IL117104A0 - Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them - Google Patents

Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them

Info

Publication number
IL117104A0
IL117104A0 IL11710496A IL11710496A IL117104A0 IL 117104 A0 IL117104 A0 IL 117104A0 IL 11710496 A IL11710496 A IL 11710496A IL 11710496 A IL11710496 A IL 11710496A IL 117104 A0 IL117104 A0 IL 117104A0
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
tetrahydrocarbazole derivatives
derivatives process
Prior art date
Application number
IL11710496A
Other versions
IL117104A (en
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL117104(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of IL117104A0 publication Critical patent/IL117104A0/en
Publication of IL117104A publication Critical patent/IL117104A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL117104A 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them IL117104A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
US08/167,846 US5464864A (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists
IL102322A IL102322A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments

Publications (2)

Publication Number Publication Date
IL117104A0 true IL117104A0 (en) 1996-06-18
IL117104A IL117104A (en) 1997-09-30

Family

ID=10697363

Family Applications (4)

Application Number Title Priority Date Filing Date
IL117105A IL117105A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them
IL11710596A IL117105A0 (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them
IL117104A IL117104A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them
IL102322A IL102322A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL117105A IL117105A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives, process for their preparation and pharmaceutical compositions containing them
IL11710596A IL117105A0 (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL102322A IL102322A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives for use as 5-ht1-like agonist medicaments

Country Status (35)

Country Link
US (2) US5464864A (en)
EP (1) EP0591280B1 (en)
JP (1) JP3261502B2 (en)
KR (1) KR100251571B1 (en)
CN (1) CN1034072C (en)
AP (1) AP344A (en)
AT (1) ATE170746T1 (en)
BR (2) BR9206237A (en)
CA (1) CA2113726C (en)
CZ (3) CZ282083B6 (en)
DE (2) DE10299042I2 (en)
DK (1) DK0591280T3 (en)
FI (1) FI103967B1 (en)
GB (1) GB9113802D0 (en)
HK (1) HK1014669A1 (en)
HU (1) HU218907B (en)
IE (1) IE922062A1 (en)
IL (4) IL117105A (en)
LU (1) LU90939I2 (en)
MA (1) MA22563A1 (en)
MX (1) MX9203444A (en)
NL (1) NL300103I2 (en)
NO (2) NO304774B1 (en)
NZ (1) NZ243288A (en)
PL (3) PL169410B1 (en)
PT (1) PT100620B (en)
RU (1) RU2137474C1 (en)
SA (1) SA92130141B1 (en)
SG (1) SG47877A1 (en)
SI (1) SI9200125B (en)
SK (3) SK280906B6 (en)
TW (1) TW214544B (en)
UA (1) UA41254C2 (en)
WO (1) WO1993000086A1 (en)
ZA (1) ZA924658B (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
EP0749962B1 (en) * 1995-06-23 2000-11-02 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
ES2297216T3 (en) 2002-06-21 2008-05-01 Suven Life Sciences Limited ARILSULFONIL TETRACICLIC INDOLES THAT HAVE AFFINITY WITH THE SEROTONINE RECEIVER.
WO2004000845A1 (en) 2002-06-21 2003-12-31 Suven Life Sciences Limited Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
ATE401307T1 (en) 2002-11-28 2008-08-15 Suven Life Sciences Ltd N-ARYLSULFONYL-2-SUBSTITUTED INDOLES WITH AFFINITY FOR THE SEROTONIN RECEPTOR, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
SI1567492T1 (en) 2002-11-28 2013-07-31 Suven Life Sciences Limited N-arylsulfonyl-3-aminoalkoxyindoles
DK1581538T3 (en) 2002-12-18 2007-06-25 Suven Life Sciences Ltd Tetracyclic 3-substituted indoles with serotonin receptor affinity
NZ574705A (en) * 2006-08-07 2011-12-22 Actelion Pharmaceuticals Ltd (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives
PL2124556T3 (en) 2006-10-09 2015-02-27 Charleston Laboratories Inc Pharmaceutical compositions
EP2425820B1 (en) 2007-02-11 2015-04-08 MAP Pharmaceuticals Inc Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
WO2009089494A2 (en) 2008-01-09 2009-07-16 Charleston Laboratories, Inc. Pharmaceutical compositions
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
EP2451274B1 (en) 2009-07-08 2017-10-04 Charleston Laboratories, Inc. Pharmaceutical compositions
US9204906B2 (en) 2009-10-22 2015-12-08 Nuvasive, Inc. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
PL2734634T3 (en) 2011-07-22 2020-03-31 The University Of Chicago Igf-1 for use in the treatment of migraine
WO2014100351A2 (en) 2012-12-21 2014-06-26 Map Pharmaceuticals, Inc. 8'-hydroxy-dihydroergotamine compounds and compositions
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
US10179109B2 (en) 2016-03-04 2019-01-15 Charleston Laboratories, Inc. Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) * 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
BE787537A (en) * 1971-08-16 1973-02-14 Sterling Drug Inc TETRAHYDROCARBAZOLES
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (en) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazol derivatives

Also Published As

Publication number Publication date
NL300103I2 (en) 2003-02-03
CZ282083B6 (en) 1997-05-14
CN1034072C (en) 1997-02-19
DE69226953T2 (en) 1999-05-12
FI103967B (en) 1999-10-29
AU652842B2 (en) 1994-09-08
CZ286193A3 (en) 1994-07-13
SK280906B6 (en) 2000-09-12
SK280907B6 (en) 2000-09-12
ZA924658B (en) 1993-12-24
IL117105A0 (en) 1996-06-18
AU1977592A (en) 1993-01-25
CZ150696A3 (en) 1997-06-11
NZ243288A (en) 1994-09-27
BR1100460A (en) 2000-07-18
NO304774B1 (en) 1999-02-15
US5637611A (en) 1997-06-10
HU218907B (en) 2000-12-28
NL300103I1 (en) 2002-12-02
RU2137474C1 (en) 1999-09-20
WO1993000086A1 (en) 1993-01-07
SA92130141B1 (en) 2005-12-18
SI9200125B (en) 2001-12-31
NO934800L (en) 1993-12-23
JPH06508827A (en) 1994-10-06
CA2113726C (en) 2008-02-19
SG47877A1 (en) 1998-04-17
IL117105A (en) 1998-01-04
CA2113726A1 (en) 1993-01-07
TW214544B (en) 1993-10-11
ATE170746T1 (en) 1998-09-15
HK1014669A1 (en) 1999-09-30
GB9113802D0 (en) 1991-08-14
PT100620A (en) 1993-09-30
IL102322A (en) 1997-09-30
PL169392B1 (en) 1996-07-31
SK280905B6 (en) 2000-09-12
LU90939I2 (en) 2002-09-24
KR100251571B1 (en) 2000-07-01
NO2005011I2 (en) 2008-02-11
JP3261502B2 (en) 2002-03-04
AP344A (en) 1994-07-05
PL171034B1 (en) 1997-02-28
CZ150596A3 (en) 1997-05-14
PL169410B1 (en) 1996-07-31
CN1069726A (en) 1993-03-10
SI9200125A (en) 1992-12-31
DE10299042I1 (en) 2003-02-20
EP0591280A1 (en) 1994-04-13
US5464864A (en) 1995-11-07
DE10299042I2 (en) 2005-02-03
AP9200403A0 (en) 1992-07-31
DE69226953D1 (en) 1998-10-15
FI935842A (en) 1993-12-23
IL102322A0 (en) 1993-01-14
IL117104A (en) 1997-09-30
FI935842A0 (en) 1993-12-23
IE922062A1 (en) 1992-12-30
SK131993A3 (en) 1994-06-08
NO2005011I1 (en) 2005-05-18
CZ282327B6 (en) 1997-06-11
UA41254C2 (en) 2001-09-17
MA22563A1 (en) 1992-12-31
PT100620B (en) 1999-01-29
HUT68961A (en) 1995-08-28
CZ282061B6 (en) 1997-05-14
EP0591280B1 (en) 1998-09-09
NO934800D0 (en) 1993-12-23
FI103967B1 (en) 1999-10-29
BR9206237A (en) 1995-04-11
DK0591280T3 (en) 1999-02-15
MX9203444A (en) 1993-12-01

Similar Documents

Publication Publication Date Title
IL117105A0 (en) Tetrahydrocarbazole derivatives process for their preparation and pharmaceutical compositions containing them
HK1005136A1 (en) Amido-3-pyrazole derivatives process for their preparation and pharmaceutical compositions containing them
HU9401844D0 (en) Isatin derivatives process for the preparation thereof and pharmaceutical compositions comprising the same
HUT72639A (en) Substituted thiazolidinedione derivatives, pharmaceutical compositions containing them and process for their preparation
IL103126A (en) 5-amino-4-hydroxyhexanoic acid derivatives, process for their preparation and pharmaceutical compositions containing them
IL105412A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
IL101864A0 (en) Thiopyranopyrrole derivatives,their preparation and pharmaceutical compositions containing them
IL96385A0 (en) Indole derivatives,their preparation and pharmaceutical compositions containing them
ZA927994B (en) Heterobiaryl derivatives pharmaceutical compositions containing these compounds and processes for preparing them
IL86877A (en) Carbazole derivatives,their preparation and pharmaceutical compositions containing them
IL100262A0 (en) Alpha-oxoacetamide derivatives,their preparation and pharmaceutical compositions containing them
IL109703A0 (en) Substituted carbazole derivatives, processes for their preparation and pharmaceutical compositions containing them
IL102175A0 (en) Imidazodiazepine derivatives,their preparation and pharmaceutical compositions containing them
IL97050A0 (en) 4-isoxazolecarboxamide derivatives,pharmaceutical compositions containing them and their preparation
HUT69712A (en) Process for preparing benzimidazole derivatives and pharmaceutical compositions containing them
HK1000597A1 (en) Pyridazine derivatives process for their preparation and pharmaceutical compositions containing them
AU1256792A (en) Indole derivatives and pharmaceutical compositions containing them
HUT67014A (en) Benzofuran derivatives, pharmaceutical compositions containing them and process for the preparation of thereof
IL100850A0 (en) Indole derivatives and pharmaceutical compositions containing them
IL98812A0 (en) Purine derivatives,process for their preparation and pharmaceutical compositions containing them
IL102500A0 (en) 3-deoxy-mannosamine derivatives,their preparation and pharmaceutical compositions containing them
IL102116A (en) Hetaryloxy-beta-carboline derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
HU903016D0 (en) Process for the preparation of indole derivatives and pharmaceutical compositions containing them
HUT56345A (en) Process for producing indole derivatives and pharmaceutical compositions comprising such compounds
HU895817D0 (en) Process for the preparation of phenyloxy-propanol-amine derivatives and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired