LT3091011T - Atp surišančios kasetės transporterių moduliatoriai - Google Patents

Atp surišančios kasetės transporterių moduliatoriai

Info

Publication number
LT3091011T
LT3091011T LTEP16155334.2T LT16155334T LT3091011T LT 3091011 T LT3091011 T LT 3091011T LT 16155334 T LT16155334 T LT 16155334T LT 3091011 T LT3091011 T LT 3091011T
Authority
LT
Lithuania
Prior art keywords
atp
modulators
binding cassette
cassette transporters
transporters
Prior art date
Application number
LTEP16155334.2T
Other languages
English (en)
Lithuanian (lt)
Inventor
Sara S. Hadida Ruah
Peter D.J. Grootenhuis
Fredrick Van Goor
Jinglan Zhou
Brian Bear
Mark T. Miller
Jason Mccartney
Mehdi Michel Jamel Numa
Xiaoqing Yang
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of LT3091011T publication Critical patent/LT3091011T/lt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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LTEP16155334.2T 2006-04-07 2007-04-09 Atp surišančios kasetės transporterių moduliatoriai LT3091011T (lt)

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US (9) US7776905B2 (enExample)
EP (5) EP3327016B1 (enExample)
JP (3) JP5420395B2 (enExample)
CN (2) CN101460489A (enExample)
AU (1) AU2007235260B2 (enExample)
BR (1) BRPI0710965B8 (enExample)
CA (2) CA2869945C (enExample)
CY (3) CY1116979T1 (enExample)
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ES (4) ES2580803T3 (enExample)
HU (4) HUE055205T2 (enExample)
IL (1) IL194576A (enExample)
IN (1) IN2014KN02423A (enExample)
LT (1) LT3091011T (enExample)
MX (1) MX2008012945A (enExample)
NZ (3) NZ611485A (enExample)
PL (4) PL2007756T3 (enExample)
PT (3) PT3091011T (enExample)
RU (1) RU2451018C2 (enExample)
SI (4) SI3327016T1 (enExample)
WO (1) WO2007117715A2 (enExample)
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Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200602755B (en) 2003-09-06 2007-06-27 Vertex Pharma Modulators of ATP-binding cassette transporters
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US8598181B2 (en) 2013-12-03
PL2674428T3 (pl) 2017-01-31
EP3091011A1 (en) 2016-11-09
WO2007117715A2 (en) 2007-10-18
ES2659364T3 (es) 2018-03-15
HUE026145T2 (en) 2016-05-30
MX2008012945A (es) 2009-01-15
US20140057906A1 (en) 2014-02-27
PL3327016T3 (pl) 2021-10-04
CY1117731T1 (el) 2017-05-17
NZ571803A (en) 2011-12-22
US10239867B2 (en) 2019-03-26
SI2674428T1 (sl) 2016-07-29
US20160332997A1 (en) 2016-11-17
BRPI0710965B8 (pt) 2021-05-25
HUE055205T2 (hu) 2021-11-29
ES2580803T3 (es) 2016-08-26
DK3091011T3 (en) 2018-02-26
JP2009533351A (ja) 2009-09-17
RU2008144124A (ru) 2010-05-20
DK2007756T3 (en) 2015-10-05
BRPI0710965B1 (pt) 2020-08-18
EP2674428B1 (en) 2016-04-06
US20180162842A1 (en) 2018-06-14
JP5827297B2 (ja) 2015-12-02
JP2015120762A (ja) 2015-07-02
CY1116979T1 (el) 2017-04-05
EP2007756B1 (en) 2015-08-26
IL194576A0 (en) 2009-08-03
PT3091011T (pt) 2018-03-07
EP3327016A1 (en) 2018-05-30
ES2882684T3 (es) 2021-12-02
US20150119441A1 (en) 2015-04-30
SI3091011T1 (en) 2018-06-29
US9758510B2 (en) 2017-09-12
AU2007235260B2 (en) 2013-05-30
NZ611485A (en) 2014-09-26
EP3327016B1 (en) 2021-06-16
ZA200809290B (en) 2009-10-28
CN103254177A (zh) 2013-08-21
US20070244159A1 (en) 2007-10-18
CN101460489A (zh) 2009-06-17
US20240092766A1 (en) 2024-03-21
HUE027630T2 (en) 2016-10-28
US11639347B2 (en) 2023-05-02
EP2674428A1 (en) 2013-12-18
EP3091011B1 (en) 2017-12-27
PT2674428T (pt) 2016-07-14
NZ596889A (en) 2013-06-28
SI3327016T1 (sl) 2021-09-30
SI2007756T1 (sl) 2015-11-30
EP2007756A2 (en) 2008-12-31
CA2648719C (en) 2015-02-24
BRPI0710965A2 (pt) 2012-01-31
US10975061B2 (en) 2021-04-13
IL194576A (en) 2016-12-29
PL3091011T3 (pl) 2018-06-29
ES2554353T3 (es) 2015-12-18
WO2007117715A3 (en) 2008-01-10
US7776905B2 (en) 2010-08-17
US20220411410A1 (en) 2022-12-29
IN2014KN02423A (enExample) 2015-05-01
US20100331344A1 (en) 2010-12-30

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