UA41254C2 - ПОХІДНЕ ТЕТРАГІДРОКАРБАЗОЛУ АБО ЙОГО СІЛЬ, СОЛЬВАТ АБО ГІДРАТ ЯК АГОНІСТ 5-НТ<sub>1</sub>-ПОДІБНОГО РЕЦЕПТОРА, СПОСІБ ЇХ ОДЕРЖАННЯ ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ - Google Patents

ПОХІДНЕ ТЕТРАГІДРОКАРБАЗОЛУ АБО ЙОГО СІЛЬ, СОЛЬВАТ АБО ГІДРАТ ЯК АГОНІСТ 5-НТ<sub>1</sub>-ПОДІБНОГО РЕЦЕПТОРА, СПОСІБ ЇХ ОДЕРЖАННЯ ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ

Info

Publication number
UA41254C2
UA41254C2 UA93002251A UA93002251A UA41254C2 UA 41254 C2 UA41254 C2 UA 41254C2 UA 93002251 A UA93002251 A UA 93002251A UA 93002251 A UA93002251 A UA 93002251A UA 41254 C2 UA41254 C2 UA 41254C2
Authority
UA
Ukraine
Prior art keywords
sub
alkyl
sile
solvate
agonist
Prior art date
Application number
UA93002251A
Other languages
English (en)
Russian (ru)
Inventor
Френсіс Девід Кінг
Ларамі Мері Гастер
Альберто Джуліо Кауманн
Родні Крістофер Янг
Original Assignee
Смісклайн Бічем Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA41254(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Смісклайн Бічем Плс filed Critical Смісклайн Бічем Плс
Publication of UA41254C2 publication Critical patent/UA41254C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
UA93002251A 1991-06-26 1992-06-17 ПОХІДНЕ ТЕТРАГІДРОКАРБАЗОЛУ АБО ЙОГО СІЛЬ, СОЛЬВАТ АБО ГІДРАТ ЯК АГОНІСТ 5-НТ<sub>1</sub>-ПОДІБНОГО РЕЦЕПТОРА, СПОСІБ ЇХ ОДЕРЖАННЯ ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ UA41254C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
PCT/GB1992/001082 WO1993000086A1 (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5ht1 receptor agonists

Publications (1)

Publication Number Publication Date
UA41254C2 true UA41254C2 (uk) 2001-09-17

Family

ID=10697363

Family Applications (1)

Application Number Title Priority Date Filing Date
UA93002251A UA41254C2 (uk) 1991-06-26 1992-06-17 ПОХІДНЕ ТЕТРАГІДРОКАРБАЗОЛУ АБО ЙОГО СІЛЬ, СОЛЬВАТ АБО ГІДРАТ ЯК АГОНІСТ 5-НТ<sub>1</sub>-ПОДІБНОГО РЕЦЕПТОРА, СПОСІБ ЇХ ОДЕРЖАННЯ ТА ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ

Country Status (35)

Country Link
US (2) US5464864A (uk)
EP (1) EP0591280B1 (uk)
JP (1) JP3261502B2 (uk)
KR (1) KR100251571B1 (uk)
CN (1) CN1034072C (uk)
AP (1) AP344A (uk)
AT (1) ATE170746T1 (uk)
BR (2) BR9206237A (uk)
CA (1) CA2113726C (uk)
CZ (3) CZ282083B6 (uk)
DE (2) DE10299042I2 (uk)
DK (1) DK0591280T3 (uk)
FI (1) FI103967B1 (uk)
GB (1) GB9113802D0 (uk)
HK (1) HK1014669A1 (uk)
HU (1) HU218907B (uk)
IE (1) IE922062A1 (uk)
IL (4) IL117104A (uk)
LU (1) LU90939I2 (uk)
MA (1) MA22563A1 (uk)
MX (1) MX9203444A (uk)
NL (1) NL300103I2 (uk)
NO (2) NO304774B1 (uk)
NZ (1) NZ243288A (uk)
PL (3) PL169392B1 (uk)
PT (1) PT100620B (uk)
RU (1) RU2137474C1 (uk)
SA (1) SA92130141B1 (uk)
SG (1) SG47877A1 (uk)
SI (1) SI9200125B (uk)
SK (3) SK280907B6 (uk)
TW (1) TW214544B (uk)
UA (1) UA41254C2 (uk)
WO (1) WO1993000086A1 (uk)
ZA (1) ZA924658B (uk)

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GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
EP0749962B1 (en) * 1995-06-23 2000-11-02 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9808069D0 (en) 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
BR0312176A (pt) 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmaceutica, uso de um composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso, processo para a preparação de um composto, novo intermediario e processo para a preparação de um novo intermediario
CN1662538A (zh) 2002-06-21 2005-08-31 苏文生命科学有限公司 可作为治疗剂的对血清素受体具有亲和力的芳烷基吲哚、其制备工艺及其含有该物质的药物组合物
NZ540842A (en) 2002-11-28 2008-05-30 Suven Life Sciences Ltd N-arylsulfonyl-3-aminoalkoxyindoles
KR100818508B1 (ko) 2002-11-28 2008-03-31 수벤 라이프 사이언시스 리미티드 세로토닌 수용체 친화력을 가지는 엔-아릴술포닐-3-치환인돌, 그 제조방법 및 그를 포함하는 약제학적 조성물
EP1581538B1 (en) 2002-12-18 2007-02-28 Suven Life Sciences Limited Tetracyclic 3-substituted indoles having serotonin receptor affinity
DK2051962T3 (da) * 2006-08-07 2012-01-02 Actelion Pharmaceuticals Ltd (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-eddikesyrederivater
PL2124556T3 (pl) 2006-10-09 2015-02-27 Charleston Laboratories Inc Kompozycje farmaceutyczne
EP2120875B1 (en) 2007-02-11 2018-07-11 Map Pharmaceuticals Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
JP5714910B2 (ja) 2008-01-09 2015-05-07 チャールストン ラボラトリーズ，インコーポレイテッド 薬学的組成物
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
WO2011006012A1 (en) 2009-07-08 2011-01-13 Charleston Laboratories Inc. Pharmaceutical compositions
WO2011050140A1 (en) 2009-10-22 2011-04-28 Blue Fury Consulting, L.L.C. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
PL2734634T3 (pl) 2011-07-22 2020-03-31 The University Of Chicago Igf-1 do zastosowania do leczenia migreny
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
JP2019507181A (ja) 2016-03-04 2019-03-14 チャールストン ラボラトリーズ，インコーポレイテッド 医薬組成物
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan

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US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) * 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Also Published As

Publication number Publication date
SG47877A1 (en) 1998-04-17
KR100251571B1 (ko) 2000-07-01
RU2137474C1 (ru) 1999-09-20
CZ282327B6 (cs) 1997-06-11
CA2113726C (en) 2008-02-19
NO934800D0 (no) 1993-12-23
PL169392B1 (pl) 1996-07-31
CN1034072C (zh) 1997-02-19
CZ150596A3 (en) 1997-05-14
CZ286193A3 (en) 1994-07-13
CZ150696A3 (en) 1997-06-11
DE10299042I1 (de) 2003-02-20
PT100620B (pt) 1999-01-29
JPH06508827A (ja) 1994-10-06
PT100620A (pt) 1993-09-30
FI935842A (fi) 1993-12-23
IL102322A0 (en) 1993-01-14
AU1977592A (en) 1993-01-25
NL300103I2 (nl) 2003-02-03
GB9113802D0 (en) 1991-08-14
CN1069726A (zh) 1993-03-10
PL171034B1 (en) 1997-02-28
SK280907B6 (sk) 2000-09-12
CZ282061B6 (cs) 1997-05-14
US5637611A (en) 1997-06-10
US5464864A (en) 1995-11-07
ZA924658B (en) 1993-12-24
NZ243288A (en) 1994-09-27
IE922062A1 (en) 1992-12-30
IL117105A0 (en) 1996-06-18
SK280906B6 (sk) 2000-09-12
DE10299042I2 (de) 2005-02-03
EP0591280B1 (en) 1998-09-09
IL117104A (en) 1997-09-30
FI103967B (fi) 1999-10-29
MA22563A1 (fr) 1992-12-31
SI9200125A (en) 1992-12-31
LU90939I2 (fr) 2002-09-24
HUT68961A (en) 1995-08-28
TW214544B (uk) 1993-10-11
AU652842B2 (en) 1994-09-08
BR1100460A (pt) 2000-07-18
IL102322A (en) 1997-09-30
BR9206237A (pt) 1995-04-11
NO2005011I2 (no) 2008-02-11
CZ282083B6 (cs) 1997-05-14
NO2005011I1 (no) 2005-05-18
AP9200403A0 (en) 1992-07-31
NL300103I1 (nl) 2002-12-02
SI9200125B (en) 2001-12-31
FI103967B1 (fi) 1999-10-29
FI935842A0 (fi) 1993-12-23
DK0591280T3 (da) 1999-02-15
NO304774B1 (no) 1999-02-15
AP344A (en) 1994-07-05
DE69226953T2 (de) 1999-05-12
NO934800L (no) 1993-12-23
IL117105A (en) 1998-01-04
DE69226953D1 (de) 1998-10-15
MX9203444A (es) 1993-12-01
SK280905B6 (sk) 2000-09-12
WO1993000086A1 (en) 1993-01-07
PL169410B1 (pl) 1996-07-31
SA92130141B1 (ar) 2005-12-18
IL117104A0 (en) 1996-06-18
EP0591280A1 (en) 1994-04-13
HK1014669A1 (en) 1999-09-30
JP3261502B2 (ja) 2002-03-04
CA2113726A1 (en) 1993-01-07
ATE170746T1 (de) 1998-09-15
HU218907B (hu) 2000-12-28
SK131993A3 (en) 1994-06-08

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