AR107967A1 - Ácido hialurónico modificado, método para su preparación y usos del mismo - Google Patents
Ácido hialurónico modificado, método para su preparación y usos del mismoInfo
- Publication number
- AR107967A1 AR107967A1 ARP170100730A ARP170100730A AR107967A1 AR 107967 A1 AR107967 A1 AR 107967A1 AR P170100730 A ARP170100730 A AR P170100730A AR P170100730 A ARP170100730 A AR P170100730A AR 107967 A1 AR107967 A1 AR 107967A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- hyaluronic acid
- same
- hydrogel
- modified hyaluronic
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 6
- 229920002674 hyaluronan Polymers 0.000 abstract 3
- 229960003160 hyaluronic acid Drugs 0.000 abstract 3
- 239000000017 hydrogel Substances 0.000 abstract 3
- 230000002500 effect on skin Effects 0.000 abstract 2
- 239000000945 filler Substances 0.000 abstract 2
- CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical compound OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 abstract 1
- 230000003416 augmentation Effects 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Materials For Medical Uses (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente se relaciona, en general, con un ácido hialurónico modificado (HA) y con un método para su preparación, más específicamente con un derivado HA modificado con (poli)glicerol preparado mediante el injerto de glicidol en HA. La presente también se relaciona con el uso del derivado de HA para la preparación de una composición de relleno dérmico, un hidrogel que comprende HA entrecruzado y el derivado de HA modificado con (poli)glicerol, y un método para la preparación de dicho hidrogel. Además, la presente se relaciona con el uso del hidrogel como producto cosmético y/o estético, en particular como relleno dérmico para relleno, reemplazo y/o aumento de tejidos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16000715 | 2016-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR107967A1 true AR107967A1 (es) | 2018-07-04 |
Family
ID=55642206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170100730A AR107967A1 (es) | 2016-03-24 | 2017-03-23 | Ácido hialurónico modificado, método para su preparación y usos del mismo |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US10640578B2 (es) |
| EP (1) | EP3433284A1 (es) |
| JP (1) | JP6946323B2 (es) |
| KR (1) | KR102316644B1 (es) |
| CN (1) | CN108779185B (es) |
| AR (1) | AR107967A1 (es) |
| AU (1) | AU2017237457B2 (es) |
| BR (1) | BR112018068559B8 (es) |
| CA (1) | CA3016272A1 (es) |
| IL (1) | IL261574B2 (es) |
| MX (1) | MX2018011053A (es) |
| RU (1) | RU2733444C2 (es) |
| SG (1) | SG11201807185UA (es) |
| TW (1) | TWI727014B (es) |
| WO (1) | WO2017162676A1 (es) |
| ZA (1) | ZA201805424B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7501908B2 (ja) * | 2017-09-19 | 2024-06-18 | 香港科技大学 | 生体適合性材料、並びにそれを作製及び使用する方法 |
| US20210008249A1 (en) | 2018-03-12 | 2021-01-14 | Merz Pharma Gmbh & Co. Kgaa | Porous biomaterials for tissue regeneration |
| AU2019407867B2 (en) * | 2018-12-19 | 2024-09-26 | Merz Pharma Gmbh & Co. Kgaa | Aldehyde-modified hyaluronic acid, method for preparing same and applications thereof |
| BR112021012042A2 (pt) * | 2018-12-20 | 2021-09-21 | Lg Chem, Ltd. | Preenchedor com excelentes propriedades de preenchedor compreendendo hidrogel de ácido hialurônico |
| EP4038105B1 (en) * | 2019-10-01 | 2024-01-10 | Biopolimeri S.r.l. | A hyperbranched polyglycerol polyglycidyl ether and its use as crosslinker for polysaccharides |
| FR3111903B1 (fr) | 2020-06-24 | 2022-12-02 | Lab Vivacy | Procede d’incorporation de composes organiques en solution au sein d’un hydrogel |
| FR3113522A1 (fr) | 2020-08-20 | 2022-02-25 | Laboratoires Vivacy | procédé d’évaluation des caractéristiques rhéologiques d’un gel |
| TW202317214A (zh) | 2021-06-23 | 2023-05-01 | 德商莫茲製藥有限兩合公司 | 以絲蛋白交聯多醣及所得材料之用途 |
| CN118742576A (zh) | 2022-01-11 | 2024-10-01 | 维库有限公司 | 作为创新填充剂的新透明质酸衍生物 |
| ES2947097A1 (es) * | 2022-02-01 | 2023-08-01 | Martinez Miguel Angel Gomariz | Metodo cosmetico de rejuvenecimiento de la piel |
| FR3135399A1 (fr) | 2022-03-30 | 2023-11-17 | Laboratoires Vivacy | émulsion comprenant un hydrogel et de la graisse ou un dérivé de graisse |
| WO2024126649A1 (en) | 2022-12-15 | 2024-06-20 | Merz Pharma Gmbh & Co. Kgaa | Injectable gel comprising botulinum toxin and uses thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61150844A (ja) | 1984-12-21 | 1986-07-09 | Meidensha Electric Mfg Co Ltd | 電鉄用回生インパ−タの制御方法 |
| TWI251596B (en) * | 2002-12-31 | 2006-03-21 | Ind Tech Res Inst | Method for producing a double-crosslinked hyaluronate material |
| FR2865737B1 (fr) | 2004-02-03 | 2006-03-31 | Anteis Sa | Gel reticule biocompatible |
| WO2006025556A1 (en) * | 2004-08-31 | 2006-03-09 | Showa Denko K.K. | Surface-modified packing material for liquid chromatography and production method thereof |
| JP5022618B2 (ja) * | 2005-04-05 | 2012-09-12 | 株式会社 資生堂 | ヒドロキシアルキル化ヒアルロン酸 |
| KR100849185B1 (ko) * | 2006-01-19 | 2008-07-30 | 서울산업대학교 산학협력단 | 키토산 또는 히알루론산-폴리에틸렌옥사이드 및키토산-히알루론산-폴리에틸렌옥사이드를 기저로 하는하이드로젤과 이의 제조방법 |
| WO2008034176A1 (en) * | 2006-09-19 | 2008-03-27 | Ultraceuticals R & D Pty Ltd | Cross-linked polysaccharide gels |
| FR2909560B1 (fr) | 2006-12-06 | 2012-12-28 | Fabre Pierre Dermo Cosmetique | Gel d'acide hyaluronique pour injection intradermique |
| CN101502677B (zh) * | 2008-02-04 | 2013-06-26 | 凌沛学 | 一种注射用交联透明质酸钠凝胶及其制备方法 |
| CN101538377A (zh) * | 2008-03-20 | 2009-09-23 | 上海昊海生物科技有限公司 | 一种交联透明质酸凝胶及其制备方法 |
| US8357795B2 (en) * | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| US9371402B2 (en) * | 2009-04-09 | 2016-06-21 | Scivision Biotech Inc. | Method for producing cross-linked hyaluronic acid |
| US20100261893A1 (en) * | 2009-04-09 | 2010-10-14 | Scivision Biotech Inc. | Method for producing cross-linked hyaluronic acid |
| FR2945949B1 (fr) * | 2009-05-26 | 2011-05-13 | Anteis Sa | Hydrogel injectable permettant une supplementation en glycerol dans la peau sur le long terme. |
| EP2459239A1 (en) * | 2009-07-30 | 2012-06-06 | Carbylan Biosurgery, Inc. | Modified hyaluronic acid polymer compositions and related methods |
| KR101726016B1 (ko) * | 2010-02-19 | 2017-04-11 | 큐피가부시키가이샤 | 치환 히알루론산 및/또는 그 염, 그리고 그 제조 방법 및 이것을 함유하는 화장료 |
| BR112013003895A2 (pt) * | 2010-08-19 | 2016-07-12 | Merz Pharma Gmbh & Co Kgaa | composição de enchimento e seu uso, processo para a preparação da composição de enchimento, kit e dispositivo de injeção |
| RU2496793C1 (ru) * | 2012-06-14 | 2013-10-27 | Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук | Способ получения 2,3-дигидроксипропилхитозана |
| BR112014031412B1 (pt) | 2012-06-15 | 2021-01-05 | Merz Pharma Gmbh & Co. Kgaa | método de preparação de uma composição |
| US20140275340A1 (en) | 2013-03-15 | 2014-09-18 | Lake Region Manufacturing, Inc. d/b/a Lake Region Medical | Modified hyaluronate hydrophilic compositions, coatings and methods |
| FR3006689A1 (fr) * | 2013-06-11 | 2014-12-12 | Benedicte Vincente Tauzin | Procede de reticulation de l'acide hyaluronique; procede de preparation d'un hydrogel injectable; hydrogel obtenu; utilisation de l'hydroget obtenu |
| AR099900A1 (es) * | 2014-04-01 | 2016-08-24 | Merz Pharma Gmbh & Co Kgaa | Rellenos para tejidos blandos con polisacáridos con persistencia mejorada, kit, procedimiento, uso |
| CN104194008B (zh) * | 2014-08-08 | 2017-09-15 | 陕西佰傲再生医学有限公司 | 一种交联透明质酸凝胶微粒及其制备方法 |
-
2017
- 2017-03-10 TW TW106107945A patent/TWI727014B/zh active
- 2017-03-21 JP JP2018548401A patent/JP6946323B2/ja active Active
- 2017-03-21 KR KR1020187026925A patent/KR102316644B1/ko active IP Right Grant
- 2017-03-21 SG SG11201807185UA patent/SG11201807185UA/en unknown
- 2017-03-21 AU AU2017237457A patent/AU2017237457B2/en active Active
- 2017-03-21 CN CN201780018177.6A patent/CN108779185B/zh active Active
- 2017-03-21 US US16/087,248 patent/US10640578B2/en active Active
- 2017-03-21 RU RU2018129659A patent/RU2733444C2/ru active
- 2017-03-21 WO PCT/EP2017/056701 patent/WO2017162676A1/en active Application Filing
- 2017-03-21 CA CA3016272A patent/CA3016272A1/en active Pending
- 2017-03-21 EP EP17710992.3A patent/EP3433284A1/en active Pending
- 2017-03-21 IL IL261574A patent/IL261574B2/en unknown
- 2017-03-21 MX MX2018011053A patent/MX2018011053A/es unknown
- 2017-03-21 BR BR112018068559A patent/BR112018068559B8/pt active IP Right Grant
- 2017-03-23 AR ARP170100730A patent/AR107967A1/es active IP Right Grant
-
2018
- 2018-08-14 ZA ZA2018/05424A patent/ZA201805424B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3016272A1 (en) | 2017-09-28 |
| EP3433284A1 (en) | 2019-01-30 |
| IL261574B2 (en) | 2024-03-01 |
| JP6946323B2 (ja) | 2021-10-06 |
| KR102316644B1 (ko) | 2021-10-26 |
| SG11201807185UA (en) | 2018-09-27 |
| WO2017162676A1 (en) | 2017-09-28 |
| MX2018011053A (es) | 2019-03-28 |
| KR20180127983A (ko) | 2018-11-30 |
| CN108779185A (zh) | 2018-11-09 |
| RU2018129659A3 (es) | 2020-05-27 |
| IL261574B1 (en) | 2023-11-01 |
| AU2017237457A1 (en) | 2018-09-06 |
| BR112018068559B8 (pt) | 2022-11-01 |
| US10640578B2 (en) | 2020-05-05 |
| RU2733444C2 (ru) | 2020-10-01 |
| JP2019509385A (ja) | 2019-04-04 |
| CN108779185B (zh) | 2021-09-17 |
| TWI727014B (zh) | 2021-05-11 |
| TW201805008A (zh) | 2018-02-16 |
| BR112018068559A2 (pt) | 2019-04-16 |
| IL261574A (en) | 2018-10-31 |
| ZA201805424B (en) | 2019-04-24 |
| BR112018068559B1 (pt) | 2022-09-20 |
| US20190100605A1 (en) | 2019-04-04 |
| AU2017237457B2 (en) | 2021-04-08 |
| RU2018129659A (ru) | 2020-04-24 |
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