LV12605B - Aizvietoti oksazīn- un tiazīn-oksazolidinoni kā pretmikrobu līdzekļi - Google Patents

Aizvietoti oksazīn- un tiazīn-oksazolidinoni kā pretmikrobu līdzekļi Download PDF

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Publication number
LV12605B
LV12605B LVP-00-142A LV000142A LV12605B LV 12605 B LV12605 B LV 12605B LV 000142 A LV000142 A LV 000142A LV 12605 B LV12605 B LV 12605B
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LV
Latvia
Prior art keywords
oxo
fluoro
phenyl
oxazolidinyl
methyl
Prior art date
Application number
LVP-00-142A
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English (en)
Other versions
LV12605A (en
Inventor
Michael R. Barbachyn
Steven J. Brickner
Douglas K. Hutchinson
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Pharmacia & Upjohn Company
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26817181&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV12605(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company
Publication of LV12605A publication Critical patent/LV12605A/xx
Publication of LV12605B publication Critical patent/LV12605B/lv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Claims (16)

  1. LV 12605 IZGUDROJUMA FORMULA 1. Savienojums ar formulu I 5
  2. 2. Savienojums saskaņā ar 1. punktu, kur X ir O.
  3. 3. Savienojums saskaņā ar 1. punktu, kur n ir 1 un X ir S, SO vai S02.
  4. 4. Savienojums saskaņā ar 1. punktu, kur n ir 0.
  5. 5. Savienojums saskaņā ar 1. punktu, kur n ir 2. 35 2
  6. 6. Savienojums saskaņā ar 2. punktu, kur katrs R2 ir fluora atoms.
  7. 7. Savienojums saskaņā ar jebkuru no 1. līdz 5. punktam, kur viens R2 ir 5 ūdeņraža atoms un otrs ir fluora atoms.
  8. 8. Savienojums saskaņā ar jebkuru iepriekšējo punktu, kur R ir H, CH3, OCH3, CHCĻ vai CH2OH.
  9. 9. Savienojums saskaņā ar jebkuru iepriekšējo punktu, kurš ir optiski tīrs enantiomērs ar S-konfigurāciju pie C5 oksazolidinona ciklā.
  10. 10. Savienojums saskaņā ar 1. punktu, kurš ir: 15 (S)-N-[[3-[3-fluor-4-(4-tiomorfolinil)fenil]-2-okso-5-oksazolidinil]me- tiljacetamīds; (S)-N-[[3-[3-fluor-4-(1,1-dioksotiomorfolin-4-il)fenil]-2-okso-5-oksa* zolidiniljmetiljacetamīds; (S)-N-[[3-[3-f!uor-4-(1-oksotiomorfolin-4-il)fenil]-2-okso-5-oksazolidi-20 nil]metil]acetamīds; (S)-N-[[3-[3,5-difluor-4-(4-morfolinil)fenil]-2-okso-5-oksazolidinil]me- tilļacetamīds; (S)-N-[[3-[3-fluor-4*(4-morfolinil)fenil]-2-okso-5-oksazolidinil]me- tiljacetamīds; 25 (S)-N-[[3-[3-fluor-4-(4-morfolinil)fenil]-2-okso-5-oksazolidinil]me- tiljhidroksiacetamīds; (S)-N-[[3-[3-fluor-4-(4-morfolinil)fenil]-2'Okso-5-oksazolidinil]me- tiljformamīds; (S)-N-[[3-[3-fluor-4-(4-morfolinil)fenil]-2-okso-5-oksazolidinil]me-30 tiljkarbamāts; vai (S)-N-[[3-[3-fluor-4-(4-morfolinil)fenil]-2-okso-5-oksazolidinil]me- tiljdihloracetamīds.
    10 vai tā farmaceitiski pieņemams sāls, kur X ir O, S, SO vai S02; R ir 15 20 25 (a) ūdeņraža atoms, (b) CrCg alkilgrupa, kas neobligāti ir aizvietota ar vienu vai vairākiem F, Cl, hidroksigrupām, Cļ-Cg alkoksigrupām, C,-C8 acil-oksigrupām un -0-CH2-Ph, (c) C3-C6 cikloalkilgrupa, (d) aminogrupa, (e) CrC8 alkilaminogrupa, (f) Cļ-Cg dialkilaminogrupa vai (g) CrC8 alkoksigrupa; R1 ir H, izņemot, kad X ir O, tad R1 var būt H vai (CH2)mR11, kur m ir 1 vai 2 un R11 ir ūdeņraža atoms, OH, OR, NH2 vai NHCOR; R2 ir neatkarīgi H, F vai Cl; R3 ir H, izņemot, kad X ir O un R1 ir CH3, tad R3 var būt H vai CH3; un n ir 0,1 vai 2.
  11. 11. Savienojums saskaņā ar 10. punktu, kurš ir (S)-N-[[3-[3-fluor-4-(4- 35 morfolinil)fenil]-2-okso-5-oksazolidinil]metil]acetamīds. 3 LV 12605
  12. 12. Savienojums saskaņā ar 1. punktu, kurš ir: (S)-N-[[3-[3-fluor-4-(3-tiazolidinil)fenil]-2-okso-5*oksazolidinil]me- tiljacetamīds; 5 (S)-N-[[3-[3-fluor-4-(1,1 -dioksotiazolidin-3-il)fenil]-2-okso-5-oksa- zolidiniljmetiljacetamīds; (S)-N-[[3-[3-fluor-4-(1-oksotiazolidin-3-il)fenil]-2-okso-5-oksa-zolidiniljmetiljacetamīds; vai (S)-N-[[3-[3-fluor-4-(3-oksazolidinil)fenil]-2-okso-5-oksazolidinil]me-10 tiljacetamīds.
  13. 13. Savienojums saskaņā ar 1. punktu, kurš ir: (S)-N-[[3-[3-fluor-4-(heksahidrotiazepīn-4-il)fenil]-2-okso-5-oksa* 15 zolidiniljmetiljacetamīds; (S)-N-[[3-[3*fluor-4-(1,1-dioksoheksahidrotiazepīn-4-il)fenil]-2-okso-5- oksazolidiniljmetiljacetamīds; (S)-N-[[3-[3-fluor-4-(1-oksoheksahidrotiazepīn-4-il)fenil]-2-okso-5-oksa-zolidiniljmetiljacetamīds; vai 20 (S)-N-[[3-[3-fluor-4-(heksahidrooksazepin-4-il)fenil]-2-okso-5-oksa- zolidiniljmetiljacetamīds.
  14. 14. Savienojuma saskaņā ar jebkuru iepriekšējo punktu izmantošana medikamenta izgatavošanā izmantošanai mikrobiālas infekcijas ārstēšanā. 25
  15. 15. Izmantošana saskaņā ar 14. punktu, kur medikaments ir piemērots perorālai, parenterālai vai vietējai pielietošanai.
  16. 16. Izmantošana saskaņā ar 14. vai 15. punktu, kur mikrobiālā infekcija ir 30 izraisīta ar stafilokokiem, streptokokiem, enterokokiem, Bacteroides spp., Clostridia spp., Mycobacterium tuberculosis, Mycobacterium avium vai Mycobacterium spp.
LVP-00-142A 1993-09-09 2000-10-20 Aizvietoti oksazīn- un tiazīn-oksazolidinoni kā pretmikrobu līdzekļi LV12605B (lv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11927993A 1993-09-09 1993-09-09
US22615894A 1994-04-11 1994-04-11

Publications (2)

Publication Number Publication Date
LV12605A LV12605A (en) 2001-01-20
LV12605B true LV12605B (lv) 2001-05-20

Family

ID=26817181

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-00-142A LV12605B (lv) 1993-09-09 2000-10-20 Aizvietoti oksazīn- un tiazīn-oksazolidinoni kā pretmikrobu līdzekļi

Country Status (20)

Country Link
EP (1) EP0717738B1 (lv)
JP (1) JP3176630B2 (lv)
KR (1) KR100301269B1 (lv)
CN (1) CN1057087C (lv)
AT (1) ATE185804T1 (lv)
AU (1) AU687866B2 (lv)
CA (1) CA2168560C (lv)
DE (2) DE69421285T2 (lv)
DK (1) DK0717738T3 (lv)
ES (1) ES2139093T3 (lv)
GR (1) GR3031809T3 (lv)
IL (1) IL110802A (lv)
LV (1) LV12605B (lv)
MY (1) MY115155A (lv)
NL (1) NL300079I1 (lv)
NZ (1) NZ271805A (lv)
PH (1) PH31634A (lv)
SI (1) SI0717738T1 (lv)
TW (1) TW293817B (lv)
WO (1) WO1995007271A1 (lv)

Families Citing this family (239)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU702733B2 (en) * 1994-11-15 1999-03-04 Pharmacia & Upjohn Company Bicyclic oxazine and thiazine oxazolidinone antibacterials
RU2154645C2 (ru) * 1995-02-03 2000-08-20 Фармация Энд Апджон Компани Фенилоксазолидиноны, замещенные в кольце гетероароматическими кольцами, в качестве антимикробных агентов
ES2162047T3 (es) * 1995-05-11 2001-12-16 Upjohn Co Oxazolidinonas con resto diazinilo y carbazinilo espirociclico y biciclico.
DE69631347T2 (de) * 1995-09-15 2004-10-07 Upjohn Co Aminoaryl oxazolidinone n-oxide
ATE229014T1 (de) * 1995-09-15 2002-12-15 Upjohn Co Alpha,beta-gesättigte und -ungesättigte 3-aryl-5- aminomethyl-butyrolactone antibakterielle mittel
GB9521508D0 (en) * 1995-10-20 1995-12-20 Zeneca Ltd Chemical compounds
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
GB9604301D0 (en) * 1996-02-29 1996-05-01 Zeneca Ltd Chemical compounds
KR100530297B1 (ko) * 1996-04-11 2005-11-22 파마시아 앤드 업존 캄파니 엘엘씨 옥사졸리디논의 제조 방법
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
DE19709443C1 (de) * 1997-03-07 1998-10-08 Clariant Gmbh Verfahren zur Herstellung von N-Carboxyalkyl-3-fluor-4-dialkylaminoanilinen und N-Carboxymethyl-3-fluor-4-morpholinoanilin und N-Carboxyisobutyl-3-fluor-4-morpholinoanilin
WO1998054161A1 (en) * 1997-05-30 1998-12-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
US6255304B1 (en) 1997-05-30 2001-07-03 Pharmacia & Upjohn Company Oxazolidinone antibacterial agents having a thiocarbonyl functionality
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
EP1028940B1 (en) 1997-11-07 2007-04-18 Pharmacia & Upjohn Company LLC Process to produce oxazolidinones
GB9725244D0 (en) * 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US7002020B1 (en) 1998-01-23 2006-02-21 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
CA2318969A1 (en) 1998-01-23 1999-07-29 Mikhail F. Gordeev Oxazolidinone combinatorial libraries, compositions and methods of preparation
US6562844B2 (en) 1998-01-23 2003-05-13 Pharmacia & Upjohn Company Oxazolidinone combinatorial libraries, compositions and methods of preparation
JP2002503655A (ja) * 1998-02-13 2002-02-05 ファルマシア・アンド・アップジョン・カンパニー 抗菌剤として有用な置換アミノフェニルイソオキサゾリン誘導体
CA2319495A1 (en) * 1998-06-08 1999-12-16 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
AU1379900A (en) * 1998-11-17 2000-06-05 Bayer Aktiengesellschaft Novel substituted phenyloxazolidone derivatives
CN1322204A (zh) * 1998-11-27 2001-11-14 法玛西雅厄普约翰美国公司 具有硫代羰基官能团的噁唑烷酮抗菌剂
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6413981B1 (en) 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6297242B1 (en) 1999-08-12 2001-10-02 Ortho-Mcneil Pharmaceutical, Inc. N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof
CA2389482A1 (en) * 1999-12-21 2001-06-28 Jackson B. Hester, Jr. Oxazolidinones having a sulfoximine functionality and their use as antimicrobial agents
US6518285B2 (en) * 1999-12-21 2003-02-11 Ortho Mcneil Pharmaceutical, Inc. Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
KR100355345B1 (ko) * 2000-01-21 2002-10-12 한국과학기술연구원 티오펜환을 함유한 신규한 옥사졸리디논 유도체, 그의 제조방법 및 조성물
AR027261A1 (es) * 2000-02-02 2003-03-19 Upjohn Co Linezolid forma cristalina ii
US6642238B2 (en) 2000-02-10 2003-11-04 Pharmacia And Upjohn Company Oxazolidinone thioamides with piperazine amide substituents
US6562820B2 (en) 2000-07-05 2003-05-13 Pharmacia & Upjohn Company Method for treatment and prevention of mastitis
US6638908B1 (en) 2000-08-09 2003-10-28 Yale University Crystals of the large ribosomal subunit
US6947844B2 (en) 2000-08-09 2005-09-20 Yale University Modulators of ribosomal function and identification thereof
CA2423599A1 (en) 2000-10-17 2002-04-25 Pharmacia & Upjohn Company Methods of producing oxazolidinone compounds
US7160912B2 (en) 2000-12-26 2007-01-09 Dr.Reddy's Laboratories Ltd. Heterocyclic compounds having antibacterial activity: process for their preparation and pharmaceutical compositions containing them
YU52403A (sh) * 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
AU2002256995A1 (en) * 2001-02-07 2002-08-28 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods
GB0108793D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
GB0108794D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compound
DE60212959T2 (de) * 2001-04-07 2007-02-15 Astrazeneca Ab Eine sulfonimid-gruppe enthaltende oxazolidinone als antibiotika
GB0108764D0 (en) * 2001-04-07 2001-05-30 Astrazeneca Ab Chemical compounds
CA2439959A1 (en) * 2001-04-20 2002-10-31 Pharmacia & Upjohn Company A method for the preparation of oxazolidinones
ES2186550B2 (es) 2001-06-27 2003-11-16 Vita Lab Nuevos derivados de oxazolidinonas como antibacterianos.
JP2005502628A (ja) * 2001-07-10 2005-01-27 ファルマシア・アンド・アップジョン・カンパニー 結晶性チアジンオキサゾリジノン
US6952650B2 (en) 2001-08-03 2005-10-04 Yale University Modulators of ribosomal function and identification thereof
IL151012A0 (en) 2001-08-03 2003-02-12 Ribosomes Structure And Protei Ribosomes structure and protein synthesis inhibitors
BR0307103A (pt) 2002-01-24 2004-12-28 Upjohn Co Dihidrotiazina e dihidrotiopirano oxazolidinovas antimicrobianas
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
MXPA04008273A (es) 2002-02-28 2004-11-10 Astrazeneca Ab Derivados de oxazolidinona, procesos para su preparacion, y composiciones farmaceuticas que los contienen.
KR20040087329A (ko) 2002-02-28 2004-10-13 아스트라제네카 아베 3-시클릴-5-(질소-함유 5-원 고리) 메틸-옥사졸리디논유도체 및 그의 항균제로서의 용도
AU2003224345A1 (en) * 2002-04-30 2003-11-17 Orchid Chemicals & Pharmaceuticals Antibacterial agents
DE60304360T2 (de) 2002-08-12 2006-11-16 Pharmacia & Upjohn Co. Llc, Kalamazoo N-aryl-2-oxazolidinone und deren derivate
WO2004026848A1 (en) 2002-09-20 2004-04-01 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
TW200420573A (en) 2002-09-26 2004-10-16 Rib X Pharmaceuticals Inc Bifunctional heterocyclic compounds and methods of making and using same
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
KR100490643B1 (ko) * 2002-10-29 2005-05-19 한국과학기술연구원 새로운 메틸리덴 피페리딘일 옥사졸리딘온 유도체 및이들의 제조방법
ES2271660T3 (es) 2002-11-21 2007-04-16 PHARMACIA & UPJOHN COMPANY LLC Derivados de n-(4-piperazin-1-il)-fenil-2-oxazolidinona-5-carboxamida y compuestos relacionados como agentes antibacterianos.
US7012088B2 (en) 2003-02-24 2006-03-14 Pharmacia & Upjohn Company Indolone oxazolidinones and derivatives thereof
EP1615916A1 (en) 2003-04-09 2006-01-18 Pharmacia & Upjohn Company LLC Antimicrobial 3.1.0 bicyclohexylphenyl-oxazolidinone derivatives and analogues
JP4256744B2 (ja) * 2003-08-14 2009-04-22 三菱レイヨン株式会社 （メタ）アクリル系重合体の製造方法
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
ES2331001T3 (es) 2003-10-16 2009-12-18 Symed Labs Limited Forma cristalina de linezolid.
KR100854211B1 (ko) 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물
EP1723159B1 (en) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same
EP1737850B1 (en) 2004-04-19 2007-10-03 Symed Labs Limited A novel process for the preparation of linezolid and related compounds
WO2005113520A1 (en) * 2004-05-20 2005-12-01 Pharmacia & Upjohn Company Llc Substituted 2,3,5-trifluorphenyl oxazolidinones for use as antibacterial agents
JP2007504173A (ja) * 2004-06-29 2007-03-01 テバ ファーマシューティカル インダストリーズ リミティド リネゾリドのｉｖ型結晶
ATE429423T1 (de) 2004-07-20 2009-05-15 Symed Labs Ltd Neue zwischenprodukte für linezolid und verwandte verbindungen
JP2008530028A (ja) * 2005-02-24 2008-08-07 テバ ファーマシューティカル インダストリーズ リミティド リネゾリッド中間体の調製方法
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
JP2008544979A (ja) 2005-06-29 2008-12-11 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてのホモモルホリンオキサゾリジノン
US20070197529A1 (en) * 2005-12-01 2007-08-23 Viviana Braude Isolated desfluoro-linezolid, preparation thereof and its use as a reference marker and standard
CN101460495B (zh) 2006-03-31 2013-08-14 财团法人乙卯研究所 具有杂环的化合物
US8841334B2 (en) 2006-05-31 2014-09-23 Abbvie Inc. Compounds as cannabinoid receptor ligands and uses thereof
WO2007140439A2 (en) 2006-05-31 2007-12-06 Abbott Laboratories Compounds as cannabinoid receptor ligands and uses thereof
WO2007140385A2 (en) 2006-05-31 2007-12-06 Abbott Laboratories Thiazole compounds as cannabinoid receptor ligands and uses thereof
WO2008121558A1 (en) 2007-03-28 2008-10-09 Abbott Laboratories 1, 3-thiazol-2 (3h) -ylidene compounds as cannabinoid receptor ligands
US8501794B2 (en) 2007-04-17 2013-08-06 Abbvie Inc. Compounds as cannabinoid receptor ligands
US7872033B2 (en) 2007-04-17 2011-01-18 Abbott Laboratories Compounds as cannabinoid receptor ligands
JP2010527929A (ja) 2007-05-18 2010-08-19 アボット・ラボラトリーズ カンナビノイド受容体リガンドとしての新規な化合物
EP2033960A3 (en) 2007-09-04 2009-04-29 Dipharma Francis S.r.l. Linezolid crystalline hydrate form and linezolid salts
WO2009032294A2 (en) * 2007-09-06 2009-03-12 Teva Pharmaceutical Industries Ltd. Processes for the preparation of a linezolid intermediate, linezolid hydroxide
US8530646B2 (en) 2007-10-02 2013-09-10 Research Foundation Itsuu Laboratory Oxazolidinone derivative having 7-membered hetero ring
WO2009063505A2 (en) * 2007-10-08 2009-05-22 Usv Limited Process for preparation of (s) (n-[[3-[3-fluoro-4-(4-morpholinyl) hen l -2-oxo-5-oxazolidin l methyl]acetamide
US9193713B2 (en) 2007-10-12 2015-11-24 Abbvie Inc. Compounds as cannabinoid receptor ligands
ITMI20072359A1 (it) 2007-12-18 2009-06-19 Dipharma Francis Srl Procedimento per la preparazione di derivati ossazolidinonici
CA2716857A1 (en) 2008-03-11 2009-09-17 Teodozyi Kolasa Novel compounds as cannabinoid receptor ligands
ES2397764T3 (es) 2008-04-01 2013-03-11 Abbott Gmbh & Co. Kg Tetrahidroisoquinolinas, composiciones farmacéuticas que las contienen, y su uso en terapia
WO2009157423A1 (ja) 2008-06-24 2009-12-30 財団法人乙卯研究所 縮合環を有するオキサゾリジノン誘導体
EP2331516B1 (en) 2008-08-15 2013-03-13 Abbott Laboratories Imine derivatives as cannabinoid receptor ligands
US8846730B2 (en) 2008-09-08 2014-09-30 Abbvie Inc. Compounds as cannabinoid receptor ligands
US8859596B2 (en) 2008-09-16 2014-10-14 Abbvie Inc. Compounds as cannabinoid receptor ligands
EP2163547A1 (en) 2008-09-16 2010-03-17 Unión Químico Farmacéutica, S.A. (UQUIFA) Process for the preparation of an oxazolidinone antibacterial agent and intermediates thereof
KR101023174B1 (ko) * 2008-09-24 2011-03-18 주식회사 레고켐 바이오사이언스 사이클릭 아미독심 또는 사이클릭 아미드라존 기를 가지는 신규한 옥사졸리디논 유도체 및 이를 함유하는 의약 조성물
US8815838B2 (en) 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
PL2346509T3 (pl) 2008-10-07 2021-03-08 Horizon Orphan Llc Lewofloksacyna w postaci aerozolu dla zmniejszania stanu zapalnego płuc
KR101674146B1 (ko) 2008-10-10 2016-11-08 머크 샤프 앤드 돔 코포레이션 옥사졸리디논 및 이를 포함하는 조성물을 제조하는 방법
TW201020236A (en) 2008-10-17 2010-06-01 Abbott Lab TRPV1 antagonists
WO2010045402A1 (en) 2008-10-17 2010-04-22 Abbott Laboratories Trpv1 antagonists
UA108193C2 (uk) 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8557983B2 (en) 2008-12-04 2013-10-15 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8563735B2 (en) 2008-12-05 2013-10-22 Abbvie Inc. Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
HUE029289T2 (en) 2008-12-05 2017-02-28 Abbvie Inc Sulfonamide derivatives as Bcl-2 selective apoptosis inducers for the treatment of cancer and immune diseases
US8586754B2 (en) 2008-12-05 2013-11-19 Abbvie Inc. BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
PA8854001A1 (es) 2008-12-16 2010-07-27 Abbott Lab Compuestos novedosos como ligandos de receptores de canabinoides
CN101774978B (zh) 2009-01-13 2011-09-21 联化科技股份有限公司 一种利奈唑胺的制备方法及其中间体
SG172393A1 (en) 2009-01-19 2011-07-28 Abbott Lab Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
DK2511264T3 (da) 2009-01-19 2015-06-22 Abbvie Inc Apoptose-inducerende midler til behandling af cancer og immunsygdomme og autoimmune sygdomme
CN102439006A (zh) 2009-02-03 2012-05-02 特留斯治疗学公司 (r)-3-(4-(2-(2-甲基四唑-5-基)吡啶-5-基)-3-氟苯基)-5-羟甲基噁唑烷-2-酮二氢磷酸酯的晶型
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
TW201038569A (en) 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
TWI519530B (zh) 2009-02-20 2016-02-01 艾伯維德國有限及兩合公司 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途
ES2540119T3 (es) 2009-03-27 2015-07-08 Abbvie Inc. Compuestos como ligandos de receptores cannabinoides
CA2756178A1 (en) 2009-03-27 2010-09-30 Abbott Laboratories Compounds as cannabinoid receptor ligands
US8236822B2 (en) 2009-03-27 2012-08-07 Abbott Laboratories Compounds as cannabinoid receptor ligands
EP2243479A3 (en) 2009-04-20 2011-01-19 Abbott Laboratories Novel amide and amidine derivates and uses thereof
US8236798B2 (en) 2009-05-07 2012-08-07 Abbott Gmbh & Co. Kg Carboxamide compounds and their use as calpain inhibitors
US9034875B2 (en) 2009-05-26 2015-05-19 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
PE20120345A1 (es) 2009-05-26 2012-05-17 Abbvie Bahamas Ltd Derivados de 2-(1h-pirrolo[2,3-b]piridin-5-iloxi)-n-fenilsulfonilbenzamida como inhibidores de proteinas anti-apoptoticas
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US20220315555A1 (en) 2009-05-26 2022-10-06 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
US8580767B2 (en) 2009-05-28 2013-11-12 Trius Therapeutics, Inc. Oxazolidinone containing dimer compounds, compositions and methods to make and use
US8962639B2 (en) 2009-05-29 2015-02-24 Abbvie Inc. Potassium channel modulators
MX353288B (es) 2009-09-04 2018-01-08 Raptor Pharmaceuticals Inc Uso de levofloxacina aerosolizada para el tratamiento de fibrosis quistica.
WO2011029460A1 (en) * 2009-09-09 2011-03-17 Synthon B.V. Nonhygroscopic linezolid salts
US20110095033A1 (en) 2009-10-28 2011-04-28 Belkin International, Inc. Portable Multi-Media Communication Device Protective Carrier and Method of Manufacture Therefor
WO2011050826A1 (en) 2009-10-28 2011-05-05 Synthon B.V. Process for making crystalline form a of linezolid
JP2013512241A (ja) 2009-11-25 2013-04-11 アボット・ラボラトリーズ カリウムチャネルモジュレーター
TW201130855A (en) 2009-12-16 2011-09-16 Abbott Lab Prodrug compounds useful as cannabinoid ligands
JP5959501B2 (ja) 2010-03-25 2016-08-02 アッヴィ・インコーポレイテッド 癌ならびに免疫および自己免疫疾患の治療のためのアポトーシス誘導物質
TWI520960B (zh) 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑
WO2011159785A1 (en) 2010-06-15 2011-12-22 Abbott Laboratories Novel compounds as cannabinoid receptor ligands
CN103140476A (zh) 2010-08-10 2013-06-05 Abbvie公司 新颖的trpv3调节剂
EP2603505A1 (en) * 2010-08-11 2013-06-19 Synthon BV Process for making linezolid
EP2603506A1 (en) 2010-08-11 2013-06-19 Synthon BV Process for making linezolid
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9266855B2 (en) 2010-09-27 2016-02-23 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
KR20180059560A (ko) 2010-10-29 2018-06-04 애브비 인코포레이티드 아폽토시스―유도제를 포함하는 고체 분산체
UA113500C2 (xx) 2010-10-29 2017-02-10 Одержані екструзією розплаву тверді дисперсії, що містять індукуючий апоптоз засіб
WO2012059432A1 (en) 2010-11-01 2012-05-10 Abbott Gmbh & Co. Kg N-phenyl-(homo)piperazinyl-benzenesulfonyl or benzenesulfonamide compounds suitable for treating disorders that respond to the modulation of the 5-ht6 receptor
WO2012059431A1 (en) 2010-11-01 2012-05-10 Abbott Gmbh & Co. Kg Benzenesulfonyl or sulfonamide compounds suitable for treating disorders that respond to the modulation of the serotonin 5-ht6 receptor
CN103313968A (zh) 2010-11-15 2013-09-18 Abbvie公司 Nampt和rock抑制剂
CA2817093A1 (en) 2010-11-15 2012-05-24 Abbvie Inc. Nampt inhibitors
US8609674B2 (en) 2010-11-16 2013-12-17 Abbvie Inc. Potassium channel modulators
WO2012067822A1 (en) 2010-11-16 2012-05-24 Abbott Laboratories Pyrazolo [1, 5 -a] pyrimidin potassium channel modulators
RU2628560C2 (ru) 2010-11-23 2017-08-18 Эббви Инк. Соли и кристаллические формы индуцирующего апоптоз агента
DK2642999T3 (en) 2010-11-23 2017-01-09 Abbvie Ireland Unlimited Co METHODS OF TREATMENT FOR USING selectivity-VE BCL-2 INHIBITORS
KR101264903B1 (ko) * 2010-11-24 2013-05-15 한국과학기술연구원 2-피롤리돈기를 포함하는 옥사졸리디논 유도체 또는 이의 약학적으로 허용 가능한 염 및 이들의 제조방법
US9090592B2 (en) 2010-12-30 2015-07-28 AbbVie Deutschland GmbH & Co. KG Heterocyclic compounds and their use as glycogen synthase kinase-3 inhibitors
CN102617500B (zh) * 2011-01-31 2016-07-13 山东信立泰药业有限公司 一种利奈唑胺中间体、其制备方法和利奈唑胺的制备方法
WO2012104874A2 (en) * 2011-02-02 2012-08-09 Mylan Laboratories Limited. Aqueous concentrated formulation of linezolid
US8802693B1 (en) 2011-03-09 2014-08-12 Abbvie Inc. Azaadamantane derivatives and methods of use
WO2012119653A1 (en) 2011-03-09 2012-09-13 Synthon Bv Process for making crystalline form a of linezolid
US9012651B2 (en) 2011-03-24 2015-04-21 Abbvie Inc. TRPV3 modulators
WO2012134943A1 (en) 2011-03-25 2012-10-04 Abbott Laboratories Trpv1 antagonists
CN102229577A (zh) * 2011-05-11 2011-11-02 石药集团中诺药业（石家庄）有限公司 利奈唑胺中间体的制备及纯化方法
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8859549B2 (en) 2011-05-13 2014-10-14 Abbvie, Inc. Potassium channel modulators
KR101271224B1 (ko) 2011-07-05 2013-06-10 한국과학기술연구원 항균활성을 갖는 신규 이중고리를 포함하는 옥사졸리디논 유도체 및 이의 제조방법
MX2014001457A (es) 2011-08-05 2014-08-21 Abbvie Deutschland Derivados de aminocromano, de aminotiocromano y de amino-1,2,3,4-tetrahidroquinolina composiciones farmaceuticas que los contienen, y su uso en terapia.
WO2013072923A1 (en) 2011-09-19 2013-05-23 Cadila Healthcare Limited Process for the preparation of crystalline linezolid
US9233989B2 (en) * 2011-10-11 2016-01-12 Council Of Scientific & Industrial Research Sila analogs of oxazolidinone derivatives and synthesis thereof
TWI561521B (en) 2011-10-14 2016-12-11 Abbvie Inc Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI571466B (zh) 2011-10-14 2017-02-21 艾伯維有限公司 用於治療癌症及免疫與自體免疫疾病之細胞凋亡誘發劑
WO2013062964A2 (en) 2011-10-24 2013-05-02 Abbvie Inc. Novel trpv3 modulators
US20130116241A1 (en) 2011-11-09 2013-05-09 Abbvie Inc. Novel inhibitor compounds of phosphodiesterase type 10a
WO2013072520A1 (en) 2011-11-18 2013-05-23 AbbVie Deutschland GmbH & Co. KG N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8969325B2 (en) 2011-12-19 2015-03-03 Abbvie Inc. TRPV1 antagonists
US8859584B2 (en) 2011-12-19 2014-10-14 Abbvie, Inc. TRPV1 antagonists
EP2852580A1 (en) * 2012-01-24 2015-04-01 Jubilant Life Sciences Ltd. Improved process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2013120496A1 (en) 2012-02-14 2013-08-22 Pharmathen S.A. Process for the preparation of linezolid in crystalline form and salts thereof
CN103254148B (zh) 2012-02-15 2016-04-13 浙江海正药业股份有限公司 利奈唑胺中间体的制备方法
WO2013149376A1 (en) 2012-04-02 2013-10-10 Abbott Laboratories Chemokine receptor antagonists
CN102643251B (zh) * 2012-04-17 2016-08-10 四川美大康佳乐药业有限公司 利奈唑胺的降解杂质及其制备方法
EP2838881B1 (en) 2012-04-20 2018-08-08 AbbVie Inc. Isoindolone derivatives
CN102702125B (zh) * 2012-05-10 2014-09-03 浙江工业大学 一种利奈唑胺的化学合成方法
MX2014013752A (es) 2012-05-11 2014-12-08 Abbvie Inc Inhibidores de nampt.
CN104428301A (zh) 2012-05-11 2015-03-18 艾伯维公司 Nampt抑制剂
MX2014013758A (es) 2012-05-11 2015-02-05 Abbvie Inc Derivados de tiazolcarboxamida para usarse como inhibidores de nampt.
CA2873097A1 (en) 2012-05-11 2013-11-14 Todd M. Hansen Pyridazine and pyridine derivatives as nampt inhibitors
US20130317055A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Neuronal nicotinic agonist and methods of use
US20130317054A1 (en) 2012-05-24 2013-11-28 Abbvie Inc. Neuronal nicotinic agonist and methods of use
CN104364240B (zh) * 2012-06-08 2017-02-22 四川贝力克生物技术有限责任公司 一种用于预防或治疗分支杆菌疾病的药物
BR112014031068A2 (pt) 2012-06-12 2017-06-27 Abbvie Inc derivados piridinona e piridazinona
US8796328B2 (en) 2012-06-20 2014-08-05 Abbvie Inc. TRPV1 antagonists
CN103570639B (zh) * 2012-08-08 2016-02-03 成都国弘医药有限公司 一种利奈唑胺的合成方法
IN2015DN02070A (lv) 2012-09-14 2015-08-14 Abbvie Deutschland
US20140080813A1 (en) 2012-09-14 2014-03-20 AbbVie Deutschland GmbH & Co. KG Tricyclic quinoline and quinoxaline derivatives
EP2917189B1 (en) 2012-11-09 2016-08-17 Synthon BV Process for making linezolid
CN103896963B (zh) * 2012-12-26 2017-06-09 中国科学院上海药物研究所 苯并噁嗪噁唑烷酮类化合物及其制备方法和用途
WO2014118809A1 (en) 2013-01-29 2014-08-07 Actavis Group Ptc Ehf. Pharmaceutical composition with linezolid
BR112015021549A2 (pt) 2013-03-13 2017-07-18 Abbvie Inc inibidores de piridina cinase cdk9
AU2014244263A1 (en) 2013-03-13 2015-08-13 Abbvie Inc. CDK9 kinase inhibitors
AU2014231567A1 (en) 2013-03-14 2015-10-01 Abbvie Inc. Pyrrolo[2,3-b]pyridine CDK9 kinase inhibitors
WO2014151444A1 (en) 2013-03-14 2014-09-25 Abbvie Inc. Pyrrolo[2,3-b]pyridine cdk9 kinase inhibitors
US20140275082A1 (en) 2013-03-14 2014-09-18 Abbvie Inc. Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
CN105339366A (zh) 2013-03-14 2016-02-17 艾伯维德国有限责任两合公司 带有取代的氧杂环丁烷的2-吲哚酮衍生物及其治疗血管加压素相关疾病的用途
JP2016512560A (ja) 2013-03-14 2016-04-28 アッヴィ・インコーポレイテッド ピロロピリミジン系ｃｄｋ９キナーゼ阻害薬
MX2015012008A (es) 2013-03-14 2016-04-15 Abbvie Deutschland Compuestos inhibidores novedosos de fosfodiesterasa tipo 10a.
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
SG11201602982YA (en) 2013-10-17 2016-05-30 Abbvie Deutschland Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
AU2014336154A1 (en) 2013-10-17 2016-04-28 AbbVie Deutschland GmbH & Co. KG Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2015068121A1 (en) 2013-11-06 2015-05-14 Unimark Remedies Ltd. Process for preparation of crystalline form i of linezolid and its compositions
WO2015068171A1 (en) * 2013-11-08 2015-05-14 Lee Pharma Limited Novel oxazolidinone compounds
WO2015068173A1 (en) * 2013-11-08 2015-05-14 Lee Pharma Limited Novel oxazolidinone antibacterial compound
US9840495B2 (en) 2013-12-20 2017-12-12 AbbVie Deutschland GmbH & Co. KG Oxindole derivatives carrying a piperidyl-substituted azetidinyl substituent and use thereof for treating vasopressine-related diseases
US9328112B2 (en) 2014-02-06 2016-05-03 Abbvie Inc. Tetracyclic CDK9 kinase inhibitors
WO2015173392A1 (en) 2014-05-15 2015-11-19 AbbVie Deutschland GmbH & Co. KG Oxindole compounds carrying a co-bound spiro substituent and use thereof for treating vasopressin-related diseases
EP3191459A1 (en) 2014-09-05 2017-07-19 AbbVie Deutschland GmbH & Co. KG Fused heterocyclic or carbocyclic compounds carrying a substituted cycloaliphatic radical and use thereof for treating vasopressin-related diseases
US9550754B2 (en) 2014-09-11 2017-01-24 AbbVie Deutschland GmbH & Co. KG 4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2016160938A1 (en) 2015-04-02 2016-10-06 Abbvie Inc. N-(1,3-thiazol-2-yl)pyrimidine-5-carboxamides as trpv3 modulators
ES2897973T3 (es) * 2015-07-17 2022-03-03 The Global Alliance For Tb Drug Dev Inc Feniloxazolidinonas sustituidas para terapia antimicrobiana
KR101660874B1 (ko) 2015-09-04 2016-09-30 주식회사 알에스텍 리네졸리드의 제조방법 및 그 중간체
WO2017066964A1 (en) * 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
US20180339996A1 (en) 2015-11-25 2018-11-29 AbbVie Deutschland GmbH & Co. KG Hexahydropyrazinobenz- or -pyrido-oxazepines carrying an oxygen-containing substituent and use thereof in the treatment of 5-ht2c-dependent disorders
WO2017156519A1 (en) 2016-03-11 2017-09-14 The Board Of Trustees Of The University Of Illinois Small-molecules active against gram-negative bacteria
MX2018013573A (es) 2016-05-07 2019-08-01 Shanghai Fochon Pharmaceutical Co Ltd Ciertos inhibidores de la proteína cinasa.
US11168078B2 (en) 2016-11-28 2021-11-09 Shanghai Fochon Pharmaceutical Co., Ltd. Sulfoximine, sulfonimidamide, sulfondiimine and diimidosulfonamide compounds as inhibitors of indoleamine 2,3-dioxygenase
EP3601255A1 (en) 2017-03-21 2020-02-05 AbbVie Deutschland GmbH & Co. KG Proline amide compounds and their azetidine analogues carrying a specifically substituted benzyl radical
SI3612531T1 (sl) 2017-04-18 2022-11-30 Shanghai Fochon Pharmaceutical Co., Ltd. Sredstva, ki sprožajo apoptozo
WO2018237140A1 (en) 2017-06-23 2018-12-27 The Board Of Trustees Of The University Of Illinois TOPOISOMERASE INHIBITORS HAVING ANTIBACTERIAL ACTIVITY AND ANTI-CANCER ACTIVITY
JP7294677B2 (ja) 2018-03-14 2023-06-20 フォチョン・ファーマシューティカルズ・リミテッド ＴＲＫキナーゼ阻害剤としての置換（２－アザビシクロ［３．１．０］ヘキサン－２－イル）ピラゾロ［１，５－ａ］ピリミジン化合物及び置換（２－アザビシクロ［３．１．０］ヘキサン－２－イル）イミダゾ［１，２－ｂ］ピリダジン化合物
US11485707B2 (en) 2018-03-23 2022-11-01 Fochon Pharmaceuticals, Ltd. Deuterated compounds as rock inhibitors
CN108997247A (zh) * 2018-08-10 2018-12-14 泰州申合泰尔生物医药有限公司 一种利伐沙班中间体的制备方法
CN112409286B (zh) 2019-08-20 2022-08-05 杭州迪克科技有限公司 一种n-取代苯基-5-羟甲基-2-噁唑烷酮的合成方法
CN114957232B (zh) * 2021-05-28 2023-06-30 四川大学 一种苯并二氢恶嗪类化合物及其制备方法和抗结核的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54160371A (en) * 1978-06-02 1979-12-19 Kyowa Hakko Kogyo Co Ltd Novel piperidine derivative and hypotensive agents comprising it
ES8506659A1 (es) * 1983-06-07 1985-08-01 Du Pont Un procedimiento para la preparacion de nuevos derivados del amino-metil-oxooxazolidinil-benzeno.
CA1260948A (en) * 1984-12-05 1989-09-26 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
AU667198B2 (en) * 1991-11-01 1996-03-14 Pharmacia & Upjohn Company Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny

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ATE185804T1 (de) 1999-11-15
KR960704866A (ko) 1996-10-09
LV12605A (en) 2001-01-20
EP0717738A1 (en) 1996-06-26
CA2168560C (en) 2001-08-14
EP0717738B1 (en) 1999-10-20
MY115155A (en) 2003-04-30
IL110802A0 (en) 1994-11-11
KR100301269B1 (ko) 2001-10-22
DE69421285T2 (de) 2000-02-24
ES2139093T3 (es) 2000-02-01
NZ271805A (en) 1998-02-26
DE10299007I1 (de) 2002-07-04
PH31634A (en) 1999-01-12
CA2168560A1 (en) 1995-03-16
DK0717738T3 (da) 2000-05-08
AU687866B2 (en) 1998-03-05
TW293817B (lv) 1996-12-21
DE10299007I2 (de) 2008-09-18
DE69421285D1 (de) 1999-11-25
SI0717738T1 (en) 2000-02-29
NL300079I1 (nl) 2002-04-02
JP3176630B2 (ja) 2001-06-18
AU7557094A (en) 1995-03-27
CN1130379A (zh) 1996-09-04
WO1995007271A1 (en) 1995-03-16
GR3031809T3 (en) 2000-02-29
CN1057087C (zh) 2000-10-04
IL110802A (en) 2000-09-28
JPH09502436A (ja) 1997-03-11

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