LT3806B - Hyaluronic acid associates, composition containing them, process for preparing the composition, process for preparing zinc hyaluronate aqueous solution - Google Patents

Hyaluronic acid associates, composition containing them, process for preparing the composition, process for preparing zinc hyaluronate aqueous solution Download PDF

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Publication number
LT3806B
LT3806B LTIP1418A LTIP1418A LT3806B LT 3806 B LT3806 B LT 3806B LT IP1418 A LTIP1418 A LT IP1418A LT IP1418 A LTIP1418 A LT IP1418A LT 3806 B LT3806 B LT 3806B
Authority
LT
Lithuania
Prior art keywords
hyaluronate
zinc
hyaluronic acid
solution
periodic table
Prior art date
Application number
LTIP1418A
Other languages
English (en)
Lithuanian (lt)
Inventor
Kalman Burger
Geza Takacsi-Nagy
Ivan Rethey-Prikkel
Janos Illes
Bela Stefko
Erzsebet Neszmelyi
Istvan Gebhardt
Istvan Racz
Gyongyver Kiraly
Viktoria Varkonyi
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of LTIP1418A publication Critical patent/LTIP1418A/xx
Publication of LT3806B publication Critical patent/LT3806B/lt

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/00272-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58Metal complex; Coordination compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
LTIP1418A 1989-02-24 1993-10-26 Hyaluronic acid associates, composition containing them, process for preparing the composition, process for preparing zinc hyaluronate aqueous solution LT3806B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU89891A HU203372B (en) 1989-02-24 1989-02-24 Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient

Publications (2)

Publication Number Publication Date
LTIP1418A LTIP1418A (en) 1995-05-25
LT3806B true LT3806B (en) 1996-03-25

Family

ID=10951903

Family Applications (2)

Application Number Title Priority Date Filing Date
LTIP1418A LT3806B (en) 1989-02-24 1993-10-26 Hyaluronic acid associates, composition containing them, process for preparing the composition, process for preparing zinc hyaluronate aqueous solution
LTIP1474A LT3873B (en) 1989-02-24 1993-11-18 Compositions containing deprotonated hyaluronic acid associates and procrss for preparing same

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTIP1474A LT3873B (en) 1989-02-24 1993-11-18 Compositions containing deprotonated hyaluronic acid associates and procrss for preparing same

Country Status (33)

Country Link
US (1) US5554598A (ja)
EP (1) EP0413016B1 (ja)
JP (1) JP2571312B2 (ja)
KR (1) KR960015624B1 (ja)
CN (2) CN1051228C (ja)
AR (1) AR243538A1 (ja)
AT (1) ATE98964T1 (ja)
AU (1) AU623232B2 (ja)
BG (1) BG61515B2 (ja)
CA (1) CA2027596C (ja)
CZ (1) CZ281000B6 (ja)
DD (1) DD292263A5 (ja)
DE (1) DE69005394T2 (ja)
DK (1) DK0413016T3 (ja)
ES (1) ES2061016T3 (ja)
FI (1) FI101707B1 (ja)
GE (2) GEP19981358B (ja)
GR (1) GR1000869B (ja)
HK (1) HK1003003A1 (ja)
HU (2) HU203372B (ja)
IE (1) IE62408B1 (ja)
IL (1) IL93489A (ja)
LT (2) LT3806B (ja)
LV (2) LV10112B (ja)
MY (1) MY105168A (ja)
NO (1) NO301169B1 (ja)
PL (1) PL163417B1 (ja)
PT (1) PT93237B (ja)
RU (2) RU2099350C1 (ja)
SK (1) SK85790A3 (ja)
UA (2) UA26324A (ja)
WO (1) WO1990010020A1 (ja)
ZA (1) ZA901357B (ja)

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GR920100122A (el) * 1991-04-05 1993-03-16 Ethicon Inc Πολυσακχαρίτες οι οποίοι περιέχουν καρβοξύλιο με σταυροειδείς δεσμούς δια την πρόληψιν της προσφύσεως.
DE4115454A1 (de) * 1991-05-11 1992-11-12 Basf Ag Eisen-(iii)-hyaluronate
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
IT1273742B (it) * 1994-08-01 1997-07-09 Lifegroup Spa Composizioni ad elevata bioadesivita' e mucoadesivita' utili per il trattamento di epitali e mucose
CN1064372C (zh) * 1994-08-26 2001-04-11 顾其胜 透明质酸钠制剂的制备方法
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
HU225329B1 (en) * 1996-09-12 2006-09-28 Richter Gedeon Vegyeszet Use of zinc or cobalt hyaluronate associate for the manufacture of pharmaceutical compositions of antimicrobial activity
HU225991B1 (en) 1997-04-29 2008-02-28 Richter Gedeon Nyrt Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer
US7192984B2 (en) 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
JP2003089647A (ja) 1999-03-10 2003-03-28 Takada Seiyaku Kk 関節性疾患治療剤
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
CZ12015U1 (cs) * 2002-01-18 2002-02-25 Cpn Spol. S R.O. Přípravek pro prevenci adheze bandáľe na ránu
GB2392913B (en) * 2002-09-11 2007-04-04 Johnson & Johnson Medical Ltd Wound dressings comprising complexes of oxidised celluloses with silver
PL207044B1 (pl) 2002-09-11 2010-10-29 Johnson & Johnson Medical Ltd Materiał opatrunkowy na rany zawierający kompleks utlenionej celulozy ze srebrem, opatrunek zawierający ten materiał, oraz zastosowanie kompleksu do wytwarzania materiału opatrunkowego
HUP0303779A2 (en) * 2003-11-20 2006-02-28 Richter Gedeon Vegyeszet Pharmaceutical compositions containing hyaluronan complex for the treatment of sclerosis multiplex
WO2006121210A1 (ja) * 2005-05-13 2006-11-16 Takata Seiyaku Co., Ltd. 皮膚状態改善剤
JPWO2006121209A1 (ja) * 2005-05-13 2008-12-18 高田製薬株式会社 湿疹・皮膚炎群治療剤
JP4220513B2 (ja) * 2005-12-01 2009-02-04 株式会社資生堂 カチオン化ヒアルロン酸
CN100348621C (zh) 2005-12-02 2007-11-14 凌沛学 透明质酸铋及其制备方法和应用
CN1329414C (zh) * 2005-12-02 2007-08-01 凌沛学 透明质酸铋钾及其制备方法和应用
FR2918565B1 (fr) * 2007-07-12 2009-10-30 Biopharmex Holding Sa Hydrogel de carboxyalkylamide de chitosan, sa preparation et son utilisation cosmetique et dermatologique
ES2326721B1 (es) 2008-01-04 2010-07-16 Endor Nanotechnologies, S.L. Conjugado de acido hialuronico para el tratamiento cosmetico y procedimiento de preparacion.
TWI516269B (zh) 2009-08-14 2016-01-11 禾伸堂生技股份有限公司 使用於炎症性腸疾病(ibd)治療和預防之透明質酸混合物
TWI383796B (zh) 2009-08-14 2013-02-01 Holy Stone Healthcare Co Ltd Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer
HUP0900717A3 (en) 2009-11-18 2012-02-28 Richter Gedeon Nyrt Pharmaceutical composition for urological use containing zinc hyaluronate
CN102834417B (zh) * 2010-04-14 2015-11-25 丘比株式会社 透明质酸金属盐的制造方法、包含透明质酸金属盐的化妆品的制造方法以及透明质酸锌及其制造方法
ES2376680B8 (es) 2010-08-16 2013-04-30 Nylstar, S.A. Fibra textil cosmética, procedimiento de obtención y su empleo.
CN102552309B (zh) * 2010-12-15 2013-06-05 北京理工大学 一种透明质酸金的用途及其制备方法
JP5763953B2 (ja) * 2011-03-31 2015-08-12 ロート製薬株式会社 外用組成物
CN102961396A (zh) * 2012-12-17 2013-03-13 程玉李 透明质酸金属盐在制备治疗皮肤病药物中的应用、其药物组合物及其制备方法
JP2016535781A (ja) 2013-11-03 2016-11-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 経皮薬物送達のためのイオン性液体
EP3503927A1 (en) * 2016-08-29 2019-07-03 The Regents of the University of California Topical formulations based on ionic species for skin treatment
US10898613B2 (en) 2016-09-21 2021-01-26 Nestlé Skin Health Sa Hyaluronic acid gel with a divalent zinc cation
WO2019001784A1 (en) 2017-06-28 2019-01-03 Nestlé Skin Health Sa HYALURONIC ACID GEL WITH A DIVALENT CATION
HRP20240485T1 (hr) 2017-08-24 2024-07-05 Novo Nordisk A/S Pripravci glp-1 i njihova upotreba
US20230082544A1 (en) 2020-02-18 2023-03-16 Novo Nordisk A/S Pharmaceutical formulations
CN111647100B (zh) * 2020-07-14 2022-03-01 山东华熙海御生物医药有限公司 一种高分子量透明质酸锌的制备方法

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US4141973A (en) 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4303676A (en) 1980-03-21 1981-12-01 Balazs Endre A Hyaluronate based compositions and cosmetic formulations containing same
EP0144019A2 (en) 1983-11-25 1985-06-12 Miles Inc. Ultrapure hyaluronic acid and method of making it
BE904547A (fr) 1985-04-05 1986-10-03 Fidia Spa Nouveaux medicaments a usage topique.
WO1987005517A1 (en) 1986-03-14 1987-09-24 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid useful as antimicrobial agents

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US4623539A (en) 1983-02-04 1986-11-18 Tunc Deger C Nutrient barrier polysaccharide compositions and method of use
JPS61286310A (ja) * 1985-06-10 1986-12-16 Kanebo Ltd メ−クアツプ化粧料
US4746504A (en) * 1986-03-14 1988-05-24 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
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US4141973A (en) 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4141973B1 (ja) 1975-10-17 1989-08-08
US4303676A (en) 1980-03-21 1981-12-01 Balazs Endre A Hyaluronate based compositions and cosmetic formulations containing same
EP0144019A2 (en) 1983-11-25 1985-06-12 Miles Inc. Ultrapure hyaluronic acid and method of making it
BE904547A (fr) 1985-04-05 1986-10-03 Fidia Spa Nouveaux medicaments a usage topique.
WO1987005517A1 (en) 1986-03-14 1987-09-24 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid useful as antimicrobial agents

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Title
BERNARD WEISSMANN, KARL MEYER: "The Structure of Hyalobiuronic Acid and of Hyaluronic Acid from Umbilical Cord", J. AM. CHEM. SOC., 1954, pages 1753 - 1757
KARL MEYER AND JOHN W. PALMER: "THE POLYSACCHARIDE OF THE VITREOUS HUMOR", J. BIOL. CHEM., 1934, pages 629 - 634
NARA FIGUEROA, BIRESWAR CHAKRABARTI: "Circular dichroism studies of copper (II)‐hyaluronic acid complexes in relation to conformation of the polymer", BIOPOLYMERS, 1978, pages 2415 - 2426

Also Published As

Publication number Publication date
EP0413016A1 (en) 1991-02-20
CN1024557C (zh) 1994-05-18
IE62408B1 (en) 1995-01-25
NO904584D0 (no) 1990-10-23
AR243538A1 (es) 1993-08-31
CA2027596C (en) 2001-01-02
PT93237A (pt) 1990-08-31
ES2061016T3 (es) 1994-12-01
KR920700231A (ko) 1992-02-19
DD292263A5 (de) 1991-07-25
GR1000869B (el) 1993-03-16
UA39174C2 (uk) 2001-06-15
JPH03505231A (ja) 1991-11-14
WO1990010020A1 (en) 1990-09-07
EP0413016B1 (en) 1993-12-22
MY105168A (en) 1994-08-30
GR900100137A (en) 1991-06-28
HU203372B (en) 1991-07-29
RU2021304C1 (ru) 1994-10-15
NO301169B1 (no) 1997-09-22
IL93489A (en) 1994-05-30
HU211465A9 (en) 1995-11-28
CN1051228C (zh) 2000-04-12
AU623232B2 (en) 1992-05-07
ATE98964T1 (de) 1994-01-15
CA2027596A1 (en) 1990-08-25
SK279530B6 (sk) 1998-12-02
IE900637L (en) 1990-08-24
US5554598A (en) 1996-09-10
CZ85790A3 (en) 1995-02-15
HUT53128A (en) 1990-09-28
JP2571312B2 (ja) 1997-01-16
KR960015624B1 (ko) 1996-11-18
HK1003003A1 (en) 1998-09-30
FI905109A0 (fi) 1990-10-17
LT3873B (en) 1996-04-25
GEP19971015B (en) 1997-05-30
FI101707B (fi) 1998-08-14
GEP19981358B (en) 1998-08-25
LV10965A (lv) 1995-12-20
DE69005394T2 (de) 1994-07-28
BG61515B2 (bg) 1997-10-31
CZ281000B6 (cs) 1996-05-15
LV10112B (en) 1995-02-20
AU5108890A (en) 1990-09-26
RU2099350C1 (ru) 1997-12-20
CN1045394A (zh) 1990-09-19
NO904584L (no) 1990-12-21
FI101707B1 (fi) 1998-08-14
SK85790A3 (en) 1998-12-02
LV10112A (lv) 1994-05-10
PL163417B1 (pl) 1994-03-31
ZA901357B (en) 1990-11-28
UA26324A (uk) 1999-08-30
LTIP1418A (en) 1995-05-25
LTIP1474A (en) 1995-06-26
PL283942A1 (en) 1991-01-28
CN1086422A (zh) 1994-05-11
DK0413016T3 (da) 1994-02-14
DE69005394D1 (de) 1994-02-03
PT93237B (pt) 1996-01-31
LV10965B (en) 1996-08-20

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