ATE229014T1 - Alpha,beta-gesättigte und -ungesättigte 3-aryl-5- aminomethyl-butyrolactone antibakterielle mittel - Google Patents
Alpha,beta-gesättigte und -ungesättigte 3-aryl-5- aminomethyl-butyrolactone antibakterielle mittelInfo
- Publication number
- ATE229014T1 ATE229014T1 AT96929740T AT96929740T ATE229014T1 AT E229014 T1 ATE229014 T1 AT E229014T1 AT 96929740 T AT96929740 T AT 96929740T AT 96929740 T AT96929740 T AT 96929740T AT E229014 T1 ATE229014 T1 AT E229014T1
- Authority
- AT
- Austria
- Prior art keywords
- spp
- organisms
- substituted
- beta
- alpha
- Prior art date
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229920006395 saturated elastomer Polymers 0.000 title abstract 2
- -1 troponyl Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 abstract 2
- 150000003457 sulfones Chemical class 0.000 abstract 2
- 150000003462 sulfoxides Chemical class 0.000 abstract 2
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical class O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 abstract 1
- 241001148536 Bacteroides sp. Species 0.000 abstract 1
- 241001112696 Clostridia Species 0.000 abstract 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 abstract 1
- 241000186359 Mycobacterium Species 0.000 abstract 1
- 241000186367 Mycobacterium avium Species 0.000 abstract 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 abstract 1
- 241000204031 Mycoplasma Species 0.000 abstract 1
- 241000295644 Staphylococcaceae Species 0.000 abstract 1
- 241001148470 aerobic bacillus Species 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000002785 azepinyl group Chemical group 0.000 abstract 1
- 125000002393 azetidinyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 244000052769 pathogen Species 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 125000004305 thiazinyl group Chemical group S1NC(=CC=C1)* 0.000 abstract 1
- 125000001984 thiazolidinyl group Chemical group 0.000 abstract 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US383795P | 1995-09-15 | 1995-09-15 | |
| PCT/US1996/013726 WO1997010235A1 (en) | 1995-09-15 | 1996-09-05 | 5-AMIDOMETHYL α, β-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE229014T1 true ATE229014T1 (de) | 2002-12-15 |
Family
ID=21707825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96929740T ATE229014T1 (de) | 1995-09-15 | 1996-09-05 | Alpha,beta-gesättigte und -ungesättigte 3-aryl-5- aminomethyl-butyrolactone antibakterielle mittel |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5708169A (de) |
| EP (1) | EP0863890B1 (de) |
| JP (1) | JPH11511467A (de) |
| AT (1) | ATE229014T1 (de) |
| AU (1) | AU6902096A (de) |
| DE (1) | DE69625238T2 (de) |
| DK (1) | DK0863890T3 (de) |
| ES (1) | ES2185800T3 (de) |
| PT (1) | PT863890E (de) |
| WO (1) | WO1997010235A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9717807D0 (en) * | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| GB9725244D0 (en) | 1997-11-29 | 1998-01-28 | Zeneca Ltd | Chemical compounds |
| NZ508174A (en) | 1998-06-05 | 2003-10-31 | Astrazeneca Ab | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
| US6420349B1 (en) | 1998-08-24 | 2002-07-16 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
| TW572757B (en) * | 1998-08-24 | 2004-01-21 | Bristol Myers Squibb Co | Novel isoxazolinone antibacterial agents |
| AU5871000A (en) * | 1999-06-11 | 2001-01-02 | Paul G. Abrams | High dose radionuclide complexes for bone marrow suppression |
| US7094885B2 (en) * | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| US6465456B2 (en) | 2000-06-29 | 2002-10-15 | Bristol-Myers Squibb Company | Isoxazolinone antibacterial agents |
| CA2434302A1 (en) | 2001-01-08 | 2002-08-15 | Neorx Corporation | Therapeutic and diagnostic compounds, compositions, and methods |
| JP2005516933A (ja) | 2001-12-13 | 2005-06-09 | ダウ グローバル テクノロジーズ インコーポレイティド | 放射性医薬による骨髄炎の治療 |
| AR042086A1 (es) | 2002-11-21 | 2005-06-08 | Upjohn Co | N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos |
| WO2013086201A1 (en) | 2011-12-06 | 2013-06-13 | Dowd Scot E | Universal or broad range assays and multi-tag sample specific diagnostic process using non-optical sequencing |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3446821A (en) * | 1964-09-17 | 1969-05-27 | Squibb & Sons Inc | Intermediates useful in preparation of butenolides and process therefor |
| US3331837A (en) * | 1964-10-30 | 1967-07-18 | Schering Ag | alpha, beta-unsaturated gamma-lactone compounds and process for the production of same |
| US3496187A (en) * | 1967-03-20 | 1970-02-17 | American Home Prod | N-(heterocyclyl)aconamides |
| US3444178A (en) * | 1967-06-16 | 1969-05-13 | Monsanto Co | Certain halogenated 2-(2-thiazolyl) aminofuran-5-ones |
| US3576010A (en) * | 1967-06-16 | 1971-04-20 | Monsanto Co | Substituted anilino halogenated furanones |
| US3647656A (en) * | 1969-04-09 | 1972-03-07 | Ibm | Method of preparing alpha substituted beta gamma unsaturated lactones from alkoxyfurans |
| JPS495961A (de) * | 1972-05-10 | 1974-01-19 | ||
| FR2456097A1 (fr) * | 1979-05-07 | 1980-12-05 | Delalande Sa | Nouveaux derives de la 5 h-furanone-2 et de la 3 h-dihydrofuranone-2, leur procede de preparation et leur application en therapeutique |
| JPS5746975A (en) * | 1980-09-04 | 1982-03-17 | Sanwa Chem:Kk | Preparation of alpha- or beta-substituted -deltaalpha,beta-or deltabeta-,gamma-butenolide |
| JPS5932466B2 (ja) * | 1981-03-04 | 1984-08-09 | 理化学研究所 | ５員環不飽和ラクトンの製造方法 |
| JPS5932467B2 (ja) * | 1981-03-04 | 1984-08-09 | 理化学研究所 | ５員環不飽和ラクトンの製造方法 |
| JPS5852995B2 (ja) * | 1981-09-28 | 1983-11-26 | 武田薬品工業株式会社 | フルフラ−ル誘導体の製造法 |
| JPS59164787A (ja) * | 1983-03-09 | 1984-09-17 | Rikagaku Kenkyusho | ５員環不飽和ラクトンの製造方法 |
| GB8401149D0 (en) * | 1984-01-17 | 1984-02-22 | Fujisawa Pharmaceutical Co | Furanone derivatives |
| JPS6393774A (ja) * | 1986-10-09 | 1988-04-25 | Sumitomo Chem Co Ltd | ４−アミノ−２（５ｈ）−フラノン誘導体の製造法 |
| JP2765001B2 (ja) * | 1988-02-23 | 1998-06-11 | 武田薬品工業株式会社 | プロテアーゼ阻害剤 |
| JPH01313476A (ja) * | 1988-06-13 | 1989-12-18 | Kao Corp | ３−ｏ−アシル−５，６−ｏ−ベンジリデンアスコルビン酸 |
| JPH05294952A (ja) * | 1992-04-16 | 1993-11-09 | Wakamoto Pharmaceut Co Ltd | 抗生物質ｗａｐ−４０６８および誘導体ならびにそれらの製造法 |
| DK0673370T3 (da) * | 1992-12-08 | 1998-09-07 | Upjohn Co | Troponsubstituerede phenyloxazolidinoner som antibakterielle midler |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
-
1996
- 1996-09-05 ES ES96929740T patent/ES2185800T3/es not_active Expired - Lifetime
- 1996-09-05 AT AT96929740T patent/ATE229014T1/de not_active IP Right Cessation
- 1996-09-05 DK DK96929740T patent/DK0863890T3/da active
- 1996-09-05 JP JP9511972A patent/JPH11511467A/ja not_active Withdrawn
- 1996-09-05 PT PT96929740T patent/PT863890E/pt unknown
- 1996-09-05 EP EP96929740A patent/EP0863890B1/de not_active Expired - Lifetime
- 1996-09-05 US US08/708,765 patent/US5708169A/en not_active Expired - Fee Related
- 1996-09-05 AU AU69020/96A patent/AU6902096A/en not_active Abandoned
- 1996-09-05 WO PCT/US1996/013726 patent/WO1997010235A1/en not_active Ceased
- 1996-09-05 DE DE69625238T patent/DE69625238T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69625238T2 (de) | 2003-07-24 |
| EP0863890A1 (de) | 1998-09-16 |
| EP0863890B1 (de) | 2002-12-04 |
| DE69625238D1 (de) | 2003-01-16 |
| AU6902096A (en) | 1997-04-01 |
| PT863890E (pt) | 2003-04-30 |
| US5708169A (en) | 1998-01-13 |
| WO1997010235A1 (en) | 1997-03-20 |
| DK0863890T3 (da) | 2003-03-24 |
| ES2185800T3 (es) | 2003-05-01 |
| JPH11511467A (ja) | 1999-10-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE229014T1 (de) | Alpha,beta-gesättigte und -ungesättigte 3-aryl-5- aminomethyl-butyrolactone antibakterielle mittel | |
| ATE233766T1 (de) | Antibakterielle bizyklische oxazin und thiazin- oxazolidinone | |
| DE69421285D1 (de) | Substituierte oxazine und thiazine oxazolidinone als antimikrobielle mittel | |
| ATE263172T1 (de) | Oxazolidinone mit tricyclische substituente als antibacterielle mittel | |
| ATE257829T1 (de) | Aminoaryl oxazolidinone n-oxide | |
| BR9509136A (pt) | Composto e uso do mesmo | |
| ATE304536T1 (de) | Bicyclo(3,1,0)hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate | |
| MX9703040A (es) | Antimicrobianos de feniloxazolidinona. | |
| MX9301361A (es) | Derivados de carbapenema antimicrobianos y su preparacion. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0863890 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |