BR112018068559A2 - ácido hialurônico modificado, método de fabricação do mesmo e usos do mesmo - Google Patents

ácido hialurônico modificado, método de fabricação do mesmo e usos do mesmo

Info

Publication number
BR112018068559A2
BR112018068559A2 BR112018068559-3A BR112018068559A BR112018068559A2 BR 112018068559 A2 BR112018068559 A2 BR 112018068559A2 BR 112018068559 A BR112018068559 A BR 112018068559A BR 112018068559 A2 BR112018068559 A2 BR 112018068559A2
Authority
BR
Brazil
Prior art keywords
hyaluronic acid
hydrogel
present
derivative
manufacture
Prior art date
Application number
BR112018068559-3A
Other languages
English (en)
Other versions
BR112018068559B1 (pt
BR112018068559B8 (pt
Inventor
Klause Andreas
Linko Alexander
Villain Franck
Original Assignee
Merz Pharma Gmbh & Co. Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merz Pharma Gmbh & Co. Kgaa filed Critical Merz Pharma Gmbh & Co. Kgaa
Publication of BR112018068559A2 publication Critical patent/BR112018068559A2/pt
Publication of BR112018068559B1 publication Critical patent/BR112018068559B1/pt
Publication of BR112018068559B8 publication Critical patent/BR112018068559B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Abstract

a presente invenção refere-se, de modo geral, a um ácido hialurônico modificado (ha) e a um método para fabricar o mesmo, mais especificamente a um derivado de ha modificado por (poli)glicerol preparado enxertando-se glicidol em ha. a presente invenção também se refere ao uso do derivado de ha para preparar uma composição de preenchedor dérmico, um hidrogel que compreende ha reticulado e o derivado de ha modificado por (poli)glicerol e a um método para preparar o dito hidrogel. ademais, a presente invenção se refere ao uso do hidrogel como um produto cosmético e/ou estético, em particular como um preenchedor dérmico para preencher, substituir e/ou aumentar tecido.
BR112018068559A 2016-03-24 2017-03-21 Ácido hialurônico modificado, método de fabricação do mesmo e usos do mesmo BR112018068559B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16000715.9 2016-03-24
EP16000715 2016-03-24
PCT/EP2017/056701 WO2017162676A1 (en) 2016-03-24 2017-03-21 Modified hyaluronic acid, method for making same and uses thereof

Publications (3)

Publication Number Publication Date
BR112018068559A2 true BR112018068559A2 (pt) 2019-04-16
BR112018068559B1 BR112018068559B1 (pt) 2022-09-20
BR112018068559B8 BR112018068559B8 (pt) 2022-11-01

Family

ID=55642206

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018068559A BR112018068559B8 (pt) 2016-03-24 2017-03-21 Ácido hialurônico modificado, método de fabricação do mesmo e usos do mesmo

Country Status (16)

Country Link
US (1) US10640578B2 (pt)
EP (1) EP3433284A1 (pt)
JP (1) JP6946323B2 (pt)
KR (1) KR102316644B1 (pt)
CN (1) CN108779185B (pt)
AR (1) AR107967A1 (pt)
AU (1) AU2017237457B2 (pt)
BR (1) BR112018068559B8 (pt)
CA (1) CA3016272A1 (pt)
IL (1) IL261574B2 (pt)
MX (1) MX2018011053A (pt)
RU (1) RU2733444C2 (pt)
SG (1) SG11201807185UA (pt)
TW (1) TWI727014B (pt)
WO (1) WO2017162676A1 (pt)
ZA (1) ZA201805424B (pt)

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US20200254004A1 (en) * 2017-09-19 2020-08-13 The Hong Kong University Of Science And Technology Biocompatible material and methods for making and using thereof
US20210008249A1 (en) 2018-03-12 2021-01-14 Merz Pharma Gmbh & Co. Kgaa Porous biomaterials for tissue regeneration
WO2020127407A1 (en) * 2018-12-19 2020-06-25 Merz Pharma Gmbh & Co. Kgaa Aldehyde-modified hyaluronic acid, method for preparing same and applications thereof
AU2019401735B2 (en) * 2018-12-20 2022-08-25 Lg Chem, Ltd. Filler having excellent filler properties comprising hyaluronic acid hydrogel
WO2021064006A1 (en) * 2019-10-01 2021-04-08 Biopolimeri S.R.L. A hyperbranched polyglycerol polyglycidyl ether and its use as crosslinker for polysaccharides
FR3111903B1 (fr) 2020-06-24 2022-12-02 Lab Vivacy Procede d’incorporation de composes organiques en solution au sein d’un hydrogel
FR3113522A1 (fr) 2020-08-20 2022-02-25 Laboratoires Vivacy procédé d’évaluation des caractéristiques rhéologiques d’un gel
TW202317214A (zh) 2021-06-23 2023-05-01 德商莫茲製藥有限兩合公司 以絲蛋白交聯多醣及所得材料之用途
TW202333793A (zh) 2022-01-11 2023-09-01 義大利商Ｇｐｑ有限公司 作為創新填充劑之新玻尿酸衍生物
ES2947097A1 (es) * 2022-02-01 2023-08-01 Martinez Miguel Angel Gomariz Metodo cosmetico de rejuvenecimiento de la piel
FR3135399A1 (fr) 2022-03-30 2023-11-17 Laboratoires Vivacy émulsion comprenant un hydrogel et de la graisse ou un dérivé de graisse

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JPS61150844A (ja) 1984-12-21 1986-07-09 Meidensha Electric Mfg Co Ltd 電鉄用回生インパ−タの制御方法
TWI251596B (en) * 2002-12-31 2006-03-21 Ind Tech Res Inst Method for producing a double-crosslinked hyaluronate material
FR2865737B1 (fr) 2004-02-03 2006-03-31 Anteis Sa Gel reticule biocompatible
WO2006025556A1 (en) * 2004-08-31 2006-03-09 Showa Denko K.K. Surface-modified packing material for liquid chromatography and production method thereof
JP5022618B2 (ja) 2005-04-05 2012-09-12 株式会社 資生堂 ヒドロキシアルキル化ヒアルロン酸
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Also Published As

Publication number Publication date
CA3016272A1 (en) 2017-09-28
TW201805008A (zh) 2018-02-16
JP2019509385A (ja) 2019-04-04
EP3433284A1 (en) 2019-01-30
SG11201807185UA (en) 2018-09-27
BR112018068559B1 (pt) 2022-09-20
US20190100605A1 (en) 2019-04-04
BR112018068559B8 (pt) 2022-11-01
RU2018129659A (ru) 2020-04-24
KR20180127983A (ko) 2018-11-30
RU2733444C2 (ru) 2020-10-01
CN108779185A (zh) 2018-11-09
MX2018011053A (es) 2019-03-28
IL261574A (en) 2018-10-31
CN108779185B (zh) 2021-09-17
US10640578B2 (en) 2020-05-05
TWI727014B (zh) 2021-05-11
AR107967A1 (es) 2018-07-04
RU2018129659A3 (pt) 2020-05-27
JP6946323B2 (ja) 2021-10-06
IL261574B1 (en) 2023-11-01
KR102316644B1 (ko) 2021-10-26
ZA201805424B (en) 2019-04-24
IL261574B2 (en) 2024-03-01
AU2017237457B2 (en) 2021-04-08
WO2017162676A1 (en) 2017-09-28
AU2017237457A1 (en) 2018-09-06

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