KR920700231A - 히알루론산 회합체를 함유하는 신규 조성물 및 그 제조방법 - Google Patents

히알루론산 회합체를 함유하는 신규 조성물 및 그 제조방법

Info

Publication number
KR920700231A
KR920700231A KR1019900702327A KR900702327A KR920700231A KR 920700231 A KR920700231 A KR 920700231A KR 1019900702327 A KR1019900702327 A KR 1019900702327A KR 900702327 A KR900702327 A KR 900702327A KR 920700231 A KR920700231 A KR 920700231A
Authority
KR
South Korea
Prior art keywords
manufacturing
same
composition containing
hyaluronic acid
novel composition
Prior art date
Application number
KR1019900702327A
Other languages
English (en)
Other versions
KR960015624B1 (ko
Inventor
칼만 부르거
나기 게자 타칵시
이반 레테이
야노스 일레스
벨라 스테프코
에르쩨베트 네쯔멜리이
이스트반 게바르트
이스트반 락즈
아르파드네 키랄리
빅토리아 바르코니이
Original Assignee
케미칼 웍스 오브 게데온 리히터 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 케미칼 웍스 오브 게데온 리히터 리미티드 filed Critical 케미칼 웍스 오브 게데온 리히터 리미티드
Publication of KR920700231A publication Critical patent/KR920700231A/ko
Application granted granted Critical
Publication of KR960015624B1 publication Critical patent/KR960015624B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
KR1019900702327A 1989-02-24 1990-02-20 히알루론산 회합체를 함유하는 신규 조성물 및 그 제조방법 KR960015624B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU89891A HU203372B (en) 1989-02-24 1989-02-24 Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
HU891/1989 1989-02-24
PCT/HU1990/000013 WO1990010020A1 (en) 1989-02-24 1990-02-20 Novel compositions containing hyaluronic acid associates and a process for preparing same

Publications (2)

Publication Number Publication Date
KR920700231A true KR920700231A (ko) 1992-02-19
KR960015624B1 KR960015624B1 (ko) 1996-11-18

Family

ID=10951903

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900702327A KR960015624B1 (ko) 1989-02-24 1990-02-20 히알루론산 회합체를 함유하는 신규 조성물 및 그 제조방법

Country Status (33)

Country Link
US (1) US5554598A (ko)
EP (1) EP0413016B1 (ko)
JP (1) JP2571312B2 (ko)
KR (1) KR960015624B1 (ko)
CN (2) CN1024557C (ko)
AR (1) AR243538A1 (ko)
AT (1) ATE98964T1 (ko)
AU (1) AU623232B2 (ko)
BG (1) BG61515B2 (ko)
CA (1) CA2027596C (ko)
CZ (1) CZ281000B6 (ko)
DD (1) DD292263A5 (ko)
DE (1) DE69005394T2 (ko)
DK (1) DK0413016T3 (ko)
ES (1) ES2061016T3 (ko)
FI (1) FI101707B1 (ko)
GE (2) GEP19981358B (ko)
GR (1) GR1000869B (ko)
HK (1) HK1003003A1 (ko)
HU (2) HU203372B (ko)
IE (1) IE62408B1 (ko)
IL (1) IL93489A (ko)
LT (2) LT3806B (ko)
LV (2) LV10112B (ko)
MY (1) MY105168A (ko)
NO (1) NO301169B1 (ko)
PL (1) PL163417B1 (ko)
PT (1) PT93237B (ko)
RU (2) RU2099350C1 (ko)
SK (1) SK85790A3 (ko)
UA (2) UA26324A (ko)
WO (1) WO1990010020A1 (ko)
ZA (1) ZA901357B (ko)

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DE4115454A1 (de) * 1991-05-11 1992-11-12 Basf Ag Eisen-(iii)-hyaluronate
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IT1273742B (it) * 1994-08-01 1997-07-09 Lifegroup Spa Composizioni ad elevata bioadesivita' e mucoadesivita' utili per il trattamento di epitali e mucose
CN1064372C (zh) * 1994-08-26 2001-04-11 顾其胜 透明质酸钠制剂的制备方法
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
HU225991B1 (en) * 1997-04-29 2008-02-28 Richter Gedeon Nyrt Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer
HU225329B1 (en) * 1996-09-12 2006-09-28 Richter Gedeon Vegyeszet Use of zinc or cobalt hyaluronate associate for the manufacture of pharmaceutical compositions of antimicrobial activity
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US7192984B2 (en) 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
JP2003089647A (ja) 1999-03-10 2003-03-28 Takada Seiyaku Kk 関節性疾患治療剤
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
CZ12015U1 (cs) * 2002-01-18 2002-02-25 Cpn Spol. S R.O. Přípravek pro prevenci adheze bandáľe na ránu
WO2004024197A1 (en) 2002-09-11 2004-03-25 Johnson & Johnson Medical Limited Wound dressing materials comprising complexes of anionic polysaccharides with silver
GB2392913B (en) * 2002-09-11 2007-04-04 Johnson & Johnson Medical Ltd Wound dressings comprising complexes of oxidised celluloses with silver
HUP0303779A2 (en) * 2003-11-20 2006-02-28 Richter Gedeon Vegyeszet Pharmaceutical compositions containing hyaluronan complex for the treatment of sclerosis multiplex
JPWO2006121210A1 (ja) * 2005-05-13 2008-12-18 高田製薬株式会社 皮膚状態改善剤
WO2006121209A1 (ja) * 2005-05-13 2006-11-16 Takata Seiyaku Co., Ltd. 湿疹・皮膚炎群治療剤
JP4220513B2 (ja) * 2005-12-01 2009-02-04 株式会社資生堂 カチオン化ヒアルロン酸
CN100348621C (zh) * 2005-12-02 2007-11-14 凌沛学 透明质酸铋及其制备方法和应用
CN1329414C (zh) * 2005-12-02 2007-08-01 凌沛学 透明质酸铋钾及其制备方法和应用
FR2918565B1 (fr) * 2007-07-12 2009-10-30 Biopharmex Holding Sa Hydrogel de carboxyalkylamide de chitosan, sa preparation et son utilisation cosmetique et dermatologique
ES2326721B1 (es) * 2008-01-04 2010-07-16 Endor Nanotechnologies, S.L. Conjugado de acido hialuronico para el tratamiento cosmetico y procedimiento de preparacion.
TWI383796B (zh) 2009-08-14 2013-02-01 Holy Stone Healthcare Co Ltd Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer
TWI516269B (zh) 2009-08-14 2016-01-11 禾伸堂生技股份有限公司 使用於炎症性腸疾病（ｉｂｄ）治療和預防之透明質酸混合物
HUP0900717A3 (en) * 2009-11-18 2012-02-28 Richter Gedeon Nyrt Pharmaceutical composition for urological use containing zinc hyaluronate
EP2559708B1 (en) * 2010-04-14 2018-06-20 Kewpie Corporation Process for producing zinc hyaluronate, process for producing cosmetic containing zinc hyaluronate, zinc hyaluronate and process for producing the same
ES2376680B8 (es) 2010-08-16 2013-04-30 Nylstar, S.A. Fibra textil cosmética, procedimiento de obtención y su empleo.
CN102552309B (zh) * 2010-12-15 2013-06-05 北京理工大学 一种透明质酸金的用途及其制备方法
JP5763953B2 (ja) * 2011-03-31 2015-08-12 ロート製薬株式会社 外用組成物
CN102961396A (zh) * 2012-12-17 2013-03-13 程玉李 透明质酸金属盐在制备治疗皮肤病药物中的应用、其药物组合物及其制备方法
ES2908345T3 (es) 2013-11-03 2022-04-28 Univ California Líquidos iónicos para la administración transdérmica de medicamentos
WO2018044920A1 (en) * 2016-08-29 2018-03-08 The Regents Of The University Of California Topical formulations based on ionic species for skin treatment
US10898613B2 (en) 2016-09-21 2021-01-26 Nestlé Skin Health Sa Hyaluronic acid gel with a divalent zinc cation
WO2019001784A1 (en) 2017-06-28 2019-01-03 Nestlé Skin Health Sa HYALURONIC ACID GEL WITH A DIVALENT CATION
PE20211202A1 (es) 2017-08-24 2021-07-05 Novo Nordisk As Composiciones de glp-1 y sus usos
WO2021144476A1 (en) 2020-02-18 2021-07-22 Novo Nordisk A/S Pharmaceutical formulations
CN111647100B (zh) * 2020-07-14 2022-03-01 山东华熙海御生物医药有限公司 一种高分子量透明质酸锌的制备方法

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IT1229075B (it) * 1985-04-05 1991-07-17 Fidia Farmaceutici Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
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Also Published As

Publication number Publication date
EP0413016A1 (en) 1991-02-20
IE62408B1 (en) 1995-01-25
GEP19981358B (en) 1998-08-25
AU623232B2 (en) 1992-05-07
PT93237A (pt) 1990-08-31
JPH03505231A (ja) 1991-11-14
JP2571312B2 (ja) 1997-01-16
AR243538A1 (es) 1993-08-31
CA2027596C (en) 2001-01-02
UA26324A (uk) 1999-08-30
SK279530B6 (sk) 1998-12-02
CN1051228C (zh) 2000-04-12
MY105168A (en) 1994-08-30
FI101707B (fi) 1998-08-14
PL163417B1 (pl) 1994-03-31
IE900637L (en) 1990-08-24
ES2061016T3 (es) 1994-12-01
KR960015624B1 (ko) 1996-11-18
NO904584L (no) 1990-12-21
LV10112B (en) 1995-02-20
NO904584D0 (no) 1990-10-23
ATE98964T1 (de) 1994-01-15
FI101707B1 (fi) 1998-08-14
UA39174C2 (uk) 2001-06-15
AU5108890A (en) 1990-09-26
LTIP1474A (en) 1995-06-26
SK85790A3 (en) 1998-12-02
EP0413016B1 (en) 1993-12-22
CZ281000B6 (cs) 1996-05-15
PT93237B (pt) 1996-01-31
CN1045394A (zh) 1990-09-19
IL93489A (en) 1994-05-30
LT3806B (en) 1996-03-25
CN1024557C (zh) 1994-05-18
LT3873B (en) 1996-04-25
US5554598A (en) 1996-09-10
DK0413016T3 (da) 1994-02-14
PL283942A1 (en) 1991-01-28
HK1003003A1 (en) 1998-09-30
DD292263A5 (de) 1991-07-25
GR1000869B (el) 1993-03-16
BG61515B2 (bg) 1997-10-31
LV10965A (lv) 1995-12-20
NO301169B1 (no) 1997-09-22
HU211465A9 (en) 1995-11-28
GEP19971015B (en) 1997-05-30
HU203372B (en) 1991-07-29
GR900100137A (en) 1991-06-28
HUT53128A (en) 1990-09-28
DE69005394T2 (de) 1994-07-28
DE69005394D1 (de) 1994-02-03
LTIP1418A (en) 1995-05-25
WO1990010020A1 (en) 1990-09-07
RU2021304C1 (ru) 1994-10-15
CN1086422A (zh) 1994-05-11
CA2027596A1 (en) 1990-08-25
ZA901357B (en) 1990-11-28
CZ85790A3 (en) 1995-02-15
RU2099350C1 (ru) 1997-12-20
LV10965B (en) 1996-08-20
LV10112A (lv) 1994-05-10
FI905109A0 (fi) 1990-10-17

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