BR112019005391A2 - métodos para preparar uma composição de hidrogel injetável esterilizada e para tratar cosmeticamente a pele, e, composição de hidrogel injetável esterilizada. - Google Patents

métodos para preparar uma composição de hidrogel injetável esterilizada e para tratar cosmeticamente a pele, e, composição de hidrogel injetável esterilizada.

Info

Publication number
BR112019005391A2
BR112019005391A2 BR112019005391A BR112019005391A BR112019005391A2 BR 112019005391 A2 BR112019005391 A2 BR 112019005391A2 BR 112019005391 A BR112019005391 A BR 112019005391A BR 112019005391 A BR112019005391 A BR 112019005391A BR 112019005391 A2 BR112019005391 A2 BR 112019005391A2
Authority
BR
Brazil
Prior art keywords
hydrogel composition
sterile injectable
injectable hydrogel
preparing
skin
Prior art date
Application number
BR112019005391A
Other languages
English (en)
Inventor
Karlsson Anders
Steven Harris Craig
Säwén Elin
Jing Jing Laura
Original Assignee
Nestle Skin Health Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nestle Skin Health Sa filed Critical Nestle Skin Health Sa
Publication of BR112019005391A2 publication Critical patent/BR112019005391A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body

Abstract

a presente invenção se refere a um método para preparar uma composição de hidrogel injetável esterilizada, compreendendo as etapas de: a) covalentemente reticular uma glicosaminoglicana usando um agente de reticulação bi- ou polifuncional para formar uma glicosaminoglicana covalentemente reticulada, b) intumescer a glicosaminoglicana covalentemente reticulada em uma solução compreendendo um cátion divalente para formar uma composição de hidrogel e c) esterilizar a composição de hidrogel por autoclavagem para formar uma composição de hidrogel injetável esterilizada, e a composições injetáveis de hidrogel esterilizadas obtidas por um método como este.
BR112019005391A 2016-09-21 2017-09-20 métodos para preparar uma composição de hidrogel injetável esterilizada e para tratar cosmeticamente a pele, e, composição de hidrogel injetável esterilizada. BR112019005391A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16189972 2016-09-21
PCT/EP2017/073823 WO2018055002A1 (en) 2016-09-21 2017-09-20 Hyaluronic acid gel with a divalent zinc cation

Publications (1)

Publication Number Publication Date
BR112019005391A2 true BR112019005391A2 (pt) 2019-06-04

Family

ID=56979489

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019005391A BR112019005391A2 (pt) 2016-09-21 2017-09-20 métodos para preparar uma composição de hidrogel injetável esterilizada e para tratar cosmeticamente a pele, e, composição de hidrogel injetável esterilizada.

Country Status (11)

Country Link
US (1) US10898613B2 (pt)
EP (1) EP3515511A1 (pt)
JP (1) JP2019532708A (pt)
KR (1) KR20190070327A (pt)
CN (1) CN109952117A (pt)
AU (1) AU2017329872A1 (pt)
BR (1) BR112019005391A2 (pt)
CA (1) CA3037651A1 (pt)
MX (1) MX2019003206A (pt)
RU (1) RU2019111102A (pt)
WO (1) WO2018055002A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11679076B2 (en) * 2020-08-06 2023-06-20 T-ACE Medical Co., Ltd. Composition for submucosal injection and preparation method thereof
KR102581434B1 (ko) * 2021-02-09 2023-09-22 (주)제테마 히알루론산 필러 조성물의 제조에 사용되는 용액 및 이를 이용한 히알루론산 필러 조성물
FR3122082A1 (fr) * 2021-04-26 2022-10-28 Noxelis Produit biocompatible a matrice comprenant un polysaccharide et du chitosane co-reticules

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU203372B (en) 1989-02-24 1991-07-29 Richter Gedeon Vegyeszet Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient
US5827937A (en) 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
IT1303735B1 (it) 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S Acidi ialuronici reticolati e loro usi medici.
JP3779200B2 (ja) 2001-11-28 2006-05-24 電気化学工業株式会社 ヒアルロン酸及び／又はその塩の水溶液の安定化組成物
FR2945293B1 (fr) * 2009-05-11 2011-06-17 Teoxane Procede de preparation d'un gel reticule.
FR2979539B1 (fr) 2011-09-05 2013-09-27 Teoxane Composition sterile dermo-injectable
CN103181902B (zh) * 2011-12-30 2016-06-08 张文芳 一种凝胶微球及其质控方法
FR2994846B1 (fr) * 2012-08-29 2014-12-26 Vivacy Lab Composition, sterilisee, comprenant au moins un acide hyaluronique et de l'ascorbyl phosphate de magnesium
FR3032617B1 (fr) 2015-02-16 2018-03-16 Kylane Laboratoires Sa Procede de preparation d un hydrogel injectable; hydrogel obtenu; utilisation de l hydrogel obtenu
CN105670008B (zh) * 2016-02-02 2019-01-08 华熙福瑞达生物医药有限公司 一种水溶性交联透明质酸干粉及应用
CN105536046B (zh) * 2016-02-26 2018-08-07 闫策 一种含双硫键的可注射骨水泥及制备方法

Also Published As

Publication number Publication date
EP3515511A1 (en) 2019-07-31
WO2018055002A1 (en) 2018-03-29
AU2017329872A1 (en) 2019-04-11
US10898613B2 (en) 2021-01-26
MX2019003206A (es) 2019-09-18
CN109952117A (zh) 2019-06-28
US20190351105A1 (en) 2019-11-21
RU2019111102A (ru) 2020-10-22
KR20190070327A (ko) 2019-06-20
CA3037651A1 (en) 2018-03-29
JP2019532708A (ja) 2019-11-14

Similar Documents

Publication Publication Date Title
BR112018067368A2 (pt) terapia de combinação com anticorpos anti-cd73
CL2017002767A1 (es) Nuevas proteínas específicas para cd137.
BR112018068559A2 (pt) ácido hialurônico modificado, método de fabricação do mesmo e usos do mesmo
BR112018070580A2 (pt) métodos e composições para terapia com células t car
BR112016023979A2 (pt) métodos de melhora ou aceleração da recuperação física após cirurgia para fratura óssea
MY169328A (en) Compositions for the treatment of dry eye
PE20150223A1 (es) Anticuerpos antagonistas mejorados contra factor-8 de crecimiento y diferenciacion y usos de los mismos
MX2016008158A (es) Metodos para dar forma a material fibroso y composiciones de tratamiento para este.
BR112017016759A2 (pt) recipiente de plástico pré-carregado, kit, uso do recipiente de plástico pré-carregado, método para o tratamento de uma doença ou condição, método para o tratamento cosmético da pele
BR112013002319A2 (pt) compostos e métodos para reparo da pele
BR112016019432A8 (pt) composição terapêutica, kit e seus usos na terapia gênica contra degeneração da retina
BR112016022318A2 (pt) método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo
BR112014020156A8 (pt) Derivado baseado em ácido hialurônico, método de preparação do derivado, hidrogel baseado no derivado de ligações cruzadas, método de produção do hidrogel e uso do hidrogel
TR201901077T4 (tr) Kanser Veya Enfeksiyon Tedavisine Yönelik Birleşik Preparasyonlar
BR112019005391A2 (pt) métodos para preparar uma composição de hidrogel injetável esterilizada e para tratar cosmeticamente a pele, e, composição de hidrogel injetável esterilizada.
MX2015017273A (es) Composiciones que comprenden acido hialuronico reticulado y ciclodextrina.
BR112015024234A2 (pt) composição de liberação sustentada injetável e método para o uso da mesma para tratar inflamação em articulações e dor associada com a mesma
BR112017015387A2 (pt) composição em gel tópica, método de tratamento de uma infecção da pele, composição em gel oftálmica, e, método de tratamento de uma afecção infecciosa do olho ou pálpebra
BR112017023788A2 (pt) composições de ácido nucleico?polímero catiônico e processo para a preparação de dita composição
MX2016012933A (es) Composiciones de relleno de tejidos y metodos de uso.
BR112016030758B8 (pt) Uso de células estromais multipotentes derivadas de tecido adiposo mesenquimal
BR102016007036A8 (pt) material de reparo de tecido derivado de pele de peixe e método de fabricação do mesmo
BR112016030326A2 (pt) ?poliepítopo quimérico, polinucleotídeo, vetores, célula, partículas de vírus, composição imunogênica, método para prevenir e/ou tratar infecções e método de produção de partículas de mv?
BR112016009178A8 (pt) método de preparação de um produto de tecido, e, uso de um produto de tecido
MX2019007572A (es) Composiciones que comprenden acido acetico y acido hipocloroso y metodos para tratar biopelicula.

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]