KR970701004A - 키메라 cd4 수용체-포함 세포에 의한 hiv 감염 세포의 표적화 세포용해 - Google Patents
키메라 cd4 수용체-포함 세포에 의한 hiv 감염 세포의 표적화 세포용해Info
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- 206010057248 Cell death Diseases 0.000 title 1
- 230000009089 cytolysis Effects 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 239000012634 fragment Substances 0.000 claims abstract 11
- 230000003834 intracellular effect Effects 0.000 claims abstract 7
- 230000001225 therapeutic effect Effects 0.000 claims abstract 7
- 108700010039 chimeric receptor Proteins 0.000 claims abstract 6
- 108020003175 receptors Proteins 0.000 claims abstract 6
- 102000005962 receptors Human genes 0.000 claims abstract 6
- 241000124008 Mammalia Species 0.000 claims abstract 4
- 208000031886 HIV Infections Diseases 0.000 claims abstract 3
- 208000037357 HIV infectious disease Diseases 0.000 claims abstract 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims abstract 3
- 239000012528 membrane Substances 0.000 claims abstract 3
- 230000024932 T cell mediated immunity Effects 0.000 claims abstract 2
- 239000013598 vector Substances 0.000 claims abstract 2
- 210000004027 cell Anatomy 0.000 claims 21
- 238000000034 method Methods 0.000 claims 10
- 108091008874 T cell receptors Proteins 0.000 claims 4
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 210000000170 cell membrane Anatomy 0.000 claims 4
- 108091008875 B cell receptors Proteins 0.000 claims 2
- 108010087819 Fc receptors Proteins 0.000 claims 2
- 102000009109 Fc receptors Human genes 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 210000003630 histaminocyte Anatomy 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 210000000440 neutrophil Anatomy 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 230000011664 signaling Effects 0.000 abstract 1
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Abstract
본 발명은 (a) HIV- 감염된 세포를 특이적으로 인식해서 결합할 수 있지만 HIV 감염을 매개하지는 않는 CD4의 단편을 포함하는 세포외 부분 및 (b) 치료세포에게 수용체-결합 HIV-감염 세포를 파괴하도록 신호할 수 있는 세포내 부분을 포함하는, 막-결합 단백성 키메라 수용체를 발현하는 유효량의 치료세포를 포유동물에 투여하는 과정을 포함하는 포유동물에서 HIV- 감염된 세포에 대하여 세포 면역반응을 지시하는 방법을 제공하는 것이다. 본 발명은 또한 키메라 수용체를 발현하는 세포들 및 키메라 수용체를 코드화하는 DNA 및 벡터들에도 관계한다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (19)
- (a) HIV- 감염된 세포를 특이적으로 인식해서 결합할 수 있지만 HIV 감염을 매개하지는 않는 CD4의 단편을 포함하는 세포외 부분 및 (b) 치료세포에게 수용체-결합 HIV - 감염 세포를 파괴하도록 신호할 수 있는 세포내 부분을 포함하는, 막-결합 단백성 키메라 수용체를 발현하는 유효량의 치료 세포를 포유동물에 투여하는 과정을 포함하는 포유동물에서 HIV-감염된 세포에 대하여 세포 면역반응을 지시하는 방법.
- 제1항에 있어서, 상기 CD4 단편이 아미노산 1-394 또는 아미노산 1-200으로 구성되는 방법.
- 제1항에 있어서, 상기 CD4 단편이 제26도에 도시된 CD7 막간 도메인에 의해 또는 제25도에 도시된 사람 IgC1 분자의 힌즈,CH2 및 CH3 도메인들에 의해 상기 세포내 부분으로부터 분리되어 있는 방법.
- 제1항에 있어서, 상기 CD4 단편이 상기 치료 세포막으로부터 적어도 48Å 또는 적어도 72Å 정도 떨어져 있는 방법.
- 제1항에 있어서, 상기 세포내 부분이 T 세포 수용체 단백질, B 세포 수용체 단백질, 또는 Fc 수용체 단백질의 신호- 변환 부분인 방법.
- 제5에 있어서, 상기 T 세포 수용체 단백질이인 방법.
- 제1항에 있어서, 상기 치료 세포들이 (a) T 림프구; (b) 세포독성 T 림프구; (c) 자연세포 독성세포; (d) 호중구; (e) 과립구; (f) 대식세포; (g) 비만세포; (h) 헬라(HeLa) 세포; 및 (i) 태아 간세포(ES)로 구성되는 군으로부터 선택되는 방법.
- 제1항에 있어서, 상기 수용체가 CD7 막간 부분, CD5 막간 부분 또는 CD34 막간 부분을 포함하는 방법.
- 제1항에 있어서, 상기 CD4 단편이 상기 치료 세포막으로부터 하나 이상의 단백성 알파나선에 의해 분리 되어 있는 방법.
- (a) HIV-감염된 세포를 특이적으로 인식해서 결합할 수 있지만 HIV 감염을 매개하지는 않은 CD4의 단편을 포함하는 세포의 부분 및 (b) 치료세포에게 수용체- 결합 HIV - 감염 세포를 파괴하도록 신호할 수 있는 세포내 부분을 포함하는, 단백성 막- 결합 키메라 수용체를 발현하는 세포.
- 제10항에 있어서, 상기 CD4 단편이 아미노산 1-394 또는 아미노산 1-200으로 구성되는 세포.
- 제10항에 있어서, 상기 CD4 단편이 제26도에 도시된 CD7 막간 도메인에 의해 또는 제25도에 도시된 사람 IgG1 분자 힌즈, CH2 및 CH3 도메인들에 의해 상기 세포내 부분으로부터 분리되어 있는 세포.
- 제10항에 있어서, 상기 CD4 단편이 상기 치료 세포막으로부터 적어도 48Å 또는 적어도 72Å 정도 떨어져 있는 세포.
- 제10항에 있어서, 상기 세포내 부분이 T 세포 수용체 단백질, B 세포 수용체 단백질, 또는 Fc 수용체 단백질의 신호- 변환 부분인 세포
- 제14항에 있어서, 상기 T 세포 수용체 단백질이인 세포.
- 제10항에 있어서, 상기 수용체가 CD7 막간 부분, CD5 막간 부분 또는 CD34 막간 부분을 포함하는 세포.
- 제10항에 있어서, 상기 CD4 단편이 상기 치료 세포막으로부터 하나 이상의 단백성 알파 나선에 의해 분리되어 있는 세포.
- 제10항의 키메라 수용체를 코드화하는 DNA.
- 제18항의 키메라 수용체 DNA를 포함하는 벡터.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19539594A | 1994-02-14 | 1994-02-14 | |
US08/195,395 | 1994-02-14 | ||
US08/284,391 US5851828A (en) | 1991-03-07 | 1994-08-02 | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
US08/284,391 | 1994-08-02 | ||
PCT/US1995/000454 WO1995021528A1 (en) | 1994-02-14 | 1995-01-12 | Targeted cytolysis of hiv-infected cells by chimeric cd4 receptor-bearing cells |
Publications (2)
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KR970701004A true KR970701004A (ko) | 1997-03-17 |
KR100289253B1 KR100289253B1 (ko) | 2001-11-30 |
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Application Number | Title | Priority Date | Filing Date |
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KR1019960704450A KR100289253B1 (ko) | 1994-02-14 | 1995-01-12 | 키메라cd4수용체-포함세포에의한hiv감염세포의표적화세포용해 |
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US (3) | US5851828A (ko) |
EP (1) | EP0750457B1 (ko) |
JP (1) | JP3832850B2 (ko) |
KR (1) | KR100289253B1 (ko) |
CN (1) | CN1318576C (ko) |
AT (1) | ATE308888T1 (ko) |
AU (1) | AU690204B2 (ko) |
BR (1) | BR9506783A (ko) |
CA (1) | CA2182890C (ko) |
CZ (1) | CZ293969B6 (ko) |
DE (1) | DE69534589T2 (ko) |
DK (1) | DK0750457T3 (ko) |
ES (1) | ES2249766T3 (ko) |
FI (1) | FI120264B (ko) |
HU (1) | HU220100B (ko) |
IL (1) | IL112390A (ko) |
NO (1) | NO319378B1 (ko) |
NZ (1) | NZ279123A (ko) |
PL (1) | PL180066B1 (ko) |
UA (1) | UA42760C2 (ko) |
WO (1) | WO1995021528A1 (ko) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6319494B1 (en) | 1990-12-14 | 2001-11-20 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
US6407221B1 (en) | 1990-12-14 | 2002-06-18 | Cell Genesys, Inc. | Chimeric chains for receptor-associated signal transduction pathways |
US5912170A (en) | 1991-03-07 | 1999-06-15 | The General Hospital Corporation | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
US5851828A (en) * | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
US6004811A (en) | 1991-03-07 | 1999-12-21 | The Massachussetts General Hospital | Redirection of cellular immunity by protein tyrosine kinase chimeras |
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