CA2756876A1 - Methode de preparation du frovatriptan et du succinate de frovatriptan et de leurs intermediaires de synthese - Google Patents

Methode de preparation du frovatriptan et du succinate de frovatriptan et de leurs intermediaires de synthese Download PDF

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Publication number
CA2756876A1
CA2756876A1 CA2756876A CA2756876A CA2756876A1 CA 2756876 A1 CA2756876 A1 CA 2756876A1 CA 2756876 A CA2756876 A CA 2756876A CA 2756876 A CA2756876 A CA 2756876A CA 2756876 A1 CA2756876 A1 CA 2756876A1
Authority
CA
Canada
Prior art keywords
carboxamido
tetrahydrocarbazole
solvate
hydrate
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2756876A
Other languages
English (en)
Inventor
Vinayak Govind Gore
Maheshkumar Gadkar
Anilkumar Tripathi
Viraj Mankar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Generics UK Ltd
Original Assignee
Generics UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Generics UK Ltd filed Critical Generics UK Ltd
Publication of CA2756876A1 publication Critical patent/CA2756876A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne le principe actif pharmaceutique frovatriptan et des sels pharmaceutiquement acceptables associés. En particulier, l'invention concerne des procédés efficaces pour la préparation de frovatriptan et de ses produits intermédiaires de synthèse, ces procédés s'adaptant à la production commerciale à grande échelle et permettant de fournir les produits souhaités avec un rendement et une pureté améliorés.
CA2756876A 2009-04-23 2010-04-22 Methode de preparation du frovatriptan et du succinate de frovatriptan et de leurs intermediaires de synthese Abandoned CA2756876A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN657KO2009 2009-04-23
IN657/KOL/2009 2009-04-23
PCT/GB2010/050658 WO2010122343A1 (fr) 2009-04-23 2010-04-22 Procédé pour la préparation de frovatriptan et de succinate de frovatriptan et de leurs produits intermédiaires de synthèse

Publications (1)

Publication Number Publication Date
CA2756876A1 true CA2756876A1 (fr) 2010-10-28

Family

ID=42316095

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2756876A Abandoned CA2756876A1 (fr) 2009-04-23 2010-04-22 Methode de preparation du frovatriptan et du succinate de frovatriptan et de leurs intermediaires de synthese

Country Status (3)

Country Link
AU (1) AU2010240641A1 (fr)
CA (1) CA2756876A1 (fr)
WO (1) WO2010122343A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011095803A1 (fr) 2010-02-02 2011-08-11 Generics [Uk] Limited Méthode hplc pour l'analyse de frovatriptan
CN102964270B (zh) * 2012-11-21 2015-01-07 合肥星宇化学有限责任公司 一种亚硫酸钠还原重氮盐合成肼的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226530D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
US20070299123A1 (en) * 2006-06-27 2007-12-27 Glenmark Pharmaceuticals Limited Amorphous frovatriptan succinate and process for the preparation thereof

Also Published As

Publication number Publication date
WO2010122343A1 (fr) 2010-10-28
AU2010240641A1 (en) 2011-12-01

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130422

FZDE Discontinued

Effective date: 20130422