MX2010004173A - Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino ]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida y sus formas cristalinas. - Google Patents

Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino ]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida y sus formas cristalinas.

Info

Publication number
MX2010004173A
MX2010004173A MX2010004173A MX2010004173A MX2010004173A MX 2010004173 A MX2010004173 A MX 2010004173A MX 2010004173 A MX2010004173 A MX 2010004173A MX 2010004173 A MX2010004173 A MX 2010004173A MX 2010004173 A MX2010004173 A MX 2010004173A
Authority
MX
Mexico
Prior art keywords
pyridinylmethoxy
butenamide
anilino
quinolinyl
dimethylamino
Prior art date
Application number
MX2010004173A
Other languages
English (en)
Spanish (es)
Inventor
Warren Chew
Gloria K Cheal
Mannching Sherry Ku
Qinghong Lu
Anthony F Hadfield
Mahmoud Mirmehrabi
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40347915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010004173(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of MX2010004173A publication Critical patent/MX2010004173A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
MX2010004173A 2007-10-17 2008-10-16 Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino ]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida y sus formas cristalinas. MX2010004173A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12479607P 2007-10-17 2007-10-17
PCT/US2008/080130 WO2009052264A2 (en) 2007-10-17 2008-10-16 Maleate salts of (e)-n-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof

Publications (1)

Publication Number Publication Date
MX2010004173A true MX2010004173A (es) 2010-04-30

Family

ID=40347915

Family Applications (5)

Application Number Title Priority Date Filing Date
MX2010004173A MX2010004173A (es) 2007-10-17 2008-10-16 Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino ]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida y sus formas cristalinas.
MX2016009168A MX349332B (es) 2007-10-17 2008-10-16 Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino ]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida y sus formas cristalinas.
MX2012006904A MX342681B (es) 2007-10-17 2008-10-16 Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino ]-3-ciano-7-etoxi-6-quinolinil)-4-(dimetilamino)-2-butenamida y sus formas cristalinas.
MX2017009527A MX387683B (es) 2007-10-17 2008-10-16 Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida y sus formas cristalinas.
MX2021013585A MX2021013585A (es) 2007-10-17 2010-04-16 Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino ]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida y sus formas cristalinas.

Family Applications After (4)

Application Number Title Priority Date Filing Date
MX2016009168A MX349332B (es) 2007-10-17 2008-10-16 Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino ]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida y sus formas cristalinas.
MX2012006904A MX342681B (es) 2007-10-17 2008-10-16 Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino ]-3-ciano-7-etoxi-6-quinolinil)-4-(dimetilamino)-2-butenamida y sus formas cristalinas.
MX2017009527A MX387683B (es) 2007-10-17 2008-10-16 Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida y sus formas cristalinas.
MX2021013585A MX2021013585A (es) 2007-10-17 2010-04-16 Sales de maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetoxi)anilino ]-3-ciano-7-etoxi-6-quinolinil}-4-(dimetilamino)-2-butenamida y sus formas cristalinas.

Country Status (20)

Country Link
US (6) US8022216B2 (enExample)
EP (6) EP2212311A2 (enExample)
JP (11) JP2011500712A (enExample)
KR (5) KR20180041753A (enExample)
CN (7) CN101918390B (enExample)
AR (2) AR068932A1 (enExample)
AU (1) AU2008312474B2 (enExample)
BR (2) BR122019023745B8 (enExample)
CA (2) CA2928071C (enExample)
CL (1) CL2008003088A1 (enExample)
ES (3) ES2586435T3 (enExample)
IL (3) IL308687A (enExample)
IN (1) IN2015DN01135A (enExample)
MX (5) MX2010004173A (enExample)
NZ (3) NZ705641A (enExample)
PA (1) PA8800701A1 (enExample)
RU (2) RU2463300C2 (enExample)
SG (2) SG185312A1 (enExample)
TW (1) TW200934761A (enExample)
WO (1) WO2009052264A2 (enExample)

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PL1848414T3 (pl) 2005-02-03 2011-10-31 Wyeth Llc Sposób leczenia nowotworu opornego na gefitinib
WO2007056118A1 (en) 2005-11-04 2007-05-18 Wyeth Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
CA2725598C (en) 2008-06-17 2013-10-08 Wyeth Llc Antineoplastic combinations containing hki-272 and vinorelbine
SMT201700084T1 (it) 2008-08-04 2017-03-08 Wyeth Llc Associazioni antineoplastiche di 4-anilino-3-cianochinoline e capecitabina
HUE061640T2 (hu) 2009-04-06 2023-07-28 Wyeth Llc Gyógykezelési rendszer mellrákhoz neratinib alkalmazásával
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AU2010315362B2 (en) 2009-11-09 2015-01-22 Wyeth Llc Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
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CN105949176B (zh) * 2016-06-24 2018-10-26 浙江海正药业股份有限公司 一种来那替尼的纯化方法
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CN107721986A (zh) * 2016-08-12 2018-02-23 山东轩竹医药科技有限公司 喹唑啉类酪氨酸激酶抑制剂的晶型
CN107721985A (zh) * 2016-08-12 2018-02-23 山东轩竹医药科技有限公司 喹唑啉类酪氨酸激酶抑制剂的晶型
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CN107721987A (zh) * 2016-08-12 2018-02-23 山东轩竹医药科技有限公司 喹唑啉类酪氨酸激酶抑制剂的晶型
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WO2019015394A1 (zh) * 2017-07-17 2019-01-24 苏州科睿思制药有限公司 一种来那替尼单马来酸盐的晶型及其制备方法和用途
JP2021503506A (ja) 2017-11-20 2021-02-12 テリジーン リミテッドＴｅｌｉｇｅｎｅ Ｌｔｄ． （ｅ）−ｎ−（３−シアノ−７−エトキシ−４−（（４−フェノキシフェニル）アミノ）キノリン−６−イル）−４−（ジメチルアミノ）ブタ−２−エンアミドのマレイン酸塩及びその結晶形態
CN107698563B (zh) * 2017-11-23 2020-10-30 江苏创诺制药有限公司 制备马来酸来那替尼晶型的方法
CN108299394A (zh) * 2018-02-28 2018-07-20 江苏创诺制药有限公司 来那替尼二马来酸盐晶型及其制备方法
CN110357855A (zh) * 2018-03-26 2019-10-22 江苏创诺制药有限公司 一种来那替尼盐酸盐晶型及其制备方法
CN109053683A (zh) * 2018-07-27 2018-12-21 苏州晶云药物科技股份有限公司 来那替尼马来酸盐晶型c的制备方法以及来那替尼马来酸盐晶型c
CN109053702A (zh) * 2018-08-13 2018-12-21 扬子江药业集团有限公司 一种阿法替尼类似物及其制备方法和用途
CN109503479A (zh) * 2018-12-03 2019-03-22 四川自豪时代药业有限公司 一种磷酸萘酚喹工艺杂质及其合成方法
CN111848581B (zh) * 2020-08-19 2021-08-10 昆明学院 3-氰基-4-苯胺基-6-氨基喹啉衍生物的制备方法
CN111943933B (zh) * 2020-09-02 2021-05-28 重庆医科大学 一种来那替尼杂质d的制备方法
CN111995618B (zh) * 2020-09-02 2021-06-11 重庆医科大学 一种来那替尼杂质g的制备方法
CN114380745A (zh) * 2020-10-19 2022-04-22 江苏苏中药业集团股份有限公司 一种取代丁烯酰胺颗粒混合物及晶型ii制备方法与应用
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JP6126382B2 (ja) 2010-01-13 2017-05-10 ワイス・エルエルシー 腫瘍を正確に識別し、かつＰＡＮ‐ＥｒｂＢ阻害剤に対する薬物応答を予測するＰＴＥＮタンパク質発現におけるカットポイント

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