MA22563A1 - Procede de preparation de derives de tetrahydrocarbazole - Google Patents

Procede de preparation de derives de tetrahydrocarbazole

Info

Publication number
MA22563A1
MA22563A1 MA22853A MA22853A MA22563A1 MA 22563 A1 MA22563 A1 MA 22563A1 MA 22853 A MA22853 A MA 22853A MA 22853 A MA22853 A MA 22853A MA 22563 A1 MA22563 A1 MA 22563A1
Authority
MA
Morocco
Prior art keywords
preparation
tetrahydrocarbazole derivatives
tetrahydrocarbazole
derivatives
Prior art date
Application number
MA22853A
Other languages
English (en)
Inventor
Mary Gaster Laramie
David King Francis
Young Rc
Julio Kaumann Alberto
Original Assignee
Vernalis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA22563(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vernalis Ltd filed Critical Vernalis Ltd
Publication of MA22563A1 publication Critical patent/MA22563A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
MA22853A 1991-06-26 1992-06-24 Procede de preparation de derives de tetrahydrocarbazole MA22563A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments

Publications (1)

Publication Number Publication Date
MA22563A1 true MA22563A1 (fr) 1992-12-31

Family

ID=10697363

Family Applications (1)

Application Number Title Priority Date Filing Date
MA22853A MA22563A1 (fr) 1991-06-26 1992-06-24 Procede de preparation de derives de tetrahydrocarbazole

Country Status (35)

Country Link
US (2) US5464864A (fr)
EP (1) EP0591280B1 (fr)
JP (1) JP3261502B2 (fr)
KR (1) KR100251571B1 (fr)
CN (1) CN1034072C (fr)
AP (1) AP344A (fr)
AT (1) ATE170746T1 (fr)
BR (2) BR9206237A (fr)
CA (1) CA2113726C (fr)
CZ (3) CZ282083B6 (fr)
DE (2) DE10299042I2 (fr)
DK (1) DK0591280T3 (fr)
FI (1) FI103967B (fr)
GB (1) GB9113802D0 (fr)
HK (1) HK1014669A1 (fr)
HU (1) HU218907B (fr)
IE (1) IE922062A1 (fr)
IL (4) IL102322A (fr)
LU (1) LU90939I2 (fr)
MA (1) MA22563A1 (fr)
MX (1) MX9203444A (fr)
NL (1) NL300103I2 (fr)
NO (2) NO304774B1 (fr)
NZ (1) NZ243288A (fr)
PL (3) PL169392B1 (fr)
PT (1) PT100620B (fr)
RU (1) RU2137474C1 (fr)
SA (1) SA92130141B1 (fr)
SG (1) SG47877A1 (fr)
SI (1) SI9200125B (fr)
SK (3) SK280907B6 (fr)
TW (1) TW214544B (fr)
UA (1) UA41254C2 (fr)
WO (1) WO1993000086A1 (fr)
ZA (1) ZA924658B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
EP0749962B1 (fr) * 1995-06-23 2000-11-02 Eli Lilly And Company 1,2,3,4-Tétrahydro-9H-carbazoles, 6-substituées et 1OH-cyclohepta(7,6-B)-indoles, 7-substituées
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
RU2320663C2 (ru) 2002-06-21 2008-03-27 Сувен Лайф Сайенсиз Лимитед Новые арилалкилиндолы с аффинностью к серотониновым рецепторам, пригодные в качестве лекарственных средств, способ их получения и содержащие их фармацевтические композиции
DE60317333T2 (de) 2002-06-21 2008-08-28 Suven Life Sciences Ltd. Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptor
PT1581492E (pt) 2002-11-28 2008-09-19 Suven Life Sciences Ltd Indoles n-arilsulfonil-3-substituídos possuindo afinidade de receptor de serotonina, processo para a sua preparação e composição farmacêutica contendo os mesmos
CN1720227A (zh) 2002-11-28 2006-01-11 苏文生命科学有限公司 N－芳基磺酰基－3－氨基烷氧基吲哚
CN100378109C (zh) 2002-12-18 2008-04-02 苏文生命科学有限公司 具有5-羟色胺受体亲和性的四环3-取代的吲哚类化合物
PL2051962T3 (pl) * 2006-08-07 2012-03-30 Actelion Pharmaceuticals Ltd Pochodne kwasu (3-amino-1,2,3,4-tetrahydro-9h-karbazol-9-ilo)-octowego
EP2813144A1 (fr) 2006-10-09 2014-12-17 Charleston Laboratories, Inc. Compositions analgésiques comprenant un antihistaminique
EP2425820B1 (fr) 2007-02-11 2015-04-08 MAP Pharmaceuticals Inc Procédé pour l'administration thérapeutique de DHE pour soulager rapidement la migraine tout en diminuant son profil d'effets secondaires
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
ES2620672T3 (es) 2008-01-09 2017-06-29 Charleston Laboratories, Inc. Comprimidos de doble capa que comprenden oxicodona y prometazina
WO2010073253A1 (fr) * 2008-12-22 2010-07-01 Natco Pharma Limited Procédé de préparation de frovatripan optiquement actif
WO2011006012A1 (fr) 2009-07-08 2011-01-13 Charleston Laboratories Inc. Compositions pharmaceutiques
US9204906B2 (en) 2009-10-22 2015-12-08 Nuvasive, Inc. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
AU2012287120B2 (en) 2011-07-22 2017-02-23 The University Of Chicago Treatments for migraine and related disorders
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions
EP2816030A1 (fr) 2013-06-20 2014-12-24 Duke Chem, S. A. Procédés de préparation de frovatriptan et ses énantiomères
GB201312768D0 (en) * 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
EP3423041A4 (fr) 2016-03-04 2019-09-11 Charleston Laboratories, Inc. Compositions pharmaceutiques
EP3766483A1 (fr) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Composition de poudre orodispersible comprenant un triptane

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) * 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (fr) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Dérivés de tétrahydrocarbazole

Also Published As

Publication number Publication date
SI9200125B (en) 2001-12-31
NZ243288A (en) 1994-09-27
PL169410B1 (pl) 1996-07-31
SI9200125A (en) 1992-12-31
AP9200403A0 (en) 1992-07-31
MX9203444A (es) 1993-12-01
WO1993000086A1 (fr) 1993-01-07
SA92130141B1 (ar) 2005-12-18
US5637611A (en) 1997-06-10
BR1100460A (pt) 2000-07-18
RU2137474C1 (ru) 1999-09-20
NO2005011I2 (no) 2008-02-11
GB9113802D0 (en) 1991-08-14
EP0591280B1 (fr) 1998-09-09
AU652842B2 (en) 1994-09-08
SG47877A1 (en) 1998-04-17
KR100251571B1 (ko) 2000-07-01
PL171034B1 (en) 1997-02-28
FI103967B1 (fi) 1999-10-29
NO934800D0 (no) 1993-12-23
DE69226953D1 (de) 1998-10-15
NO304774B1 (no) 1999-02-15
FI103967B (fi) 1999-10-29
IE922062A1 (en) 1992-12-30
NL300103I1 (nl) 2002-12-02
DK0591280T3 (da) 1999-02-15
NO2005011I1 (no) 2005-05-18
JPH06508827A (ja) 1994-10-06
ZA924658B (en) 1993-12-24
TW214544B (fr) 1993-10-11
LU90939I2 (fr) 2002-09-24
SK280905B6 (sk) 2000-09-12
IL117104A (en) 1997-09-30
CN1034072C (zh) 1997-02-19
FI935842A (fi) 1993-12-23
IL102322A0 (en) 1993-01-14
DE10299042I2 (de) 2005-02-03
PL169392B1 (pl) 1996-07-31
IL117104A0 (en) 1996-06-18
IL117105A0 (en) 1996-06-18
CZ282083B6 (cs) 1997-05-14
UA41254C2 (uk) 2001-09-17
JP3261502B2 (ja) 2002-03-04
EP0591280A1 (fr) 1994-04-13
US5464864A (en) 1995-11-07
DE69226953T2 (de) 1999-05-12
CZ150696A3 (en) 1997-06-11
SK280907B6 (sk) 2000-09-12
HU218907B (hu) 2000-12-28
IL102322A (en) 1997-09-30
ATE170746T1 (de) 1998-09-15
DE10299042I1 (de) 2003-02-20
HUT68961A (en) 1995-08-28
IL117105A (en) 1998-01-04
SK280906B6 (sk) 2000-09-12
CA2113726A1 (fr) 1993-01-07
NO934800L (no) 1993-12-23
NL300103I2 (nl) 2003-02-03
CZ286193A3 (en) 1994-07-13
CZ282061B6 (cs) 1997-05-14
HK1014669A1 (en) 1999-09-30
CZ150596A3 (en) 1997-05-14
PT100620B (pt) 1999-01-29
FI935842A0 (fi) 1993-12-23
PT100620A (pt) 1993-09-30
CA2113726C (fr) 2008-02-19
BR9206237A (pt) 1995-04-11
CZ282327B6 (cs) 1997-06-11
AP344A (en) 1994-07-05
CN1069726A (zh) 1993-03-10
SK131993A3 (en) 1994-06-08
AU1977592A (en) 1993-01-25

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