DK0413016T3 - Hidtil ukendte kompositioner indeholdende hyaluronnsyreassociater og fremgangsmåde til fremstilling heraf - Google Patents

Hidtil ukendte kompositioner indeholdende hyaluronnsyreassociater og fremgangsmåde til fremstilling heraf

Info

Publication number
DK0413016T3
DK0413016T3 DK90903397.9T DK90903397T DK0413016T3 DK 0413016 T3 DK0413016 T3 DK 0413016T3 DK 90903397 T DK90903397 T DK 90903397T DK 0413016 T3 DK0413016 T3 DK 0413016T3
Authority
DK
Denmark
Prior art keywords
processes
preparation
hyaluronic acid
compositions containing
new compositions
Prior art date
Application number
DK90903397.9T
Other languages
Danish (da)
English (en)
Inventor
Kalman Burger
Nagy Geza Takacsi
Ivan Rethey
Janos Illes
Bela Stefko
Erzsebet Neszmelyi
Istvan Gebhardt
Istvan Racz
Arpadne Kiraly
Viktoria Varkonyi
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Application granted granted Critical
Publication of DK0413016T3 publication Critical patent/DK0413016T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/58—Metal complex; Coordination compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Inorganic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DK90903397.9T 1989-02-24 1990-02-20 Hidtil ukendte kompositioner indeholdende hyaluronnsyreassociater og fremgangsmåde til fremstilling heraf DK0413016T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU89891A HU203372B (en) 1989-02-24 1989-02-24 Process for producing hyaluronic associates and pharmaceutical compositions and cosmetics comprising such active ingredient

Publications (1)

Publication Number Publication Date
DK0413016T3 true DK0413016T3 (da) 1994-02-14

Family

ID=10951903

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90903397.9T DK0413016T3 (da) 1989-02-24 1990-02-20 Hidtil ukendte kompositioner indeholdende hyaluronnsyreassociater og fremgangsmåde til fremstilling heraf

Country Status (33)

Country Link
US (1) US5554598A (pt)
EP (1) EP0413016B1 (pt)
JP (1) JP2571312B2 (pt)
KR (1) KR960015624B1 (pt)
CN (2) CN1024557C (pt)
AR (1) AR243538A1 (pt)
AT (1) ATE98964T1 (pt)
AU (1) AU623232B2 (pt)
BG (1) BG61515B2 (pt)
CA (1) CA2027596C (pt)
CZ (1) CZ281000B6 (pt)
DD (1) DD292263A5 (pt)
DE (1) DE69005394T2 (pt)
DK (1) DK0413016T3 (pt)
ES (1) ES2061016T3 (pt)
FI (1) FI101707B (pt)
GE (2) GEP19981358B (pt)
GR (1) GR1000869B (pt)
HK (1) HK1003003A1 (pt)
HU (2) HU203372B (pt)
IE (1) IE62408B1 (pt)
IL (1) IL93489A (pt)
LT (2) LT3806B (pt)
LV (2) LV10112B (pt)
MY (1) MY105168A (pt)
NO (1) NO301169B1 (pt)
PL (1) PL163417B1 (pt)
PT (1) PT93237B (pt)
RU (2) RU2099350C1 (pt)
SK (1) SK85790A3 (pt)
UA (2) UA39174C2 (pt)
WO (1) WO1990010020A1 (pt)
ZA (1) ZA901357B (pt)

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IT1273742B (it) * 1994-08-01 1997-07-09 Lifegroup Spa Composizioni ad elevata bioadesivita' e mucoadesivita' utili per il trattamento di epitali e mucose
CN1064372C (zh) * 1994-08-26 2001-04-11 顾其胜 透明质酸钠制剂的制备方法
US6368356B1 (en) 1996-07-11 2002-04-09 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
HU225329B1 (en) * 1996-09-12 2006-09-28 Richter Gedeon Vegyeszet Use of zinc or cobalt hyaluronate associate for the manufacture of pharmaceutical compositions of antimicrobial activity
HU225991B1 (en) 1997-04-29 2008-02-28 Richter Gedeon Nyrt Use of the zinc hyaluronate associate (complex) for the preparation of pharmaceutical compositions for oral use against peptic ulcer
US6869938B1 (en) 1997-06-17 2005-03-22 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use in reducing adhesions
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US5906997A (en) * 1997-06-17 1999-05-25 Fzio Med, Inc. Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions
JP2003089647A (ja) 1999-03-10 2003-03-28 Takada Seiyaku Kk 関節性疾患治療剤
US6566345B2 (en) 2000-04-28 2003-05-20 Fziomed, Inc. Polyacid/polyalkylene oxide foams and gels and methods for their delivery
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GB2392913B (en) * 2002-09-11 2007-04-04 Johnson & Johnson Medical Ltd Wound dressings comprising complexes of oxidised celluloses with silver
HUP0303779A2 (en) * 2003-11-20 2006-02-28 Richter Gedeon Vegyeszet Pharmaceutical compositions containing hyaluronan complex for the treatment of sclerosis multiplex
JPWO2006121210A1 (ja) * 2005-05-13 2008-12-18 高田製薬株式会社 皮膚状態改善剤
JPWO2006121209A1 (ja) * 2005-05-13 2008-12-18 高田製薬株式会社 湿疹・皮膚炎群治療剤
JP4220513B2 (ja) * 2005-12-01 2009-02-04 株式会社資生堂 カチオン化ヒアルロン酸
CN1329414C (zh) * 2005-12-02 2007-08-01 凌沛学 透明质酸铋钾及其制备方法和应用
CN100348621C (zh) 2005-12-02 2007-11-14 凌沛学 透明质酸铋及其制备方法和应用
FR2918565B1 (fr) * 2007-07-12 2009-10-30 Biopharmex Holding Sa Hydrogel de carboxyalkylamide de chitosan, sa preparation et son utilisation cosmetique et dermatologique
ES2326721B1 (es) * 2008-01-04 2010-07-16 Endor Nanotechnologies, S.L. Conjugado de acido hialuronico para el tratamiento cosmetico y procedimiento de preparacion.
TWI516269B (zh) 2009-08-14 2016-01-11 禾伸堂生技股份有限公司 使用於炎症性腸疾病（ｉｂｄ）治療和預防之透明質酸混合物
TWI383796B (zh) 2009-08-14 2013-02-01 Holy Stone Healthcare Co Ltd Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer
HUP0900717A3 (en) 2009-11-18 2012-02-28 Richter Gedeon Nyrt Pharmaceutical composition for urological use containing zinc hyaluronate
JP5852560B2 (ja) * 2010-04-14 2016-02-03 キユーピー株式会社 ヒアルロン酸金属塩の製造方法、ヒアルロン酸金属塩を含む化粧品の製造方法、ならびにヒアルロン酸亜鉛およびその製造方法
ES2376680B8 (es) 2010-08-16 2013-04-30 Nylstar, S.A. Fibra textil cosmética, procedimiento de obtención y su empleo.
CN102552309B (zh) * 2010-12-15 2013-06-05 北京理工大学 一种透明质酸金的用途及其制备方法
JP5763953B2 (ja) * 2011-03-31 2015-08-12 ロート製薬株式会社 外用組成物
CN102961396A (zh) * 2012-12-17 2013-03-13 程玉李 透明质酸金属盐在制备治疗皮肤病药物中的应用、其药物组合物及其制备方法
CA3100536A1 (en) 2013-11-03 2015-05-07 The Regents Of The University Of California Ionic liquids for transdermal drug delivery
KR102552848B1 (ko) * 2016-08-29 2023-07-06 더 리전츠 오브 더 유니버시티 오브 캘리포니아 피부 치료를 위한 이온성 약제에 기초한 국소 제형
KR20190070327A (ko) 2016-09-21 2019-06-20 네슬레 스킨 헬스 소시에떼 아노님 2가 아연 양이온을 갖는 히알루론산 겔
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Also Published As

Publication number Publication date
PT93237B (pt) 1996-01-31
NO904584L (no) 1990-12-21
CZ281000B6 (cs) 1996-05-15
LTIP1474A (en) 1995-06-26
FI101707B1 (fi) 1998-08-14
UA26324A (uk) 1999-08-30
FI905109A0 (fi) 1990-10-17
LV10965A (lv) 1995-12-20
GR1000869B (el) 1993-03-16
RU2021304C1 (ru) 1994-10-15
AU623232B2 (en) 1992-05-07
GR900100137A (en) 1991-06-28
JP2571312B2 (ja) 1997-01-16
GEP19971015B (en) 1997-05-30
DE69005394D1 (de) 1994-02-03
AR243538A1 (es) 1993-08-31
CA2027596C (en) 2001-01-02
PL283942A1 (en) 1991-01-28
RU2099350C1 (ru) 1997-12-20
AU5108890A (en) 1990-09-26
NO904584D0 (no) 1990-10-23
CN1024557C (zh) 1994-05-18
LV10112B (en) 1995-02-20
HU211465A9 (en) 1995-11-28
IE62408B1 (en) 1995-01-25
EP0413016A1 (en) 1991-02-20
PL163417B1 (pl) 1994-03-31
LTIP1418A (en) 1995-05-25
ATE98964T1 (de) 1994-01-15
CA2027596A1 (en) 1990-08-25
CN1051228C (zh) 2000-04-12
KR960015624B1 (ko) 1996-11-18
KR920700231A (ko) 1992-02-19
FI101707B (fi) 1998-08-14
UA39174C2 (uk) 2001-06-15
IL93489A (en) 1994-05-30
LT3806B (en) 1996-03-25
HK1003003A1 (en) 1998-09-30
CZ85790A3 (en) 1995-02-15
ZA901357B (en) 1990-11-28
EP0413016B1 (en) 1993-12-22
ES2061016T3 (es) 1994-12-01
BG61515B2 (bg) 1997-10-31
DD292263A5 (de) 1991-07-25
GEP19981358B (en) 1998-08-25
LT3873B (en) 1996-04-25
WO1990010020A1 (en) 1990-09-07
CN1086422A (zh) 1994-05-11
NO301169B1 (no) 1997-09-22
IE900637L (en) 1990-08-24
PT93237A (pt) 1990-08-31
SK279530B6 (sk) 1998-12-02
CN1045394A (zh) 1990-09-19
HUT53128A (en) 1990-09-28
JPH03505231A (ja) 1991-11-14
HU203372B (en) 1991-07-29
LV10965B (en) 1996-08-20
LV10112A (lv) 1994-05-10
DE69005394T2 (de) 1994-07-28
SK85790A3 (en) 1998-12-02
MY105168A (en) 1994-08-30
US5554598A (en) 1996-09-10

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