CN101918390B - (e)-n-{4-[3-氯-4-(2-吡啶基甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基}-4-(二甲基氨基)-2-丁烯酰胺的马来酸盐及其结晶形式 - Google Patents

(e)-n-{4-[3-氯-4-(2-吡啶基甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基}-4-(二甲基氨基)-2-丁烯酰胺的马来酸盐及其结晶形式 Download PDF

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CN101918390B
CN101918390B CN200880118789.3A CN200880118789A CN101918390B CN 101918390 B CN101918390 B CN 101918390B CN 200880118789 A CN200880118789 A CN 200880118789A CN 101918390 B CN101918390 B CN 101918390B
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chloro
anilino
maleate
dimethylamino
cyano
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CN101918390A (zh
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吕庆红
M·S·库
W·丘
G·K·奇尔
A·F·哈德菲尔德
M·米尔梅拉比
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Wyeth LLC
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Priority to CN201910667051.2A priority Critical patent/CN110452221A/zh
Priority to CN202310689097.0A priority patent/CN117143077A/zh
Priority to CN202310691104.0A priority patent/CN116715654A/zh
Priority to CN201710057547.9A priority patent/CN106822127B/zh
Priority to CN202310690478.0A priority patent/CN116715653A/zh
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
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    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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CN200880118789.3A 2007-10-17 2008-10-16 (e)-n-{4-[3-氯-4-(2-吡啶基甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基}-4-(二甲基氨基)-2-丁烯酰胺的马来酸盐及其结晶形式 Active CN101918390B (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201910667051.2A CN110452221A (zh) 2007-10-17 2008-10-16 (e)-n-{4-[3-氯-4-(2-吡啶甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基}-4-(二甲氨基)-2-丁烯酰胺马来酸盐及晶形
CN202310689097.0A CN117143077A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN202310691104.0A CN116715654A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN201710057547.9A CN106822127B (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN202310690478.0A CN116715653A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形

Applications Claiming Priority (3)

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US12479607P 2007-10-17 2007-10-17
US61/124,796 2007-10-17
PCT/US2008/080130 WO2009052264A2 (en) 2007-10-17 2008-10-16 Maleate salts of (e)-n-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof

Related Child Applications (6)

Application Number Title Priority Date Filing Date
CN202310691104.0A Division CN116715654A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN202310690478.0A Division CN116715653A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN201910667051.2A Division CN110452221A (zh) 2007-10-17 2008-10-16 (e)-n-{4-[3-氯-4-(2-吡啶甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基}-4-(二甲氨基)-2-丁烯酰胺马来酸盐及晶形
CN201310576791.8A Division CN103554086A (zh) 2007-10-17 2008-10-16 (e)-n-｛4-[3-氯-4-(2-吡啶甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基｝-4-(二甲氨基)-2-丁烯酰胺马来酸盐及晶形
CN201710057547.9A Division CN106822127B (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN202310689097.0A Division CN117143077A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形

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CN101918390A CN101918390A (zh) 2010-12-15
CN101918390B true CN101918390B (zh) 2014-06-18

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CN201310576791.8A Pending CN103554086A (zh) 2007-10-17 2008-10-16 (e)-n-｛4-[3-氯-4-(2-吡啶甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基｝-4-(二甲氨基)-2-丁烯酰胺马来酸盐及晶形
CN201710057547.9A Active CN106822127B (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN202310691104.0A Pending CN116715654A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN201910667051.2A Pending CN110452221A (zh) 2007-10-17 2008-10-16 (e)-n-{4-[3-氯-4-(2-吡啶甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基}-4-(二甲氨基)-2-丁烯酰胺马来酸盐及晶形
CN200880118789.3A Active CN101918390B (zh) 2007-10-17 2008-10-16 (e)-n-{4-[3-氯-4-(2-吡啶基甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基}-4-(二甲基氨基)-2-丁烯酰胺的马来酸盐及其结晶形式
CN202310690478.0A Pending CN116715653A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN202310689097.0A Pending CN117143077A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形

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CN201310576791.8A Pending CN103554086A (zh) 2007-10-17 2008-10-16 (e)-n-｛4-[3-氯-4-(2-吡啶甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基｝-4-(二甲氨基)-2-丁烯酰胺马来酸盐及晶形
CN201710057547.9A Active CN106822127B (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN202310691104.0A Pending CN116715654A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN201910667051.2A Pending CN110452221A (zh) 2007-10-17 2008-10-16 (e)-n-{4-[3-氯-4-(2-吡啶甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基}-4-(二甲氨基)-2-丁烯酰胺马来酸盐及晶形

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CN202310690478.0A Pending CN116715653A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形
CN202310689097.0A Pending CN117143077A (zh) 2007-10-17 2008-10-16 来那替尼马来酸盐及晶形

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Cited By (2)

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WO2016110270A1 (zh) 2015-01-09 2016-07-14 苏州晶云药物科技有限公司 来那替尼马来酸盐的新晶型及其制备方法
CN111344280B (zh) * 2017-11-20 2022-08-12 苏州韬略生物科技股份有限公司 (e)-n-(3-氰基-7-乙氧基-4-((4-苯氧基苯基)氨基)喹啉-6-基)-4-(二甲基氨基) 丁-2-烯酰胺马来酸盐及晶型

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DE10349113A1 (de) 2003-10-17 2005-05-12 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Aminocrotonylverbindungen
CN113952459B (zh) 2005-02-03 2025-02-11 综合医院公司 治疗吉非替尼耐药性癌症的方法
CN103110948A (zh) 2005-11-04 2013-05-22 惠氏公司 mTOR抑制剂、赫赛汀和/或HKI-272的抗肿瘤组合
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
CN102641270A (zh) 2008-06-17 2012-08-22 惠氏有限责任公司 含有hki-272和长春瑞滨的抗肿瘤组合
HUE032958T2 (hu) 2008-08-04 2017-11-28 Wyeth Llc 4-Anilino-3-ciano-kinolinok és capecitabin antineoplasztikus kombinációi
LT3000467T (lt) 2009-04-06 2023-04-11 Wyeth Llc Krūties vėžio gydymo schema naudojant neratinibą
ES2660146T3 (es) * 2009-04-29 2018-03-21 Nerviano Medical Sciences S.R.L. Sales del inhibidor de cdk
EP2498751B1 (en) 2009-11-09 2019-04-03 Wyeth LLC Coated drug spheroids and uses thereof for eliminating or reducing conditions such as emesis and diarrhea
CA2783743C (en) 2009-12-11 2022-10-04 Wyeth Llc Phosphatidylinositol-3-kinase pathway biomarkers
US8338456B2 (en) 2010-01-13 2012-12-25 Wyeth Llc Cut-point in PTEN protein expression that accurately identifies tumors and is predictive of drug response to a pan-ErbB inhibitor
CN102675287A (zh) * 2011-03-11 2012-09-19 江苏恒瑞医药股份有限公司 (e)-n-[4-[[3-氯-4-(2-吡啶基甲氧基)苯基]氨基]-3-氰基-7-乙氧基-6-喹啉基]-3-[(2r)-1-甲基吡咯烷-2-基]丙-2-烯酰胺的可药用的盐、其制备方法及其在医药上的应用
DK2716633T3 (en) 2011-05-26 2017-07-17 Xuanzhu Pharma Co Ltd QUINAZOLINE DERIVATIVE AS A TYROSIN-KINASE INHIBITOR, PROCEDURE FOR PREPARING IT AND USING THEREOF
CN103539783A (zh) * 2012-07-12 2014-01-29 江苏恒瑞医药股份有限公司 一种酪氨酸激酶抑制剂的二马来酸盐的i型结晶及制备方法
CN104513200B (zh) * 2013-09-26 2017-05-03 江苏苏中药业集团股份有限公司 取代丁烯酰胺的马来酸盐及其晶型
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CN106999649A (zh) * 2014-12-12 2017-08-01 赛诺菲 医疗设备包装
US10774068B2 (en) 2015-06-25 2020-09-15 The Scripps Research Institute Composition and methods for inhibiting mammalian sterile 20-like kinase 1
CN105949176B (zh) * 2016-06-24 2018-10-26 浙江海正药业股份有限公司 一种来那替尼的纯化方法
EP3475269A1 (en) 2016-06-27 2019-05-01 Pliva Hrvatska D.O.O. Solid state forms of neratinib and salts thereof
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CN107721987A (zh) * 2016-08-12 2018-02-23 山东轩竹医药科技有限公司 喹唑啉类酪氨酸激酶抑制剂的晶型
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WO2018134843A1 (en) * 2017-01-23 2018-07-26 Msn Laboratories Private Limited, R&D Center Polymorphic forms of (e)-n-{4-[3-chloro-4-((pyridin-2-yl methoxy)anilino]-3-cyano-7- ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide, its maleate salt and process for preparation thereof
WO2018189695A1 (en) * 2017-04-11 2018-10-18 Lupin Limited Neratinib crystalline forms and process for preparation thereof
WO2019015394A1 (zh) * 2017-07-17 2019-01-24 苏州科睿思制药有限公司 一种来那替尼单马来酸盐的晶型及其制备方法和用途
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