PT93237A - Processo para a preparacao de novos sais complexos derivados de acido hialuronico desprotonizado e de metais de transicao do 4 periodo da tabela periodica e de composicoes farmaceuticas e/ou cosmeticas que os contem - Google Patents

Processo para a preparacao de novos sais complexos derivados de acido hialuronico desprotonizado e de metais de transicao do 4 periodo da tabela periodica e de composicoes farmaceuticas e/ou cosmeticas que os contem

Info

Publication number
PT93237A
PT93237A PT93237A PT9323790A PT93237A PT 93237 A PT93237 A PT 93237A PT 93237 A PT93237 A PT 93237A PT 9323790 A PT9323790 A PT 9323790A PT 93237 A PT93237 A PT 93237A
Authority
PT
Portugal
Prior art keywords
deprotonized
pharmaceutical
contain
preparation
period
Prior art date
Application number
PT93237A
Other languages
English (en)
Other versions
PT93237B (pt
Inventor
Geza Takacsi Nagy
Bela Stefko
Istvan Gebhardt
Kalman Burger
Ivan Rethey
Janos Illes
Erzsebet Neszmelyi
Istvan Racz
Gyongyver Kiraly
Viktoria Varkonyi
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of PT93237A publication Critical patent/PT93237A/pt
Publication of PT93237B publication Critical patent/PT93237B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PT93237A 1989-02-24 1990-02-22 Processo para a preparacao de novos sais complexos derivados de acido hialuronico desprotonizado e de metais de transicao do 4 periodo da tabela periodica e de composicoes farmaceuticas e/ou cosmeticas que os contem PT93237B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU89891A HU203372B (en) 1989-02-24 1989-02-24 Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient

Publications (2)

Publication Number Publication Date
PT93237A true PT93237A (pt) 1990-08-31
PT93237B PT93237B (pt) 1996-01-31

Family

ID=10951903

Family Applications (1)

Application Number Title Priority Date Filing Date
PT93237A PT93237B (pt) 1989-02-24 1990-02-22 Processo para a preparacao de novos sais complexos derivados de acido hialuronico desprotonizado e de metais de transicao do 4 periodo da tabela periodica e de composicoes farmaceuticas e/ou cosmeticas que os contem

Country Status (33)

Country Link
US (1) US5554598A (pt)
EP (1) EP0413016B1 (pt)
JP (1) JP2571312B2 (pt)
KR (1) KR960015624B1 (pt)
CN (2) CN1024557C (pt)
AR (1) AR243538A1 (pt)
AT (1) ATE98964T1 (pt)
AU (1) AU623232B2 (pt)
BG (1) BG61515B2 (pt)
CA (1) CA2027596C (pt)
CZ (1) CZ281000B6 (pt)
DD (1) DD292263A5 (pt)
DE (1) DE69005394T2 (pt)
DK (1) DK0413016T3 (pt)
ES (1) ES2061016T3 (pt)
FI (1) FI101707B1 (pt)
GE (2) GEP19981358B (pt)
GR (1) GR1000869B (pt)
HK (1) HK1003003A1 (pt)
HU (2) HU203372B (pt)
IE (1) IE62408B1 (pt)
IL (1) IL93489A (pt)
LT (2) LT3806B (pt)
LV (2) LV10112B (pt)
MY (1) MY105168A (pt)
NO (1) NO301169B1 (pt)
PL (1) PL163417B1 (pt)
PT (1) PT93237B (pt)
RU (2) RU2099350C1 (pt)
SK (1) SK279530B6 (pt)
UA (2) UA39174C2 (pt)
WO (1) WO1990010020A1 (pt)
ZA (1) ZA901357B (pt)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR920100122A (el) * 1991-04-05 1993-03-16 Ethicon Inc Πολυσακχαρίτες οι οποίοι περιέχουν καρβοξύλιο με σταυροειδείς δεσμούς δια την πρόληψιν της προσφύσεως.
DE4115454A1 (de) * 1991-05-11 1992-11-12 Basf Ag Eisen-(iii)-hyaluronate
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
IT1273742B (it) * 1994-08-01 1997-07-09 Lifegroup Spa Composizioni ad elevata bioadesivita' e mucoadesivita' utili per il trattamento di epitali e mucose
CN1064372C (zh) * 1994-08-26 2001-04-11 顾其胜 透明质酸钠制剂的制备方法
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
HU225991B1 (en) 1997-04-29 2008-02-28 Richter Gedeon Nyrt Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer
HU225329B1 (en) * 1996-09-12 2006-09-28 Richter Gedeon Vegyeszet Use of zinc or cobalt hyaluronate associate for the manufacture of pharmaceutical compositions of antimicrobial activity
US7192984B2 (en) 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
JP2003089647A (ja) 1999-03-10 2003-03-28 Takada Seiyaku Kk 関節性疾患治療剤
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6913765B2 (en) 2001-03-21 2005-07-05 Scimed Life Systems, Inc. Controlling resorption of bioresorbable medical implant material
CZ12015U1 (cs) * 2002-01-18 2002-02-25 Cpn Spol. S R.O. Přípravek pro prevenci adheze bandáľe na ránu
RU2220729C2 (ru) * 2002-01-31 2004-01-10 Общество с ограниченной ответственностью "Научный Центр системных исследований и технологий 2000" Гелевая композиция, используемая в стоматологии
PT1536845E (pt) 2002-09-11 2007-06-01 Johnson & Johnson Medical Ltd Materiais de penso compreendendo complexos de polissacarídeos aniónicos com prata
GB2392913B (en) * 2002-09-11 2007-04-04 Johnson & Johnson Medical Ltd Wound dressings comprising complexes of oxidised celluloses with silver
RU2227742C1 (ru) * 2002-09-25 2004-04-27 Представительство фирмы "Гедеон Рихтер" на Волге Средство для профилактики послеоперационного спаечного процесса
HUP0303779A2 (en) * 2003-11-20 2006-02-28 Richter Gedeon Vegyeszet Pharmaceutical compositions containing hyaluronan complex for the treatment of sclerosis multiplex
RU2280041C1 (ru) * 2005-04-21 2006-07-20 Общество с ограниченной ответственностью Научно-производственное предприятие "Тульская индустрия ЛТД" Способ получения водорастворимых солевых комплексов гиалуроновой кислоты (варианты)
JPWO2006121210A1 (ja) * 2005-05-13 2008-12-18 高田製薬株式会社 皮膚状態改善剤
WO2006121209A1 (ja) * 2005-05-13 2006-11-16 Takata Seiyaku Co., Ltd. 湿疹・皮膚炎群治療剤
JP4220513B2 (ja) * 2005-12-01 2009-02-04 株式会社資生堂 カチオン化ヒアルロン酸
CN100348621C (zh) 2005-12-02 2007-11-14 凌沛学 透明质酸铋及其制备方法和应用
CN1329414C (zh) * 2005-12-02 2007-08-01 凌沛学 透明质酸铋钾及其制备方法和应用
FR2918565B1 (fr) * 2007-07-12 2009-10-30 Biopharmex Holding Sa Hydrogel de carboxyalkylamide de chitosan, sa preparation et son utilisation cosmetique et dermatologique
ES2326721B1 (es) 2008-01-04 2010-07-16 Endor Nanotechnologies, S.L. Conjugado de acido hialuronico para el tratamiento cosmetico y procedimiento de preparacion.
TWI516269B (zh) 2009-08-14 2016-01-11 禾伸堂生技股份有限公司 使用於炎症性腸疾病（ｉｂｄ）治療和預防之透明質酸混合物
TWI383796B (zh) 2009-08-14 2013-02-01 Holy Stone Healthcare Co Ltd Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer
HUP0900717A3 (en) 2009-11-18 2012-02-28 Richter Gedeon Nyrt Pharmaceutical composition for urological use containing zinc hyaluronate
JP5728865B2 (ja) 2010-01-07 2015-06-03 株式会社リコー 放熱機構、及び放熱板の支え金具
WO2011129370A1 (ja) 2010-04-14 2011-10-20 キユーピー株式会社 ヒアルロン酸金属塩の製造方法、ヒアルロン酸金属塩を含む化粧品の製造方法、ならびにヒアルロン酸亜鉛およびその製造方法
ES2376680B8 (es) 2010-08-16 2013-04-30 Nylstar, S.A. Fibra textil cosmética, procedimiento de obtención y su empleo.
CN102552309B (zh) * 2010-12-15 2013-06-05 北京理工大学 一种透明质酸金的用途及其制备方法
JP5763953B2 (ja) * 2011-03-31 2015-08-12 ロート製薬株式会社 外用組成物
CN102961396A (zh) * 2012-12-17 2013-03-13 程玉李 透明质酸金属盐在制备治疗皮肤病药物中的应用、其药物组合物及其制备方法
JP2016535781A (ja) 2013-11-03 2016-11-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 経皮薬物送達のためのイオン性液体
JP6608620B2 (ja) * 2015-05-26 2019-11-20 ロート製薬株式会社 皮膚外用剤
EP3503927B1 (en) * 2016-08-29 2025-02-19 The Regents of the University of California Topical formulations based on ionic species for skin treatment
JP2019532708A (ja) 2016-09-21 2019-11-14 ネスレ スキン ヘルス エス アー 二価の亜鉛カチオンを含むヒアルロン酸ゲル
WO2019001784A1 (en) 2017-06-28 2019-01-03 Nestlé Skin Health Sa Hyaluronic acid gel with a divalent cation
MX2020001525A (es) 2017-08-24 2020-03-20 Novo Nordisk As Composiciones de peptido similar al glucagon tipo 1 (glp-1) y sus usos.
IL294520A (en) 2020-02-18 2022-09-01 Novo Nordisk As Pharmaceutical formulations
CN111647100B (zh) * 2020-07-14 2022-03-01 山东华熙海御生物医药有限公司 一种高分子量透明质酸锌的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US441973A (en) 1890-12-02 rapieff
US3074927A (en) * 1960-04-12 1963-01-22 Paul D Saltman Metallic complexes of reducing sugars
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
HU172831B (hu) * 1976-03-31 1978-12-28 Egyt Gyogyszervegyeszeti Gyar Sposob poluchenija kompleksov oligo- i poligalakturonnyk kislot s ionami zhiznenno vazhnykh metallov
US4303676A (en) 1980-03-21 1981-12-01 Balazs Endre A Hyaluronate based compositions and cosmetic formulations containing same
IT1229075B (it) 1985-04-05 1991-07-17 Fidia Farmaceutici Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
US4623539A (en) 1983-02-04 1986-11-18 Tunc Deger C Nutrient barrier polysaccharide compositions and method of use
NO161573C (no) 1983-11-25 1989-08-30 Miles Inc Fremgangsmaate til fremstilling av hyaluronsyre.
JPS61286310A (ja) * 1985-06-10 1986-12-16 Kanebo Ltd メ−クアツプ化粧料
AU600483B2 (en) * 1986-03-14 1990-08-16 Bio-Technology General Corporation Heavy metal salts of hyaluronic acid
US4746504A (en) * 1986-03-14 1988-05-24 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
US4742215A (en) * 1986-05-07 1988-05-03 Personal Computer Card Corporation IC card system
EP0356435B1 (en) * 1987-03-19 1995-10-18 Arthropharm Pty. Limited Anti-inflammatory compounds and compositions

Also Published As

Publication number Publication date
IE900637L (en) 1990-08-24
SK85790A3 (en) 1998-12-02
PL283942A1 (en) 1991-01-28
LTIP1474A (en) 1995-06-26
UA39174C2 (uk) 2001-06-15
JPH03505231A (ja) 1991-11-14
CN1024557C (zh) 1994-05-18
MY105168A (en) 1994-08-30
CN1045394A (zh) 1990-09-19
DD292263A5 (de) 1991-07-25
FI101707B (fi) 1998-08-14
LV10112A (lv) 1994-05-10
EP0413016A1 (en) 1991-02-20
NO904584D0 (no) 1990-10-23
WO1990010020A1 (en) 1990-09-07
AU5108890A (en) 1990-09-26
UA26324A (uk) 1999-08-30
HU211465A9 (en) 1995-11-28
GR900100137A (en) 1991-06-28
JP2571312B2 (ja) 1997-01-16
EP0413016B1 (en) 1993-12-22
ES2061016T3 (es) 1994-12-01
FI905109A0 (fi) 1990-10-17
LTIP1418A (en) 1995-05-25
KR960015624B1 (ko) 1996-11-18
LT3873B (en) 1996-04-25
LV10112B (en) 1995-02-20
CZ281000B6 (cs) 1996-05-15
DE69005394D1 (de) 1994-02-03
HK1003003A1 (en) 1998-09-30
GEP19981358B (en) 1998-08-25
DK0413016T3 (da) 1994-02-14
LV10965B (en) 1996-08-20
HUT53128A (en) 1990-09-28
BG61515B2 (bg) 1997-10-31
PT93237B (pt) 1996-01-31
LV10965A (lv) 1995-12-20
ATE98964T1 (de) 1994-01-15
CA2027596A1 (en) 1990-08-25
RU2021304C1 (ru) 1994-10-15
AR243538A1 (es) 1993-08-31
CA2027596C (en) 2001-01-02
NO904584L (no) 1990-12-21
CN1086422A (zh) 1994-05-11
US5554598A (en) 1996-09-10
IL93489A (en) 1994-05-30
GEP19971015B (en) 1997-05-30
GR1000869B (el) 1993-03-16
LT3806B (en) 1996-03-25
NO301169B1 (no) 1997-09-22
SK279530B6 (sk) 1998-12-02
HU203372B (en) 1991-07-29
IE62408B1 (en) 1995-01-25
DE69005394T2 (de) 1994-07-28
FI101707B1 (fi) 1998-08-14
RU2099350C1 (ru) 1997-12-20
AU623232B2 (en) 1992-05-07
PL163417B1 (pl) 1994-03-31
CN1051228C (zh) 2000-04-12
ZA901357B (en) 1990-11-28
KR920700231A (ko) 1992-02-19
CZ85790A3 (en) 1995-02-15

Similar Documents

Publication Publication Date Title
PT93237A (pt) Processo para a preparacao de novos sais complexos derivados de acido hialuronico desprotonizado e de metais de transicao do 4 periodo da tabela periodica e de composicoes farmaceuticas e/ou cosmeticas que os contem
PT93094A (pt) Processo para a preparacao de 1,3-oxatiolanos substituidos e de composicoes farmaceuticas que os contem
PT98369A (pt) Processo para a preparacao de azois substituidos e de composicoes farmaceuticas que os contem
PT99400A (pt) Processo para a preparacao de derivados de 3-amido- e 3-sulfamido-indolilo e de composicoes farmaceuticas que os contem
PT99671A (pt) Processo para a preparacao de heparosanos-n,o-sulfatados e de composicoes farmaceuticas que os contem
PT88186A (pt) Processo para a preparacao de derivados 4'-fosfato de glucosidos da epipodofilotoxina e de composicoes farmaceuticas que os contem
PT91968A (pt) Processo para a preparacao de novos piperidinil-benzimidazois e de composicoes farmaceuticas que os contem
PT89094A (pt) Processo para a preparacao de 1-aril-3-quinolina-e 1-aril-3-isoquinolina-carboxamidas e de composicoes farmaceuticas que as contem
PT89497A (pt) Processo para a preparacao de compostos piperidinilicos 1,4-dissubstituidos e de composicoes farmaceuticas que os contem
PT89405B (pt) Processo para a preparacao de derivados de isoquinolina e de composicoes farmaceuticas que os contem
PT89655A (pt) Processo para a preparacao de novas lactamas substituidas e de composicoes farmaceuticas que as contem
PT82414B (pt) Processo para a preparacao de agentes bactericidas a base de 5,6-difluoronaftiridinas e de 5,6,8-difluoroquinolinas e de composicoes farmaceuticas que os contem
PT82307B (pt) Processo para a preparacao de derivados da 4'-demetil-4-epipodofilotoxina e de composicoes farmaceuticas que os contem
PT84460B (pt) Processo para a preparacao de derivados de ciclopropano 1,1-dissubstituidos e de composicoes farmaceuticas que os contem
PT94083A (pt) Processo para a preparacao de polidextrose pulverizada substancialmente isenta de acidos e de composicoes alimentares que as contem
PT91870A (pt) Processo para apreparacao de novas quinoliloxazol-2-onas e de composicoes farmaceuticas que as contem
PT99795A (pt) Processo para a preparacao e novos derivados de piperidinil-benzimidazol e de composicoes farmaceuticas que os contem
PT89486A (pt) Processo para a preparacao de derivados 16-de-hidro de vitamina d3 e de composicoes farmaceuticas que os contem
PT84187B (pt) Processo para a preparacao de novos derivados da isoquinolina e de composicoes farmaceuticas que os contem
PT94225A (pt) Processo para a preparacao de novos compostos derivados de cromano e de composicoes farmaceuticas que os contem
PT94792A (pt) Processo para a preparacao de novos compostos derivados de cromano e de composicoes farmaceuticas que os contem
PT88335A (pt) Processo para a preparacao de derivados do acido 1,4-dihidro-4-oxo-3-quinolinocarboxilico e de composicoes farmaceuticas que os contem
PT91803A (pt) Processo para a preparacao de novos derivados da 2'-halogenometilideno-, 2'-etenilideno- e 2'-etinil-adenosina e de composicoes farmaceuticas que os contem
PT89145A (pt) Processo para a preparacao de derivados da manumicina e de composicoes farmaceuticas que os contem
PT94629A (pt) Processo para a preparacao de derivados de cromado e de composicoes farmaceuticas que os contem

Legal Events

Date Code Title Description
FG3A Patent granted, date of granting

Effective date: 19951020