BR122019023745B8 - método para a preparação de (e)-n-{4-[3-cloro-4-(2-piridinilmetóxi)anilina]-3-ciano-7-etóxi-6-quinolinil}-4-(dimetilamino)-2-butenamida anidro como um sal maleato - Google Patents

método para a preparação de (e)-n-{4-[3-cloro-4-(2-piridinilmetóxi)anilina]-3-ciano-7-etóxi-6-quinolinil}-4-(dimetilamino)-2-butenamida anidro como um sal maleato

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Publication number
BR122019023745B8
BR122019023745B8 BR122019023745A BR122019023745A BR122019023745B8 BR 122019023745 B8 BR122019023745 B8 BR 122019023745B8 BR 122019023745 A BR122019023745 A BR 122019023745A BR 122019023745 A BR122019023745 A BR 122019023745A BR 122019023745 B8 BR122019023745 B8 BR 122019023745B8
Authority
BR
Brazil
Prior art keywords
pyridinylmethoxy
butenamide
quinolinyl
maleate salt
aniline
Prior art date
Application number
BR122019023745A
Other languages
English (en)
Portuguese (pt)
Other versions
BR122019023745B1 (pt
Inventor
F Hadfield Anthony
K Cheal Gloria
Mirmehrabi Mahmoud
Sherry Ku Mannching
Lu Qinghong
Chew Warren
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40347915&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR122019023745(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of BR122019023745B1 publication Critical patent/BR122019023745B1/pt
Publication of BR122019023745B8 publication Critical patent/BR122019023745B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
BR122019023745A 2007-10-17 2008-10-16 método para a preparação de (e)-n-{4-[3-cloro-4-(2-piridinilmetóxi)anilina]-3-ciano-7-etóxi-6-quinolinil}-4-(dimetilamino)-2-butenamida anidro como um sal maleato BR122019023745B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12479607P 2007-10-17 2007-10-17
US61/124.796 2007-10-17
PCT/US2008/080130 WO2009052264A2 (en) 2007-10-17 2008-10-16 Maleate salts of (e)-n-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
BRPI0818464A BRPI0818464B8 (pt) 2007-10-17 2008-10-16 método para preparar maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetóxi)anilina]-3-ciano-7-etóxi-6-quinolinil}-4-(dimetilamino)-2-butenamida sob a forma de um monoidrato cristalino

Publications (2)

Publication Number Publication Date
BR122019023745B1 BR122019023745B1 (pt) 2021-02-02
BR122019023745B8 true BR122019023745B8 (pt) 2021-07-27

Family

ID=40347915

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122019023745A BR122019023745B8 (pt) 2007-10-17 2008-10-16 método para a preparação de (e)-n-{4-[3-cloro-4-(2-piridinilmetóxi)anilina]-3-ciano-7-etóxi-6-quinolinil}-4-(dimetilamino)-2-butenamida anidro como um sal maleato
BRPI0818464A BRPI0818464B8 (pt) 2007-10-17 2008-10-16 método para preparar maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetóxi)anilina]-3-ciano-7-etóxi-6-quinolinil}-4-(dimetilamino)-2-butenamida sob a forma de um monoidrato cristalino

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0818464A BRPI0818464B8 (pt) 2007-10-17 2008-10-16 método para preparar maleato de (e)-n-{4-[3-cloro-4-(2-piridinilmetóxi)anilina]-3-ciano-7-etóxi-6-quinolinil}-4-(dimetilamino)-2-butenamida sob a forma de um monoidrato cristalino

Country Status (20)

Country Link
US (6) US8022216B2 (enExample)
EP (6) EP2212311A2 (enExample)
JP (11) JP2011500712A (enExample)
KR (5) KR20180041753A (enExample)
CN (7) CN116715654A (enExample)
AR (2) AR068932A1 (enExample)
AU (1) AU2008312474B2 (enExample)
BR (2) BR122019023745B8 (enExample)
CA (2) CA2928071C (enExample)
CL (1) CL2008003088A1 (enExample)
ES (3) ES2612273T3 (enExample)
IL (3) IL308687A (enExample)
IN (1) IN2015DN01135A (enExample)
MX (5) MX2010004173A (enExample)
NZ (3) NZ616136A (enExample)
PA (1) PA8800701A1 (enExample)
RU (2) RU2463300C2 (enExample)
SG (2) SG10201900175TA (enExample)
TW (1) TW200934761A (enExample)
WO (1) WO2009052264A2 (enExample)

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US8173814B2 (en) 2012-05-08
EP2537843B1 (en) 2016-09-14
KR20150039872A (ko) 2015-04-13
AR068932A1 (es) 2009-12-16
JP2021185200A (ja) 2021-12-09
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NZ616136A (en) 2015-04-24
JP6412090B2 (ja) 2018-10-24
MX2021013585A (es) 2022-05-18
AR103866A2 (es) 2017-06-07
EP2537843A2 (en) 2012-12-26
US9139558B2 (en) 2015-09-22
EP2626353B1 (en) 2016-11-23
EP3088398A1 (en) 2016-11-02
ES2602123T3 (es) 2017-02-17
KR20130025862A (ko) 2013-03-12
EP2537843A3 (en) 2013-03-13
WO2009052264A3 (en) 2009-06-11
MX342681B (es) 2016-10-07
JP2023164747A (ja) 2023-11-10
BRPI0818464A2 (pt) 2016-01-05
RU2621719C2 (ru) 2017-06-07
CA2928071A1 (en) 2009-04-23
ES2586435T3 (es) 2016-10-14
JP2017043640A (ja) 2017-03-02
CA2702930C (en) 2016-07-05
IL205024A0 (en) 2010-11-30
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US9630946B2 (en) 2017-04-25
US20130281488A1 (en) 2013-10-24
US8022216B2 (en) 2011-09-20
IL308687A (en) 2024-01-01
CN101918390A (zh) 2010-12-15
EP2258698A3 (en) 2011-02-16
NZ705641A (en) 2016-07-29
CA2702930A1 (en) 2009-04-23
EP2617719A1 (en) 2013-07-24
US8394959B2 (en) 2013-03-12
BRPI0818464B1 (pt) 2020-06-30
JP2011063610A (ja) 2011-03-31
KR20160136474A (ko) 2016-11-29
KR20180041753A (ko) 2018-04-24
AU2008312474A1 (en) 2009-04-23
CN117143077A (zh) 2023-12-01
MX387683B (es) 2025-03-18
CN116715654A (zh) 2023-09-08
US20160068511A1 (en) 2016-03-10
US20170320852A1 (en) 2017-11-09
NZ600349A (en) 2013-12-20
JP2018109071A (ja) 2018-07-12
EP2212311A2 (en) 2010-08-04
PA8800701A1 (es) 2009-05-15
IL205024B (en) 2018-04-30
US10035788B2 (en) 2018-07-31
US20090176827A1 (en) 2009-07-09
CN103554086A (zh) 2014-02-05
EP2626353A1 (en) 2013-08-14
MX2010004173A (es) 2010-04-30
RU2463300C2 (ru) 2012-10-10
IL258440A (en) 2018-05-31
CN101918390B (zh) 2014-06-18
IN2015DN01135A (enExample) 2015-07-10
BR122019023745B1 (pt) 2021-02-02
RU2012126864A (ru) 2014-01-10
CA2928071C (en) 2017-04-25
CN106822127B (zh) 2022-07-29
CL2008003088A1 (es) 2009-03-20
CN116715653A (zh) 2023-09-08

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