GB1451912A - 2-1-piperazino-5-oxopyrido-2,3-d-pyridine-6-carboxylic acids their preparation and pharmaceutical compositions thereof - Google Patents
2-1-piperazino-5-oxopyrido-2,3-d-pyridine-6-carboxylic acids their preparation and pharmaceutical compositions thereofInfo
- Publication number
- GB1451912A GB1451912A GB1539276A GB1539276A GB1451912A GB 1451912 A GB1451912 A GB 1451912A GB 1539276 A GB1539276 A GB 1539276A GB 1539276 A GB1539276 A GB 1539276A GB 1451912 A GB1451912 A GB 1451912A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- group
- dec
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
1451912 Piperazino-pyrimidopyridines DAINIPPON PHARMACEUTICAL CO Ltd 8 Aug 1973 [14 Aug 1972 19 Dec 1972 22 Dec 1972 26 Dec 1972 27 Dec 1972 25 May 1973 19 June 1973] 15392/76 Divided out of 1451911 Heading C2C The invention comprises compounds of the formula wherein R 1 is H, (C 1 -C 4 )alkyl, hydroxy (C 2 -C 4 )alkyl, benzyl, methoxybenzyl, phenyl, propargyl or carboxylic or carbonic acyl and R 3 is H or (C 1 -C 6 )alkyl, and salts thereof. They may be prepared by (1) reacting a compound of the formula wherein X is halogen, (C 1 -C 4 )alkylthio or (C 1 -C 4 )alkoxy, with a compound of the formula (2) compounds in which R 3 is H, hydrolysing a compound of Formula (I) wherein R 3 is (C 1 -C 6 ) alkyl; (3) compounds in which R 1 is H, hydrolysing a compound of formula wherein R<SP>1</SP> 1 is a (carboxylic or carbonic) acyl arylsulphonyl, vinyl, trityl or a group of formula wherein Z is halogen, (C 1 -C 4 )alkoxy, benzyloxy, alcoholic hydroxy, acyloxy, arylsulphonyloxy, (C 1 -C 4 )sulphonyloxy, s-aryldithiocarbonyloxy, (C 1 -C 4 )alkyldithiocarbonyloxy group or group forming with the -CH 2 CH 2 -moiety a tertiary or quaternary amino group; and (4) heating a compound of the formula wherein each of Y and Z are H or a group as defined above for Z, at least one of Y and Z being H. The compounds of Formula I have antibacterial activity and may be administered perorally, parenterally, enterally or locally in conventional forms.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8128872A JPS5336478B2 (en) | 1972-08-14 | 1972-08-14 | |
JP12802272A JPS5617352B2 (en) | 1972-12-19 | 1972-12-19 | |
JP26973A JPS569507B2 (en) | 1972-12-22 | 1972-12-22 | |
JP733108A JPS569508B2 (en) | 1972-12-26 | 1972-12-26 | |
JP73570A JPS578110B2 (en) | 1972-12-27 | 1972-12-27 | |
JP5890973A JPS565754B2 (en) | 1973-05-25 | 1973-05-25 | |
JP6965173A JPS5616796B2 (en) | 1973-06-19 | 1973-06-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1451912A true GB1451912A (en) | 1976-10-06 |
Family
ID=27563068
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1539276A Expired GB1451912A (en) | 1972-08-14 | 1973-08-08 | 2-1-piperazino-5-oxopyrido-2,3-d-pyridine-6-carboxylic acids their preparation and pharmaceutical compositions thereof |
GB3762173A Expired GB1451911A (en) | 1972-08-14 | 1973-08-08 | 2-1-piperazino-5-oxopyrido-2,3,d-pyrimidine-6-carboxylic acids their preparation and pharmaceutical compositions thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB3762173A Expired GB1451911A (en) | 1972-08-14 | 1973-08-08 | 2-1-piperazino-5-oxopyrido-2,3,d-pyrimidine-6-carboxylic acids their preparation and pharmaceutical compositions thereof |
Country Status (10)
Country | Link |
---|---|
AR (5) | AR202799A1 (en) |
CA (1) | CA1073456A (en) |
CH (3) | CH601293A5 (en) |
DE (1) | DE2341146A1 (en) |
FI (1) | FI54481C (en) |
FR (1) | FR2196159B1 (en) |
GB (2) | GB1451912A (en) |
NL (1) | NL181483C (en) |
NO (1) | NO137966C (en) |
SE (1) | SE433215B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0014390A1 (en) * | 1979-02-01 | 1980-08-20 | Bayer Ag | 2-Amino-8-cyclopropyl-5-oxo-5,8-dihydro-pyrido (2,3-d) pyrimidine-6-carboxylic acids, pharmaceutical compositions containing them and processes for their preparation |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1484138A (en) * | 1974-03-14 | 1977-08-24 | Bellon Labor Sa Roger | Pyrido pyrimidine derivatives |
GB1553436A (en) * | 1976-09-17 | 1979-09-26 | Bellon R Lab | Derivatives of pipemidic acid |
JPS53141286A (en) | 1977-05-16 | 1978-12-08 | Kyorin Seiyaku Kk | Novel substituted quinolinecarboxylic acid |
FR2453157A1 (en) * | 1979-04-02 | 1980-10-31 | Fabre Sa Pierre | 2-Undecyl imidazole salts - having Gram positive and negative antibacterial activity |
DE3028520A1 (en) * | 1980-07-28 | 1982-02-25 | Dynamit Nobel Ag, 5210 Troisdorf | METHOD FOR PRODUCING CHINOLINES, NAPHTYRIDINES AND OTHER NITROGEN BI-HETEROCYCLES |
US4730000A (en) * | 1984-04-09 | 1988-03-08 | Abbott Laboratories | Quinoline antibacterial compounds |
NZ210847A (en) * | 1984-01-26 | 1988-02-29 | Abbott Lab | Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions |
AT392789B (en) * | 1985-01-23 | 1991-06-10 | Toyama Chemical Co Ltd | METHOD FOR PRODUCING 1-SUBSTITUTED ARYL-1,4-DIHYDRO-4-OXONAPHTHYRIDINE DERIVATIVES |
US4851535A (en) * | 1985-01-23 | 1989-07-25 | Toyama Chemical Co., Ltd. | Nicotinic acid derivatives |
EP0224121A3 (en) * | 1985-11-19 | 1987-11-11 | ROTTAPHARM S.p.A. | 7-[4-amino-piperazinyl]- or 7-[4-chloro-piperazinyl]quinolinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing them |
US4687770A (en) * | 1985-12-23 | 1987-08-18 | Abbott Laboratories | Isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives |
US4689325A (en) * | 1985-12-23 | 1987-08-25 | Abbott Laboratories | Isoxazolo-pyrido-phenoxazine and isothiazolo-pyrido-phenoxazine derivatives |
US7196200B2 (en) * | 2004-01-21 | 2007-03-27 | Abbott Laboratories | Antibacterial compounds |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR7582M (en) * | 1965-09-08 | 1970-01-12 |
-
1973
- 1973-08-08 GB GB1539276A patent/GB1451912A/en not_active Expired
- 1973-08-08 GB GB3762173A patent/GB1451911A/en not_active Expired
- 1973-08-10 FI FI2519/73A patent/FI54481C/en active
- 1973-08-13 CA CA178,687A patent/CA1073456A/en not_active Expired
- 1973-08-13 NO NO733211A patent/NO137966C/en unknown
- 1973-08-14 FR FR7329718A patent/FR2196159B1/fr not_active Expired
- 1973-08-14 DE DE19732341146 patent/DE2341146A1/en not_active Withdrawn
- 1973-08-14 CH CH1169473A patent/CH601293A5/xx not_active IP Right Cessation
- 1973-08-14 NL NLAANVRAGE7311190,A patent/NL181483C/en not_active IP Right Cessation
- 1973-08-14 AR AR249573A patent/AR202799A1/en active
- 1973-08-14 CH CH316477A patent/CH605947A5/xx not_active IP Right Cessation
- 1973-08-14 CH CH316577A patent/CH605948A5/xx not_active IP Right Cessation
-
1974
- 1974-08-30 AR AR255408A patent/AR203047A1/en active
- 1974-08-30 AR AR255407A patent/AR200347A1/en active
-
1975
- 1975-06-30 AR AR259397A patent/AR203164A1/en active
- 1975-06-30 AR AR259398A patent/AR203165A1/en active
-
1979
- 1979-01-15 SE SE7900334A patent/SE433215B/en not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0014390A1 (en) * | 1979-02-01 | 1980-08-20 | Bayer Ag | 2-Amino-8-cyclopropyl-5-oxo-5,8-dihydro-pyrido (2,3-d) pyrimidine-6-carboxylic acids, pharmaceutical compositions containing them and processes for their preparation |
Also Published As
Publication number | Publication date |
---|---|
NL181483C (en) | 1987-09-01 |
NO137966B (en) | 1978-02-20 |
CH605947A5 (en) | 1978-10-13 |
AR203165A1 (en) | 1975-08-14 |
FI54481C (en) | 1978-12-11 |
CH605948A5 (en) | 1978-10-13 |
NL181483B (en) | 1987-04-01 |
FI54481B (en) | 1978-08-31 |
AR202799A1 (en) | 1975-07-24 |
CH601293A5 (en) | 1978-07-14 |
AR200347A1 (en) | 1974-10-31 |
NL7311190A (en) | 1974-02-18 |
GB1451911A (en) | 1976-10-06 |
AU5909273A (en) | 1975-02-13 |
AR203164A1 (en) | 1975-08-14 |
DE2341146A1 (en) | 1974-02-28 |
SE433215B (en) | 1984-05-14 |
FR2196159A1 (en) | 1974-03-15 |
AR203047A1 (en) | 1975-08-08 |
SE7900334L (en) | 1979-01-15 |
CA1073456A (en) | 1980-03-11 |
NO137966C (en) | 1978-05-31 |
FR2196159B1 (en) | 1978-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] |