BR112012002280A2 - hidrogéis insolúveis em água baseados em polietileno glicol biodegradáveis - Google Patents

hidrogéis insolúveis em água baseados em polietileno glicol biodegradáveis

Info

Publication number
BR112012002280A2
BR112012002280A2 BR112012002280A BR112012002280A BR112012002280A2 BR 112012002280 A2 BR112012002280 A2 BR 112012002280A2 BR 112012002280 A BR112012002280 A BR 112012002280A BR 112012002280 A BR112012002280 A BR 112012002280A BR 112012002280 A2 BR112012002280 A2 BR 112012002280A2
Authority
BR
Brazil
Prior art keywords
polyethylene glycol
water insoluble
hydrogels based
biodegradable polyethylene
insoluble hydrogels
Prior art date
Application number
BR112012002280A
Other languages
English (en)
Other versions
BR112012002280B1 (pt
Inventor
Dirk Vetter
Harald Rau
Mathias Krusch
Tobias Voigt
Ulrich Hersel
Original Assignee
Ascendis Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ascendis Pharma As filed Critical Ascendis Pharma As
Publication of BR112012002280A2 publication Critical patent/BR112012002280A2/pt
Publication of BR112012002280B1 publication Critical patent/BR112012002280B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/02Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075Macromolecular gels
BR112012002280A 2009-07-31 2010-07-30 hidrogel insolúvel em água baseado em polietileno glicol biodegradável, seu processo de preparação, conjugado, composto ligado a veículo e composição farmacêutica. BR112012002280B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09167026 2009-07-31
EP09172339 2009-10-06
PCT/EP2010/061155 WO2011012715A1 (en) 2009-07-31 2010-07-30 Biodegradable polyethylene glycol based water-insoluble hydrogels

Publications (2)

Publication Number Publication Date
BR112012002280A2 true BR112012002280A2 (pt) 2016-06-14
BR112012002280B1 BR112012002280B1 (pt) 2020-04-07

Family

ID=43027631

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012002280A BR112012002280B1 (pt) 2009-07-31 2010-07-30 hidrogel insolúvel em água baseado em polietileno glicol biodegradável, seu processo de preparação, conjugado, composto ligado a veículo e composição farmacêutica.

Country Status (23)

Country Link
US (1) US11559482B2 (pt)
EP (2) EP2459220B1 (pt)
JP (1) JP5904941B2 (pt)
KR (1) KR101770844B1 (pt)
CN (1) CN102573913B (pt)
AU (1) AU2010277556B2 (pt)
BR (1) BR112012002280B1 (pt)
CA (1) CA2769162C (pt)
ES (1) ES2833035T3 (pt)
HK (1) HK1173082A1 (pt)
HR (1) HRP20201609T1 (pt)
HU (1) HUE052816T2 (pt)
IL (1) IL217743A (pt)
LT (1) LT2459220T (pt)
MX (1) MX343925B (pt)
MY (1) MY156872A (pt)
NZ (1) NZ597960A (pt)
PL (1) PL2459220T3 (pt)
RU (1) RU2554854C9 (pt)
SG (1) SG177761A1 (pt)
SI (1) SI2459220T1 (pt)
WO (1) WO2011012715A1 (pt)
ZA (1) ZA201200686B (pt)

Families Citing this family (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2556340C2 (ru) 2009-07-31 2015-07-10 Санофи-Авентис Дойчланд Гмбх Композиция инсулина длительного действия
PE20120918A1 (es) 2009-07-31 2012-08-14 Sanofi Aventis Deutschland Profarmacos que comprenden un conjugado de insulina-conector
MX2012004499A (es) 2009-10-29 2012-05-29 Ascendis Pharma As Esterilizacion de hidrogeles biodegradables.
ES2667025T3 (es) 2009-12-15 2018-05-09 Ascendis Pharma Endocrinology Division A/S Composición seca de hormona de crecimiento unida transitoriamente a un portador de polímero
WO2011089216A1 (en) 2010-01-22 2011-07-28 Ascendis Pharma As Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
US9561285B2 (en) 2010-01-22 2017-02-07 Ascendis Pharma As Carrier-linked carbamate prodrug linkers
WO2011089215A1 (en) 2010-01-22 2011-07-28 Ascendis Pharma As Dipeptide-based prodrug linkers for aromatic amine-containing drugs
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
CN108117586A (zh) 2010-08-10 2018-06-05 洛桑聚合联合学院 红细胞结合性治疗剂
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
EP2438930A1 (en) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrugs comprising an exendin linker conjugate
US10451897B2 (en) 2011-03-18 2019-10-22 Johnson & Johnson Vision Care, Inc. Components with multiple energization elements for biomedical devices
EP2704695A1 (en) * 2011-05-03 2014-03-12 Telik, Inc. Excipient compatibility with ezatiostat
WO2012177825A1 (en) * 2011-06-21 2012-12-27 Bvw Holding Ag Medical device comprising boswellic acid
KR20140082649A (ko) * 2011-08-12 2014-07-02 아센디스 파마 에이에스 프로스타사이클린의 서방형 조성물
AU2012296955B2 (en) 2011-08-12 2016-12-15 Ascendis Pharma A/S Carrier-linked prodrugs having reversible carboxylic ester linkages
CN103857413A (zh) 2011-08-12 2014-06-11 阿森迪斯药物股份有限公司 载体连接的曲罗尼尔前药
RU2014118642A (ru) * 2011-10-12 2015-11-20 Асцендис Фарма Офтальмолоджи Дивижн А/С Предотвращение и лечение глазных нарушений
IN2014DN03213A (pt) * 2011-11-03 2015-05-22 Bayer Ip Gmbh
US8857983B2 (en) 2012-01-26 2014-10-14 Johnson & Johnson Vision Care, Inc. Ophthalmic lens assembly having an integrated antenna structure
CA2868925C (en) 2012-04-25 2020-01-21 Ascendis Pharma A/S Prodrugs of hydroxyl-comprising drugs
US20140073589A1 (en) * 2012-06-27 2014-03-13 Shire Ag Amphetamine Prodrugs
AU2013305938B2 (en) 2012-08-21 2017-08-17 Saladax Biomedical Inc. Antibodies to paliperidone haptens and use thereof
EP3556759B1 (en) * 2012-08-21 2023-11-29 Janssen Pharmaceutica NV Haptens of paliperidone
JP6389176B2 (ja) 2012-08-21 2018-09-12 ヤンセン ファーマシューティカ エヌ.ベー. アリピプラゾールハプテンに対する抗体及びその使用
PT2888593T (pt) 2012-08-21 2018-12-12 Janssen Pharmaceutica Nv Anticorpos contra risperidona e utilizações dos mesmos
CA2882490A1 (en) 2012-08-21 2014-02-27 Ortho-Clinical Diagnostics, Inc. Antibodies to paliperidone and use thereof
PL2888284T3 (pl) 2012-08-21 2023-02-27 Janssen Pharmaceutica Nv Przeciwciała przeciwko haptenom rysperydonu i ich zastosowanie
EP3321254B1 (en) 2012-08-21 2020-08-12 Janssen Pharmaceutica NV Haptens of aripiprazole and their use in immunoassays
PL3354751T3 (pl) 2012-08-21 2020-03-31 Janssen Pharmaceutica Nv Przeciwciała dla arypiprazolu i ich zastosowanie
AU2013328785B2 (en) * 2012-10-11 2016-07-21 Ascendis Pharma A/S Hydrogel prodrugs
US10980860B2 (en) * 2012-10-11 2021-04-20 Ascendis Pharma A/S Diagnosis, prevention and treatment of diseases of the joint
SG11201501914XA (en) * 2012-10-11 2015-05-28 Ascendis Pharma Ophthalmology Division As Vegf neutralizing prodrugs for the treatment of ocular conditions
CN104884093A (zh) * 2012-12-07 2015-09-02 阿森迪斯药物股份有限公司 载体连接型前列腺素类前药
US20140271885A1 (en) * 2013-03-15 2014-09-18 Intezyne Technologies, Inc. Copolymers for stable micelle formulations
EP2988783A1 (en) 2013-04-22 2016-03-02 Ascendis Pharma A/S Hydrogel-linked prodrugs releasing modified drugs
US20160089446A1 (en) * 2013-04-22 2016-03-31 Ascendis Pharma A/S Modified Hydrogels
US10130711B2 (en) 2013-06-19 2018-11-20 The Regents Of The University Of California Chemical structures for localized delivery of therapeutic agents
RU2543375C1 (ru) * 2013-07-29 2015-02-27 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Башкирский государственный университет" Комплексное соединение производного метилурацила с органической кислотой и способ его получения
WO2015023675A2 (en) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
WO2015049651A1 (en) 2013-10-01 2015-04-09 Glaxosmithkline Intellectual Property Development Limited Compounds for affinity chromatography and for extending the half-life of a therapeutic agent
US20180042996A1 (en) * 2013-10-08 2018-02-15 Ascendis Pharma Osteoarthritis Division A/S Hydrogel-Linked IL-1ra Prodrug
CN103554296B (zh) * 2013-10-12 2015-09-16 天津大学 一种亚油酸改性葡聚糖及制备高分子脂质体的方法
WO2015067791A1 (en) 2013-11-11 2015-05-14 Ascendis Pharma Relaxin Division A/S Relaxin prodrugs
US9675607B2 (en) * 2013-11-13 2017-06-13 Northwestern University Epimorphic regeneration and related hydrogel delivery systems
CN103706233A (zh) * 2013-12-17 2014-04-09 杨亮月 一种环氧乙烷零排放处理体系及方法
WO2015095391A1 (en) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
JP6744227B2 (ja) 2014-02-21 2020-08-19 エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ(ウペエフエル)Ecole Polytechnique Federale de Lausanne (EPFL) 糖標的化治療剤
AU2015229014B2 (en) * 2014-03-14 2019-07-25 The Regents Of The University Of California TCO conjugates and methods for delivery of therapeutic agents
WO2016010771A1 (en) 2014-07-17 2016-01-21 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
KR102421923B1 (ko) 2014-07-17 2022-07-18 더 리전트 오브 더 유니버시티 오브 캘리포니아 생물의학적 적용을 위한 제어가능한 자기-어닐링 마이크로겔 입자
EP3193941A1 (en) 2014-08-06 2017-07-26 Ascendis Pharma A/S Prodrugs comprising an aminoalkyl glycine linker
US9923177B2 (en) * 2014-08-21 2018-03-20 Johnson & Johnson Vision Care, Inc. Biocompatibility of biomedical energization elements
US10381687B2 (en) 2014-08-21 2019-08-13 Johnson & Johnson Vision Care, Inc. Methods of forming biocompatible rechargable energization elements for biomedical devices
US9793536B2 (en) 2014-08-21 2017-10-17 Johnson & Johnson Vision Care, Inc. Pellet form cathode for use in a biocompatible battery
US9715130B2 (en) 2014-08-21 2017-07-25 Johnson & Johnson Vision Care, Inc. Methods and apparatus to form separators for biocompatible energization elements for biomedical devices
US9383593B2 (en) 2014-08-21 2016-07-05 Johnson & Johnson Vision Care, Inc. Methods to form biocompatible energization elements for biomedical devices comprising laminates and placed separators
US9941547B2 (en) 2014-08-21 2018-04-10 Johnson & Johnson Vision Care, Inc. Biomedical energization elements with polymer electrolytes and cavity structures
US10361405B2 (en) 2014-08-21 2019-07-23 Johnson & Johnson Vision Care, Inc. Biomedical energization elements with polymer electrolytes
US9599842B2 (en) 2014-08-21 2017-03-21 Johnson & Johnson Vision Care, Inc. Device and methods for sealing and encapsulation for biocompatible energization elements
US10627651B2 (en) 2014-08-21 2020-04-21 Johnson & Johnson Vision Care, Inc. Methods and apparatus to form biocompatible energization primary elements for biomedical devices with electroless sealing layers
US10361404B2 (en) 2014-08-21 2019-07-23 Johnson & Johnson Vision Care, Inc. Anodes for use in biocompatible energization elements
JP2017531026A (ja) 2014-10-20 2017-10-19 ファーマシューティカル マニュファクチュアリング リサーチ サービシズ,インコーポレーテッド 徐放性乱用抑止性液体充填剤形
EP3210623B1 (en) * 2014-10-24 2022-10-05 NOF Corporation Antibody-drug complex having cyclic benzylidene acetal linker
US11298427B2 (en) 2015-05-29 2022-04-12 Ascendis Pharma A/S Prodrugs comprising a pyroglutamate linker
TWI748962B (zh) 2015-09-23 2021-12-11 美商建南德克公司 抗vegf抗體之最佳化變異體
WO2017062770A1 (en) * 2015-10-08 2017-04-13 Silverberg Noah Punctal plug and bioadhesives
AU2016353345B2 (en) 2015-11-12 2021-12-23 University Of Virginia Patent Foundation Compositions and methods for vas-occlusive contraception and reversal thereof
CN108431040B (zh) 2015-12-17 2022-07-26 詹森药业有限公司 利培酮的抗体及其用途
US11285103B2 (en) * 2015-12-18 2022-03-29 Jie Han Degradable hydrogel under physiological conditions
WO2017112704A1 (en) 2015-12-23 2017-06-29 Viking Scientific, Inc. Hydrogel prodrug for treatment
WO2017142879A1 (en) 2016-02-16 2017-08-24 The Regents Of The University Of California Methods for immune system modulation with microporous annealed particle gels
US10345620B2 (en) 2016-02-18 2019-07-09 Johnson & Johnson Vision Care, Inc. Methods and apparatus to form biocompatible energization elements incorporating fuel cells for biomedical devices
EP3423103A1 (en) 2016-03-01 2019-01-09 Ascendis Pharma Bone Diseases A/S Pth prodrugs
WO2017175200A1 (en) 2016-04-08 2017-10-12 The Regents Of The University Of California Modified hyaluronic acid hydrogels and proteins for the time-controlled release of biologic agents
CN105963792B (zh) * 2016-04-29 2019-03-22 深圳迈普再生医学科技有限公司 医用水凝胶组合物,医用水凝胶及其制备方法与应用
WO2018011266A1 (en) 2016-07-13 2018-01-18 Ascendis Pharma A/S Conjugation method for carrier-linked prodrugs
CN117257922A (zh) 2016-09-29 2023-12-22 阿森迪斯药物骨疾病股份有限公司 具有低峰-谷比的pth化合物
CN109789189B (zh) 2016-09-29 2024-01-23 阿森迪斯药物骨疾病股份有限公司 控释pth化合物的剂量方案
CN109843295B (zh) 2016-09-29 2022-04-05 阿森迪斯药物生长障碍股份有限公司 控释cnp激动剂的组合疗法
JP7039574B2 (ja) 2016-09-29 2022-03-22 アセンディス ファーマ ボーン ディジージズ エー/エス 放出制御pth化合物の漸増用量設定
CN110446508A (zh) 2016-12-29 2019-11-12 泰普治疗公司 用于治疗医疗植入物部位的方法和系统
LT3592392T (lt) * 2017-03-10 2024-01-25 University Of Louisville Research Foundation, Inc. Fasl modifikuotos biomedžiagos su imunomoduliacine funkcija
JP7216006B2 (ja) 2017-03-22 2023-01-31 ジェネンテック, インコーポレイテッド ヒドロゲル架橋ヒアルロン酸プロドラッグ組成物及び方法
JOP20190245A1 (ar) * 2017-04-20 2019-10-15 Novartis Ag أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
CN108864258A (zh) * 2017-05-12 2018-11-23 北京康明海慧生物科技有限公司 具有抑制肿瘤功能的peg化多肽及其制备方法与应用
WO2018232176A1 (en) 2017-06-16 2018-12-20 The University Of Chicago Compositions and methods for inducing immune tolerance
CN107583104B (zh) * 2017-10-31 2020-12-01 无锡中科光远生物材料有限公司 一种可注射的用于脊柱修复的凝胶材料
BR112020008631A2 (pt) * 2017-11-02 2020-10-20 Tarsius Pharma Ltd. conjugado de fosforilcolina-tuftsina para tratamento de inflamação ocular
CN107880288A (zh) * 2017-11-29 2018-04-06 桂林华诺威生物科技有限公司 一种透明质酸钠凝胶的制备方法
CN108096630B (zh) * 2018-01-29 2020-09-04 暨南大学 一种载淫羊藿苷和去铁胺的聚乳酸基骨组织支架及制备方法和应用
AU2019246389A1 (en) 2018-03-28 2020-08-27 Ascendis Pharma Oncology Division A/S IL-2 conjugates
FR3079421A1 (fr) * 2018-03-28 2019-10-04 Edix Sa Presentations injectables, seringues et compositions a liberation prolongee et/ou controlee de lanreotide
CN110865130B (zh) * 2018-08-27 2023-08-22 北京海晶生物医药科技有限公司 一种盐酸奥洛他定及其有关物质的检测方法
CA3114329A1 (en) 2018-09-26 2020-04-02 Ascendis Pharma A/S Novel hydrogel conjugates
AR116566A1 (es) * 2018-10-03 2021-05-19 Novartis Ag Administración sostenida de polipéptidos similares a la angiopoyetina 3
CN111077235B (zh) * 2018-10-19 2023-09-08 重庆医药工业研究院有限责任公司 一种测定2-[(2-甲基-5-溴苯基)甲基]-5-(4-氟苯基)噻吩杂质的方法
JP2022516308A (ja) 2019-01-04 2022-02-25 アセンディス ファーマ オンコロジー ディヴィジョン エー/エス パターン認識受容体アゴニストのコンジュゲート
US20220054477A1 (en) 2019-01-04 2022-02-24 Ascendis Pharma Oncology Division A/S Induction of sustained local inflammation
US20220054478A1 (en) 2019-01-04 2022-02-24 Ascendis Pharma Oncology Division A/S Minimization of systemic inflammation
JP2022516314A (ja) 2019-01-04 2022-02-25 アセンディス ファーマ オンコロジー ディヴィジョン エー/エス 自然免疫アゴニストのための持続性局所性薬物レベル
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
US20220233454A1 (en) * 2019-06-07 2022-07-28 Likarda, LLC Tunable degradation in hydrogel microparticles
WO2020254613A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pk properties
WO2020254612A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pd properties
WO2020254607A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pd properties
WO2020254602A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma A/S Conjugates of an electron-donating nitrogen or tertiary amine comprising compounds
CA3143442A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma A/S Conjugates of heteroaromatic nitrogen-comprising compounds
US20230102309A1 (en) 2019-06-21 2023-03-30 Ascendis Pharma Oncology Division A/S Tyrosine kinase inhibitor conjugates
WO2020254617A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pk properties
AU2020295721A1 (en) 2019-06-21 2021-12-23 Ascendis Pharma A/S Conjugates of π-electron-pair-donating heteroaromatic nitrogen-comprising compounds
WO2020254611A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 conjugates
EP3990028A4 (en) * 2019-06-26 2023-08-09 Biorchestra Co., Ltd. MICELLAR NANOPARTICLES AND ASSOCIATED USES
CA3145024A1 (en) * 2019-07-03 2021-01-07 Molly Sandra Shoichet Hydrogel compositions and uses thereof
CN112168820B (zh) * 2019-07-05 2023-09-29 中国科学院生物物理研究所 SRCAP ATPase抑制剂在结直肠癌治疗中的应用
BR112022003689A2 (pt) * 2019-08-29 2022-05-24 Douglas Godfrin Paul Matriz de hidrogel
WO2021102136A1 (en) * 2019-11-19 2021-05-27 Lubrizol Advanced Materials, Inc. Polyurethane compositions salted with bisbiguanide
JP2023512427A (ja) 2020-01-03 2023-03-27 アセンディス ファーマ エー/エス 分子内転位を受けるコンジュゲート
CN111138293B (zh) * 2020-01-10 2023-07-07 蚌埠丰原医药科技发展有限公司 一种用微通道反应器合成富马酸伊布利特中间体的方法
JP7451732B2 (ja) 2020-02-06 2024-03-18 オキュラ セラピューティクス,インコーポレイテッド 眼疾患を治療するための組成物及び方法
KR102375663B1 (ko) * 2020-03-24 2022-03-16 재단법인대구경북과학기술원 무손실 세포 염색 방법 및 장치
WO2021195163A1 (en) 2020-03-25 2021-09-30 Ocular Therapeutix, Inc. Ocular implant containing a tyrosine kinase inhibitor
EP4146281A1 (en) 2020-05-04 2023-03-15 Ascendis Pharma A/S Hydrogel irradiation
CN113694261B (zh) * 2020-05-21 2022-09-09 江苏百赛飞生物科技有限公司 一种抗菌复合涂层及其制备方法和制品
US20210369651A1 (en) * 2020-05-28 2021-12-02 Sollievo Pharmaceuticals, Inc Parenteral delivery of avizafone
EP4161956A1 (en) 2020-06-03 2023-04-12 Ascendis Pharma Oncology Division A/S Il-2 sequences and uses thereof
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
AU2021319863A1 (en) 2020-08-05 2023-02-16 Ascendis Pharma A/S Conjugates comprising reversible linkers and uses thereof
JP2023540701A (ja) 2020-08-28 2023-09-26 アセンディス ファーマ オンコロジー ディヴィジョン エー/エス グリコシル化il-2タンパク質及びその使用
IL301411A (en) 2020-09-28 2023-05-01 Ascendis Pharma Bone Diseases As Improving the physical and mental condition of patients with hypoparathyroidism
CN112316156B (zh) * 2020-10-27 2022-03-15 四川大学 具抗氧化和抗菌性的胶原蛋白修复膜、其制备方法及应用
KR102437315B1 (ko) * 2020-11-02 2022-08-30 아주대학교산학협력단 하이브리드 하이드로겔 및 이의 생의학적 용도
KR20230164709A (ko) 2021-04-01 2023-12-04 아센디스 파마 에이에스 염증 유발 질환을 치료하기 위한 지속형 성장 호르몬의 용도
CN113304139B (zh) * 2021-06-30 2022-04-29 贵州医科大学 Viniferifuran在制备黄嘌呤氧化酶抑制药物中的应用
CN113398145B (zh) * 2021-07-02 2022-10-14 合肥康诺生物制药有限公司 含nad与氨氯地平的药物组合物及其用途
CN113461979A (zh) * 2021-07-19 2021-10-01 吉林大学 一种通过血红蛋白催化交联的仿贻贝类水凝胶的制备方法
WO2023110727A2 (en) 2021-12-13 2023-06-22 Ascendis Pharma Oncology Division A/S Novel cancer treatments with tlr7/8 agonists
CN114469926B (zh) * 2022-01-28 2023-06-27 吉林省健维天然生物科技有限公司 二氢槲皮素的新用途及二氢槲皮素水凝胶的制备方法
CN115109275B (zh) * 2022-08-29 2022-11-01 杭州艾名医学科技有限公司 一种动态交联可降解水凝胶、制备方法及应用
CN115444840B (zh) * 2022-09-15 2023-08-25 四川大学 一种前药、两性离子水凝胶及其制备方法、应用
CN115322397B (zh) * 2022-09-23 2024-04-30 福州大学 一种预防术后腹腔粘连的两性离子水凝胶及其制备方法
CN115537017B (zh) * 2022-09-27 2023-09-01 四川大学 一种水凝胶及其制备方法和应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69329594T2 (de) 1992-02-28 2001-05-31 Univ Texas Photopolymerinierbare, biologisch abbaubare hydrogele als gewebekontaktmaterialien und trägerstoffe für kontrollierte freisetzung
US20020064546A1 (en) * 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
US6624142B2 (en) 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
US6348558B1 (en) 1999-12-10 2002-02-19 Shearwater Corporation Hydrolytically degradable polymers and hydrogels made therefrom
US6413507B1 (en) 1999-12-23 2002-07-02 Shearwater Corporation Hydrolytically degradable carbamate derivatives of poly (ethylene glycol)
US20050260259A1 (en) * 2004-04-23 2005-11-24 Bolotin Elijah M Compositions for treatment with glucagon-like peptide, and methods of making and using the same
CA2479810A1 (en) 2002-04-04 2003-10-16 Enzon, Inc. Polymeric acyl derivatives of indoles
WO2004066704A2 (en) * 2003-01-17 2004-08-12 Cornell Research Foundation, Inc. Injectable hydrogel microspheres from aqueous two-phase system
CA2843439A1 (en) 2003-04-08 2004-10-21 Yeda Research And Development Co. Ltd Reversible pegylated drugs
TR201907313T4 (tr) 2003-05-23 2019-06-21 Nektar Therapeutics İki PEG zinciri içeren PEG türevleri.
CA2786794C (en) * 2004-03-23 2017-09-12 Complex Biosystems Gmbh Aromatic polymeric cascade prodrug linker reagent
US7968085B2 (en) * 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
DE102004051715A1 (de) 2004-10-23 2005-06-30 Clariant Gmbh Flüssigwaschmittel enthaltend Farbfixiermittel
KR100665672B1 (ko) * 2005-04-13 2007-01-09 성균관대학교산학협력단 새로운 온도 및 pH 민감성 블록 공중합체 및 이를 이용한고분자 하이드로겔
GB2427360A (en) 2005-06-22 2006-12-27 Complex Biosystems Gmbh Aliphatic prodrug linker
JP2009523494A (ja) 2006-01-12 2009-06-25 ヒストジェニックス コーポレイション 破壊された靱帯又は腱の修復及び再構築のための、及び靱帯及び腱の損傷の処置のための方法
MX2009002859A (es) 2006-09-15 2009-03-30 Enzon Pharmaceuticals Inc Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos.
GB0619175D0 (en) * 2006-09-29 2006-11-08 Univ Nottingham Polymer
CN101541857B (zh) * 2006-11-27 2012-12-12 阿克塔马克斯手术器材有限责任公司 多官能聚环氧烷、水凝胶和组织粘合剂
CA2677532A1 (en) 2007-02-06 2008-08-14 Incept, Llc Polymerization with precipitation of proteins for elution in physiological solution
US20080220047A1 (en) * 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
MX2009011005A (es) 2007-04-13 2009-11-02 Kuros Biosurgery Ag Sellador polimerico para tejido.
EP2596805B1 (en) 2008-02-01 2021-10-27 Ascendis Pharma A/S Prodrug comprising a drug-linker conjugate
EP2756756B1 (en) * 2008-04-28 2016-01-06 Zogenix, Inc. Novel formulations for treatment of migraine
MX2012004499A (es) * 2009-10-29 2012-05-29 Ascendis Pharma As Esterilizacion de hidrogeles biodegradables.
EP2438930A1 (en) * 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrugs comprising an exendin linker conjugate

Also Published As

Publication number Publication date
CN102573913A (zh) 2012-07-11
US20120156259A1 (en) 2012-06-21
JP5904941B2 (ja) 2016-04-20
HRP20201609T1 (hr) 2021-01-08
CA2769162C (en) 2017-12-05
RU2012107137A (ru) 2013-09-10
SG177761A1 (en) 2012-03-29
LT2459220T (lt) 2020-12-28
IL217743A0 (en) 2012-03-29
JP2013500950A (ja) 2013-01-10
AU2010277556B2 (en) 2014-10-09
KR101770844B1 (ko) 2017-08-23
KR20120090039A (ko) 2012-08-16
MX343925B (es) 2016-11-29
US11559482B2 (en) 2023-01-24
MY156872A (en) 2016-04-15
PL2459220T3 (pl) 2021-03-08
RU2554854C2 (ru) 2015-06-27
BR112012002280B1 (pt) 2020-04-07
EP2459220B1 (en) 2020-09-09
WO2011012715A1 (en) 2011-02-03
RU2554854C9 (ru) 2017-02-03
SI2459220T1 (sl) 2020-12-31
HUE052816T2 (hu) 2021-05-28
CN102573913B (zh) 2014-06-18
EP2459220A1 (en) 2012-06-06
NZ597960A (en) 2013-07-26
EP3782649A1 (en) 2021-02-24
ES2833035T3 (es) 2021-06-14
CA2769162A1 (en) 2011-02-03
AU2010277556A1 (en) 2012-02-02
MX2012001061A (es) 2012-03-26
ZA201200686B (en) 2012-10-31
IL217743A (en) 2017-01-31
HK1173082A1 (en) 2013-05-10

Similar Documents

Publication Publication Date Title
BR112012002280A2 (pt) hidrogéis insolúveis em água baseados em polietileno glicol biodegradáveis
BR112012001710A2 (pt) copolímero hidrofobicamente associado solúvel de água
IT1399032B1 (it) Poliestere biodegradabile alifatico-aromatico
DK2627713T3 (da) Polymerblandinger
DK2216871T3 (da) Ladestation
BRPI1009677A2 (pt) Gelificação de polímero de óleos
BR112012005251A2 (pt) fluido refrigerante binário
DK2312744T3 (da) Effektfordelingssystemer
DE102010040438A8 (de) Radarvorrichtung
FR2940940B1 (fr) Pare-chocs
BRPI0920488A2 (pt) estação de carga
BR112012027899A2 (pt) péletes biodegrádaveis espumados por irradiação.
FI20095468A0 (fi) Antenniyhdistelmä
DK2259869T3 (da) Polymerskum
BR112012005092A2 (pt) recipiente de água
FI20095085A0 (fi) Moniresonanssiantenni
BR112012001899A2 (pt) soluções compreendendo polietileno glicol e eletrólitos
UA21651S (uk) Заряджальна станція
BR112012006343A2 (pt) composições de polimero de propileno
BRPI1011055A2 (pt) composicoes poliméricas de propileno
BRPI1007245A2 (pt) composição polimérica
ITBS20090136A1 (it) Docking station
BR112012003250A2 (pt) Sistema híbrido de embutimento
BR112012001230A2 (pt) célula galvânica
BRPI1012278A2 (pt) "reparo de cartilagem."

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 30/07/2010, OBSERVADAS AS CONDICOES LEGAIS.