DE69809892T2 - N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung - Google Patents

N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung

Info

Publication number
DE69809892T2
DE69809892T2 DE69809892T DE69809892T DE69809892T2 DE 69809892 T2 DE69809892 T2 DE 69809892T2 DE 69809892 T DE69809892 T DE 69809892T DE 69809892 T DE69809892 T DE 69809892T DE 69809892 T2 DE69809892 T2 DE 69809892T2
Authority
DE
Germany
Prior art keywords
production
derivatives
hyaluronic acid
acid compounds
sulphated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69809892T
Other languages
English (en)
Other versions
DE69809892D1 (de
Inventor
David Renier
Lanfranco Callegaro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia Farmaceutici SpA
Original Assignee
Fidia Advanced Biopolymers SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITPD970064 external-priority patent/IT1291444B1/it
Priority claimed from ITPD980022 external-priority patent/ITPD980022A1/it
Application filed by Fidia Advanced Biopolymers SRL filed Critical Fidia Advanced Biopolymers SRL
Publication of DE69809892D1 publication Critical patent/DE69809892D1/de
Application granted granted Critical
Publication of DE69809892T2 publication Critical patent/DE69809892T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/043—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/049—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69809892T 1997-04-04 1998-04-03 N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung Expired - Lifetime DE69809892T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITPD970064 IT1291444B1 (it) 1997-04-04 1997-04-04 Composti n-solfatati dell'acido ialuronico e dei suoi derivati ad attivita' anticoagulante e non-trombogenica e processo per la loro
ITPD980022 ITPD980022A1 (it) 1998-02-10 1998-02-10 Composti n-solfatati dell'acido ialuronico e dei suoi derivati ad atti vita' anticoagualante e antitrombotica e processo per la preparazione
PCT/EP1998/001973 WO1998045335A1 (en) 1997-04-04 1998-04-03 N-sulphated hyaluronic acid compounds, derivatives thereof and a process for their preparation

Publications (2)

Publication Number Publication Date
DE69809892D1 DE69809892D1 (de) 2003-01-16
DE69809892T2 true DE69809892T2 (de) 2003-08-28

Family

ID=26331866

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69809892T Expired - Lifetime DE69809892T2 (de) 1997-04-04 1998-04-03 N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung

Country Status (11)

Country Link
US (2) US6579978B1 (de)
EP (1) EP0971961B1 (de)
JP (1) JP4278716B2 (de)
AT (1) ATE229038T1 (de)
AU (1) AU738788B2 (de)
CA (1) CA2285542C (de)
DE (1) DE69809892T2 (de)
DK (1) DK0971961T3 (de)
ES (1) ES2189166T3 (de)
HK (1) HK1025105A1 (de)
WO (1) WO1998045335A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10329296A1 (de) * 2003-06-24 2005-01-27 Institut Für Polymerforschung Dresden E.V. Beschichtungssystem für Biomaterialien

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITPD980037A1 (it) * 1998-02-25 1999-08-25 Fidia Advanced Biopolymers Srl Acido ialuronico solfatato e i suoi derivati legati covalentemente a polimeri sintetici pe la preparazione di biomateriali e per il rivesti
DE19813234A1 (de) * 1998-03-26 1999-09-30 Knoell Hans Forschung Ev Verfahren zur Herstellung hochsulfatierter Hyaluronsäuren
ITPD980149A1 (it) 1998-06-17 1999-12-17 Fidia Advanced Biopolymers Srl Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
ITPD980169A1 (it) * 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
JP4790911B2 (ja) 1999-01-13 2011-10-12 アルケミア オンコロジー ピーティワイ リミテッド 薬物の効力を増強するための組成物および方法
IT1306644B1 (it) 1999-04-08 2001-10-02 Fidia Advanced Biopolymers Srl Strutture tridimensionali comprendenti derivati dell'acido ialuronicoottenibili mediante la tecnica antisolvente supercritico.
WO2001009646A1 (en) * 1999-08-03 2001-02-08 Galin Miles A Polysaccharide coating of contact lenses
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
AUPQ879500A0 (en) * 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
IT1317359B1 (it) * 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl Polisaccaridi percarbossilati, quali l'acido ialuronico, processo perla loro preparazione e loro impiego in campo farmaceutico e
DE10053053A1 (de) * 2000-10-19 2002-05-16 Knoell Hans Forschung Ev Pharmazeutische Formulierungen zur Hemmung von entzündlichen Arthritiden
AU2002316696B2 (en) * 2001-07-16 2007-08-30 Depuy Products, Inc. Cartilage repair and regeneration scaffold and method
US20050042303A1 (en) * 2001-08-27 2005-02-24 Brown Tracey Jean Therapeutic protocols
ITPD20020003A1 (it) * 2002-01-11 2003-07-11 Fidia Advanced Biopolymers Srl Biomateriali a base di acido ialuronico come terapia anti-angiogenicanella cura dei tumori.
ITPD20020064A1 (it) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl Derivati esterei dell'acido ialuronico per la preparazione di idrogelda utilizzare in campo biomedico, sanitario e chirurgico e come sistem
US7816316B2 (en) 2002-11-21 2010-10-19 Chugai Seiyaku Kabushiki Kaisha Sustained release drug carrier
US7597903B2 (en) * 2002-12-02 2009-10-06 Shenkar College Of Engineering And Design Method and composition for producing catheters with antibacterial property
JP2006522135A (ja) 2003-03-31 2006-09-28 ザ ブライアム アンド ウィミンズ ホスピタル インコーポレーテッド 喘息およびアレルギーの処置のための両性イオン免疫調節剤
CA2520045A1 (en) * 2003-04-04 2004-10-14 Bayco Consulting Limited Vascular stent having a hyaluronic acid polymer coating
FR2856305B1 (fr) * 2003-06-19 2007-08-24 Inst Nat Sante Rech Med Protheses avec revetements biologiquement actifs
DE10352137A1 (de) 2003-11-04 2005-06-16 Beschorner, Katharina, Dr. Verwendung sulfatierter Hyaluronsäure
US20070118211A1 (en) * 2003-11-07 2007-05-24 Gianluca Gazza Method for preparing drug eluting medical devices and devices obtained therefrom
US8124120B2 (en) * 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
DE102004002990A1 (de) * 2004-01-21 2005-08-18 Robert Dr. Simmoteit Material und Verfahren zum Stoffaustausch und Stofftransfer
CA2570521C (en) * 2004-07-12 2013-06-25 Isto Technologies, Inc. Tissue matrix system
US8512730B2 (en) * 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
ITPD20040245A1 (it) * 2004-10-08 2005-01-08 Fidia Advanced Biopolymers Srl Biomateriali costituiti da acido ialuronico solfatato e gellano utilizzabili nella prevenzione delle adesioni spinali
ITPD20050056A1 (it) * 2005-03-02 2006-09-03 Fidia Farmaceutici Derivati ammidici del'acido ialuronico in osteoartrosi
AU2006274509B2 (en) 2005-07-27 2012-01-19 Alchemia Oncology Pty Limited Therapeutic protocols using hyaluronan
EA013877B1 (ru) 2005-09-07 2010-08-30 Алкемиа Онколоджи Пти Лимитед Терапевтические композиции, содержащие гиалуроновую кислоту и терапевтические антитела, а также способы лечения
JP2009518132A (ja) * 2005-12-07 2009-05-07 イスト・テクノロジーズ・インコーポレイテッド 軟骨修復方法
IE20060049A1 (en) * 2006-01-25 2007-08-08 Eurand Pharmaceuticals Ltd A novel drug delivery system: use of hyaluronic acid as a carrier moleclue for different classes of therapeutic active agents
WO2007092451A2 (en) 2006-02-06 2007-08-16 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
JP2007275388A (ja) * 2006-04-10 2007-10-25 Toshie Tsuchiya 細胞の分化を促進し、かつ炎症を抑制する人工器官
ITPD20060219A1 (it) 2006-05-31 2007-12-01 Fidia Farmaceutici Composizioni farmaceutiche contenenti acido ialuronico solfatato nel trattamento dell'osteoartrosi
JP5088864B2 (ja) * 2007-03-16 2012-12-05 オリンパス株式会社 生体組織補填材とその製造方法
US8278406B2 (en) * 2007-04-27 2012-10-02 Wisconsin Alumni Research Foundation Bioactive and biocompatible polyurethane-buthanediol-glycosaminoglycan salt copolymers
US8133553B2 (en) 2007-06-18 2012-03-13 Zimmer, Inc. Process for forming a ceramic layer
US8309521B2 (en) 2007-06-19 2012-11-13 Zimmer, Inc. Spacer with a coating thereon for use with an implant device
ITMI20071267A1 (it) 2007-06-22 2008-12-23 Fidia Farmaceutici Uso di coniugati dell'acido ialuronico nel trattamento locale di malattie cutanee iperproliferative
US8608049B2 (en) 2007-10-10 2013-12-17 Zimmer, Inc. Method for bonding a tantalum structure to a cobalt-alloy substrate
WO2009062132A2 (en) 2007-11-09 2009-05-14 California Institute Of Technology Immunomodulating compounds and related compositions and methods
US20110130473A1 (en) 2007-11-13 2011-06-02 Bio-Technology General (Israel) Ltd. Dilute filtration sterilization process for viscoelastic biopolymers
US8343942B2 (en) 2008-04-04 2013-01-01 University Of Utah Research Foundation Methods for treating interstitial cystitis
BRPI0909849A2 (pt) 2008-04-04 2015-10-06 Univ Utah Res Found éteres semi-sintéticos de glicosaminoglicosanos e métodos para fazê-los e usá-los
JP5722217B2 (ja) 2008-09-02 2015-05-20 アラーガン・ホールディングス・フランス・ソシエテ・パール・アクシオン・サンプリフィエＡｌｌｅｒｇａｎ Ｈｏｌｄｉｎｇｓ Ｆｒａｎｃｅ Ｓ．Ａ．Ｓ． ヒアルロン酸および／またはその誘導体の糸、その作製方法、ならびにその使用
IT1397247B1 (it) * 2009-05-14 2013-01-04 Fidia Farmaceutici Nuovi agenti regolatori dell'attivita' citochinica
IT1397246B1 (it) 2009-05-14 2013-01-04 Fidia Farmaceutici Nuovi medicamenti ad uso topico a base di acido ialuronico solfatato come agente attivante o inibente l'attivita' citochinica
EP2498763A4 (de) 2009-11-09 2015-10-07 Spotlight Technology Partners Llc Hydrogele auf polysaccharidbasis
JP2013509963A (ja) 2009-11-09 2013-03-21 スポットライト テクノロジー パートナーズ エルエルシー 断片化ヒドロゲル
ES2694100T3 (es) 2010-04-07 2018-12-18 California Institute Of Technology Vehículo para distribuir un compuesto en una membrana mucosa y composiciones, procedimientos y sistemas relacionados
WO2011135578A1 (en) 2010-04-28 2011-11-03 Chetan Balar Composition comprising chitin and tinosporin for use in the treatment of viral diseases
US8546353B2 (en) * 2010-05-06 2013-10-01 Glykos Finland Oy Compounds and combinations
JP2013530949A (ja) 2010-05-20 2013-08-01 エル ラウンド ジューン 抗原特異的Ｔｒｅｇ並びに関連する組成物、方法及びシステム
WO2012087826A2 (en) * 2010-12-22 2012-06-28 Boston Scientific Scimed, Inc. Urological medical devices
EP2688402B1 (de) 2011-03-23 2018-10-24 University of Utah Research Foundation Mittel zur behandlung bzw. prävention von harnwegsentzündungen
WO2013009945A1 (en) 2011-07-12 2013-01-17 The Brigham And Women's Hospital, Inc. Lipid-containing psa compositions, methods of isolation and methods of use thereof
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
EP3569226A1 (de) 2012-12-04 2019-11-20 Phosphorex, Inc. Mikropartikel und nanopartikel mit negativen oberflächenladungen
US10000582B2 (en) * 2013-04-02 2018-06-19 The Regents Of The University Of California Ethylsulfonated hyaluronic acid biopolymers and methods of use thereof
JP2016521284A (ja) 2013-05-10 2016-07-21 カリフォルニア インスティチュート オブ テクノロジー 大腸ガンのプロバイオティクスによる防止および処置
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
WO2016201342A1 (en) 2015-06-10 2016-12-15 California Institute Of Technology Sepsis treatment and related compositions methods and systems
CA2997211A1 (en) 2015-08-19 2017-02-23 President And Fellows Of Harvard College Lipidated psa compositions and methods
RU2018141386A (ru) 2016-04-27 2020-05-27 Аника Терапьютикс, Инк. Композиция для применения в лечении дегенерации сухожилий
WO2018014012A1 (en) 2016-07-15 2018-01-18 President And Fellows Of Harvard College Glycolipid compositions and methods of use
WO2018053111A1 (en) 2016-09-15 2018-03-22 University Of Utah Research Foundation In situ gelling compositions for the treatment or prevention of inflammation and tissue damage
WO2019002370A1 (en) * 2017-06-28 2019-01-03 Nestlé Skin Health Sa GLYCOSAMINOGLYCANES RETICULATED AND FUNCTIONALIZED
IT201700122135A1 (it) * 2017-10-26 2019-04-26 Jointherapeutics S R L Acido ialuronico funzionalizzato o suo derivato nel trattamento di stati infiammatori
WO2020016820A1 (en) 2018-07-18 2020-01-23 Bio-Technology General (Israel) Ltd. Process of, and arrangement for, sterile filtering a non-newtonian liquid and formulation of a liquid obtainable thereby
KR102248721B1 (ko) * 2018-09-13 2021-05-07 주식회사 엘지화학 황산화 히알루론산 기반의 하이드로겔 및 이를 포함하는 약제학적 조성물
IT202000032243A1 (it) 2020-12-23 2022-06-23 Fidia Farm Spa Nuovi agenti antivirali
IT202100012737A1 (it) 2021-05-18 2022-11-18 Jointherapeutics S R L Miscele di polisaccaridi e poliamminosaccaridi con proprietà reologiche migliorate
IT202100013787A1 (it) 2021-05-27 2022-11-27 Farmigea Spa Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery
IT202200004613A1 (it) 2022-03-10 2023-09-10 Cmed Aesthetics S R L “procedimento di preparazione di prodotti sterili”

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1229075B (it) * 1985-04-05 1991-07-17 Fidia Farmaceutici Medicamenti per uso topico, ottenuti tramite l'impiego dell'acido ialuronico
US4784991A (en) * 1986-03-14 1988-11-15 Bio-Technology General Corp. Heavy metal salts of hyaluronic acid and their use as antimicrobial agents
IT1198449B (it) * 1986-10-13 1988-12-21 F I D I Farmaceutici Italiani Esteri di alcoli polivalenti di acido ialuronico
IT1217458B (it) * 1988-05-02 1990-03-22 Crinos Ind Farmacoriologica S Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche
IT1219587B (it) * 1988-05-13 1990-05-18 Fidia Farmaceutici Polisaccaridi carbossiilici autoreticolati
US6458774B1 (en) * 1989-02-24 2002-10-01 Richter Gedeon Vegyeszeti Gyar Rt. Compositions containing hyaluronic acid associates and a process for preparing same
DE4021066A1 (de) * 1990-07-03 1992-01-09 Hoechst Ag Langzeitprophylaxe gegen erkrankungen, die durch viren oder durch unkonventionelle viren verursacht werden
JP2855307B2 (ja) * 1992-02-05 1999-02-10 生化学工業株式会社 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法
IT1260154B (it) * 1992-07-03 1996-03-28 Lanfranco Callegaro Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn)
US5879359A (en) * 1992-08-03 1999-03-09 Fidia S.P.A. Biodegradable guide channels comprised of esters of hyaluronic acid for use in tissue repair as surgical aids
IT1263316B (it) * 1993-02-12 1996-08-05 Fidia Advanced Biopolymers Srl Tessuto non tessuto multistrato in cui uno degli strati e' costituito essenzialmente da esteri dell'acido ialuronico
BE1007273A3 (fr) 1993-07-16 1995-05-09 Lhoist Rech & Dev Sa Procede de preparation de derives magnesiens.
ITPD940054A1 (it) * 1994-03-23 1995-09-23 Fidia Advanced Biopolymers Srl Polisaccaridi solfatati
US6017901A (en) * 1995-05-10 2000-01-25 Fidia Advanced Bioplymers S.R.L. Heavy metal salts of succinic acid hemiesters with hyaluronic acid or hyaluronic acid esters, a process for their preparation and relative pharmaceutical compositions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10329296A1 (de) * 2003-06-24 2005-01-27 Institut Für Polymerforschung Dresden E.V. Beschichtungssystem für Biomaterialien
DE10329296B4 (de) * 2003-06-24 2007-07-12 Leibniz-Institut Für Polymerforschung Dresden E.V. Beschichtungssystem für Biomaterialien

Also Published As

Publication number Publication date
WO1998045335A1 (en) 1998-10-15
HK1025105A1 (en) 2000-11-03
DE69809892D1 (de) 2003-01-16
AU7429198A (en) 1998-10-30
JP2001522385A (ja) 2001-11-13
ES2189166T3 (es) 2003-07-01
CA2285542C (en) 2007-07-17
EP0971961A1 (de) 2000-01-19
DK0971961T3 (da) 2003-03-24
ATE229038T1 (de) 2002-12-15
US6833363B2 (en) 2004-12-21
US20020037874A1 (en) 2002-03-28
EP0971961B1 (de) 2002-12-04
AU738788B2 (en) 2001-09-27
JP4278716B2 (ja) 2009-06-17
US6579978B1 (en) 2003-06-17
CA2285542A1 (en) 1998-10-15

Similar Documents

Publication Publication Date Title
ATE229038T1 (de) N-sulfatierte hyaluronsäureverbindungen, ihre derivate und verfahren zu ihrer herstellung
DE50310322D1 (de) Hemokompatibel beschichtete medizinprodukte, deren herstellung und verwendung
IT1317358B1 (it) Derivati cross-linkati dell'acido ialuronico.
AU2072795A (en) Novel heparin-like sulfated polysaccharides
DE69513458D1 (de) Verfahren zur Herstellung von hochmolekularen Milchsäure-Copolyestern
DE59506068D1 (de) Verfahren zur Herstellung niedermolekularer Polysaccharidether
BR0007447A (pt) 2-aril-3-(heteroaril)-imidazo[1,2-a]pirimidinas substituìdas, composições farmacêuticas e métodos
ATE242018T1 (de) Poröse kompositmatrix, deren herstellung und verwendung
ATE170833T1 (de) Polysiloxan-zusammensetzungen, verfahren zu ihrer herstellung und ihre verwendung für beschichtungen
BR0303452A (pt) Composição polimérica, partìcula compósita, composição aquosa, e, partìcula polimérica de estágios múltiplos
DE69820933D1 (de) Biostabile, wässrige Lacke und Verfahren zur deren Herstellung
ATE419022T1 (de) Hydrophobe mehrkomponenten-heparinkonjugate, ein verfahren zur ihrer herstellung und verwendung
ES2021905A6 (es) Procedimiento para la preparacion de fracciones de sulfato de dermatano.
DE69901800D1 (de) Kovalent an polyurethane gebundene sulphatisierte hyaluronsäure und sulphatisierte hyaluronsäurederivate und verfahren zu ihrer herstellung
IT1290814B1 (it) Glicosaminoglicani aventi elevata attivita' antitrombotica
DE60022052D1 (de) Zusammensetzungen geeignet zur herstellung von elastomeren artikeln
ATE150468T1 (de) Dermatansulfatoligosaccharide, verfahren zu ihrer herstellung und diese enthaltende phamazeutische zusammensetzungen
DE3587907D1 (de) Mikrobielle zusammensetzung und deren herstellung.
DE69927251D1 (de) Verfahren zur herstellung von purinderivaten und dessen zwischenprodukte
DE69313826D1 (de) Sulfatierte polysaccharide, verfahren zu deren herstellung, pharmazeutische zusammensetzung und ihre verwendung
DE59700225D1 (de) Kontinuierliches Verfahren zur Herstellung lagerstabiler Organopolysiloxanzusammensetzungen
IL171981A (en) Glycosaminoglycans for treatment of emotional dysfunctions
DE59005411D1 (de) Beschichtungsmassen auf der Basis von (Poly)borosiloxanen und Verfahren zur Herstellung von gläsernen Überzügen sowie deren Verwendung.
JPS643116A (en) Plaster for patch
DE59504617D1 (de) Verfahren zur Herstellung von Thiophen-2,5-dicarbonsäure und deren Dichlorid

Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: FIDIA FARMACEUTICI S.P.A., ABANO TERME, PADUA/PADO