ATE419022T1 - Hydrophobe mehrkomponenten-heparinkonjugate, ein verfahren zur ihrer herstellung und verwendung - Google Patents

Hydrophobe mehrkomponenten-heparinkonjugate, ein verfahren zur ihrer herstellung und verwendung

Info

Publication number
ATE419022T1
ATE419022T1 AT00973237T AT00973237T ATE419022T1 AT E419022 T1 ATE419022 T1 AT E419022T1 AT 00973237 T AT00973237 T AT 00973237T AT 00973237 T AT00973237 T AT 00973237T AT E419022 T1 ATE419022 T1 AT E419022T1
Authority
AT
Austria
Prior art keywords
heparin conjugates
hydrophobic
production
present
conjugates
Prior art date
Application number
AT00973237T
Other languages
English (en)
Inventor
Young Ro Byun
Hyun Tae Moon
Original Assignee
Mediplex Corp Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediplex Corp Korea filed Critical Mediplex Corp Korea
Application granted granted Critical
Publication of ATE419022T1 publication Critical patent/ATE419022T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0081—Reaction with amino acids, peptides, or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Polymers & Plastics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Surgery (AREA)
  • Materials For Medical Uses (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT00973237T 2000-10-24 2000-11-03 Hydrophobe mehrkomponenten-heparinkonjugate, ein verfahren zur ihrer herstellung und verwendung ATE419022T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-2000-0062668A KR100378109B1 (ko) 2000-10-24 2000-10-24 소수성 다중복합 헤파린 결합체, 그의 제조방법 및 용도

Publications (1)

Publication Number Publication Date
ATE419022T1 true ATE419022T1 (de) 2009-01-15

Family

ID=19695171

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00973237T ATE419022T1 (de) 2000-10-24 2000-11-03 Hydrophobe mehrkomponenten-heparinkonjugate, ein verfahren zur ihrer herstellung und verwendung

Country Status (9)

Country Link
US (1) US7129224B1 (de)
EP (1) EP1333871B1 (de)
JP (1) JP3927118B2 (de)
KR (1) KR100378109B1 (de)
CN (1) CN1209171C (de)
AT (1) ATE419022T1 (de)
AU (1) AU2001211769A1 (de)
DE (1) DE60041283D1 (de)
WO (1) WO2002034312A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100449889B1 (ko) * 2001-08-30 2004-09-22 동국제약 주식회사 음이온 고분자와 인지질의 결합체가 함유된 인지질 리포좀및 그의 제조방법과 응용
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
US6702850B1 (en) 2002-09-30 2004-03-09 Mediplex Corporation Korea Multi-coated drug-eluting stent for antithrombosis and antirestenosis
US8293890B2 (en) 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
US7563780B1 (en) * 2004-06-18 2009-07-21 Advanced Cardiovascular Systems, Inc. Heparin prodrugs and drug delivery stents formed therefrom
WO2006067959A1 (ja) 2004-12-21 2006-06-29 Shinshu University 医療機器
ATE532540T1 (de) 2005-05-04 2011-11-15 Suprapolix Bv Modulare bioresorbierbare oder biomedizinische biologisch aktive supramolekulare stoffe
WO2008063057A2 (en) 2006-11-20 2008-05-29 Suprapolix B.V. Supramolecular polymers from low-melting, easily processable building blocks
US20080200421A1 (en) * 2007-02-21 2008-08-21 Zhao Jonathon Z Coating for a medical device having an anti-thrombotic conjugate
US20090281059A1 (en) * 2007-02-21 2009-11-12 Robert Falotico Coating for a medical device having an anti-thrombotic conjugate
US8628789B2 (en) 2007-03-23 2014-01-14 Suprapolix, B.V. Strong reversible hydrogels
US9693841B2 (en) 2007-04-02 2017-07-04 Ension, Inc. Surface treated staples, sutures and dental floss and methods of manufacturing the same
US8114465B2 (en) 2007-04-02 2012-02-14 Ension, Inc. Process for preparing a substrate coated with a biomolecule
US8383156B2 (en) 2007-04-30 2013-02-26 Cordis Corporation Coating for a medical device having an anti-thrombotic conjugate
US8088753B2 (en) * 2007-06-29 2012-01-03 Mediplex Corporation, Korea Heparin conjugates and methods
WO2009005258A2 (en) * 2007-06-29 2009-01-08 Mediplex Corp. Heparin conjugates and methods
US20090018646A1 (en) * 2007-07-10 2009-01-15 Zhao Jonathon Z Coating Employing an Anti-Thrombotic Conjugate
US20100021538A1 (en) * 2008-02-29 2010-01-28 Youngro Byun Pharmaceutical compositions containing heparin derivatives
EP2310376B1 (de) 2008-07-04 2014-11-05 SupraPolix B.V. Supramolekulare verbindungen mit hohem durchfluss
GB201004101D0 (en) 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities
US9446216B2 (en) 2010-10-14 2016-09-20 Medtronic, Inc. Cannular device and method of manufacture
US9006386B2 (en) 2010-11-05 2015-04-14 Suprapolix B.V. Process for the preparation of a supramolecular polymer
ES2881278T3 (es) * 2013-04-26 2021-11-29 Biointeractions Ltd Recubrimientos bioactivos
WO2014189835A2 (en) * 2013-05-20 2014-11-27 Yale University Anti-thrombogenic grafts
US9339770B2 (en) 2013-11-19 2016-05-17 Applied Membrane Technologies, Inc. Organosiloxane films for gas separations
KR101881541B1 (ko) * 2016-07-25 2018-07-24 가톨릭대학교산학협력단 골형성 또는 골 유착능 향상을 위한 생분해성 고분자의 표면처리 방법
CN106986955B (zh) * 2017-04-28 2019-04-09 华南理工大学 一种肝素的叠氮化修饰方法和叠氮化肝素及应用
CN109925536B (zh) * 2017-12-15 2021-01-26 先健科技(深圳)有限公司 可吸收铁基植入式器械
TWI653993B (zh) 2018-03-20 2019-03-21 國立臺灣大學 血管取代物
CN114767325A (zh) * 2022-04-11 2022-07-22 江苏理工学院 一种表面具有微结构的人造血管及其制备方法
CN115990297B (zh) * 2023-03-09 2023-11-07 上海宏普医疗器械有限公司 一种基于ptfe材料的肝素抗凝涂层及其制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5357288A (en) 1976-11-04 1978-05-24 Nippon Zeon Co Ltd Anticoagulant medical polymer its preparation and use
JPS6229532A (ja) * 1985-07-31 1987-02-07 Koken:Kk 抗血栓性医用材料及びその製造方法
JPH01262869A (ja) 1988-04-15 1989-10-19 Ube Ind Ltd 抗血液凝固性医療用具
US5270046A (en) * 1988-09-27 1993-12-14 Ube Industries, Ltd. Heparin bound anti-thrombotic material
US5069899A (en) * 1989-11-02 1991-12-03 Sterilization Technical Services, Inc. Anti-thrombogenic, anti-microbial compositions containing heparin
GB9009570D0 (en) * 1990-04-27 1990-06-20 Biocompatibles Ltd Antithrombogenic polymers
DE4217917A1 (de) * 1992-05-30 1993-12-02 Job Prof Dr Med Harenberg Immobilisation von chemisch kovalent gebundenem Heparin an Polymere mit Arylresten im Polymer
FR2723847A1 (fr) * 1994-08-29 1996-03-01 Debiopharm Sa Compositions antithrombotiques et non hemorragiques a base d'heparine, procede pour leur preparation et applications therapeutiques.
JP3341503B2 (ja) * 1994-11-09 2002-11-05 東レ株式会社 抗血栓性医療材料およびそれを用いたカテーテル
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
KR0175975B1 (ko) * 1995-11-03 1999-05-15 김은영 항응혈성 술폰산화 블록 공중합체 및 이로부터 제조된 의료 용품
FR2752843B1 (fr) * 1996-08-30 1998-10-16 Sod Conseils Rech Applic Copolymeres reticules a base de polymeres polycarboxyliques et leur utilisation comme support de composition pharmaceutique
US6071532A (en) * 1996-10-15 2000-06-06 Emory University Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
US6229009B1 (en) * 1997-08-29 2001-05-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Polycarboxylic based cross-linked copolymers
US5955588A (en) * 1997-12-22 1999-09-21 Innerdyne, Inc. Non-thrombogenic coating composition and methods for using same
US6258371B1 (en) * 1998-04-03 2001-07-10 Medtronic Inc Method for making biocompatible medical article
DE19981169B4 (de) * 1998-05-28 2007-09-13 Mediplex Corporation, Korea Kovalent an Gallensäuren oder Sterine gebundenes Heparin, dessen Verwendung und diese enthaltende pharmazeutische Zusammensetzung
KR100314496B1 (ko) * 1998-05-28 2001-11-22 윤동진 항혈전성이 있는 헤파린 유도체, 그의 제조방법 및 용도
JP4358331B2 (ja) * 1998-11-12 2009-11-04 Ｊｕｎｋｅｎ Ｍｅｄｉｃａｌ株式会社 透明性の優れた抗血液凝固性材料および抗血液凝固性材料を塗布した医療用具
US6702850B1 (en) * 2002-09-30 2004-03-09 Mediplex Corporation Korea Multi-coated drug-eluting stent for antithrombosis and antirestenosis

Also Published As

Publication number Publication date
EP1333871A1 (de) 2003-08-13
CN1209171C (zh) 2005-07-06
EP1333871B1 (de) 2008-12-31
AU2001211769A1 (en) 2002-05-06
CN1455687A (zh) 2003-11-12
EP1333871A4 (de) 2004-07-07
JP3927118B2 (ja) 2007-06-06
WO2002034312A1 (en) 2002-05-02
KR20020031894A (ko) 2002-05-03
DE60041283D1 (de) 2009-02-12
KR100378109B1 (ko) 2003-03-29
JP2004512397A (ja) 2004-04-22
US7129224B1 (en) 2006-10-31

Similar Documents

Publication Publication Date Title
ATE419022T1 (de) Hydrophobe mehrkomponenten-heparinkonjugate, ein verfahren zur ihrer herstellung und verwendung
DE60025833D1 (de) Synthetische melanine auf pflanzenbasis, verfahren zu deren herstellung sowie diese enthaltende zusammensetzungen
ATE241948T1 (de) Wasserabsorbierende polymere mit hohlraumverbindungen, verfahren zu deren herstellung und deren verwendung
DE69737834D1 (de) Folienzusammensetzungen aus Polymerisat zur Herstellung von Kapseln
DE502005002359D1 (de) Verfahren zur herstellung wässriger wirkstoffzusammensetzungen von in wasser schwer löslichen wirkstoffen
DE60328421D1 (de) Verfahren zur herstellung von super-hydrophoben oberflächen, daraus hergestellte oberflächen und deren verwendung
DE69917784D1 (de) Flüssige chitosan-enthaltende zusammensetzungen und verfahren zur herstellung und verwendung
DE60335608D1 (de) Zusammensetzungen zur abgabe von therapeutika und anderen materialien und verfahren zu ihrer herstellung und verwendung
WO2005028631A3 (en) A novel biodegradable elastomeric scaffold for tissue engineering and light scattering fingerprinting methods for testing the same
DE602004015570D1 (de) Makromolekulare ketoaldehyden und verfahren zu dessen herstellung
DE602004015907D1 (de) Konjugierte Dienamide, Verfahren zur deren Herstellung, diese enthaltende Zusammensetzungen sowie deren Verwendung
ATE426628T1 (de) Polyurethanderivatzusammensetzungen und verfahren zu ihrer herstellung
DE60012127D1 (de) Verfahren zur Herstellung von Perfluoropolyoxyalkylenen mit Hydroxylendgruppen
ATE327257T1 (de) Fester, stabiler und konzentrierter biologisch verdaulicher komplex von orthokieselsäure und prozess zur dessen herstellung
DE60108372D1 (de) Verfahren zur herstellung fester reinigungsmittel-komponenten
DE50100858D1 (de) Verfahren zur Herstellung von Uretdionpolysocyanaten mit verbesserter Monomerenstabilität
DE69931367D1 (de) Konjugierter dien-kautschuk, verfahren zu dessen herstellung und kautschukzusammensetzung
DE60115971D1 (de) Verfahren zur Herstellung von Cellulosepolymeren
ATE370981T1 (de) Verfahren zur herstellung von gut in wasser redispergierbaren polymerisatpulvern
DE602005009978D1 (de) Verfahren zur herstellung von zwei- und dreidimensionalen polymergerüsten
DE60018982D1 (de) Harzadditiv-zusammensetzung und verfahren zu dessen herstellung
DE60139702D1 (de) Zusammensetzungen aus lignin und verfahren zu ihrer herstellung und verwendung
DE602004023316D1 (de) Verfahren zur herstellung von aspartaten
DE69118294D1 (de) Verfahren zur Herstellung von im Wasser schwerlöslichen Düngergranulaten
DE60025096D1 (de) Verfahren zur herstellung von n,n'-dialkylalkandiaminen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties