DE69002795T2 - Stabilisierte, den epidermalen Wachstumsfaktor enthaltende Mittel. - Google Patents

Stabilisierte, den epidermalen Wachstumsfaktor enthaltende Mittel.

Info

Publication number
DE69002795T2
DE69002795T2 DE90305185T DE69002795T DE69002795T2 DE 69002795 T2 DE69002795 T2 DE 69002795T2 DE 90305185 T DE90305185 T DE 90305185T DE 69002795 T DE69002795 T DE 69002795T DE 69002795 T2 DE69002795 T2 DE 69002795T2
Authority
DE
Germany
Prior art keywords
growth factor
epidermal growth
agents containing
stabilized
stabilized agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE90305185T
Other languages
English (en)
Other versions
DE69002795D1 (de
Inventor
John K Cini
Amy L Finkenaur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethicon Inc
Original Assignee
Ethicon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethicon Inc filed Critical Ethicon Inc
Publication of DE69002795D1 publication Critical patent/DE69002795D1/de
Application granted granted Critical
Publication of DE69002795T2 publication Critical patent/DE69002795T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/315—Zinc compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
DE90305185T 1989-05-16 1990-05-15 Stabilisierte, den epidermalen Wachstumsfaktor enthaltende Mittel. Expired - Lifetime DE69002795T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/353,131 US5130298A (en) 1989-05-16 1989-05-16 Stabilized compositions containing epidermal growth factor

Publications (2)

Publication Number Publication Date
DE69002795D1 DE69002795D1 (de) 1993-09-23
DE69002795T2 true DE69002795T2 (de) 1994-01-13

Family

ID=23387889

Family Applications (1)

Application Number Title Priority Date Filing Date
DE90305185T Expired - Lifetime DE69002795T2 (de) 1989-05-16 1990-05-15 Stabilisierte, den epidermalen Wachstumsfaktor enthaltende Mittel.

Country Status (11)

Country Link
US (1) US5130298A (de)
EP (1) EP0398619B1 (de)
JP (1) JP2763815B2 (de)
KR (1) KR900017580A (de)
AU (1) AU630952B2 (de)
CA (1) CA2016659C (de)
DE (1) DE69002795T2 (de)
DK (1) DK0398619T3 (de)
ES (1) ES2058799T3 (de)
GR (1) GR1000392B (de)
PT (1) PT94037B (de)

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WO1993003757A1 (en) * 1991-08-16 1993-03-04 Chiron Corporation Muteins of epidermal growth factor exhibiting enhanced binding at low ph
US5618544A (en) * 1992-08-12 1997-04-08 Bays-Brown Dermatologics, Inc. Method of decreasing cutaneous senescence
US5759548A (en) * 1993-11-30 1998-06-02 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
WO1995022560A1 (en) * 1994-02-22 1995-08-24 The Syntex-Synergen Neuroscience Joint Venture Pharmaceutical formulations of cntf
US6048545A (en) * 1994-06-24 2000-04-11 Biozone Laboratories, Inc. Liposomal delivery by iontophoresis
CN1043732C (zh) * 1994-12-22 1999-06-23 大连医科大学 治疗口腔糜烂面的新型药膜
EP0861089B1 (de) * 1995-11-13 2002-07-17 Medtronic MiniMed, Inc. Verfahren und zusammensetzungen zur verabreichung monomerer proteine
US6593456B1 (en) * 1996-11-06 2003-07-15 The Regents Of The University Of California Tumor necrosis factor receptor releasing enzyme
ATE403714T1 (de) 1996-11-06 2008-08-15 Univ California Tumor necrosis factor rezeptor abspaltendes enzym,dessen zubereitungen und verwendungen
US20050191661A1 (en) * 1996-11-06 2005-09-01 Tetsuya Gatanaga Treatment of inflammatory disease by cleaving TNF receptors
US6495532B1 (en) * 1997-03-19 2002-12-17 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US6949528B1 (en) 1998-03-18 2005-09-27 Goddard John G Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
US7033615B2 (en) * 1999-07-09 2006-04-25 Cancer2 Inc. Methods for regulating levels of zinc, cadmium and calcium in humans and for diagnosing, or screening for the risk of developing, diseases associated with abnormal levels of cadmium, zinc and calcium in body fluids and tissues
US6541447B1 (en) 1999-09-01 2003-04-01 B & M Healthcare Technologies, Inc. Wound healing composition and method for use thereof
GB0001621D0 (en) 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
US20060063738A1 (en) * 2000-02-28 2006-03-23 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US20070087965A1 (en) * 2005-10-03 2007-04-19 Neirinckx Rudi D Treatment of psoriasis through down-regulation of the egf-receptor with topically applied egf
US7015199B1 (en) * 2000-06-02 2006-03-21 Neirinckx Rudi D Treatment of psoriasis through down-regulation of the EGF-receptor with topically-applied EGF
CA2417331C (en) * 2000-07-28 2011-03-22 Christopher J. Murphy Transplant media comprising bnp-1
HK1077740A1 (en) * 2001-12-20 2006-02-24 Ct Ingenieria Genetica Biotech Use of epidermal growth factor in the manufacture of a pharmaceutical injection composition for preventing diabetic limb amputation
WO2003075949A1 (en) * 2002-03-12 2003-09-18 Bio-Click Technologies Ltd. Method and composition for treating skin wounds with epidermal growth factor
SE0202719D0 (sv) * 2002-09-13 2002-09-13 Pharmacia Ab Process for mfg crystals of growth hormone
US20050214382A1 (en) * 2004-03-29 2005-09-29 Erning Xia Zinc preservative composition and method of use
US20070207209A1 (en) * 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
BRPI0610704B8 (pt) 2005-05-27 2021-05-25 Bharat Biotech Int Ltd composição do fator de crescimento epidérmico, o processo para isso e sua aplicação
CU23411B6 (es) * 2005-12-29 2009-09-08 Ct Ingenieria Genetica Biotech Uso tópico del factor de crecimiento epidérmico en liposomas para prevenir la amputación del pie diabético
CU23388B6 (es) * 2006-01-31 2009-07-16 Ct Ingenieria Genetica Biotech Composición farmacéutica de microesferas para prevenir la amputación del pie diabético
TWI394564B (zh) * 2006-09-21 2013-05-01 Alcon Res Ltd 自行保存型水性藥學組成物
EP2066300B2 (de) * 2006-09-28 2019-01-23 Novartis Ag Sich selbst konservierende pharmazeutische zusammensetzungen
CU23526B6 (es) * 2006-10-03 2010-05-19 Ct Ingenieria Genetica Biotech Método para la restauración morfofuncional de nervios periféricos en la neuropatía diabética
KR100784134B1 (ko) * 2006-10-09 2007-12-12 주식회사 대웅 상피세포성장인자를 함유하는 안정한 구내염 치료용 액상조성물
JP5583111B2 (ja) * 2008-03-17 2014-09-03 アルコン リサーチ， リミテッド ボレート−ポリオール錯体を含有する水性薬学的組成物
JP5303322B2 (ja) * 2009-03-13 2013-10-02 ピアス株式会社 皮膚外用組成物
TWI489997B (zh) * 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸－多元醇錯合物之水性藥學組成物
RU2012133444A (ru) * 2010-01-06 2014-02-20 Орф Лифтаекни Хф Способ, применения стабильного фактора роста растительного происхождения в уходе за кожей
US20140005128A1 (en) 2010-08-11 2014-01-02 Forest Laboratories Holdings Limited Treatments of gastrointestinal disorders
JP5798356B2 (ja) * 2011-04-06 2015-10-21 一般財団法人化学及血清療法研究所 新規インフルエンザワクチン安定化剤
SG11201507429TA (en) 2013-03-15 2015-10-29 Genentech Inc Il-22 polypeptides and il-22 fc fusion proteins and methods of use
US9283172B2 (en) 2013-12-13 2016-03-15 Growgene Biotech Inc. Use of stem cell conditioned medium to induce ZO-1 proteins expression for skin regeneration, repair and firming
KR101868966B1 (ko) * 2016-05-12 2018-06-19 주식회사 엔씨엘바이오 열 안정성을 증진시킨 사람 상피세포 성장인자의 조성물
CR20200327A (es) 2018-01-26 2020-11-05 Genentech Inc Proteínas de fusión fc il-22 y métodos de uso
CA3088763A1 (en) 2018-01-26 2019-08-01 Genentech, Inc. Compositions and methods of use
AU2019226085A1 (en) 2018-02-21 2020-09-17 Genentech, Inc. Dosing for treatment with IL-22 Fc fusion proteins

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA972288A (en) * 1971-01-20 1975-08-05 Gyorgy Hajos Process for the preparation of new complexes of biologically active peptides, polypeptides, proteins or derivatives or salts thereof having prolonged and/or increased activity
US3887704A (en) * 1974-03-12 1975-06-03 Joseph Lichtenstein Aqueous zinc solutions for physiological use
FI78616C (fi) * 1982-02-05 1989-09-11 Novo Industri As Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
HU194280B (en) * 1985-10-22 1988-01-28 Richter Gedeon Vegyeszet Process for producing new gonadoliberin analogues of high effectivity and pharmaceutical compositions containing them
US4816568A (en) * 1986-05-16 1989-03-28 International Minerals & Chemical Corp. Stabilization of growth hormones
AU8175387A (en) * 1986-10-20 1988-05-06 Novo Industri A/S Protamine zinc insulin preparations
US4717717A (en) * 1986-11-05 1988-01-05 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
US4764592A (en) * 1987-04-23 1988-08-16 Eli Lilly And Company Crystalline human proinsulin and process for its production
DE3731255A1 (de) * 1987-09-17 1989-04-06 Boehringer Ingelheim Int Stabilisierung von therapeutisch wirksamen proteinen in pharmazeutischen zubereitungen
US5272063A (en) * 1988-11-22 1993-12-21 Syntex (U.S.A.) Inc. Process of making human nerve growth factor

Also Published As

Publication number Publication date
GR1000392B (el) 1992-06-30
GR900100334A (en) 1991-10-10
DE69002795D1 (de) 1993-09-23
EP0398619A3 (de) 1991-04-03
ES2058799T3 (es) 1994-11-01
JP2763815B2 (ja) 1998-06-11
EP0398619A2 (de) 1990-11-22
JPH0334992A (ja) 1991-02-14
PT94037B (pt) 1996-11-29
CA2016659A1 (en) 1990-11-16
PT94037A (pt) 1991-01-08
AU630952B2 (en) 1992-11-12
KR900017580A (ko) 1990-12-19
CA2016659C (en) 1996-12-10
DK0398619T3 (da) 1993-10-04
US5130298A (en) 1992-07-14
EP0398619B1 (de) 1993-08-18
AU5496890A (en) 1990-11-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: BOEHMERT & BOEHMERT, 28209 BREMEN