PT100620A - Derivados de tetra-hidrocarbazol, seu uso e preparacao e composicoes farmaceuticas que os contem - Google Patents

Derivados de tetra-hidrocarbazol, seu uso e preparacao e composicoes farmaceuticas que os contem

Info

Publication number
PT100620A
PT100620A PT100620A PT10062092A PT100620A PT 100620 A PT100620 A PT 100620A PT 100620 A PT100620 A PT 100620A PT 10062092 A PT10062092 A PT 10062092A PT 100620 A PT100620 A PT 100620A
Authority
PT
Portugal
Prior art keywords
alkyl
pharmaceutical compositions
hydrocarbazol
tetra
derivatives
Prior art date
Application number
PT100620A
Other languages
English (en)
Other versions
PT100620B (pt
Inventor
Alberto Julio Kaumann
Francis David King
Laramie Mary Gaster
Rodney Christopher Young
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT100620(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of PT100620A publication Critical patent/PT100620A/pt
Publication of PT100620B publication Critical patent/PT100620B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT100620A 1991-06-26 1992-06-24 Derivados de tetra-hidrocarbazol, seu uso e preparacao e composicoes farmaceuticas que os contem PT100620B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments

Publications (2)

Publication Number Publication Date
PT100620A true PT100620A (pt) 1993-09-30
PT100620B PT100620B (pt) 1999-01-29

Family

ID=10697363

Family Applications (1)

Application Number Title Priority Date Filing Date
PT100620A PT100620B (pt) 1991-06-26 1992-06-24 Derivados de tetra-hidrocarbazol, seu uso e preparacao e composicoes farmaceuticas que os contem

Country Status (34)

Country Link
US (2) US5464864A (pt)
EP (1) EP0591280B1 (pt)
JP (1) JP3261502B2 (pt)
KR (1) KR100251571B1 (pt)
CN (1) CN1034072C (pt)
AP (1) AP344A (pt)
AT (1) ATE170746T1 (pt)
BR (2) BR9206237A (pt)
CA (1) CA2113726C (pt)
CZ (3) CZ282083B6 (pt)
DE (2) DE69226953T2 (pt)
DK (1) DK0591280T3 (pt)
FI (1) FI103967B1 (pt)
GB (1) GB9113802D0 (pt)
HU (1) HU218907B (pt)
IE (1) IE922062A1 (pt)
IL (4) IL117105A (pt)
LU (1) LU90939I2 (pt)
MA (1) MA22563A1 (pt)
MX (1) MX9203444A (pt)
NL (1) NL300103I2 (pt)
NO (2) NO304774B1 (pt)
NZ (1) NZ243288A (pt)
PL (3) PL169410B1 (pt)
PT (1) PT100620B (pt)
RU (1) RU2137474C1 (pt)
SA (1) SA92130141B1 (pt)
SG (1) SG47877A1 (pt)
SI (1) SI9200125B (pt)
SK (3) SK280906B6 (pt)
TW (1) TW214544B (pt)
UA (1) UA41254C2 (pt)
WO (1) WO1993000086A1 (pt)
ZA (1) ZA924658B (pt)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
DE69610793T2 (de) * 1995-06-23 2001-05-03 Eli Lilly And Co., Indianapolis 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
ES2291503T3 (es) * 2001-09-28 2008-03-01 F. Hoffmann-La Roche Ag Formas pseudopolimorficas de carvedilol.
BR0312176A (pt) 2002-06-21 2005-04-05 Suven Life Sciences Ltd Composto, composição farmaceutica, uso de um composto, método para o tratamento, método para reduzir a morbidez e a mortalidade associadas com o excesso de peso, processo para a preparação de um composto, novo intermediario e processo para a preparação de um novo intermediario
MXPA04012834A (es) 2002-06-21 2005-04-25 Suven Life Sciences Ltd Arilalquil indoles novedosos que tienen afinidad por el receptor de la serotonina, utiles como agentes terapeuticos, proceso para su preparacion y composiciones farmaceuticas que los contienen.
KR100776118B1 (ko) 2002-11-28 2007-11-15 수벤 라이프 사이언시스 리미티드 엔-아릴술포닐-3-아미노알콕시인돌
EP1581492B1 (en) 2002-11-28 2008-07-16 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
AU2003292510B2 (en) 2002-12-18 2009-04-23 Suven Life Sciences Limited Tetracyclic 3-substituted indoles having serotonin receptor affinity
RU2430088C2 (ru) * 2004-07-14 2011-09-27 Центарис Гмбх Производные тетрагидрокарбазола и фармацевтическая композиция на их основе
US7601856B2 (en) 2006-07-27 2009-10-13 Wyeth Benzofurans as potassium ion channel modulators
KR101411820B1 (ko) * 2006-08-07 2014-06-24 액테리온 파마슈티칼 리미티드 (3-아미노-1,2,3,4-테트라하이드로-9ｈ-카르바졸-9-일)-아세트산 유도체
EP2813144A1 (en) 2006-10-09 2014-12-17 Charleston Laboratories, Inc. Analgesic compositions comprising an antihistamine
CA2677838C (en) 2007-02-11 2017-08-01 Map Pharmaceuticals, Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
EP3090743A1 (en) 2008-01-09 2016-11-09 Charleston Laboratories, Inc. Pharmaceutical compositions for treating headache and eliminating nausea
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
CA2767576C (en) 2009-07-08 2020-03-10 Charleston Laboratories Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
WO2011050140A1 (en) 2009-10-22 2011-04-28 Blue Fury Consulting, L.L.C. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
ES2751388T3 (es) 2011-07-22 2020-03-31 Univ Chicago IGF-1 para su uso en el tratamiento de la jaqueca
CA2895816C (en) 2012-12-21 2021-02-23 Map Pharmaceuticals, Inc. 8'-hydroxy-dihydroergotamine compounds and compositions
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
EP3423041A4 (en) 2016-03-04 2019-09-11 Charleston Laboratories, Inc. PHARMACEUTICAL COMPOSITIONS
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan
WO2025038666A2 (en) * 2023-08-13 2025-02-20 GATC Health Corp Compounds and methods for treating addiction
CN119499195A (zh) * 2024-11-26 2025-02-25 青岛国信制药有限公司 一种快速吸收琥珀酸呋罗曲坦片及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
US4172834A (en) 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
DE2815926A1 (de) * 1978-04-13 1979-10-18 Boehringer Mannheim Gmbh Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Also Published As

Publication number Publication date
EP0591280A1 (en) 1994-04-13
AP344A (en) 1994-07-05
IL117104A (en) 1997-09-30
SG47877A1 (en) 1998-04-17
NL300103I2 (nl) 2003-02-03
IL102322A0 (en) 1993-01-14
CZ150696A3 (en) 1997-06-11
MX9203444A (es) 1993-12-01
ZA924658B (en) 1993-12-24
CA2113726A1 (en) 1993-01-07
CZ282061B6 (cs) 1997-05-14
IL117104A0 (en) 1996-06-18
JP3261502B2 (ja) 2002-03-04
NZ243288A (en) 1994-09-27
CZ286193A3 (en) 1994-07-13
ATE170746T1 (de) 1998-09-15
CN1069726A (zh) 1993-03-10
BR1100460A (pt) 2000-07-18
CN1034072C (zh) 1997-02-19
FI935842A0 (fi) 1993-12-23
SK131993A3 (en) 1994-06-08
US5637611A (en) 1997-06-10
PT100620B (pt) 1999-01-29
SK280907B6 (sk) 2000-09-12
SI9200125A (en) 1992-12-31
CA2113726C (en) 2008-02-19
TW214544B (pt) 1993-10-11
SA92130141B1 (ar) 2005-12-18
AU652842B2 (en) 1994-09-08
BR9206237A (pt) 1995-04-11
FI935842A7 (fi) 1993-12-23
FI103967B (fi) 1999-10-29
AU1977592A (en) 1993-01-25
NO934800L (no) 1993-12-23
NO2005011I2 (no) 2008-02-11
JPH06508827A (ja) 1994-10-06
AP9200403A0 (en) 1992-07-31
HUT68961A (en) 1995-08-28
RU2137474C1 (ru) 1999-09-20
SK280906B6 (sk) 2000-09-12
NO304774B1 (no) 1999-02-15
SI9200125B (en) 2001-12-31
DK0591280T3 (da) 1999-02-15
IL102322A (en) 1997-09-30
KR100251571B1 (ko) 2000-07-01
PL169392B1 (pl) 1996-07-31
LU90939I2 (fr) 2002-09-24
IL117105A0 (en) 1996-06-18
PL171034B1 (en) 1997-02-28
IL117105A (en) 1998-01-04
SK280905B6 (sk) 2000-09-12
DE69226953T2 (de) 1999-05-12
HK1014669A1 (en) 1999-09-30
DE10299042I2 (de) 2005-02-03
DE10299042I1 (de) 2003-02-20
UA41254C2 (uk) 2001-09-17
IE922062A1 (en) 1992-12-30
NO2005011I1 (no) 2005-05-18
WO1993000086A1 (en) 1993-01-07
NO934800D0 (no) 1993-12-23
FI103967B1 (fi) 1999-10-29
CZ282083B6 (cs) 1997-05-14
NL300103I1 (nl) 2002-12-02
MA22563A1 (fr) 1992-12-31
CZ282327B6 (cs) 1997-06-11
HU218907B (hu) 2000-12-28
CZ150596A3 (en) 1997-05-14
DE69226953D1 (de) 1998-10-15
EP0591280B1 (en) 1998-09-09
GB9113802D0 (en) 1991-08-14
US5464864A (en) 1995-11-07
PL169410B1 (pl) 1996-07-31

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