh) | 2021-04-14 | 2023-12-15 | 株式会社Lg化学 | 制备用于合成鞘氨醇-1-磷酸酯受体激动剂的中间体的方法 |
CN117120425A (zh) * | 2021-04-14 | 2023-11-24 | 株式会社Lg化学 | 鞘氨醇-1-磷酸酯受体激动剂的晶体形式 |
CN117202893A (zh) * | 2021-04-14 | 2023-12-08 | 株式会社Lg化学 | 包含鞘氨醇-1-磷酸受体激动剂的可直接压缩的药物组合物 |
CN117203197A (zh) | 2021-04-14 | 2023-12-08 | 株式会社Lg化学 | 鞘氨醇-1-磷酸酯受体激动剂的药学上可接受的盐及其结晶形式 |
TWI823341B (zh) * | 2021-04-14 | 2023-11-21 | 南韓商Lg化學股份有限公司 | 製備鞘胺醇-1-磷酸酯受體促效劑的新穎方法 |
CN117120037A (zh) | 2021-04-14 | 2023-11-24 | 株式会社Lg化学 | 包含具有受控粒度的鞘氨醇-1-磷酸酯受体激动剂的药物组合物 |
WO2022220597A1 (ko) * | 2021-04-14 | 2022-10-20 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제의 결정형 |
KR20220142378A (ko) * | 2021-04-14 | 2022-10-21 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제를 포함하는 고형 제제의 제조 방법 |
KR20220142388A (ko) * | 2021-04-14 | 2022-10-21 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제의 신규한 제조방법 |
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2014
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- 2014-02-19 KR KR1020140019113A patent/KR101939657B1/ko active IP Right Grant
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- 2014-02-19 RU RU2015139594A patent/RU2654483C2/ru active
- 2014-02-19 HU HUE14753476A patent/HUE039931T2/hu unknown
- 2014-02-19 AU AU2014219575A patent/AU2014219575B2/en active Active
- 2014-02-19 ES ES14753476T patent/ES2698359T3/es active Active
- 2014-02-19 EP EP14753476.2A patent/EP2958913B1/en active Active
- 2014-02-19 PT PT14753476T patent/PT2958913T/pt unknown
- 2014-02-19 BR BR112015019794-9A patent/BR112015019794B1/pt active IP Right Grant
- 2014-02-19 US US14/764,116 patent/US9540362B2/en active Active
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- 2014-02-19 CN CN201480009397.9A patent/CN105051037B/zh active Active
- 2014-02-19 DK DK14753476.2T patent/DK2958913T3/en active
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Also Published As
Publication number | Publication date |
---|---|
JP2016513126A (ja) | 2016-05-12 |
ES2698359T3 (es) | 2019-02-04 |
DK2958913T3 (en) | 2018-11-05 |
RU2654483C2 (ru) | 2018-05-21 |
RU2015139594A (ru) | 2017-03-27 |
AU2014219575B2 (en) | 2017-07-06 |
CN105051037B (zh) | 2018-05-18 |
SI2958913T1 (sl) | 2018-12-31 |
BR112015019794B1 (pt) | 2022-09-13 |
BR112015019794A8 (pt) | 2018-08-14 |
AU2014219575A1 (en) | 2015-08-20 |
TW201444794A (zh) | 2014-12-01 |
TWI582073B (zh) | 2017-05-11 |
EP2958913A4 (en) | 2016-10-05 |
PT2958913T (pt) | 2018-12-03 |
PL2958913T3 (pl) | 2019-03-29 |
WO2014129796A1 (en) | 2014-08-28 |
CN105051037A (zh) | 2015-11-11 |
JP6294359B2 (ja) | 2018-03-14 |
MX370032B (es) | 2019-11-28 |
EP2958913A1 (en) | 2015-12-30 |
KR20140104376A (ko) | 2014-08-28 |
US20150376173A1 (en) | 2015-12-31 |
BR112015019794A2 (pt) | 2017-07-18 |
US9540362B2 (en) | 2017-01-10 |
EP2958913B1 (en) | 2018-10-03 |
KR101939657B1 (ko) | 2019-01-17 |
HUE039931T2 (hu) | 2019-02-28 |
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