MD663G2 - Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente - Google Patents

Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente

Info

Publication number
MD663G2
MD663G2 MD95-0431A MD950431A MD663G2 MD 663 G2 MD663 G2 MD 663G2 MD 950431 A MD950431 A MD 950431A MD 663 G2 MD663 G2 MD 663G2
Authority
MD
Moldova
Prior art keywords
carbon atoms
hydrogen atom
heteroatoms
formula
saturated
Prior art date
Application number
MD95-0431A
Other languages
English (en)
Romanian (ro)
Russian (ru)
Other versions
MD663F1 (ro
Inventor
Constantin Agouridas
Yannick Benedetti
Jean-Francois Chantot
Alexis Denis
Odile Le Martret
Original Assignee
Roussel Uclaf, Societe Anonyme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf, Societe Anonyme filed Critical Roussel Uclaf, Societe Anonyme
Publication of MD663F1 publication Critical patent/MD663F1/xx
Publication of MD663G2 publication Critical patent/MD663G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
MD95-0431A 1994-04-08 1995-04-06 Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente MD663G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404154A FR2718450B1 (fr) 1994-04-08 1994-04-08 Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
PCT/FR1995/000441 WO1995027720A1 (fr) 1994-04-08 1995-04-06 Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
MD663F1 MD663F1 (ro) 1997-01-31
MD663G2 true MD663G2 (ro) 1997-07-31

Family

ID=9461886

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0431A MD663G2 (ro) 1994-04-08 1995-04-06 Derivaţi ai eritromicinei, procedeu de obţinere a acestora şi folosirea lor ca medicamente

Country Status (49)

Country Link
US (2) US5656607A (fr)
EP (1) EP0676409B1 (fr)
JP (1) JP3000023B2 (fr)
KR (1) KR100317148B1 (fr)
CN (1) CN1059445C (fr)
AP (1) AP587A (fr)
AT (1) ATE234853T1 (fr)
AU (1) AU684939B2 (fr)
BG (1) BG61916B1 (fr)
BR (1) BR9506147A (fr)
CA (1) CA2164638C (fr)
CO (1) CO4370097A1 (fr)
CZ (1) CZ296005B6 (fr)
DE (1) DE69529934T2 (fr)
DK (1) DK0676409T3 (fr)
DZ (1) DZ1869A1 (fr)
EE (1) EE04498B1 (fr)
ES (1) ES2189820T3 (fr)
FI (1) FI111264B (fr)
FR (1) FR2718450B1 (fr)
GB (1) GB2288174A (fr)
GE (1) GEP19991836B (fr)
HR (1) HRP950217B1 (fr)
HU (1) HU215396B (fr)
IL (1) IL112954A (fr)
IS (1) IS1865B (fr)
JO (1) JO1850B1 (fr)
LV (1) LV11182B (fr)
MA (1) MA23501A1 (fr)
MD (1) MD663G2 (fr)
MY (1) MY114672A (fr)
NO (1) NO308361B1 (fr)
NZ (1) NZ284498A (fr)
OA (1) OA10200A (fr)
PE (1) PE2896A1 (fr)
PL (1) PL180837B1 (fr)
PT (1) PT676409E (fr)
RO (1) RO115634B1 (fr)
RU (1) RU2141965C1 (fr)
SA (1) SA97170757A (fr)
SI (1) SI0676409T1 (fr)
SK (1) SK284079B6 (fr)
SV (1) SV1995000018A (fr)
TN (1) TNSN95026A1 (fr)
TW (1) TW316908B (fr)
UA (1) UA44705C2 (fr)
WO (1) WO1995027720A1 (fr)
YU (1) YU49221B (fr)
ZA (1) ZA952059B (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
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FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745289B1 (fr) * 1996-02-28 1998-05-29 Roussel Uclaf Nouveaux derives de l'acide 1(2h) quinoleine carboxylique, leur procede de preparation et leur application a la synthese de produits doues de proprietes antibiotiques
US5750510A (en) * 1997-04-04 1998-05-12 Abbott Laboratories 3-descladinose-2,3-anhydroerythromycin derivatives
DK0922050T3 (da) * 1996-05-07 2003-11-24 Abbott Lab 3-Descladinose-2,3-anhydroerythromycin-derivater
FR2748746B1 (fr) * 1996-05-14 1998-08-14 Hoechst Marion Roussel Inc Nouveau procede d'isomerisation du radical methyle en 10 de derives de l'erythromycine
FR2751656B1 (fr) * 1996-07-24 1998-10-16 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
ATE299508T1 (de) * 1996-09-04 2005-07-15 Abbott Lab 6-o-substituierte ketoliden mit antibakteriellen wirkung
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
FR2757168B1 (fr) * 1996-12-12 1999-06-11 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US6165986A (en) * 1997-03-10 2000-12-26 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
WO1998042720A1 (fr) * 1997-03-24 1998-10-01 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
AU6932098A (en) * 1997-05-09 1998-12-08 Pfizer Products Inc. Erythromycin derivatives
US5922683A (en) * 1997-05-29 1999-07-13 Abbott Laboratories Multicyclic erythromycin derivatives
WO1998056800A1 (fr) * 1997-06-11 1998-12-17 Pfizer Products Inc. Derives de 9-oxime erythromycine
FR2771008B1 (fr) * 1997-11-17 2000-04-28 Hoechst Marion Roussel Inc Utilisation des ketolides pour la preparation de compositions pharmaceutiques destinees a prevenir les complications thrombotiques arterielles liees a l'atherosclerose
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
EP1115732B1 (fr) 1998-09-22 2005-06-29 Pfizer Products Inc. Antibiotiques carbamates et carbazates cetolides
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
EP1298138B1 (fr) * 1998-12-10 2006-11-02 Pfizer Products Inc. Dérivés anitiobiotiques de Carbamate et de Carbazate Kètolides
EP1749832A3 (fr) * 1998-12-10 2008-03-26 Pfizer Products Incorporated Dérivés antibiotiques de carbamate et de carbazate kétolides
ATE344269T1 (de) 1998-12-10 2006-11-15 Pfizer Prod Inc Carbamat und carbazat ketolid antibiotika
FR2789392B1 (fr) * 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US6054435A (en) * 1999-03-19 2000-04-25 Abbott Laboratories 6-O-substituted macrolides having antibacterial activity
NZ515027A (en) * 1999-04-16 2004-01-30 Kosan Biosciences Inc Erythromycin derivatives as antibiotics
WO2000062783A2 (fr) 1999-04-16 2000-10-26 Ortho-Mcneil Pharmaceutical, Inc. Agents antibacteriens cetolides
US6590083B1 (en) 1999-04-16 2003-07-08 Ortho-Mcneil Pharmaceutical, Inc. Ketolide antibacterials
EA200100983A1 (ru) * 1999-05-24 2002-10-31 Пфайзер Продактс Инк. Производные 13-метилэритромицина
JP4509553B2 (ja) * 2001-07-03 2010-07-21 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 抗菌活性を有するｃ１２修飾エリスロマイシンマクロライドおよびケトライド
CN101365785A (zh) 2002-07-01 2009-02-11 阿基昂生命科学公司,以生物技术资源部的名义经营 用于生产葡糖胺和n-乙酰氨基葡糖的方法和物质
WO2004080391A2 (fr) 2003-03-10 2004-09-23 Optimer Pharmaceuticals, Inc. Nouveaux agents antibacteriens
CA2523134A1 (fr) * 2003-04-25 2004-11-11 Chiron Corporation Antibiotiques a base de ketolide a substitution pyridyle
EP1618120A2 (fr) * 2003-04-25 2006-01-25 Chiron Corporation Nouveaux derives de ketolides
CA2703475A1 (fr) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Procede pour la preparation d'agents antibacteriens macrolides
EP2358379B1 (fr) * 2008-10-24 2015-12-16 Cempra Pharmaceuticals, Inc. Biodéfenses utilisant des macrolides contenant du triazole
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
PL2550286T3 (pl) 2010-03-22 2016-07-29 Cempra Pharmaceuticals Inc Krystaliczne postaci makrolidu i ich zastosowanie
CN102917708B (zh) 2010-05-20 2015-11-25 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
CN104470527B (zh) 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
WO2014152326A1 (fr) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Procédés pour traiter des maladies respiratoires et formulations pour la mise en œuvre de ceux-ci
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CA3130061C (fr) 2013-04-04 2024-05-28 President And Fellows Of Harvard College Macrolides et methodes de preparation et d'utilisation connexes
EP3211997A4 (fr) 2014-10-08 2018-10-24 President and Fellows of Harvard College Kétolides à 14 chaînons et leurs procédés de préparation et d'utilisation
CA2980315A1 (fr) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides a sucres modifies de type desosamine et utilisations de ceux-ci
MD1222Z (ro) * 2017-05-31 2018-08-31 ИНСТИТУТ ЭЛЕКТРОННОЙ ИНЖЕНЕРИИ И НАНОТЕХНОЛОГИЙ "D. Ghitu" АНМ Procedeu de tratare a materialului săditor al florilor înainte de plantare
JP7199722B2 (ja) 2019-12-25 2023-01-06 旭精工株式会社 硬貨搬送振分機構及びそれを備えた硬貨識別搬送装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

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US3868414A (en) * 1973-01-22 1975-02-25 Merck & Co Inc Tetrahydrofluorene carboxylic acids and related compounds
DE2842759A1 (de) * 1978-09-30 1980-04-10 Merck Patent Gmbh Basische aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
FR2692579B1 (fr) * 1992-06-19 1995-06-02 Roussel Uclaf Nouveaux dérivés de la picromycine, leur procédé de préparation et leur application comme médicaments.
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
HRP930014A2 (en) * 1993-01-08 1994-08-31 Pliva Pharm & Chem Works 9-deoxo-9a-aza-11-deoxy-9a-homoeritromycin a 9a, 11-cyclic carbamates
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0596802A1 (fr) * 1992-11-05 1994-05-11 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation, leur application comme médicaments

Also Published As

Publication number Publication date
EP0676409B1 (fr) 2003-03-19
NO954942D0 (no) 1995-12-06
AP9500743A0 (en) 1995-07-31
DZ1869A1 (fr) 2002-02-17
JPH07278177A (ja) 1995-10-24
DE69529934T2 (de) 2003-09-04
AU684939B2 (en) 1998-01-08
JP3000023B2 (ja) 2000-01-17
ATE234853T1 (de) 2003-04-15
HUT73772A (en) 1996-09-30
RU2141965C1 (ru) 1999-11-27
RO115634B1 (ro) 2000-04-28
DE69529934D1 (de) 2003-04-24
FR2718450B1 (fr) 1997-01-10
AU2310795A (en) 1995-10-30
FR2718450A1 (fr) 1995-10-13
PL311871A1 (en) 1996-03-18
MD663F1 (ro) 1997-01-31
EE04498B1 (et) 2005-06-15
HU9503505D0 (en) 1996-02-28
KR100317148B1 (ko) 2002-06-22
HU215396B (hu) 1998-12-28
FI111264B (fi) 2003-06-30
JO1850B1 (en) 1995-12-27
BR9506147A (pt) 1996-04-16
SK154695A3 (en) 1996-10-02
DK0676409T3 (da) 2003-06-23
GB9506856D0 (en) 1995-05-24
YU49221B (sh) 2004-11-25
CZ296005B6 (cs) 2005-12-14
GB2288174A (en) 1995-10-11
CA2164638C (fr) 2003-12-30
EE9500080A (et) 1996-12-16
LV11182B (en) 1997-04-20
BG61916B1 (bg) 1998-09-30
US5656607A (en) 1997-08-12
EP0676409A1 (fr) 1995-10-11
FI955913A (fi) 1995-12-08
YU21695A (sh) 1997-12-05
TW316908B (fr) 1997-10-01
IS1865B (is) 2003-05-02
WO1995027720A1 (fr) 1995-10-19
CA2164638A1 (fr) 1995-10-19
HRP950217A2 (en) 1997-08-31
NO308361B1 (no) 2000-09-04
IS4309A (is) 1995-11-17
PL180837B1 (pl) 2001-04-30
GEP19991836B (en) 1999-11-05
ES2189820T3 (es) 2003-07-16
OA10200A (fr) 1996-12-18
FI955913A0 (fi) 1995-12-08
LV11182A (lv) 1996-04-20
ZA952059B (en) 1996-03-13
UA44705C2 (uk) 2002-03-15
IL112954A0 (en) 1995-06-29
BG100150A (bg) 1996-06-28
IL112954A (en) 2000-07-16
US5760233A (en) 1998-06-02
CO4370097A1 (es) 1996-10-07
SV1995000018A (es) 1997-10-24
NZ284498A (en) 1997-07-27
CN1126997A (zh) 1996-07-17
SI0676409T1 (en) 2003-06-30
SK284079B6 (sk) 2004-09-08
PE2896A1 (es) 1996-02-12
PT676409E (pt) 2003-08-29
MA23501A1 (fr) 1995-12-31
CZ322395A3 (en) 1996-08-14
HRP950217B1 (en) 2004-06-30
CN1059445C (zh) 2000-12-13
AP587A (en) 1997-04-29
SA97170757A (ar) 2005-12-03
NO954942L (no) 1996-02-07
TNSN95026A1 (fr) 1996-02-06
MY114672A (en) 2002-12-31

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Legal Events

Date Code Title Description
FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20150406

MM4A Patent for invention definitely lapsed due to non-payment of fees