GB1369249A - Amines the preparation thereof and their use in pharmaceutical compositions - Google Patents

Amines the preparation thereof and their use in pharmaceutical compositions

Info

Publication number
GB1369249A
GB1369249A GB1725673A GB1725673A GB1369249A GB 1369249 A GB1369249 A GB 1369249A GB 1725673 A GB1725673 A GB 1725673A GB 1725673 A GB1725673 A GB 1725673A GB 1369249 A GB1369249 A GB 1369249A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
alkoxy
alkyl
hydrogen
amines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1725673A
Inventor
Timothy Henry Cronin
Hermann Faubl
William Wheeler Hoffman
James Joseph Korst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of GB1369249A publication Critical patent/GB1369249A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1369249 Amines PFIZER Inc 3 Aug 1971 [7 Aug 1970 24 May 1971] 17256/73 Divided out of 1369247 Heading C2C [Also in Division A5] The invention comprises novel therapeutic compounds (I) and the non-toxic acid addition salts thereof, wherein R 1 is hydrogen, alkyl of from 1 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, (C 1-4 alkoxy) C 1-4 alkyl or R 2 is hydrogen, alkyl of from 12 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms (C 1-4 alkoxy) C 1-4 alkyl or as Formula II above. R‹ is alkoxy of from 1 to 18 carbon atoms; each of R<SP>1</SP> and R<SP>11</SP> is hydrogen, alkyl or alkoxy of from 1 to 18 carbon atoms; or R<SP>1</SP> and R<SP>11</SP> when taken together are methylenedioxy, provided that the total number of carbon atoms in R‹, R<SP>1</SP> and R<SP>11</SP> is from 5 to 48; Y is straight chain alkylene of from 2 to 8 carbon atoms or phenylenedimethylene; and A is hydrogen, cyano, hydroxy, alkoxy of from 1 to 20 carbon atoms, alkanoyloxy of from 1 to 20 carbon atoms, phenylcarbambyloxy, chloro, bromo, #- carboxyalkanoyloxy, carbo-(C 1-4 alkoxy), alkanoylthio of from 2 to 20 carbon atoms or alkylthio of from 1 to 20 carbon atoms. They are made by standard methods.
GB1725673A 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmaceutical compositions Expired GB1369249A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6219270A 1970-08-07 1970-08-07
US14654871A 1971-05-24 1971-05-24

Publications (1)

Publication Number Publication Date
GB1369249A true GB1369249A (en) 1974-10-02

Family

ID=26741969

Family Applications (4)

Application Number Title Priority Date Filing Date
GB3652271A Expired GB1369247A (en) 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmaceutical compositions
GB1725773A Expired GB1369250A (en) 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmacejtical compositions
GB1725673A Expired GB1369249A (en) 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmaceutical compositions
GB1725573A Expired GB1369248A (en) 1970-08-07 1971-08-03 Amides the preparation thereof and their use in pharmacjeutical compositions

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB3652271A Expired GB1369247A (en) 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmaceutical compositions
GB1725773A Expired GB1369250A (en) 1970-08-07 1971-08-03 Amines the preparation thereof and their use in pharmacejtical compositions

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1725573A Expired GB1369248A (en) 1970-08-07 1971-08-03 Amides the preparation thereof and their use in pharmacjeutical compositions

Country Status (13)

Country Link
JP (1) JPS5950646B1 (en)
AR (1) AR194346A1 (en)
AU (1) AU465751B2 (en)
BE (1) BE770966A (en)
CA (1) CA1001158A (en)
CH (2) CH586184A5 (en)
DE (2) DE2167223C2 (en)
ES (2) ES393965A1 (en)
FR (2) FR2102116B1 (en)
GB (4) GB1369247A (en)
NL (1) NL172615C (en)
PH (1) PH13755A (en)
SE (3) SE399701B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2126224A (en) * 1982-08-20 1984-03-21 Midit Derivatives of ???-amino alkanoic acids
US5763495A (en) * 1996-09-30 1998-06-09 Albemarle Corporation Widely-bridged alcohol polyethoxylates and their use

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166132A (en) * 1977-08-18 1979-08-28 Pfizer Inc. Antiviral amine derivatives of glycerol and propanediols
DE2837794A1 (en) * 1978-08-30 1980-03-13 Asta Werke Ag Chem Fab BASICALLY SUBSTITUTED UREAS AND THIOURAS, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THEM
EP0018741A3 (en) * 1979-05-08 1981-05-27 Imperial Chemical Industries Plc Long chain amine derivatives and process for their preparation
FR2507083A1 (en) * 1981-06-04 1982-12-10 Pos Lab AMINO-1 DODECYCLOXY-3-PROPANE COLLYRY COMPOSITION FOR THE TREATMENT OF CONJUNCTIVITIS AND KERATIVES
US4480092A (en) * 1982-02-19 1984-10-30 The B. F. Goodrich Company Alkylated polyalkylenepolyamines, substituted oxo-piperazinyl-triazines
US4504484A (en) * 1982-11-04 1985-03-12 Chevron Research Company Certain N,N-di-substituted-pyridine carboxamides, fungicidal compositions and fungicidal method of use
JPH0761992B2 (en) * 1987-02-06 1995-07-05 武田薬品工業株式会社 Substituted amine derivative
JP2756000B2 (en) * 1989-08-25 1998-05-25 花王株式会社 Tertiary amino alcohol and method for producing the same
GB9118105D0 (en) * 1991-08-22 1991-10-09 Exxon Chemical Patents Inc Compounds and fuel compositions
DE4302860A1 (en) * 1993-01-22 1994-08-04 Chemie Linz Deutschland N-Cyclic and N, N'dicyclic ureas
AT400566B (en) * 1993-01-22 1996-01-25 Chemie Linz Gmbh Use and process for the preparation of N-cyclic and N,N'- dicyclic ureas
RU2445094C1 (en) * 2010-10-05 2012-03-20 Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" Interferon-inducing agent for treating acute respiratory viral infections (arvd)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355355A (en) * 1965-02-05 1967-11-28 Smith Kline French Lab Antiviral cycloalkylamine compositions and method
US3531489A (en) * 1968-10-18 1970-09-29 Richardson Merrell Inc Bis-basic esters and thioesters of fluoranthene

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2126224A (en) * 1982-08-20 1984-03-21 Midit Derivatives of ???-amino alkanoic acids
US5763495A (en) * 1996-09-30 1998-06-09 Albemarle Corporation Widely-bridged alcohol polyethoxylates and their use
US5902772A (en) * 1996-09-30 1999-05-11 Albemarle Corporation Widely-bridged alcohol polyethoxylates and their use

Also Published As

Publication number Publication date
CH586184A5 (en) 1977-03-31
SE7501333L (en) 1975-02-06
DE2139545C2 (en) 1986-03-27
ES419681A1 (en) 1976-05-16
FR2102116B1 (en) 1978-08-18
PH13755A (en) 1980-09-17
SE399701B (en) 1978-02-27
NL172615C (en) 1983-10-03
SE425658B (en) 1982-10-25
CA1001158A (en) 1976-12-07
NL7110906A (en) 1972-02-09
SE7501332L (en) 1975-02-06
FR2258848B1 (en) 1978-07-07
AU3200771A (en) 1973-02-08
AR194346A1 (en) 1973-07-13
GB1369247A (en) 1974-10-02
NL172615B (en) 1983-05-02
ES393965A1 (en) 1974-07-01
BE770966A (en) 1972-02-07
DE2167223C2 (en) 1982-11-18
SE425657B (en) 1982-10-25
AU465751B2 (en) 1973-02-08
DE2139545A1 (en) 1972-03-30
GB1369250A (en) 1974-10-02
FR2258848A1 (en) 1975-08-22
CH568959A5 (en) 1975-11-14
FR2102116A1 (en) 1972-04-07
GB1369248A (en) 1974-10-02
JPS5950646B1 (en) 1984-12-10

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee