FI935842A - Anvaendning av tetrahydrokarbazonderivat som 5ht1 -reseptoragonister - Google Patents

Anvaendning av tetrahydrokarbazonderivat som 5ht1 -reseptoragonister Download PDF

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Publication number
FI935842A
FI935842A FI935842A FI935842A FI935842A FI 935842 A FI935842 A FI 935842A FI 935842 A FI935842 A FI 935842A FI 935842 A FI935842 A FI 935842A FI 935842 A FI935842 A FI 935842A
Authority
FI
Finland
Prior art keywords
tetrahydrokarbazonderivat
reseptoragonister
som
analyzing
tetrahydrokarbazonderivat som
Prior art date
Application number
FI935842A
Other languages
English (en)
Other versions
FI935842A0 (fi
FI103967B (fi
FI103967B1 (fi
Inventor
Francis David King
Laramie Mary Gaster
Alberto Julio Kaumann
Rodney Christopher Young
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI935842(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of FI935842A publication Critical patent/FI935842A/fi
Publication of FI935842A0 publication Critical patent/FI935842A0/fi
Application granted granted Critical
Publication of FI103967B publication Critical patent/FI103967B/fi
Publication of FI103967B1 publication Critical patent/FI103967B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
FI935842A 1991-06-26 1993-12-23 Menetelmä tetrahydrokarbatsonijohdannaisten valmistamiseksi FI103967B1 (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
GB9113802 1991-06-26
PCT/GB1992/001082 WO1993000086A1 (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5ht1 receptor agonists
GB9201082 1992-06-17
US08/167,846 US5464864A (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists
US16784693 1993-12-23

Publications (4)

Publication Number Publication Date
FI935842A true FI935842A (fi) 1993-12-23
FI935842A0 FI935842A0 (fi) 1993-12-23
FI103967B FI103967B (fi) 1999-10-29
FI103967B1 FI103967B1 (fi) 1999-10-29

Family

ID=10697363

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935842A FI103967B1 (fi) 1991-06-26 1993-12-23 Menetelmä tetrahydrokarbatsonijohdannaisten valmistamiseksi

Country Status (35)

Country Link
US (2) US5464864A (fi)
EP (1) EP0591280B1 (fi)
JP (1) JP3261502B2 (fi)
KR (1) KR100251571B1 (fi)
CN (1) CN1034072C (fi)
AP (1) AP344A (fi)
AT (1) ATE170746T1 (fi)
BR (2) BR9206237A (fi)
CA (1) CA2113726C (fi)
CZ (3) CZ282327B6 (fi)
DE (2) DE10299042I2 (fi)
DK (1) DK0591280T3 (fi)
FI (1) FI103967B1 (fi)
GB (1) GB9113802D0 (fi)
HK (1) HK1014669A1 (fi)
HU (1) HU218907B (fi)
IE (1) IE922062A1 (fi)
IL (4) IL102322A (fi)
LU (1) LU90939I2 (fi)
MA (1) MA22563A1 (fi)
MX (1) MX9203444A (fi)
NL (1) NL300103I2 (fi)
NO (2) NO304774B1 (fi)
NZ (1) NZ243288A (fi)
PL (3) PL169410B1 (fi)
PT (1) PT100620B (fi)
RU (1) RU2137474C1 (fi)
SA (1) SA92130141B1 (fi)
SG (1) SG47877A1 (fi)
SI (1) SI9200125B (fi)
SK (3) SK280907B6 (fi)
TW (1) TW214544B (fi)
UA (1) UA41254C2 (fi)
WO (1) WO1993000086A1 (fi)
ZA (1) ZA924658B (fi)

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GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
EP0749962B1 (en) * 1995-06-23 2000-11-02 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
GB9808069D0 (en) * 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
DK1523486T3 (da) 2002-06-21 2008-03-03 Suven Life Sciences Ltd Tetracykliske arylsulfonylindoler med serotoninreceptor-affinitet
EP1537113B9 (en) 2002-06-21 2010-05-26 Suven Life Sciences Limited Arylalkyl indoles having serotonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them
ES2425143T3 (es) 2002-11-28 2013-10-11 Suven Life Sciences Limited N-Arilsulfonil-3-aminoalcoxiindoles
KR100818508B1 (ko) 2002-11-28 2008-03-31 수벤 라이프 사이언시스 리미티드 세로토닌 수용체 친화력을 가지는 엔-아릴술포닐-3-치환인돌, 그 제조방법 및 그를 포함하는 약제학적 조성물
KR100739987B1 (ko) 2002-12-18 2007-07-16 수벤 라이프 사이언시스 리미티드 세로토닌 수용체 친화력을 가지는 테트라사이클릭 3-치환인돌
SI2051962T1 (sl) * 2006-08-07 2012-02-29 Actelion Pharmaceuticals Ltd Derivati (3-amino-1,2,3,4-tetrahidro-9h-karbazol-9-il)-ocetne kisline
CA2665841C (en) 2006-10-09 2016-04-05 Charleston Laboratories, Inc. Pharmaceutical compositions
MX2009008582A (es) 2007-02-11 2009-10-30 Map Pharmaceuticals Inc Metodo para la administracion terapeutica de dihidroergotamina para permitir un rapido alivio de la migraña mientras se minimiza el perfil de efectos secundarios.
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
JP5714910B2 (ja) 2008-01-09 2015-05-07 チャールストン ラボラトリーズ，インコーポレイテッド 薬学的組成物
WO2010073253A1 (en) * 2008-12-22 2010-07-01 Natco Pharma Limited Method for preparing an optically active frovatriptan
CA2767576C (en) 2009-07-08 2020-03-10 Charleston Laboratories Inc. Pharmaceutical compositions comprising an antiemetic and an opioid analgesic
WO2011050140A1 (en) 2009-10-22 2011-04-28 Blue Fury Consulting, L.L.C. Posterior cervical fusion system and techniques
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
EP3628325A1 (en) 2011-07-22 2020-04-01 The University of Chicago Treatments for migraine and related disorders
AU2013361337A1 (en) 2012-12-21 2015-07-09 Map Pharmaceuticals, Inc. 8'-Hydroxy-Dihydroergotamine compounds and compositions
EP2816030A1 (en) 2013-06-20 2014-12-24 Duke Chem, S. A. Process for the preparation of frovatriptan and its enantiomer
GB201312768D0 (en) * 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
US10179109B2 (en) 2016-03-04 2019-01-15 Charleston Laboratories, Inc. Pharmaceutical compositions comprising 5HT receptor agonist and antiemetic particulates
EP3766483A1 (en) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Orodispersible powder composition comprising a triptan

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
US4172834A (en) * 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
EP0115607A1 (de) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Tetrahydrocarbazolderivate

Also Published As

Publication number Publication date
NL300103I2 (nl) 2003-02-03
DE69226953T2 (de) 1999-05-12
PT100620A (pt) 1993-09-30
HK1014669A1 (en) 1999-09-30
AU1977592A (en) 1993-01-25
LU90939I2 (fr) 2002-09-24
SK280906B6 (sk) 2000-09-12
AU652842B2 (en) 1994-09-08
RU2137474C1 (ru) 1999-09-20
MA22563A1 (fr) 1992-12-31
SI9200125B (en) 2001-12-31
CZ150696A3 (en) 1997-06-11
GB9113802D0 (en) 1991-08-14
CZ150596A3 (en) 1997-05-14
HU218907B (hu) 2000-12-28
CZ282327B6 (cs) 1997-06-11
SG47877A1 (en) 1998-04-17
IL117105A (en) 1998-01-04
IL117105A0 (en) 1996-06-18
IL102322A (en) 1997-09-30
UA41254C2 (uk) 2001-09-17
NO2005011I1 (no) 2005-05-18
TW214544B (fi) 1993-10-11
US5637611A (en) 1997-06-10
CN1034072C (zh) 1997-02-19
NO304774B1 (no) 1999-02-15
ZA924658B (en) 1993-12-24
NO934800L (no) 1993-12-23
PL171034B1 (en) 1997-02-28
CN1069726A (zh) 1993-03-10
IL117104A (en) 1997-09-30
IL102322A0 (en) 1993-01-14
SK280907B6 (sk) 2000-09-12
PL169392B1 (pl) 1996-07-31
DE10299042I1 (de) 2003-02-20
CZ286193A3 (en) 1994-07-13
IE922062A1 (en) 1992-12-30
AP344A (en) 1994-07-05
DE10299042I2 (de) 2005-02-03
AP9200403A0 (en) 1992-07-31
NO2005011I2 (no) 2008-02-11
SK280905B6 (sk) 2000-09-12
HUT68961A (en) 1995-08-28
KR100251571B1 (ko) 2000-07-01
FI935842A0 (fi) 1993-12-23
SA92130141B1 (ar) 2005-12-18
IL117104A0 (en) 1996-06-18
SI9200125A (en) 1992-12-31
CZ282083B6 (cs) 1997-05-14
BR1100460A (pt) 2000-07-18
EP0591280B1 (en) 1998-09-09
PT100620B (pt) 1999-01-29
NZ243288A (en) 1994-09-27
WO1993000086A1 (en) 1993-01-07
DK0591280T3 (da) 1999-02-15
NO934800D0 (no) 1993-12-23
ATE170746T1 (de) 1998-09-15
PL169410B1 (pl) 1996-07-31
EP0591280A1 (en) 1994-04-13
FI103967B (fi) 1999-10-29
CA2113726C (en) 2008-02-19
DE69226953D1 (de) 1998-10-15
MX9203444A (es) 1993-12-01
FI103967B1 (fi) 1999-10-29
US5464864A (en) 1995-11-07
CZ282061B6 (cs) 1997-05-14
JPH06508827A (ja) 1994-10-06
BR9206237A (pt) 1995-04-11
SK131993A3 (en) 1994-06-08
JP3261502B2 (ja) 2002-03-04
CA2113726A1 (en) 1993-01-07
NL300103I1 (nl) 2002-12-02

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