DE69625238D1 - Alpha,beta-gesättigte und -ungesättigte 3-aryl-5-aminomethyl-butyrolactone antibakterielle mittel - Google Patents

Alpha,beta-gesättigte und -ungesättigte 3-aryl-5-aminomethyl-butyrolactone antibakterielle mittel

Info

Publication number
DE69625238D1
DE69625238D1 DE69625238T DE69625238T DE69625238D1 DE 69625238 D1 DE69625238 D1 DE 69625238D1 DE 69625238 T DE69625238 T DE 69625238T DE 69625238 T DE69625238 T DE 69625238T DE 69625238 D1 DE69625238 D1 DE 69625238D1
Authority
DE
Germany
Prior art keywords
spp
organisms
substituted
beta
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69625238T
Other languages
English (en)
Other versions
DE69625238T2 (de
Inventor
B Hester
Joseph Brickner
Robert Barbachyn
K Hutchinson
Scott Toops
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Publication of DE69625238D1 publication Critical patent/DE69625238D1/de
Application granted granted Critical
Publication of DE69625238T2 publication Critical patent/DE69625238T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/28—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69625238T 1995-09-15 1996-09-05 Alpha,beta-gesättigte und -ungesättigte 3-aryl-5-aminomethyl-butyrolactone antibakterielle mittel Expired - Fee Related DE69625238T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US383795P 1995-09-15 1995-09-15
PCT/US1996/013726 WO1997010235A1 (en) 1995-09-15 1996-09-05 5-AMIDOMETHYL α, β-SATURATED AND -UNSATURATED 3-ARYL BUTYROLACTONE ANTIBACTERIAL AGENTS

Publications (2)

Publication Number Publication Date
DE69625238D1 true DE69625238D1 (de) 2003-01-16
DE69625238T2 DE69625238T2 (de) 2003-07-24

Family

ID=21707825

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69625238T Expired - Fee Related DE69625238T2 (de) 1995-09-15 1996-09-05 Alpha,beta-gesättigte und -ungesättigte 3-aryl-5-aminomethyl-butyrolactone antibakterielle mittel

Country Status (10)

Country Link
US (1) US5708169A (de)
EP (1) EP0863890B1 (de)
JP (1) JPH11511467A (de)
AT (1) ATE229014T1 (de)
AU (1) AU6902096A (de)
DE (1) DE69625238T2 (de)
DK (1) DK0863890T3 (de)
ES (1) ES2185800T3 (de)
PT (1) PT863890E (de)
WO (1) WO1997010235A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
GB9609919D0 (en) * 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
GB9717807D0 (en) * 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
EP1082323A2 (de) 1998-06-05 2001-03-14 AstraZeneca UK Limited Oxazolidinon-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende pharmazeutische zusammensetzungen
US6420349B1 (en) 1998-08-24 2002-07-16 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
TW572757B (en) * 1998-08-24 2004-01-21 Bristol Myers Squibb Co Novel isoxazolinone antibacterial agents
CA2371728C (en) * 1999-06-11 2009-06-02 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) * 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US6465456B2 (en) 2000-06-29 2002-10-15 Bristol-Myers Squibb Company Isoxazolinone antibacterial agents
JP2004536034A (ja) * 2001-01-08 2004-12-02 ネオルクス コーポレイション 治療的および診断的化合物、組成物および方法
AU2002364552A1 (en) 2001-12-13 2003-06-30 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
AR042086A1 (es) 2002-11-21 2005-06-08 Upjohn Co N-aril-2- oxazolidinon -5- carboxamidas y sus derivados, usados como agentes antibacterianos
US10167520B2 (en) 2011-12-06 2019-01-01 Scot E. Dowd Universal or broad range assays and multi-tag sample specific diagnostic process using non-optical sequencing

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3446821A (en) * 1964-09-17 1969-05-27 Squibb & Sons Inc Intermediates useful in preparation of butenolides and process therefor
US3331837A (en) * 1964-10-30 1967-07-18 Schering Ag alpha, beta-unsaturated gamma-lactone compounds and process for the production of same
US3496187A (en) * 1967-03-20 1970-02-17 American Home Prod N-(heterocyclyl)aconamides
US3444178A (en) * 1967-06-16 1969-05-13 Monsanto Co Certain halogenated 2-(2-thiazolyl) aminofuran-5-ones
US3576010A (en) * 1967-06-16 1971-04-20 Monsanto Co Substituted anilino halogenated furanones
US3647656A (en) * 1969-04-09 1972-03-07 Ibm Method of preparing alpha substituted beta gamma unsaturated lactones from alkoxyfurans
JPS495961A (de) * 1972-05-10 1974-01-19
FR2456097A1 (fr) * 1979-05-07 1980-12-05 Delalande Sa Nouveaux derives de la 5 h-furanone-2 et de la 3 h-dihydrofuranone-2, leur procede de preparation et leur application en therapeutique
JPS5746975A (en) * 1980-09-04 1982-03-17 Sanwa Chem:Kk Preparation of alpha- or beta-substituted -deltaalpha,beta-or deltabeta-,gamma-butenolide
JPS5932466B2 (ja) * 1981-03-04 1984-08-09 理化学研究所 ５員環不飽和ラクトンの製造方法
JPS5932467B2 (ja) * 1981-03-04 1984-08-09 理化学研究所 ５員環不飽和ラクトンの製造方法
JPS5852995B2 (ja) * 1981-09-28 1983-11-26 武田薬品工業株式会社 フルフラ−ル誘導体の製造法
JPS59164787A (ja) * 1983-03-09 1984-09-17 Rikagaku Kenkyusho ５員環不飽和ラクトンの製造方法
GB8401149D0 (en) * 1984-01-17 1984-02-22 Fujisawa Pharmaceutical Co Furanone derivatives
JPS6393774A (ja) * 1986-10-09 1988-04-25 Sumitomo Chem Co Ltd ４−アミノ−２（５ｈ）−フラノン誘導体の製造法
JP2765001B2 (ja) * 1988-02-23 1998-06-11 武田薬品工業株式会社 プロテアーゼ阻害剤
JPH01313476A (ja) * 1988-06-13 1989-12-18 Kao Corp ３−ｏ−アシル−５，６−ｏ−ベンジリデンアスコルビン酸
JPH05294952A (ja) * 1992-04-16 1993-11-09 Wakamoto Pharmaceut Co Ltd 抗生物質ｗａｐ−４０６８および誘導体ならびにそれらの製造法
ES2111188T3 (es) * 1992-12-08 1998-03-01 Upjohn Co Agentes antibacterianos derivados de feniloxazolidinona sustituida con tropona.
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.

Also Published As

Publication number Publication date
ES2185800T3 (es) 2003-05-01
PT863890E (pt) 2003-04-30
DK0863890T3 (da) 2003-03-24
US5708169A (en) 1998-01-13
DE69625238T2 (de) 2003-07-24
ATE229014T1 (de) 2002-12-15
WO1997010235A1 (en) 1997-03-20
JPH11511467A (ja) 1999-10-05
EP0863890A1 (de) 1998-09-16
EP0863890B1 (de) 2002-12-04
AU6902096A (en) 1997-04-01

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ATE263172T1 (de) Oxazolidinone mit tricyclische substituente als antibacterielle mittel
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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee