BE904547A - Nouveaux medicaments a usage topique. - Google Patents

Nouveaux medicaments a usage topique.

Info

Publication number
BE904547A
BE904547A BE1/011467A BE1011467A BE904547A BE 904547 A BE904547 A BE 904547A BE 1/011467 A BE1/011467 A BE 1/011467A BE 1011467 A BE1011467 A BE 1011467A BE 904547 A BE904547 A BE 904547A
Authority
BE
Belgium
Prior art keywords
topical use
new medicines
salt
pharmacologically active
hyaluronic acid
Prior art date
Application number
BE1/011467A
Other languages
English (en)
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36694284&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE904547(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IT48980/85A external-priority patent/IT1184675B/it
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of BE904547A publication Critical patent/BE904547A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Préparations pharmaceutiques pour l'administration topique contenant une substance pharmacologiquement active en meme temps que de l'acide hyaluronique ou une des ses fractions moléculaires. L'acide hyaluronique peut exister sous la forme d'acide libre ou sous la forme de sel avec un métal alcalin ou alcalino-terreux, le magnésium, l'aluminiué ou l'ammonium ou sous la forme d'un sel avec une ou plusieurs substances pharmacologiquement actives.
BE1/011467A 1985-04-05 1986-04-03 Nouveaux medicaments a usage topique. BE904547A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT8547924A IT1229075B (it) 1985-04-05 1985-04-05 Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
CN85102921A CN85102921B (zh) 1985-04-05 1985-04-09 制备具有药物作用的透明质酸组份及含该组份的药物的方法
IT48980/85A IT1184675B (it) 1985-12-23 1985-12-23 Procedimento per la preparazione di sali dell'acido ialuronico

Publications (1)

Publication Number Publication Date
BE904547A true BE904547A (fr) 1986-10-03

Family

ID=36694284

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/011467A BE904547A (fr) 1985-04-05 1986-04-03 Nouveaux medicaments a usage topique.

Country Status (27)

Country Link
US (1) US4736024A (fr)
EP (2) EP0197718B2 (fr)
JP (2) JP2585216B2 (fr)
KR (1) KR910006810B1 (fr)
CN (1) CN85102921B (fr)
AR (1) AR245369A1 (fr)
AT (1) ATE98495T1 (fr)
AU (1) AU592077B2 (fr)
BE (1) BE904547A (fr)
CA (2) CA1340825C (fr)
CH (1) CH672886A5 (fr)
DE (1) DE3689384T3 (fr)
DK (1) DK149886A (fr)
ES (1) ES8800055A1 (fr)
FI (1) FI83966C (fr)
FR (1) FR2579895B1 (fr)
HU (1) HU204202B (fr)
IE (1) IE64440B1 (fr)
IL (1) IL78263A0 (fr)
IN (1) IN165867B (fr)
IT (1) IT1229075B (fr)
LU (1) LU86386A1 (fr)
NO (1) NO174277C (fr)
NZ (1) NZ215676A (fr)
PH (1) PH29979A (fr)
PT (1) PT82342B (fr)
ZA (1) ZA862463B (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3806B (en) 1989-02-24 1996-03-25 Richter Gedeon Vegyeszet Hyaluronic acid associates, composition containing them, process for preparing the composition, process for preparing zinc hyaluronate aqueous solution
BG64458B1 (bg) * 1997-04-29 2005-03-31 Richter Gedeon Vegyeszeti Gyar Rt. Използване на цинков хиалуронат срещу пептична язва
EP2289522A1 (fr) 2009-08-14 2011-03-02 Holy Stone Healthcare Co.,Ltd. Utilisation d'acide hyaluronique pour le traitement d'ulcers gastro-duodenaux
EP2292243A1 (fr) 2009-08-14 2011-03-09 Holy Stone Healthcare Co.,Ltd. Mélange d'acide hyaluronique pour traiter et empêcher les maladies intestinales inflammatoires
EP2543357A1 (fr) 2011-07-07 2013-01-09 Holy Stone Healthcare Co.,Ltd. Composition pour une utilisation dans le traitement et la prévention d'une maladie liée à l'inflammation
EP2545925A1 (fr) 2011-07-12 2013-01-16 Holy Stone Healthcare Co.,Ltd. Compositions comprenant de l'acide hyaluronique pour le traitement et la prévention de maladies liées aux muqueuses
US8575130B2 (en) 2010-01-04 2013-11-05 Holy Stone Healthcare Co., Ltd. Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease
US8722644B2 (en) 2010-01-04 2014-05-13 Holy Stone Healthcare Co., Ltd. Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer
US9029347B2 (en) 2010-08-05 2015-05-12 Holy Stone Healthcare Co., Ltd. Method and mixture for treating and preventing inflammatory bowel disease

Families Citing this family (149)

* Cited by examiner, † Cited by third party
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IT1186772B (it) * 1985-10-10 1987-12-16 Crinos Industria Farmaco Composto ad attivita' pilostimolante
EP0259485A4 (fr) * 1986-03-14 1988-07-29 Bio Technology General Corp Sels de metaux lourds de l'acide hyaluronique utiles en tant qu'agents antimicrobiens.
US5668116A (en) * 1987-03-19 1997-09-16 Anthropharm Pty. Limited Anti-inflammatory compounds and compositions
CA1327354C (fr) * 1987-03-19 1994-03-01 David Cullis-Hill Composes et compositions anti-inflamatoires
EP0292220B1 (fr) * 1987-05-20 1991-08-14 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Préservatif masculin
DE3883645T2 (de) * 1987-07-01 1994-02-03 Genentech Inc Therapeutische Zusamensetzungen und Verfahren zur Verhinderung von Fibrinablagerung und Adhäsionen.
US5055298A (en) * 1987-12-01 1991-10-08 Chemisches Laboratorium Dr. Kurt Richter Gmbh Cosmetic composition comprising an extracellular connective tissue matrix
JPH01213227A (ja) * 1988-02-23 1989-08-28 Tadashi Koyake 軟膏剤及び液剤
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin
JPH0232013A (ja) * 1988-07-20 1990-02-01 Denki Kagaku Kogyo Kk 点鼻剤
JPH02200624A (ja) * 1989-01-30 1990-08-08 Nippon Kayaku Co Ltd 歯科用包帯剤
US6458774B1 (en) * 1989-02-24 2002-10-01 Richter Gedeon Vegyeszeti Gyar Rt. Compositions containing hyaluronic acid associates and a process for preparing same
US5472950A (en) * 1989-02-24 1995-12-05 Richter Gedeon Vegyeszeti Gyar Rt. Compositions containing cobalt hyaluronic acid complex
CA1340994C (fr) * 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Traitement de maladies et d'etats pathologiques
JP2945993B2 (ja) * 1989-12-05 1999-09-06 武田薬品工業株式会社 外用剤
US5141928B1 (en) * 1989-12-20 1995-11-14 Brujo Inc Ophthalmic medication
NL8903155A (nl) * 1989-12-23 1991-07-16 Stamicarbon Harssamenstelling op basis van een polyesterhars, een aminohars en een epoxyhars.
WO1991011992A1 (fr) * 1990-02-13 1991-08-22 Zerega Gere S Di Medicaments induits au niveau peritoneal
IT1240316B (it) * 1990-02-21 1993-12-07 Ricerca Di Schiena Del Dr. Michele G. Di Schiema & C. Composizioni a base di acido ialuronico ad alto peso molecolare somministrabili per via topica per il trattamento di infiammazioni del cavo orale ,per la cosmetica e l'igiene del cavo orale
US5910489A (en) * 1990-09-18 1999-06-08 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
US5639738A (en) * 1992-02-20 1997-06-17 Hyal Pharmaceutical Corporation Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs
US5990096A (en) * 1990-09-18 1999-11-23 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
CA2061703C (fr) * 1992-02-20 2002-07-02 Rudolf E. Falk Compositions renfermant de l'acide hyaluronique
US5824658A (en) * 1990-09-18 1998-10-20 Hyal Pharmaceutical Corporation Topical composition containing hyaluronic acid and NSAIDS
CA2061566C (fr) * 1992-02-20 2002-07-09 Rudolf E. Falk Traitement des maladies par l'acide hyaluronique et des ains
IT1243435B (it) * 1990-10-05 1994-06-10 Altergon Sa Composizioni farmaceutiche per uso topico comprendenti acido ialuronico sale sodico e sostanze disinfettanti
US5492936A (en) * 1990-11-30 1996-02-20 Allergan, Inc. Bimodal molecular weight hyaluronate formulations and methods for using same
US5234914A (en) * 1991-06-11 1993-08-10 Patent Biopharmaceutics, Inc. Methods of treating hemorrhoids and anorecial disease
US5817644A (en) * 1991-07-03 1998-10-06 Hyal Pharmaceutical Corporation Targeting of dosages of medicine and therapeutic agents
US5792753A (en) * 1991-07-03 1998-08-11 Hyal Pharmaceutical Corporation Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs
US5990095A (en) * 1991-07-03 1999-11-23 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US6022866A (en) * 1991-07-03 2000-02-08 Hyal Pharmaceutical Corporation Use of hyaluronic acid and forms to prevent arterial restenosis
US6103704A (en) * 1991-07-03 2000-08-15 Hyal Pharmaceutical Corporation Therapeutic methods using hyaluronic acid
US5834444A (en) * 1991-07-03 1998-11-10 Hyal Pharmaceutical Corporation Hyaluronic acid and salts thereof inhibit arterial restenosis
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US5977088A (en) * 1991-07-03 1999-11-02 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
ATE241366T1 (de) * 1992-02-10 2003-06-15 Advanced Medical Optics Inc Zusammensetzungen von hyaluronat mit bimodalem molekulargewicht und verfahren zu deren verwendung
US6218373B1 (en) 1992-02-20 2001-04-17 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
CA2061567C (fr) * 1992-02-20 1998-02-03 Rudolf E. Falk Utilisation de l'acide hyaluronique pour reparer les dommages de reperfusion de l'ischemie
US5942498A (en) * 1992-02-20 1999-08-24 Hyal Pharmaceutical Corporation Formulations containing hyaluronic acid
US5767106A (en) * 1992-02-21 1998-06-16 Hyal Pharmaceutical Corporation Treatment of disease and conditions associated with macrophage infiltration
CA2130762C (fr) * 1994-08-24 1999-07-06 Eva Anne Turley Traitement des maladies et des troubles associes a l'infiltration par des macrophages
US6114314A (en) * 1992-02-21 2000-09-05 Hyal Pharmaceutical Corp. Formulations containing hyaluronic acid
ES2079994B1 (es) * 1992-10-07 1996-08-01 Cusi Lab Formulacion farmaceutica a base de polimixina-trimetoprim y un agente antiinflamatorio para su utilizacion topica oftalmica y otica.
IT1263144B (it) * 1993-02-04 1996-08-01 Lanfranco Callegaro Composizioni farmaceutiche comprendenti materiale spugnoso costituito da derivati esterei dell'acido ialuronico in associazione con altre sostanze farmacologicamente attive
IL108808A (en) * 1993-03-04 1996-09-12 Genzyme Ltd Controlled lowering of molecular weight of polymers
US5616568A (en) * 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
JP4010574B2 (ja) * 1994-12-05 2007-11-21 電気化学工業株式会社 皮膚外用剤
US5972326A (en) * 1995-04-18 1999-10-26 Galin; Miles A. Controlled release of pharmaceuticals in the anterior chamber of the eye
CA2154103C (fr) * 1995-07-18 1998-02-24 Samuel Simon Asculai Traitement des maladies, traumatismes ou troubles de la membrane muqueuse, et pour le soulagement de la douleur
ZA966579B (en) * 1995-08-04 1998-02-02 Wakamoto Pharma Co Ltd O/W emulsion composition for eye drops.
IT1287227B1 (it) * 1996-04-04 1998-08-04 Fidia Spa In Amministrazione S Acido ialuronico quale componente del liquido di conservazione della cornea
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US6197785B1 (en) 1997-09-03 2001-03-06 Guilford Pharmaceuticals Inc. Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity
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AR245369A1 (es) 1994-01-31
KR860008202A (ko) 1986-11-12
PH29979A (en) 1996-10-29
IE860847L (en) 1986-10-05
IL78263A0 (en) 1986-07-31
PT82342B (pt) 1988-03-03
ES8800055A1 (es) 1987-11-16
EP0197718A2 (fr) 1986-10-15
EP0197718B1 (fr) 1993-12-15
FI83966B (fi) 1991-06-14
FI861395A0 (fi) 1986-04-01
ES553714A0 (es) 1987-11-16
NO861331L (no) 1986-10-06
EP0197718B2 (fr) 2001-07-25
DE3689384D1 (de) 1994-01-27
IN165867B (fr) 1990-02-03
IT1229075B (it) 1991-07-17
DE3689384T2 (de) 1994-07-07
DE3689384T3 (de) 2003-05-15
US4736024A (en) 1988-04-05
DK149886A (da) 1986-10-06
JPS61236732A (ja) 1986-10-22
NO174277C (no) 1994-04-13
IE64440B1 (en) 1995-08-09
JPH09169667A (ja) 1997-06-30
DK149886D0 (da) 1986-04-02
FR2579895A1 (fr) 1986-10-10
FR2579895B1 (fr) 1990-11-23
ATE98495T1 (de) 1994-01-15
CA1340825C (fr) 1999-11-23
AU5566286A (en) 1986-10-16
HU204202B (en) 1991-12-30
CN85102921A (zh) 1986-10-08
FI83966C (fi) 1991-09-25
EP0555898A3 (fr) 1993-10-20
EP0197718A3 (en) 1987-09-09
JP2677778B2 (ja) 1997-11-17
ZA862463B (en) 1987-12-30
KR910006810B1 (ko) 1991-09-02
IT8547924A0 (it) 1985-04-05
FI861395A (fi) 1986-10-06
CN85102921B (zh) 1988-06-08
LU86386A1 (fr) 1986-09-02
HUT40579A (en) 1987-01-28
CA1341418C (fr) 2003-01-21
NZ215676A (en) 1989-08-29
CH672886A5 (fr) 1990-01-15
EP0555898A2 (fr) 1993-08-18

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