AU2001211769A1 - Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof - Google Patents

Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof

Info

Publication number
AU2001211769A1
AU2001211769A1 AU2001211769A AU1176901A AU2001211769A1 AU 2001211769 A1 AU2001211769 A1 AU 2001211769A1 AU 2001211769 A AU2001211769 A AU 2001211769A AU 1176901 A AU1176901 A AU 1176901A AU 2001211769 A1 AU2001211769 A1 AU 2001211769A1
Authority
AU
Australia
Prior art keywords
hydrophobic
heparin conjugates
preparing method
present
conjugates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001211769A
Inventor
Young Ro Byun
Hyun Tae Moon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mediplex Corp Korea
Original Assignee
Mediplex Corp Korea
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediplex Corp Korea filed Critical Mediplex Corp Korea
Publication of AU2001211769A1 publication Critical patent/AU2001211769A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0081—Reaction with amino acids, peptides, or proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Peptides Or Proteins (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides hydrophobic heparin conjugates that are soluble in organic solvents but not in water, a method of preparing them, and a method of using them. Particularly, the present invention provides hydrophobic heparin conjugates that are prepared by covalently binding a polymer to heparin and a hydrophobic agent to the polymer. The hydrophobic heparin conjugates of the present invention maintain a good antithrombogenic effect and are insoluble in water due to their hydrophobicity, so they can be effectively used as coating agents for modifying the surfaces of medical devices.
AU2001211769A 2000-10-24 2000-11-03 Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof Abandoned AU2001211769A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR0062668 2000-10-24
KR10-2000-0062668A KR100378109B1 (en) 2000-10-24 2000-10-24 Hydrophobic multicomponant heparin conjugates, a preparing method and a use thereof
PCT/KR2000/001255 WO2002034312A1 (en) 2000-10-24 2000-11-03 Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof

Publications (1)

Publication Number Publication Date
AU2001211769A1 true AU2001211769A1 (en) 2002-05-06

Family

ID=19695171

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001211769A Abandoned AU2001211769A1 (en) 2000-10-24 2000-11-03 Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof

Country Status (9)

Country Link
US (1) US7129224B1 (en)
EP (1) EP1333871B1 (en)
JP (1) JP3927118B2 (en)
KR (1) KR100378109B1 (en)
CN (1) CN1209171C (en)
AT (1) ATE419022T1 (en)
AU (1) AU2001211769A1 (en)
DE (1) DE60041283D1 (en)
WO (1) WO2002034312A1 (en)

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KR100449889B1 (en) * 2001-08-30 2004-09-22 동국제약 주식회사 Liposome for Containing Anion Polymer and Phospholipid and Manufacturing Method the Same and Application
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
US6702850B1 (en) * 2002-09-30 2004-03-09 Mediplex Corporation Korea Multi-coated drug-eluting stent for antithrombosis and antirestenosis
US8293890B2 (en) 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
US7563780B1 (en) * 2004-06-18 2009-07-21 Advanced Cardiovascular Systems, Inc. Heparin prodrugs and drug delivery stents formed therefrom
EP1829567A4 (en) 2004-12-21 2010-07-21 Univ Shinshu Medical instrument
US8883188B2 (en) 2005-05-04 2014-11-11 Suprapolix B.V. Modular bioresorbable or biomedical, biologically active supramolecular materials
EP2087027B1 (en) 2006-11-20 2011-10-05 SupraPolix B.V. Supramolecular polymers from low-melting, easily processable building blocks
US20090281059A1 (en) 2007-02-21 2009-11-12 Robert Falotico Coating for a medical device having an anti-thrombotic conjugate
US20080200421A1 (en) 2007-02-21 2008-08-21 Zhao Jonathon Z Coating for a medical device having an anti-thrombotic conjugate
US8628789B2 (en) 2007-03-23 2014-01-14 Suprapolix, B.V. Strong reversible hydrogels
US9693841B2 (en) 2007-04-02 2017-07-04 Ension, Inc. Surface treated staples, sutures and dental floss and methods of manufacturing the same
US8114465B2 (en) 2007-04-02 2012-02-14 Ension, Inc. Process for preparing a substrate coated with a biomolecule
US8383156B2 (en) 2007-04-30 2013-02-26 Cordis Corporation Coating for a medical device having an anti-thrombotic conjugate
EP2173359A2 (en) * 2007-06-29 2010-04-14 Mediplex Corp. Heparin conjugates and methods
US8088753B2 (en) * 2007-06-29 2012-01-03 Mediplex Corporation, Korea Heparin conjugates and methods
US20090018646A1 (en) 2007-07-10 2009-01-15 Zhao Jonathon Z Coating Employing an Anti-Thrombotic Conjugate
US20100021538A1 (en) * 2008-02-29 2010-01-28 Youngro Byun Pharmaceutical compositions containing heparin derivatives
EP2310376B1 (en) 2008-07-04 2014-11-05 SupraPolix B.V. High flow supramolecular compounds
GB201004101D0 (en) 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities
US9446216B2 (en) 2010-10-14 2016-09-20 Medtronic, Inc. Cannular device and method of manufacture
EP2450394B1 (en) 2010-11-05 2017-06-07 SupraPolix B.V. A process for the preparation of a supramolecular polymer
BR112015027122B1 (en) * 2013-04-26 2020-09-29 Biointeractions Limited COMPOUND, POLYMERIC COATING, MEDICAL DEVICE, METHOD FOR PRODUCTION OF A POLYMER, AND MIXTURE OF POLYMERS
ES2829412T3 (en) * 2013-05-20 2021-05-31 Univ Yale Antithrombogenic grafts
US9339770B2 (en) 2013-11-19 2016-05-17 Applied Membrane Technologies, Inc. Organosiloxane films for gas separations
KR101881541B1 (en) * 2016-07-25 2018-07-24 가톨릭대학교산학협력단 Surface treatment method of biodegradable polymer for improvement of osteogenesis or osseointegration
CN106986955B (en) * 2017-04-28 2019-04-09 华南理工大学 The Azide method of modifying and Azide heparin of a kind of heparin and application
CN109925536B (en) * 2017-12-15 2021-01-26 先健科技(深圳)有限公司 Absorbable iron-based implantable device
TWI653993B (en) 2018-03-20 2019-03-21 國立臺灣大學 Vascular substitute
CN114767325A (en) * 2022-04-11 2022-07-22 江苏理工学院 Artificial blood vessel with microstructure on surface and preparation method thereof
CN115990297B (en) * 2023-03-09 2023-11-07 上海宏普医疗器械有限公司 Heparin anticoagulation coating based on PTFE material and preparation method thereof

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JPS5357288A (en) * 1976-11-04 1978-05-24 Nippon Zeon Co Ltd Anticoagulant medical polymer its preparation and use
JPS6229532A (en) * 1985-07-31 1987-02-07 Koken:Kk Antithrombogenetic medical material and production thereof
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JP3341503B2 (en) * 1994-11-09 2002-11-05 東レ株式会社 Antithrombotic medical material and catheter using the same
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KR0175975B1 (en) * 1995-11-03 1999-05-15 김은영 Block-copolymers with sulfonic acid for anti-coagulation and medical articles produced therefrom
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US6071532A (en) * 1996-10-15 2000-06-06 Emory University Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
US6229009B1 (en) * 1997-08-29 2001-05-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Polycarboxylic based cross-linked copolymers
US5955588A (en) * 1997-12-22 1999-09-21 Innerdyne, Inc. Non-thrombogenic coating composition and methods for using same
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WO1999061481A1 (en) * 1998-05-28 1999-12-02 Mediplex Corporation, Korea Amphiphilic polysaccharide derivatives
JP4358331B2 (en) * 1998-11-12 2009-11-04 Ｊｕｎｋｅｎ Ｍｅｄｉｃａｌ株式会社 Anti-blood coagulation material with excellent transparency and medical device coated with anti-coagulation material
US6702850B1 (en) * 2002-09-30 2004-03-09 Mediplex Corporation Korea Multi-coated drug-eluting stent for antithrombosis and antirestenosis

Also Published As

Publication number Publication date
KR20020031894A (en) 2002-05-03
EP1333871B1 (en) 2008-12-31
EP1333871A4 (en) 2004-07-07
CN1209171C (en) 2005-07-06
CN1455687A (en) 2003-11-12
EP1333871A1 (en) 2003-08-13
JP3927118B2 (en) 2007-06-06
ATE419022T1 (en) 2009-01-15
JP2004512397A (en) 2004-04-22
KR100378109B1 (en) 2003-03-29
US7129224B1 (en) 2006-10-31
WO2002034312A1 (en) 2002-05-02
DE60041283D1 (en) 2009-02-12

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