KR930017921A - 광경화성 글리코사미노글리칸 유도체, 가교결합된 글리코 사미노글리칸 및 이의 제조방법 - Google Patents

광경화성 글리코사미노글리칸 유도체, 가교결합된 글리코 사미노글리칸 및 이의 제조방법 Download PDF

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KR930017921A
KR930017921A KR1019930001545A KR930001545A KR930017921A KR 930017921 A KR930017921 A KR 930017921A KR 1019930001545 A KR1019930001545 A KR 1019930001545A KR 930001545 A KR930001545 A KR 930001545A KR 930017921 A KR930017921 A KR 930017921A
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photocurable
glycosaminoglycan
glycosaminoglycans
photoreactive compound
derivatives
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KR1019930001545A
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KR100293043B1 (ko
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다케히사 마쓰다
제이. 모그하담 미누
가쓰키요 사쿠라이
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야마다니 와다루
세아카가쿠코교 가부시키가이샤
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan

Abstract

고도로 안정하고 생혼화성인 광경화성 글리코사미노 글리칸(GSG) 유도체 및 가교결합된 글리코사미노글리칸, 경우에 따라 용매를 사용하여 주형시킴으로써 용이하게 성형가능한 광경화성 GAG 유도체를 제조하는 방법(이 방법으로 역영향을 일으키는 비반응성 물질이 용이하게 제거될 수 있다) 및 가교 결합된 GAG 및 광경화성 GAG 유도체 또는 가교결합된 GAG를 기본으로 하는 의학 물질을 제조하는 방법이 제공된다. 광경화성 GAG 유도체는 글로카사미노글리칸 및 이에 결합된 광반응성 화합물을 포함하고, 예를 들어 그리코사미 노글리칸의 하이드록실 또는 카복실 그룹을 광반응성 화합물과 각각 에스테르화 반응 또는 아미드화 반응시켜 제조할 수 있다. 가교결합된 GAG는 이에 결합된 과반응성 화합물의 분자간 가교결합에 의해 광경화성 GAG 유도체로부터 유도된다.

Description

광경화성 클리코사미노글리칸 유도체,가교결합된 그리코사미노글리칸 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 실시에 1에서 결합 신남산의 양을 측정하기 위해 사용한1H-NMR 스펙트럼을 나타낸다. 제2도는 실시예 1에서 가교결합된 히알루론산 필름 제조에 있어서 광에 대한 노출에 의해 초래된느 279nm에서의 감쇠된 흡광도를 나타내는 UV/VIS 스펙트럼을 나타낸다. 제3도는 각종의 가교결합된 히아루론산 필름에 있어서, 신남산 잔기에 의한 치환도(DS)에 대한 접촉각의 의존성을 나타내는 그래프이다.

Claims (15)

  1. 글리코사미노글리칸 및 이에 결합된 광반응성 화합물을 포함하는 광경화성 글리코사미노그리칸 유도체.
  2. 제1항에 있어서, 그리코사미노글리칸이 콜로민산, 히아루론산, 콘드로이틴, 콘드로이틴 설페이트, 테이쿠론산, 데르마탄 셀페이트, 헤파린, 헤파란 설페이트, 케라토설페이트, 케라토폴리설페이트, 키틴 및 키조산 및 이늬 유도체로 이루어진 그룹으로부터 선택된 1개 이상의 구성원이고, 광반응성 화합물은 치환되거나 비치환된 신남산 및 이의 반응성 유도체, 치환체로서 1위치에 카복시알킬 그룹을 지닌 우라실 유도체 및 이의 반응성 유도체, 치환체로서 7위치에 카복시알킬 그룹을 지닌 쿠마린 유도체 및 이의 반응성 유도체로 이루어진 그룹으로부터 선택된 1개 이상의 구성원이 광경화성 글리코사미노글리칸 유도체.
  3. 광반응성 화합물의 분자간 밍/또는 분자내 가교결합을 유발시킴으로써 제 1항에 따른 광경화성 글리코사미노글리칸 유도체로부터 유도된 가교결합된 글리코사미노글리칸.
  4. 글리코사미노글리칸의 하이드록실 또는 카복실 그룹을 광반응성 화합물과 에스테르화 반응시킴을 특징으로하여 제1항에 따른 광경화성 글리코사미노 글리칸 유도체를 제조하는 방법.
  5. 글리코사미노글리칸의 카복실 그룹을 활성화시키고, 생성된 활성화된 카복실 그룹을 광반응성 화합물과 아민화 반응시킴을 특징으로 하여 제1항에 따른 광겨와성 글리코사미노 글리칸 유도체를 제조하는 방법.
  6. 글리코사미노글리칸의 카복실 그룹을 축합제의 존재하에서 광반응성 화합물과 아미드화 반응시킴을 특징으로 하여 제1항에 따른 광경화성 그리코사미노글리칸 유도체를 제조하는 방법.
  7. 제1항에 따른 광경화성 리코사미노그리칸 유도체를 빛으로 조사시킴으로써 광반응성 화합물의 분자간및/또는 분자내 가교결합을 유발시킴을 특징으로 하여 가교결합된 글리코사미노글리칸을 제조하는 방법.
  8. 글리코사미노글리칸 및 이에 결합된 광반응성 화합물을 포함하는 광경화성 글리코사미노그리칸 유도체를 기본으로 하는 의학적 용도용 물질.
  9. 제8항에 있어서, 비부착성 물질로서 작용하기 위한 의학적 용도용 물질.
  10. 제1항에 다른 광경화성 글리코사미노그리칸 유도체를 광반응성 화합물과 분자간 및/또는 분자내 가교결합반응시킴으로써 생성된 가교결합된 글리코사미노글리칸을 기본으로 하는 의학적 용도용 물질.
  11. 제10항에 있어서, 비부착성 물질로서 작용하기 위한 의학적 용도용 물질.
  12. 제10항에 있어서, 조절된 약제 방출으리 위한 담체로서 작용하기 위한 의학적 용도용 물질.
  13. 제12항에 따른 조절된 약제 방출을 위한 담체 및 이에 포함된 약제를 포함하는 조절된 약제 방출 물질.
  14. 글리코사미노글리칸 및 이에 결합된 광반응성 화합물을 포함하는 광경화성 글리코사미노글리칸의 유도체의 세포부착 방지용 의약 조성물을 제조하기 위한 용도.
  15. 글리코사미노글리칸 및 이에 결합된 광반응성 화합물을 포함하는 가교결합된 글리코사미노글리칸 세포및/또는 조직부착 방지용 의약 조성물을 제조하기 위한 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930001545A 1992-02-05 1993-02-05 광경화성글리코사미노글리칸유도체,가교결합된글리코사미노글리칸및이의제조방법 KR100293043B1 (ko)

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Application Number Priority Date Filing Date Title
JP4774492 1992-02-05
JP92-47744 1992-02-05
JP?92-47744? 1992-02-05
JP?92-203209? 1992-07-08
JP20320992 1992-07-08
JP?92-355441? 1992-12-21
JP4355441A JP2855307B2 (ja) 1992-02-05 1992-12-21 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法

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KR930017921A true KR930017921A (ko) 1993-09-20
KR100293043B1 KR100293043B1 (ko) 2001-10-22

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EP (1) EP0554898B1 (ko)
JP (1) JP2855307B2 (ko)
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CN (1) CN1083455C (ko)
AT (1) ATE152736T1 (ko)
AU (1) AU670921B2 (ko)
CA (1) CA2088831C (ko)
DE (1) DE69310396T2 (ko)
DK (1) DK0554898T3 (ko)
ES (1) ES2102537T3 (ko)
HU (1) HU215503B (ko)
RU (1) RU2139886C1 (ko)
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