AP344A - Tetrahydrocarbazole derivatives and their use as 5-HT1-like receptor - Google Patents

Tetrahydrocarbazole derivatives and their use as 5-HT1-like receptor Download PDF

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Publication number
AP344A
AP344A APAP/P/1992/000403A AP9200403A AP344A AP 344 A AP344 A AP 344A AP 9200403 A AP9200403 A AP 9200403A AP 344 A AP344 A AP 344A
Authority
AP
ARIPO
Prior art keywords
formula
tetrahydrocarbazole
compound
amino
carboxamido
Prior art date
Application number
APAP/P/1992/000403A
Other languages
English (en)
Other versions
AP9200403A0 (en
Inventor
Francis David King
Laramie Mary Gaster
Alberto Julio Kaumann
Rodney Christopher Young
Original Assignee
Vernalis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697363&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP344(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vernalis Ltd filed Critical Vernalis Ltd
Publication of AP9200403A0 publication Critical patent/AP9200403A0/xx
Application granted granted Critical
Publication of AP344A publication Critical patent/AP344A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
APAP/P/1992/000403A 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives and their use as 5-HT1-like receptor AP344A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919113802A GB9113802D0 (en) 1991-06-26 1991-06-26 Medicaments
US08/167,846 US5464864A (en) 1991-06-26 1992-06-17 Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists

Publications (2)

Publication Number Publication Date
AP9200403A0 AP9200403A0 (en) 1992-07-31
AP344A true AP344A (en) 1994-07-05

Family

ID=10697363

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1992/000403A AP344A (en) 1991-06-26 1992-06-25 Tetrahydrocarbazole derivatives and their use as 5-HT1-like receptor

Country Status (35)

Country Link
US (2) US5464864A (fr)
EP (1) EP0591280B1 (fr)
JP (1) JP3261502B2 (fr)
KR (1) KR100251571B1 (fr)
CN (1) CN1034072C (fr)
AP (1) AP344A (fr)
AT (1) ATE170746T1 (fr)
BR (2) BR9206237A (fr)
CA (1) CA2113726C (fr)
CZ (3) CZ150696A3 (fr)
DE (2) DE10299042I2 (fr)
DK (1) DK0591280T3 (fr)
FI (1) FI103967B1 (fr)
GB (1) GB9113802D0 (fr)
HK (1) HK1014669A1 (fr)
HU (1) HU218907B (fr)
IE (1) IE922062A1 (fr)
IL (4) IL117104A (fr)
LU (1) LU90939I2 (fr)
MA (1) MA22563A1 (fr)
MX (1) MX9203444A (fr)
NL (1) NL300103I2 (fr)
NO (2) NO304774B1 (fr)
NZ (1) NZ243288A (fr)
PL (3) PL171034B1 (fr)
PT (1) PT100620B (fr)
RU (1) RU2137474C1 (fr)
SA (1) SA92130141B1 (fr)
SG (1) SG47877A1 (fr)
SI (1) SI9200125B (fr)
SK (3) SK280906B6 (fr)
TW (1) TW214544B (fr)
UA (1) UA41254C2 (fr)
WO (1) WO1993000086A1 (fr)
ZA (1) ZA924658B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US5616603A (en) * 1995-05-26 1997-04-01 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5618948A (en) * 1995-05-26 1997-04-08 Smithkline Beecham P.L.C. Process for preparing an enantiomer of a carbazole derivative
EP0749962B1 (fr) * 1995-06-23 2000-11-02 Eli Lilly And Company 1,2,3,4-Tétrahydro-9H-carbazoles, 6-substituées et 1OH-cyclohepta(7,6-B)-indoles, 7-substituées
US5917054A (en) * 1995-07-18 1999-06-29 Smithkline Beecham P.L.C. Process for preparing enantiomers of carbazole derivatives as 5-HT1 -like agonists
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9723061D0 (en) * 1997-10-31 1998-01-07 Vanguard Medica Ltd Medicaments
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
GB9808069D0 (en) 1998-04-16 1998-06-17 Vanguard Medica Ltd Novel processes
GB9817911D0 (en) * 1998-08-17 1998-10-14 Vanguard Medica Ltd New use
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
CA2490115C (fr) 2002-06-21 2009-09-01 Suven Life Sciences Limited Arylalkyl indoles a affinite de recepteur de la serotonine utilises comme agents therapeutiques, leur procede de preparation et compositions pharmaceutiques contenant lesdits indoles
ATE377603T1 (de) 2002-06-21 2007-11-15 Suven Life Sciences Ltd Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptor
US7875605B2 (en) 2002-11-28 2011-01-25 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
PT1567492E (pt) 2002-11-28 2013-07-22 Suven Life Sciences Ltd N-arilsulfonil-3-aminoalcoxi-indóis
US7781476B2 (en) 2002-12-18 2010-08-24 Suven Life Sciences Limited Tetracyclic 3-substituted indoles having serotonin receptor affinity
AU2007282949B8 (en) * 2006-08-07 2012-10-04 Actelion Pharmaceuticals Ltd. (3-Amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives
JP2010522135A (ja) 2006-10-09 2010-07-01 チャールストン ラボラトリーズ，インコーポレイテッド 医薬組成物
CA2677838C (fr) 2007-02-11 2017-08-01 Map Pharmaceuticals, Inc. Procede d'administration therapeutique de dhe pour procurer un soulagement rapide de la migraine tout en minimisant le profil des effets secondaires
US20090069399A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched frovatriptan
EP2240022B1 (fr) 2008-01-09 2016-12-28 Charleston Laboratories, Inc. Comprimés à deux couches contenant oxycodone et promethazine
WO2010073253A1 (fr) * 2008-12-22 2010-07-01 Natco Pharma Limited Procédé de préparation de frovatripan optiquement actif
CA2767576C (fr) 2009-07-08 2020-03-10 Charleston Laboratories Inc. Compositions pharmaceutiques refermant un antiemetique et un analgesiqueopioide
WO2011050140A1 (fr) 2009-10-22 2011-04-28 Blue Fury Consulting, L.L.C. Système et techniques de fusion cervicale postérieure
US10098674B2 (en) 2009-10-22 2018-10-16 Nuvasive, Inc. System and method for posterior cervical fusion
EP2734634B1 (fr) 2011-07-22 2019-08-21 The University of Chicago Igf-1 pour le traitement de la migraine
US9394314B2 (en) 2012-12-21 2016-07-19 Map Pharmaceuticals, Inc. 8′-hydroxy-dihydroergotamine compounds and compositions
EP2816030A1 (fr) 2013-06-20 2014-12-24 Duke Chem, S. A. Procédés de préparation de frovatriptan et ses énantiomères
GB201312768D0 (en) 2013-07-17 2013-08-28 Ge Healthcare Ltd Work-up procedure
JP2019507181A (ja) 2016-03-04 2019-03-14 チャールストン ラボラトリーズ，インコーポレイテッド 医薬組成物
EP3766483A1 (fr) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Composition de poudre orodispersible comprenant un triptane

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
EP0004342A1 (fr) * 1978-03-17 1979-10-03 E.I. Du Pont De Nemours And Company Carbazoles, procédé pour leur préparation, compositions pharmaceutiques les contenant et leurs intermédiaires

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642816A (en) * 1967-08-10 1972-02-15 Sterling Drug Inc 3-acetamido-1 2 3 4-tetrahydrocarbazole
US4062864A (en) * 1968-01-24 1977-12-13 Sterling Drug Inc. 3-Hydroxy carbazole derivatives
US3592824A (en) * 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
US4172834A (en) * 1971-08-16 1979-10-30 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
BE787537A (fr) * 1971-08-16 1973-02-14 Sterling Drug Inc Tetrahydrocarbazoles
US4257952A (en) * 1977-06-06 1981-03-24 Sterling Drug Inc. 3-Amino-tetrahydrocarbazoles
EP0115607A1 (fr) * 1983-01-04 1984-08-15 MERCK PATENT GmbH Dérivés de tétrahydrocarbazole

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959309A (en) * 1968-01-24 1976-05-25 Sterling Drug Inc. 3-Amido-1,2,3,4-tetrahydrocarbazoles
EP0004342A1 (fr) * 1978-03-17 1979-10-03 E.I. Du Pont De Nemours And Company Carbazoles, procédé pour leur préparation, compositions pharmaceutiques les contenant et leurs intermédiaires

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF NEUROCHEMISTRY VOL. 28 pp 995-1000 (1977) *
JOURNAL OF NEUROCHEMISTRY VOL. 35 pp 931-936 (1980) *

Also Published As

Publication number Publication date
LU90939I2 (fr) 2002-09-24
FI935842A0 (fi) 1993-12-23
UA41254C2 (uk) 2001-09-17
NO2005011I2 (no) 2008-02-11
CN1034072C (zh) 1997-02-19
NZ243288A (en) 1994-09-27
NO934800L (no) 1993-12-23
AU652842B2 (en) 1994-09-08
BR1100460A (pt) 2000-07-18
SK280906B6 (sk) 2000-09-12
AU1977592A (en) 1993-01-25
PL171034B1 (en) 1997-02-28
CN1069726A (zh) 1993-03-10
CA2113726C (fr) 2008-02-19
IL102322A (en) 1997-09-30
CZ286193A3 (en) 1994-07-13
US5637611A (en) 1997-06-10
NO304774B1 (no) 1999-02-15
US5464864A (en) 1995-11-07
CZ282327B6 (cs) 1997-06-11
SG47877A1 (en) 1998-04-17
EP0591280A1 (fr) 1994-04-13
NO934800D0 (no) 1993-12-23
CZ150696A3 (en) 1997-06-11
MX9203444A (es) 1993-12-01
SK131993A3 (en) 1994-06-08
IL117104A (en) 1997-09-30
EP0591280B1 (fr) 1998-09-09
NL300103I1 (nl) 2002-12-02
CZ282061B6 (cs) 1997-05-14
GB9113802D0 (en) 1991-08-14
KR100251571B1 (ko) 2000-07-01
SK280905B6 (sk) 2000-09-12
FI935842A (fi) 1993-12-23
IL102322A0 (en) 1993-01-14
ZA924658B (en) 1993-12-24
FI103967B (fi) 1999-10-29
CA2113726A1 (fr) 1993-01-07
NL300103I2 (nl) 2003-02-03
IE922062A1 (en) 1992-12-30
PL169410B1 (pl) 1996-07-31
FI103967B1 (fi) 1999-10-29
WO1993000086A1 (fr) 1993-01-07
JP3261502B2 (ja) 2002-03-04
DE69226953D1 (de) 1998-10-15
DE10299042I2 (de) 2005-02-03
AP9200403A0 (en) 1992-07-31
IL117104A0 (en) 1996-06-18
PT100620A (pt) 1993-09-30
HK1014669A1 (en) 1999-09-30
PT100620B (pt) 1999-01-29
SI9200125A (en) 1992-12-31
HU218907B (hu) 2000-12-28
JPH06508827A (ja) 1994-10-06
HUT68961A (en) 1995-08-28
SK280907B6 (sk) 2000-09-12
MA22563A1 (fr) 1992-12-31
SA92130141B1 (ar) 2005-12-18
BR9206237A (pt) 1995-04-11
SI9200125B (en) 2001-12-31
NO2005011I1 (no) 2005-05-18
RU2137474C1 (ru) 1999-09-20
DE10299042I1 (de) 2003-02-20
ATE170746T1 (de) 1998-09-15
IL117105A0 (en) 1996-06-18
PL169392B1 (pl) 1996-07-31
TW214544B (fr) 1993-10-11
DK0591280T3 (da) 1999-02-15
CZ282083B6 (cs) 1997-05-14
DE69226953T2 (de) 1999-05-12
CZ150596A3 (en) 1997-05-14
IL117105A (en) 1998-01-04

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