KR927003847A - 수용체-결합된 신호 변환 경로를 위한 키메라 사슬 - Google Patents

수용체-결합된 신호 변환 경로를 위한 키메라 사슬 Download PDF

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KR927003847A
KR927003847A KR1019920701966A KR920701966A KR927003847A KR 927003847 A KR927003847 A KR 927003847A KR 1019920701966 A KR1019920701966 A KR 1019920701966A KR 920701966 A KR920701966 A KR 920701966A KR 927003847 A KR927003847 A KR 927003847A
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제이. 카폰 다니엘
바이스 아아더
에이. 어어빙 브라이언
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셀 제네시스, 인코포레이티드
더 리젠츠 오브 더 유니버시티 오브 캘리포니아
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

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Abstract

내용 없음

Description

수용체-결합된 신호 변환 경로를 위한 키메라 사슬
[도면의 간단한 설명]
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (29)

  1. 리딩 프레임내에 신호서열을 코오드화하는 서열; 그 자체로 또는 제2 세포외재 도메인과 결합하여 최소한 하나의 리간드에 특이적으로 결합하는 세포외재 표면 막 단백질 도메인을 코드화하는 서열; 경막 도메인; 및, TCR 결합된 제타 사슬 또는 에타 사슬, 또는 FC, R1 수용체의 감마사슬의 세포질 도메인을 포함하고 있으며, 상기 세포외재 도메인과 세포질 도메인은 천연적으로 함께 결합되지 않는 것을 특징으로 하는 DNA 서열.
  2. 제1항에 있어서, 상기 세포질 도메인이 제타 사슬인 것을 특징으로 하는 DNA 서열.
  3. 제2항에 있어서, 상기 세포외재 도메인이 그 자체 또는 경쇄와 결합되어 있는 Ig의 중쇄, 또는 이것의 절단된 부분인 것을 특징으로 하는 DNA 서열.
  4. 제2항에 있어서,. 상기 세포외재 도메인이 CD8인 것을 특징으로 하는 DNA 서열.
  5. 제2항에 있어서, 상기 세포외재 도메인이 CD4인 것을 특징으로 하는 DNA 서열.
  6. 제1항에 있어서, 상기 경막 도메인이 상기 세포외재 도메인에 천연적으로 결합되어 있는 것을 특징으로 하는 DNA 서열.
  7. 제1항에 있어서, 상기 경막 도메인 상기 세포질 도메인에 천연적으로 결합되어 있는 것을 특징으로 하는 DNA 서열.
  8. 전사 개시영역, 전사 개시영역의 전사조절하에 있는 제1항의 DNA서열, 및 전사 종결영역으로 이루어지는 발현 카세트.
  9. 제8항에 있어서, 상기 전사 개시영역이 포유동물 숙주에서 기능적인 것을 특징으로 하는 DNA 서열.
  10. 제10항에 따르는 DNA 서열을 포함하는 세포.
  11. 제10항에 있어서, 상기 세포질 도메인이 CD3 제타사슬인 것을 특징으로 하는 세포.
  12. 제11항에 있어서, 상기 세포외재 도메인이 그 자제 또는 경쇄와 결합되어 있는 Ig의 중쇄, 또는 그것의 절단된 부분인 것을 특징으로 하는 세포.
  13. 제11항에 있어서, 상기 세포외재 도메인이 COB인 것을 특징으로 하는 세포.
  14. 제11항에 있어서, 상기 세포외재 도메인이 CD4인 것을 특징으로 하는 세포.
  15. 제10항에 있어서, 상기 전사 개시영역이 포유동물 숙주에서 기능적이고 상기 세포가 포유동물 세포인 것을 특징으로 하는 세포.
  16. 제15항에 있어서, 상기 포유동물 세포가 사람 세포인 것을 특징으로 하는 세포.
  17. N-말단에서 C-말단방향으로, 그 자체로 또는 제2세포외재 도메인과 결합하여 최소한 하나의 리간드에 특이적으로 결합되어 있는 세포외재 표면막 단백질 도메인; 경막 도메인; 및 CD3 제타 사슬, CD3의 에타사슬 또는 FC, RI 수용체의 감마사슬의 세포질 도메인을 포함하며, 상기 세포외재 도메인과 세포질 도메인이 천연적으로 함께 결합되어 있지 않은 것을 특징으로 하는 단백질.
  18. 제17항에 있어서, 상기 세포질 도메인이 CD3 제타 사슬인 것을 특징으로 하는 단백질.
  19. 제17항에 있어서, 상기 세포외재 도메인이 그 자체 또는 경쇄의 결합되어 있는 Ig의 중쇄 또는 이것의 절단된 부분인 것을 특징으로 하는 단백질.
  20. 제17항에 있어서, 상기 세포외재 도메인이 CD8인 것을 특징으로 하는 단백질.
  21. 제17항에 있어서, 상기 세포외재 도메인이 CD4인 것을 특징으로 하는 단백질.
  22. 표면 막 단백질로서 제17항의 단백질을 포함하는 포유동물 세포.
  23. 제22항에 있어서, 상기 세포외재 도메인이 결합 부위를 규정하기 위해 제2단백질에 결합되어 있는 것을 특징으로 하는 포유동물 세포.
  24. 제19항의 단백질을 표면 막 단백질로서 포함하며, 세포독성 T림프구인 것을 특징으로 하는 포유동물 세포.
  25. 제21항의 단백질을 표면 막 단백질로서 포함하며, 세포독성 T림프구인 것을 특징으로 하는 포유동물 세포.
  26. 제19항의 단백질을 포면막 단백질로서 포함하며, 최소한 하나의 클래스I 또는 클래스Ⅱ MHC의 표면 박현이 실질적으로 없는 세포인 것을 특징으로 하는 포유동물 세포.
  27. 제21항의 단백질을 표면막 단백질로서 포함하며, 최소한 하나의 클래스I 또는 클래스Ⅱ MHC의 표면 박현이 실질적으로 없는 세포인 것을 특징으로 하는 포유동물 세포.
  28. 2차 메신저 경로에 의하여 세포를 활성화시키는 방법으로서, 세포를 상기 세포외재 도메인에 결합하여 상기 세포질 도메인으로 신호를 변환시키는 리간드와 접촉시키는 단계와 그로써 상기 2차 메신저 경로가 활성화되는 단계로 이루어지는 방법.
  29. 제9항의 발현 카세트를 포합하는 래트로바이러스 RNA 또는 DNA 구조물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920701966A 1990-12-14 1991-12-12 수용체 관련된 신호 변환 경로를 위한 키메라 사슬 KR100246529B1 (ko)

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US62764390A 1990-12-14 1990-12-14
US7/627,643 1990-12-14
US627,643 1990-12-14
PCT/US1991/009431 WO1992010591A1 (en) 1990-12-14 1991-12-12 Chimeric chains for receptor-associated signal transduction pathways

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KR100246529B1 KR100246529B1 (ko) 2000-04-01

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US (1) US5359046A (ko)
EP (2) EP0517895B1 (ko)
JP (1) JP3242916B2 (ko)
KR (1) KR100246529B1 (ko)
AT (1) ATE145428T1 (ko)
AU (1) AU643109B2 (ko)
CA (1) CA2074825C (ko)
DE (1) DE69123241T2 (ko)
DK (1) DK0517895T3 (ko)
ES (1) ES2096749T3 (ko)
GR (1) GR3022538T3 (ko)
NO (1) NO308618B1 (ko)
WO (1) WO1992010591A1 (ko)

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CA2074825A1 (en) 1992-06-15
WO1992010591A1 (en) 1992-06-25
KR100246529B1 (ko) 2000-04-01
DE69123241T2 (de) 1997-04-17
AU643109B2 (en) 1993-11-04

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