BR112015019794A8 - Composto, composição farmacêutica, agonista do receptor de esfingosina-1-fosfato, e, uso de um composto - Google Patents
Composto, composição farmacêutica, agonista do receptor de esfingosina-1-fosfato, e, uso de um compostoInfo
- Publication number
- BR112015019794A8 BR112015019794A8 BR112015019794A BR112015019794A BR112015019794A8 BR 112015019794 A8 BR112015019794 A8 BR 112015019794A8 BR 112015019794 A BR112015019794 A BR 112015019794A BR 112015019794 A BR112015019794 A BR 112015019794A BR 112015019794 A8 BR112015019794 A8 BR 112015019794A8
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- sphingosine
- pharmaceutical composition
- phosphate receptor
- receptor agonist
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, AGONISTA DO RECEPTOR DE ESFINGOSINA-1-FOSFATO, E, USO DE UM COMPOSTO A presente invenção refere-se a novos compostos da Fórmula 1 como agonistas do receptor de esfingosina-1-fosfato que podem ser eficazmente usados para o tratamento de doenças autoimunes, um método para preparar os mesmos e uma composição farmacêutica compreendendo os mesmos como um componente ativo. Os compostos de acordo com a presente invenção são eficazes nas doenças autoimunes extensivas e doenças inflamatórias crônicas incluindo a esclerose múltipla remitente-recorrente e também podem ser usados para tratar ou prevenir distúrbios de imunorregulagem.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20130018293 | 2013-02-20 | ||
KR10-2013-0018293 | 2013-02-20 | ||
PCT/KR2014/001336 WO2014129796A1 (en) | 2013-02-20 | 2014-02-19 | Sphingosine-1-phosphate receptor agonists, methods of preparing the same, and pharmaceutical compositions containing the same as an active agent |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112015019794A2 BR112015019794A2 (pt) | 2017-07-18 |
BR112015019794A8 true BR112015019794A8 (pt) | 2018-08-14 |
BR112015019794B1 BR112015019794B1 (pt) | 2022-09-13 |
Family
ID=51391525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015019794-9A BR112015019794B1 (pt) | 2013-02-20 | 2014-02-19 | Composto, composição farmacêutica, agonista do receptor de esfingosina-1-fosfato, e, uso de um composto |
Country Status (17)
Country | Link |
---|---|
US (1) | US9540362B2 (pt) |
EP (1) | EP2958913B1 (pt) |
JP (1) | JP6294359B2 (pt) |
KR (1) | KR101939657B1 (pt) |
CN (1) | CN105051037B (pt) |
AU (1) | AU2014219575B2 (pt) |
BR (1) | BR112015019794B1 (pt) |
DK (1) | DK2958913T3 (pt) |
ES (1) | ES2698359T3 (pt) |
HU (1) | HUE039931T2 (pt) |
MX (1) | MX370032B (pt) |
PL (1) | PL2958913T3 (pt) |
PT (1) | PT2958913T (pt) |
RU (1) | RU2654483C2 (pt) |
SI (1) | SI2958913T1 (pt) |
TW (1) | TWI582073B (pt) |
WO (1) | WO2014129796A1 (pt) |
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JP7178357B2 (ja) * | 2017-03-07 | 2022-11-25 | エフ.ホフマン-ラ ロシュ アーゲー | オキサジアゾール一過性受容器電位チャネル阻害剤 |
CN107382965A (zh) * | 2017-08-14 | 2017-11-24 | 河南科技大学第附属医院 | 具有抗肿瘤活性的新型s1p‑1受体激动剂药物分子的合成方法 |
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CN117202893A (zh) * | 2021-04-14 | 2023-12-08 | 株式会社Lg化学 | 包含鞘氨醇-1-磷酸受体激动剂的可直接压缩的药物组合物 |
CN117203189A (zh) * | 2021-04-14 | 2023-12-08 | 株式会社Lg化学 | 制备用于合成鞘氨醇-1-磷酸酯受体激动剂的中间体的方法 |
KR20220142379A (ko) * | 2021-04-14 | 2022-10-21 | 주식회사 엘지화학 | 습식과립법에 의한 스핑고신-1-인산 수용체 효능제를 포함하는 경구용 고형 제제의 제조 방법 |
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JP5988379B2 (ja) | 2009-11-13 | 2016-09-07 | レセプトス エルエルシー | スフィンゴシン−1−リン酸受容体変調因子および不斉合成方法 |
JP5939158B2 (ja) | 2009-11-24 | 2016-06-22 | アラーガン、インコーポレイテッドAllergan,Incorporated | 治療的有用性を有する受容体調節物質としての新規化合物 |
EP2390252A1 (en) * | 2010-05-19 | 2011-11-30 | Almirall, S.A. | New pyrazole derivatives |
CN103380112A (zh) * | 2010-11-24 | 2013-10-30 | 阿勒根公司 | 作为s1p受体调节剂的吲哚衍生物 |
TWI692469B (zh) * | 2012-11-09 | 2020-05-01 | 南韓商Lg化學股份有限公司 | Gpr40受體促效劑,製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物 |
-
2014
- 2014-02-19 TW TW103105447A patent/TWI582073B/zh active
- 2014-02-19 EP EP14753476.2A patent/EP2958913B1/en active Active
- 2014-02-19 BR BR112015019794-9A patent/BR112015019794B1/pt active IP Right Grant
- 2014-02-19 PT PT14753476T patent/PT2958913T/pt unknown
- 2014-02-19 MX MX2015009986A patent/MX370032B/es active IP Right Grant
- 2014-02-19 DK DK14753476.2T patent/DK2958913T3/en active
- 2014-02-19 KR KR1020140019113A patent/KR101939657B1/ko active IP Right Grant
- 2014-02-19 RU RU2015139594A patent/RU2654483C2/ru active
- 2014-02-19 PL PL14753476T patent/PL2958913T3/pl unknown
- 2014-02-19 ES ES14753476T patent/ES2698359T3/es active Active
- 2014-02-19 HU HUE14753476A patent/HUE039931T2/hu unknown
- 2014-02-19 US US14/764,116 patent/US9540362B2/en active Active
- 2014-02-19 CN CN201480009397.9A patent/CN105051037B/zh active Active
- 2014-02-19 SI SI201430907T patent/SI2958913T1/sl unknown
- 2014-02-19 WO PCT/KR2014/001336 patent/WO2014129796A1/en active Application Filing
- 2014-02-19 JP JP2015559180A patent/JP6294359B2/ja active Active
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Also Published As
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EP2958913B1 (en) | 2018-10-03 |
EP2958913A4 (en) | 2016-10-05 |
ES2698359T3 (es) | 2019-02-04 |
JP2016513126A (ja) | 2016-05-12 |
RU2015139594A (ru) | 2017-03-27 |
KR20140104376A (ko) | 2014-08-28 |
DK2958913T3 (en) | 2018-11-05 |
US9540362B2 (en) | 2017-01-10 |
KR101939657B1 (ko) | 2019-01-17 |
RU2654483C2 (ru) | 2018-05-21 |
MX370032B (es) | 2019-11-28 |
CN105051037A (zh) | 2015-11-11 |
PL2958913T3 (pl) | 2019-03-29 |
BR112015019794B1 (pt) | 2022-09-13 |
US20150376173A1 (en) | 2015-12-31 |
SI2958913T1 (sl) | 2018-12-31 |
MX2015009986A (es) | 2015-10-05 |
AU2014219575A1 (en) | 2015-08-20 |
AU2014219575B2 (en) | 2017-07-06 |
HUE039931T2 (hu) | 2019-02-28 |
JP6294359B2 (ja) | 2018-03-14 |
CN105051037B (zh) | 2018-05-18 |
PT2958913T (pt) | 2018-12-03 |
EP2958913A1 (en) | 2015-12-30 |
BR112015019794A2 (pt) | 2017-07-18 |
TW201444794A (zh) | 2014-12-01 |
TWI582073B (zh) | 2017-05-11 |
WO2014129796A1 (en) | 2014-08-28 |
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