LU86264A1 - Nouveau procede de preparation d'un derive d'aryl-1,4-dihydro 4-oxonaphtyridine 1-substituee produits intermediaires pour ce derive et procede de preparation des produits intermediaires - Google Patents

Nouveau procede de preparation d'un derive d'aryl-1,4-dihydro 4-oxonaphtyridine 1-substituee produits intermediaires pour ce derive et procede de preparation des produits intermediaires Download PDF

Info

Publication number
LU86264A1
LU86264A1 LU86264A LU86264A LU86264A1 LU 86264 A1 LU86264 A1 LU 86264A1 LU 86264 A LU86264 A LU 86264A LU 86264 A LU86264 A LU 86264A LU 86264 A1 LU86264 A1 LU 86264A1
Authority
LU
Luxembourg
Prior art keywords
group
compound
sulfonyloxy
arene
derivative
Prior art date
Application number
LU86264A
Other languages
English (en)
French (fr)
Inventor
Hirokazu Narita
Yozo Todo
Mikako Miyajima
Isamu Saikawa
Tetsuo Yamafuji
Katsuyuki Nagumo
Isao Kitayama
Hideyoshi Nagaki
Shuntaro Takano
Yoshinori Konishi
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP60009191A external-priority patent/JPH0629247B2/ja
Priority claimed from JP60028397A external-priority patent/JPH0629246B2/ja
Priority claimed from JP60043644A external-priority patent/JPH0665670B2/ja
Priority claimed from JP60069061A external-priority patent/JPH0665671B2/ja
Priority claimed from JP60097065A external-priority patent/JPH0662619B2/ja
Priority claimed from JP60129323A external-priority patent/JPH0665672B2/ja
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Publication of LU86264A1 publication Critical patent/LU86264A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
LU86264A 1985-01-23 1986-01-23 Nouveau procede de preparation d'un derive d'aryl-1,4-dihydro 4-oxonaphtyridine 1-substituee produits intermediaires pour ce derive et procede de preparation des produits intermediaires LU86264A1 (fr)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
JP919185 1985-01-23
JP60009191A JPH0629247B2 (ja) 1985-01-23 1985-01-23 ５−フルオロニコチン酸誘導体およびその塩
JP60028397A JPH0629246B2 (ja) 1985-02-18 1985-02-18 ２−（５−フルオロニコチノイル）酢酸誘導体およびその塩
JP2839785 1985-02-18
JP4364485 1985-03-07
JP60043644A JPH0665670B2 (ja) 1985-03-07 1985-03-07 １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
JP6906185 1985-04-03
JP60069061A JPH0665671B2 (ja) 1985-04-03 1985-04-03 １−置換アリ−ル−１，４−ジヒドロ−４−オキソナフチリジン誘導体またはその塩の新規製造法
JP60097065A JPH0662619B2 (ja) 1985-05-08 1985-05-08 １，４−ジヒドロ−４−オキソナフチリジン誘導体またはその塩の新規製造法
JP9706585 1985-05-08
JP60129323A JPH0665672B2 (ja) 1985-06-14 1985-06-14 １，４−ジヒドロ−４−オキソナフチリジン誘導体またはその塩の新規製造法
JP12932385 1985-06-14

Publications (1)

Publication Number Publication Date
LU86264A1 true LU86264A1 (fr) 1986-08-04

Family

ID=27548185

Family Applications (1)

Application Number Title Priority Date Filing Date
LU86264A LU86264A1 (fr) 1985-01-23 1986-01-23 Nouveau procede de preparation d'un derive d'aryl-1,4-dihydro 4-oxonaphtyridine 1-substituee produits intermediaires pour ce derive et procede de preparation des produits intermediaires

Country Status (20)

Country Link
US (1) US4704459A (fi)
KR (1) KR880001078B1 (fi)
AT (1) AT392789B (fi)
BE (1) BE904086A (fi)
CA (2) CA1340706C (fi)
CH (2) CH671957A5 (fi)
DE (2) DE3601517A1 (fi)
DK (3) DK169570B1 (fi)
FI (2) FI83313C (fi)
FR (1) FR2576305B1 (fi)
GB (2) GB2170804B (fi)
IL (1) IL77688A (fi)
IT (1) IT1190193B (fi)
LU (1) LU86264A1 (fi)
NL (1) NL192986C (fi)
NO (1) NO163227C (fi)
NZ (1) NZ214901A (fi)
PH (2) PH22956A (fi)
PT (1) PT81889B (fi)
SE (3) SE462164B (fi)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3525108A1 (de) * 1985-06-07 1986-12-11 Bayer Ag, 5090 Leverkusen Antibakteriell wirksame chinoloncarbonsaeureester
US4916229A (en) * 1987-07-28 1990-04-10 Warner-Lambert Company Pyridine carboxylic acid derivates
IE62600B1 (en) * 1987-08-04 1995-02-22 Abbott Lab Naphtyridine antianaerobic compounds
DE3729852A1 (de) * 1987-09-05 1989-03-23 Basf Ag Verfahren zur herstellung von 1-alkylimidazol-5-carbonsaeuren sowie deren estern, amiden und nitrilen
US4920120A (en) 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents
US5585491A (en) * 1988-01-25 1996-12-17 Otsuka Pharmaceutical Co., Ltd. Antibacterial agents
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
DE3934082A1 (de) * 1989-10-12 1991-04-18 Bayer Ag Chinoloncarbonsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung als antivirale mittel
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
AU1161492A (en) * 1991-01-14 1992-08-17 Hanmi Pharmaceutical Co., Ltd. Novel quinolone compounds and processes for preparation thereof
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
BR9407283A (pt) * 1993-08-13 1996-10-01 Dong Wha Pharm Co Ltd Derivados do ácido carboxílico quinolônico e processo de preparação
EP0788801A1 (en) * 1994-07-20 1997-08-13 Toyama Chemical Co., Ltd. Sustained-release oral ointment
CN1114607C (zh) 1997-06-26 2003-07-16 同和药品工业株式会社 喹诺酮羧酸衍生物
EP1135132A2 (en) 1998-12-04 2001-09-26 Influx, Inc. Inhibitors of multidrug transporters
CA2383466C (en) 1999-09-16 2009-08-25 Tanabe Seiyaku Co., Ltd. Aromatic nitrogen-containing 6-membered cyclic compounds
US20080027037A1 (en) * 2000-04-28 2008-01-31 Tanabe Seiyaku Co., Ltd. Cyclic compounds
US7273868B2 (en) * 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
AU2001241142B2 (en) * 2000-04-28 2005-09-22 Tanabe Seiyaku Co., Ltd. Cyclic compounds
EP1364950A4 (en) * 2001-02-26 2005-03-09 Tanabe Seiyaku Co PYRIDOPYRIMIDINE OR NAPHTHYRIDINE DERIVATIVE
US6957105B2 (en) * 2002-03-26 2005-10-18 Cardiac Pacemakers, Inc. Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
US7732616B2 (en) * 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
EP1689387B1 (en) * 2003-11-19 2011-09-14 Array Biopharma, Inc. Bicyclic inhibitors of mek and methods of synthesis thereof
US7517994B2 (en) * 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
ES2405785T3 (es) * 2005-05-18 2013-06-03 Array Biopharma Inc. Inhibidores heterocíclicos de MEK y métodos de uso de los mismos
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
US20070197548A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US7973022B2 (en) * 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
WO2007123939A2 (en) 2006-04-19 2007-11-01 Laboratoires Serono S.A. Novel arylamino n-heteraryls as mek inhibitors
DE102007026550A1 (de) 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
DE102007055341A1 (de) * 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
CA2713722A1 (en) * 2008-02-11 2009-08-20 Astrazeneca Ab Process for preparing pyridone derivatives 226
WO2012049156A1 (en) 2010-10-12 2012-04-19 Bayer Animal Health Gmbh Non-starch based soft chewables
RU2693005C2 (ru) 2012-12-19 2019-07-01 Байер Энимэл Хельс ГмбХ Таблетки с улучшенным приёмом и хорошей устойчивостью при хранении
MD4291C1 (ro) * 2013-12-27 2015-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Preparat medicamentos pentru tratamentul otitelor
WO2021046305A1 (en) * 2019-09-06 2021-03-11 Bayer Healthcare Llc Palatable granular veterinary compositions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149104A (en) * 1961-01-03 1964-09-15 Sterling Drug Inc 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters
GB1147336A (en) * 1965-06-14 1969-04-02 Lilly Industries Ltd Quinoline-3-carboxylic acid derivatives
US3753993A (en) * 1971-05-17 1973-08-21 Sterling Drug Inc 1,4-dihydro-4-oxo-7-pyridyl-3-quinoline-carboxylic acid derivatives
DE2125310A1 (en) * 1971-05-21 1972-11-30 Sterling Drug Inc , New York, NY (V St A) 1-alkyl-1,4-dihydro-4-oxo-1,8-naphtyridine 3-carboxylic acids antibac
GB1451911A (en) * 1972-08-14 1976-10-06 Dainippon Pharmaceutical Co 2-1-piperazino-5-oxopyrido-2,3,d-pyrimidine-6-carboxylic acids their preparation and pharmaceutical compositions thereof
US4017622A (en) * 1972-12-18 1977-04-12 Dainippon Pharmaceutical Co., Ltd. Piperazine derivatives
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
AR223983A1 (es) * 1978-08-25 1981-10-15 Dainippon Pharmaceutical Co Un procedimiento para-preparar derivados de acido 6-halogeno-4-oxo-7-(1-piperazinil)-1,8-naftiridin-3-carboxilico
US4350817A (en) * 1980-02-28 1982-09-21 American Home Products Corporation 4-Cl, Br or I-3-Carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
DE3028520A1 (de) * 1980-07-28 1982-02-25 Dynamit Nobel Ag, 5210 Troisdorf Verfahren zur herstellung von chinolinen, naphtyridinen und anderen stickstoff-bi-heterocyclen
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS60228479A (ja) 1984-04-26 1985-11-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩

Also Published As

Publication number Publication date
IT1190193B (it) 1988-02-16
IL77688A (en) 1991-01-31
DK169570B1 (da) 1994-12-05
CA1340783C (en) 1999-10-12
FI83313B (fi) 1991-03-15
DK32286A (da) 1986-07-24
NL192986C (nl) 1998-07-03
PH23202A (en) 1989-06-06
FR2576305B1 (fr) 1991-04-19
GB2204040A (en) 1988-11-02
AT392789B (de) 1991-06-10
GB2170804A (en) 1986-08-13
DK285290A (da) 1990-11-30
DK285290D0 (da) 1990-11-30
DK170857B1 (da) 1996-02-12
SE462164B (sv) 1990-05-14
NL192986B (nl) 1998-03-02
PH22956A (en) 1989-02-03
IT8647562A0 (it) 1986-01-22
FI860250A (fi) 1986-07-24
FR2576305A1 (fr) 1986-07-25
DE3637679C1 (de) 1992-08-27
DE3601517C2 (fi) 1989-11-16
CH667456A5 (de) 1988-10-14
GB2170804B (en) 1989-09-20
NO860226L (no) 1986-07-24
PT81889B (pt) 1988-05-27
KR880001078B1 (ko) 1988-06-22
FI83313C (fi) 1991-06-25
DK285190A (da) 1990-11-30
GB8811645D0 (en) 1988-06-22
FI87647B (fi) 1992-10-30
GB8601045D0 (en) 1986-02-19
SE8902265L (sv) 1989-06-21
ATA7286A (de) 1990-11-15
CH671957A5 (fi) 1989-10-13
SE8902264D0 (sv) 1989-06-21
NO163227C (no) 1990-04-25
PT81889A (en) 1986-02-01
DE3601517A1 (de) 1986-08-21
FI893075A (fi) 1989-06-22
SE8902265D0 (sv) 1989-06-21
BE904086A (fr) 1986-07-22
NL8600138A (nl) 1986-08-18
DK285190D0 (da) 1990-11-30
SE469984B (sv) 1993-10-18
NO163227B (no) 1990-01-15
NZ214901A (en) 1989-01-27
GB2204040B (en) 1989-09-20
DK32286D0 (da) 1986-01-22
SE8902264L (sv) 1989-06-21
KR860005817A (ko) 1986-08-13
SE8600274L (sv) 1986-09-10
DK170532B1 (da) 1995-10-16
SE8600274D0 (sv) 1986-01-22
US4704459A (en) 1987-11-03
CA1340706C (en) 1999-08-17
FI87647C (fi) 1993-02-10
FI893075A0 (fi) 1989-06-22
SE469983B (sv) 1993-10-18
FI860250A0 (fi) 1986-01-20

Similar Documents

Publication Publication Date Title
LU86264A1 (fr) Nouveau procede de preparation d'un derive d'aryl-1,4-dihydro 4-oxonaphtyridine 1-substituee produits intermediaires pour ce derive et procede de preparation des produits intermediaires
JP4494205B2 (ja) カルシウム受容体調節化合物およびその用途
US9718779B2 (en) Intermediate and polymorphs of 1-(4-methoxypheny1)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetra hydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide and process thereof
RU2154635C2 (ru) Производные 4-арил-6-амино-никотиновой кислоты и их соли
CA2104883A1 (fr) Derives d'acide thienyl ou pyrrolyl carboxyliques, leur preparation et medicaments les contenant
EP3376870B1 (en) Process for the preparation of kinase inhibitors and intermediates thereof
US7868007B2 (en) Triazolopyridine carboxamide derivatives, preparation thereof and therapeutic use thereof
US20110288294A1 (en) Preparation process for an inhibitor of a blood clotting factor
NZ583317A (en) Indol-2-one derivatives disubstituted in the 3-position, preparation thereof and therapeutic use thereof as grehiln receptor antagonists
EP0228845B1 (en) N-containing heterocyclic compounds, processes for the preparation thereof and composition comprising the same
US5079255A (en) Thiazolo [4,5-6] pyridine derivatives and anti-ulcerative composition containing same
ES2892161T3 (es) Preparación de derivados de ácido 2-([1,2,3]triazol-2-il)-benzoico
NO140012B (no) Analogifremgangsmaate for fremstilling av nye terapeutisk aktive derivater av naftyridin
FI82456C (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1-fenyl-1,2,4-tiadiazin-1-oxidderivat.
WO1999009029A1 (en) PYRROLO[3,2-c]QUINOLINE DERIVATIVES CONTAINING HALOALKOXY GROUP AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF
JPH0841006A (ja) ジウレア誘導体
CZ181995A3 (en) Substituted 3-methylene-2-oxindole-1-carboxamides, their use and pharmaceutical compositions based thereon
JPH02129A (ja) ビフェニル誘導体
JPH0753565A (ja) 新規セファロスポリン系抗生物質及びその製造方法
HU192999B (en) Process for producing tricyclie thiadiazinon derivatives
US5200407A (en) Azole derivatives and anti-ulcerative composition containing same
EP0729456B1 (en) Novel process for preparing (s)-1-[2(s)-(1,3-dihydro-1,3-dioxo-isoindol-2-yl)-1-oxo-3-phenylpropyl]-1,2,3,4-tetrahydro-2-pyridine-carboxylic acid methyl ester and intermediates thereof
CA3230596A1 (en) 2,4-dihydro-3h-1,2,4-triazol-3-one p2x7 antagonists
JP2016510025A (ja) 置換された（ｒ）−３−（４−メチルカルバモイル−３−フルオロフェニルアミノ）テトラヒドロフラン−３−エンカルボン酸（変種）及びそのエステル、調製のための方法並びに使用
JP4425373B2 (ja) ヒドロキシ−２−ハロゲノピリジン誘導体の製造方法