CN1069726A - 四氢咔唑衍生物的制备方法 - Google Patents
四氢咔唑衍生物的制备方法 Download PDFInfo
- Publication number
- CN1069726A CN1069726A CN92108831A CN92108831A CN1069726A CN 1069726 A CN1069726 A CN 1069726A CN 92108831 A CN92108831 A CN 92108831A CN 92108831 A CN92108831 A CN 92108831A CN 1069726 A CN1069726 A CN 1069726A
- Authority
- CN
- China
- Prior art keywords
- amino
- tetrahydro carbazole
- compound
- formula
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Description
Claims (7)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919113802A GB9113802D0 (en) | 1991-06-26 | 1991-06-26 | Medicaments |
GB9113802.4 | 1991-06-26 | ||
US08/167,846 US5464864A (en) | 1991-06-26 | 1992-06-17 | Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1069726A true CN1069726A (zh) | 1993-03-10 |
CN1034072C CN1034072C (zh) | 1997-02-19 |
Family
ID=10697363
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN92108831A Expired - Lifetime CN1034072C (zh) | 1991-06-26 | 1992-06-25 | 四氢咔唑衍生物的制备方法 |
Country Status (35)
Country | Link |
---|---|
US (2) | US5464864A (zh) |
EP (1) | EP0591280B1 (zh) |
JP (1) | JP3261502B2 (zh) |
KR (1) | KR100251571B1 (zh) |
CN (1) | CN1034072C (zh) |
AP (1) | AP344A (zh) |
AT (1) | ATE170746T1 (zh) |
BR (2) | BR9206237A (zh) |
CA (1) | CA2113726C (zh) |
CZ (3) | CZ282083B6 (zh) |
DE (2) | DE10299042I2 (zh) |
DK (1) | DK0591280T3 (zh) |
FI (1) | FI103967B1 (zh) |
GB (1) | GB9113802D0 (zh) |
HK (1) | HK1014669A1 (zh) |
HU (1) | HU218907B (zh) |
IE (1) | IE922062A1 (zh) |
IL (4) | IL117105A (zh) |
LU (1) | LU90939I2 (zh) |
MA (1) | MA22563A1 (zh) |
MX (1) | MX9203444A (zh) |
NL (1) | NL300103I2 (zh) |
NO (2) | NO304774B1 (zh) |
NZ (1) | NZ243288A (zh) |
PL (3) | PL169410B1 (zh) |
PT (1) | PT100620B (zh) |
RU (1) | RU2137474C1 (zh) |
SA (1) | SA92130141B1 (zh) |
SG (1) | SG47877A1 (zh) |
SI (1) | SI9200125B (zh) |
SK (3) | SK280906B6 (zh) |
TW (1) | TW214544B (zh) |
UA (1) | UA41254C2 (zh) |
WO (1) | WO1993000086A1 (zh) |
ZA (1) | ZA924658B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1039491C (zh) * | 1992-12-21 | 1998-08-12 | 史密丝克莱恩比彻姆有限公司 | 四氢咔唑化合物及其制备方法和应用 |
CN105452221A (zh) * | 2013-07-17 | 2016-03-30 | 通用电气健康护理有限公司 | 2,3,4,9-四氢-1h-咔唑-4-甲酰胺衍生物的对映异构体分离和纯化 |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
US5616603A (en) * | 1995-05-26 | 1997-04-01 | Smithkline Beecham Plc | Enantiomers of carbazole derivatives as 5-HT1 -like agonists |
GB9226566D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
US5618948A (en) * | 1995-05-26 | 1997-04-08 | Smithkline Beecham P.L.C. | Process for preparing an enantiomer of a carbazole derivative |
EP0749962B1 (en) * | 1995-06-23 | 2000-11-02 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles |
US5917054A (en) * | 1995-07-18 | 1999-06-29 | Smithkline Beecham P.L.C. | Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists |
US5708187A (en) * | 1996-06-27 | 1998-01-13 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists |
US5891885A (en) * | 1996-10-09 | 1999-04-06 | Algos Pharmaceutical Corporation | Method for treating migraine |
GB9723061D0 (en) * | 1997-10-31 | 1998-01-07 | Vanguard Medica Ltd | Medicaments |
US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
US6066092A (en) * | 1997-11-06 | 2000-05-23 | Cady; Roger K. | Preemptive prophylaxis of migraine device and method |
GB9808069D0 (en) * | 1998-04-16 | 1998-06-17 | Vanguard Medica Ltd | Novel processes |
GB9817911D0 (en) * | 1998-08-17 | 1998-10-14 | Vanguard Medica Ltd | New use |
US6685951B2 (en) | 2001-07-05 | 2004-02-03 | R. T. Alamo Ventures I, Inc. | Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine |
US20030198669A1 (en) * | 2001-07-05 | 2003-10-23 | R.T. Alamo Ventures I, Llc | Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine |
US20030017175A1 (en) * | 2001-07-05 | 2003-01-23 | R.T. Alamo Ventures I, Inc. | Sublingual administration of dihydroergotamine for the treatment of migraine |
ES2297216T3 (es) | 2002-06-21 | 2008-05-01 | Suven Life Sciences Limited | Indoles tetraciclicos arilsulfonil que tienen afinidad con el receptor de la serotonina. |
WO2004000845A1 (en) | 2002-06-21 | 2003-12-31 | Suven Life Sciences Limited | Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them |
ATE401307T1 (de) | 2002-11-28 | 2008-08-15 | Suven Life Sciences Ltd | N-arylsulfonyl-2-substituierte indole mit affinität zum serotonin rezeptor, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen |
SI1567492T1 (sl) | 2002-11-28 | 2013-07-31 | Suven Life Sciences Limited | N-arilsulfonil-3-aminoalkoksiindoli |
DK1581538T3 (da) | 2002-12-18 | 2007-06-25 | Suven Life Sciences Ltd | Tetracykliske 3-substituerede indoler med serotoninreceptoraffinitet |
NZ574705A (en) * | 2006-08-07 | 2011-12-22 | Actelion Pharmaceuticals Ltd | (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives |
PL2124556T3 (pl) | 2006-10-09 | 2015-02-27 | Charleston Laboratories Inc | Kompozycje farmaceutyczne |
EP2425820B1 (en) | 2007-02-11 | 2015-04-08 | MAP Pharmaceuticals Inc | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
US20090069399A1 (en) * | 2007-09-12 | 2009-03-12 | Protia, Llc | Deuterium-enriched frovatriptan |
WO2009089494A2 (en) | 2008-01-09 | 2009-07-16 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
WO2010073253A1 (en) * | 2008-12-22 | 2010-07-01 | Natco Pharma Limited | Method for preparing an optically active frovatriptan |
EP2451274B1 (en) | 2009-07-08 | 2017-10-04 | Charleston Laboratories, Inc. | Pharmaceutical compositions |
US9204906B2 (en) | 2009-10-22 | 2015-12-08 | Nuvasive, Inc. | Posterior cervical fusion system and techniques |
US10098674B2 (en) | 2009-10-22 | 2018-10-16 | Nuvasive, Inc. | System and method for posterior cervical fusion |
PL2734634T3 (pl) | 2011-07-22 | 2020-03-31 | The University Of Chicago | Igf-1 do zastosowania do leczenia migreny |
WO2014100351A2 (en) | 2012-12-21 | 2014-06-26 | Map Pharmaceuticals, Inc. | 8'-hydroxy-dihydroergotamine compounds and compositions |
EP2816030A1 (en) | 2013-06-20 | 2014-12-24 | Duke Chem, S. A. | Process for the preparation of frovatriptan and its enantiomer |
US10179109B2 (en) | 2016-03-04 | 2019-01-15 | Charleston Laboratories, Inc. | Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates |
EP3766483A1 (en) | 2019-07-19 | 2021-01-20 | BioPharma Synergies, S. L. | Orodispersible powder composition comprising a triptan |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3642816A (en) * | 1967-08-10 | 1972-02-15 | Sterling Drug Inc | 3-acetamido-1 2 3 4-tetrahydrocarbazole |
US4062864A (en) * | 1968-01-24 | 1977-12-13 | Sterling Drug Inc. | 3-Hydroxy carbazole derivatives |
US3959309A (en) * | 1968-01-24 | 1976-05-25 | Sterling Drug Inc. | 3-Amido-1,2,3,4-tetrahydrocarbazoles |
US3592824A (en) * | 1970-03-12 | 1971-07-13 | Miles Lab | 3-substituted amino-1,2,3,4-tetrahydrocarbazoles |
US4172834A (en) * | 1971-08-16 | 1979-10-30 | Sterling Drug Inc. | 3-Amino-tetrahydrocarbazoles |
BE787537A (fr) * | 1971-08-16 | 1973-02-14 | Sterling Drug Inc | Tetrahydrocarbazoles |
US4257952A (en) * | 1977-06-06 | 1981-03-24 | Sterling Drug Inc. | 3-Amino-tetrahydrocarbazoles |
US4254134A (en) * | 1978-03-17 | 1981-03-03 | Endo Laboratories, Inc. | Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles |
EP0115607A1 (de) * | 1983-01-04 | 1984-08-15 | MERCK PATENT GmbH | Tetrahydrocarbazolderivate |
-
1991
- 1991-06-26 GB GB919113802A patent/GB9113802D0/en active Pending
-
1992
- 1992-06-17 PL PL92307118A patent/PL169410B1/pl unknown
- 1992-06-17 WO PCT/GB1992/001082 patent/WO1993000086A1/en active IP Right Grant
- 1992-06-17 CZ CS932861A patent/CZ282083B6/cs not_active IP Right Cessation
- 1992-06-17 CZ CZ961506A patent/CZ282327B6/cs not_active IP Right Cessation
- 1992-06-17 EP EP92912379A patent/EP0591280B1/en not_active Expired - Lifetime
- 1992-06-17 SG SG1996004938A patent/SG47877A1/en unknown
- 1992-06-17 PL PL92301883A patent/PL169392B1/pl unknown
- 1992-06-17 SK SK1054-98A patent/SK280906B6/sk not_active IP Right Cessation
- 1992-06-17 HU HU9303731A patent/HU218907B/hu active IP Right Revival
- 1992-06-17 SK SK1685-98A patent/SK280907B6/sk not_active IP Right Cessation
- 1992-06-17 CA CA002113726A patent/CA2113726C/en not_active Expired - Lifetime
- 1992-06-17 BR BR9206237A patent/BR9206237A/pt not_active Application Discontinuation
- 1992-06-17 PL PL92311304A patent/PL171034B1/pl unknown
- 1992-06-17 KR KR1019930704055A patent/KR100251571B1/ko not_active IP Right Cessation
- 1992-06-17 US US08/167,846 patent/US5464864A/en not_active Expired - Lifetime
- 1992-06-17 UA UA93002251A patent/UA41254C2/uk unknown
- 1992-06-17 DE DE2002199042 patent/DE10299042I2/de active Active
- 1992-06-17 SK SK1319-93A patent/SK280905B6/sk not_active IP Right Cessation
- 1992-06-17 DK DK92912379T patent/DK0591280T3/da active
- 1992-06-17 AT AT92912379T patent/ATE170746T1/de active
- 1992-06-17 DE DE69226953T patent/DE69226953T2/de not_active Expired - Lifetime
- 1992-06-17 RU RU93058534A patent/RU2137474C1/ru active Protection Beyond IP Right Term
- 1992-06-17 JP JP51108692A patent/JP3261502B2/ja not_active Expired - Lifetime
- 1992-06-17 CZ CZ961505A patent/CZ282061B6/cs not_active IP Right Cessation
- 1992-06-24 ZA ZA924658A patent/ZA924658B/xx unknown
- 1992-06-24 PT PT100620A patent/PT100620B/pt not_active IP Right Cessation
- 1992-06-24 MA MA22853A patent/MA22563A1/fr unknown
- 1992-06-24 NZ NZ243288A patent/NZ243288A/en not_active IP Right Cessation
- 1992-06-25 CN CN92108831A patent/CN1034072C/zh not_active Expired - Lifetime
- 1992-06-25 IL IL117105A patent/IL117105A/en not_active IP Right Cessation
- 1992-06-25 IL IL11710596A patent/IL117105A0/xx unknown
- 1992-06-25 TW TW081104991A patent/TW214544B/zh not_active IP Right Cessation
- 1992-06-25 AP APAP/P/1992/000403A patent/AP344A/en active
- 1992-06-25 IL IL117104A patent/IL117104A/xx not_active IP Right Cessation
- 1992-06-25 IL IL102322A patent/IL102322A/xx not_active IP Right Cessation
- 1992-06-26 MX MX9203444A patent/MX9203444A/es unknown
- 1992-06-26 SI SI9200125A patent/SI9200125B/sl unknown
- 1992-07-01 IE IE206292A patent/IE922062A1/en not_active IP Right Cessation
- 1992-10-04 SA SA92130141A patent/SA92130141B1/ar unknown
-
1993
- 1993-12-23 FI FI935842A patent/FI103967B1/fi not_active IP Right Cessation
- 1993-12-23 NO NO934759A patent/NO304774B1/no not_active IP Right Cessation
-
1995
- 1995-05-15 US US08/442,719 patent/US5637611A/en not_active Expired - Lifetime
-
1997
- 1997-05-06 BR BR1100460-6A patent/BR1100460A/pt active IP Right Grant
-
1998
- 1998-12-28 HK HK98116054A patent/HK1014669A1/xx not_active IP Right Cessation
-
2002
- 2002-07-24 LU LU90939C patent/LU90939I2/fr unknown
- 2002-10-14 NL NL300103C patent/NL300103I2/nl unknown
-
2005
- 2005-05-03 NO NO2005011C patent/NO2005011I2/no unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1039491C (zh) * | 1992-12-21 | 1998-08-12 | 史密丝克莱恩比彻姆有限公司 | 四氢咔唑化合物及其制备方法和应用 |
CN105452221A (zh) * | 2013-07-17 | 2016-03-30 | 通用电气健康护理有限公司 | 2,3,4,9-四氢-1h-咔唑-4-甲酰胺衍生物的对映异构体分离和纯化 |
US9815785B2 (en) | 2013-07-17 | 2017-11-14 | Ge Healthcare Limited | Enantiomeric separation and purification of 2,3,4,9-tetrahydro-1H-carbazole-4-carboxylic acid amide derivatives |
CN105452221B (zh) * | 2013-07-17 | 2018-11-23 | 通用电气健康护理有限公司 | 2,3,4,9-四氢-1h-咔唑-4-甲酰胺衍生物的对映异构体分离和纯化 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: VERNERREES CO., LTD. Free format text: FORMER OWNER: SMITHKLINE BEECHAM PLC Effective date: 20010709 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20010709 Address after: Beck County Patentee after: Finaris Co., Ltd. Address before: The British England Middlesex County Patentee before: Smithkline Beecham PLC |
|
C15 | Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993) | ||
OR01 | Other related matters | ||
C17 | Cessation of patent right | ||
CX01 | Expiry of patent term |
Expiration termination date: 20120626 Granted publication date: 19970219 |