MX2012001061A - Hidrogeles biodegradables insolubles en agua a base de polietilenglicol. - Google Patents

Hidrogeles biodegradables insolubles en agua a base de polietilenglicol.

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Publication number
MX2012001061A
MX2012001061A MX2012001061A MX2012001061A MX2012001061A MX 2012001061 A MX2012001061 A MX 2012001061A MX 2012001061 A MX2012001061 A MX 2012001061A MX 2012001061 A MX2012001061 A MX 2012001061A MX 2012001061 A MX2012001061 A MX 2012001061A
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MX
Mexico
Prior art keywords
water
backbone moieties
polyethylene glycol
hydrogel
hydrogels
Prior art date
Application number
MX2012001061A
Other languages
English (en)
Other versions
MX343925B (es
Inventor
Ulrich Hersel
Harald Rau
Dirk Vetter
Mathias Krusch
Tobias Voigt
Original Assignee
Ascendis Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Ascendis Pharma As filed Critical Ascendis Pharma As
Publication of MX2012001061A publication Critical patent/MX2012001061A/es
Publication of MX343925B publication Critical patent/MX343925B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Colloid Chemistry (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

La presente invención se refiere a hidrogeles insolubles en agua a base de polietilenglicol biodegradables que comprende porciones de armazón principal que están interconectadas por enlaces hidrolíticamente degradables, las porciones de armazón principal comprenden además grupos funcionales reactivos, en donde el hidrogel insoluble en agua se caracteriza además porque la relación entre el periodo de tiempo para la degradación completa del hidrogel por hidrólisis de los enlaces degradables en productos de degradación hidrosolubles que comprenden una o más porciones de armazón principal y el periodo de tiempo para liberación de los primeros 10% molares de productos de degradación hidrosolubles que comprenden una o más porciones de armazón principal con base en la cantidad total de porciones de armazón principal en el hidrogel es mayor que 1 e igual a o menor que 2. La invención se refiere además a conjugados de estos hidrogeles con ligandos o grupos de ligación, profármacos y composiciones farmacéuticas, así como a su uso en un medicamento.
MX2012001061A 2009-07-31 2010-07-30 Hidrogeles biodegradables insolubles en agua a base de polietilenglicol. MX343925B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09167026 2009-07-31
EP09172339 2009-10-06
PCT/EP2010/061155 WO2011012715A1 (en) 2009-07-31 2010-07-30 Biodegradable polyethylene glycol based water-insoluble hydrogels

Publications (2)

Publication Number Publication Date
MX2012001061A true MX2012001061A (es) 2012-03-26
MX343925B MX343925B (es) 2016-11-29

Family

ID=43027631

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012001061A MX343925B (es) 2009-07-31 2010-07-30 Hidrogeles biodegradables insolubles en agua a base de polietilenglicol.

Country Status (23)

Country Link
US (1) US11559482B2 (es)
EP (2) EP2459220B1 (es)
JP (1) JP5904941B2 (es)
KR (1) KR101770844B1 (es)
CN (1) CN102573913B (es)
AU (1) AU2010277556B2 (es)
BR (1) BR112012002280B1 (es)
CA (1) CA2769162C (es)
ES (1) ES2833035T3 (es)
HK (1) HK1173082A1 (es)
HR (1) HRP20201609T1 (es)
HU (1) HUE052816T2 (es)
IL (1) IL217743A (es)
LT (1) LT2459220T (es)
MX (1) MX343925B (es)
MY (1) MY156872A (es)
NZ (1) NZ597960A (es)
PL (1) PL2459220T3 (es)
RU (1) RU2554854C9 (es)
SG (1) SG177761A1 (es)
SI (1) SI2459220T1 (es)
WO (1) WO2011012715A1 (es)
ZA (1) ZA201200686B (es)

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