ATE531447T1 - Injizierbare hydrogel-microsphären aus wässrigem zwei-phasen-system - Google Patents

Injizierbare hydrogel-microsphären aus wässrigem zwei-phasen-system

Info

Publication number
ATE531447T1
ATE531447T1 AT03789852T AT03789852T ATE531447T1 AT E531447 T1 ATE531447 T1 AT E531447T1 AT 03789852 T AT03789852 T AT 03789852T AT 03789852 T AT03789852 T AT 03789852T AT E531447 T1 ATE531447 T1 AT E531447T1
Authority
AT
Austria
Prior art keywords
aquate
phase system
microspheres
injectable hydrogel
hydrogel microspheres
Prior art date
Application number
AT03789852T
Other languages
English (en)
Inventor
Chih-Chang Chu
Xian-Zheng Zhang
Da-Qing Wu
Original Assignee
Cornell Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell Res Foundation Inc filed Critical Cornell Res Foundation Inc
Application granted granted Critical
Publication of ATE531447T1 publication Critical patent/ATE531447T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Colloid Chemistry (AREA)
  • Polymerisation Methods In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03789852T 2003-01-17 2003-12-04 Injizierbare hydrogel-microsphären aus wässrigem zwei-phasen-system ATE531447T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44064603P 2003-01-17 2003-01-17
PCT/US2003/037076 WO2004066704A2 (en) 2003-01-17 2003-12-04 Injectable hydrogel microspheres from aqueous two-phase system

Publications (1)

Publication Number Publication Date
ATE531447T1 true ATE531447T1 (de) 2011-11-15

Family

ID=32825136

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03789852T ATE531447T1 (de) 2003-01-17 2003-12-04 Injizierbare hydrogel-microsphären aus wässrigem zwei-phasen-system

Country Status (8)

Country Link
US (2) US7776240B2 (de)
EP (1) EP1631375B1 (de)
JP (1) JP2006517523A (de)
CN (1) CN100418619C (de)
AT (1) ATE531447T1 (de)
AU (1) AU2003294369B2 (de)
CA (1) CA2513483C (de)
WO (1) WO2004066704A2 (de)

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US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
AU2006321809A1 (en) 2005-12-07 2007-06-14 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
EP1801135B1 (de) 2005-12-22 2010-09-29 Zimmer Inc. Perfluorcyclobutanvernetzte Hydrogele
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US8062739B2 (en) 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US20110008404A1 (en) * 2007-12-19 2011-01-13 Georgia Tech Research Corporation Modification Of Biomaterials With Microgel Films
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
US9814657B2 (en) 2009-04-27 2017-11-14 Premier Dental Products Company Buffered microencapsulated compositions and methods
US10688026B2 (en) 2009-04-27 2020-06-23 Premier Dental Products Company Buffered microencapsulated compositions and methods
ES2833035T3 (es) * 2009-07-31 2021-06-14 Ascendis Pharma As Hidrogeles biodegradables insolubles en agua a base de polietilenglicol
WO2011103143A1 (en) 2010-02-16 2011-08-25 The University Of North Carolina At Chapel Hill Array of micromolded structures for sorting adherent cells
US20120231072A1 (en) * 2011-03-11 2012-09-13 Chemisches Institut Schaefer Ag Thermo-responsive hydrogel compositions
CN102627779B (zh) * 2012-02-23 2014-12-10 宁波争光树脂有限公司 一种魔芋葡甘聚糖凝胶微球的制备方法
US10538864B2 (en) 2012-10-24 2020-01-21 Dsm Ip Assets, B.V. Fibers comprising polyesteramide copolymers for drug delivery
WO2015042461A1 (en) 2013-09-19 2015-03-26 Microvention, Inc. Polymer particles
CA2923741C (en) 2013-09-19 2022-06-07 Microvention, Inc. Polymer films
WO2015070094A1 (en) 2013-11-08 2015-05-14 Microvention, Inc. Polymer particles
WO2016154592A1 (en) 2015-03-26 2016-09-29 Microvention, Inc. Embiolic particles
US20160303281A1 (en) 2015-04-17 2016-10-20 Rochal Industries, Llc Composition and kits for pseudoplastic microgel matrices
JP6560166B2 (ja) 2015-07-13 2019-08-14 コスメディ製薬株式会社 薬物徐放性担体及びその製造方法
CA2992692C (en) * 2015-09-09 2021-12-21 Eth Zurich Injectable macroporous hydrogels
EP3205393A1 (de) * 2016-02-12 2017-08-16 Basf Se Verfahren zur herstellung von mikrokapseln
WO2017147147A1 (en) * 2016-02-23 2017-08-31 PixarBio Corporation Compositions comprising nav1.7 selective inhibitors for treating acute, post-operative, or chronic pain and methods of using the same
CN109789222B (zh) 2016-09-28 2022-02-25 泰尔茂株式会社 聚合物颗粒
CN106589264B (zh) * 2016-11-10 2019-01-08 江苏大学 一种丙烯酸基复合水凝胶的制备方法
EP3600441A1 (de) 2017-03-22 2020-02-05 Genentech, Inc. Hydrogelvernetzte hyaluronsäure-prodrug-zusammensetzungen und verfahren
EP3953400A4 (de) * 2019-04-12 2023-01-04 The Regents of The University of Michigan Triblockcopolymere und nanofasergeliermikrokugeln damit
WO2021094468A1 (en) 2019-11-12 2021-05-20 Dsm Ip Assets B.V. Polyesteramide copolymers possessing high glass transition temperatures
CN111096924A (zh) * 2020-02-20 2020-05-05 山东大学 一种水包水防晒乳液及制备方法及应用
CN111304189A (zh) * 2020-02-28 2020-06-19 西南交通大学 一种基于双水相体系的载酶海藻酸钙微球强化级联酶促反应方法
JP7688055B2 (ja) * 2021-02-05 2025-06-03 花王株式会社 ハイドロゲル構造体
CN115212813B (zh) * 2022-07-19 2023-07-25 西南交通大学 一种全水相双层多孔凝胶微球及其制备方法和应用
CN115785479B (zh) * 2022-10-19 2024-08-23 山东省药学科学院 一种无油相乳液凝胶的制备方法

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Also Published As

Publication number Publication date
EP1631375A2 (de) 2006-03-08
AU2003294369A1 (en) 2004-08-23
CA2513483A1 (en) 2004-08-12
US7776240B2 (en) 2010-08-17
US8323794B2 (en) 2012-12-04
US20060073281A1 (en) 2006-04-06
WO2004066704A2 (en) 2004-08-12
AU2003294369B2 (en) 2008-08-14
US20100316717A1 (en) 2010-12-16
WO2004066704A3 (en) 2005-12-08
CN1835792A (zh) 2006-09-20
JP2006517523A (ja) 2006-07-27
CA2513483C (en) 2011-11-29
CN100418619C (zh) 2008-09-17
EP1631375B1 (de) 2011-11-02
EP1631375A4 (de) 2008-07-02

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