JPH09512421A - キメラcd4レセプターを有する細胞によるhiv感染細胞を標的とする細胞傷害 - Google Patents
キメラcd4レセプターを有する細胞によるhiv感染細胞を標的とする細胞傷害Info
- Publication number
- JPH09512421A JPH09512421A JP7521213A JP52121395A JPH09512421A JP H09512421 A JPH09512421 A JP H09512421A JP 7521213 A JP7521213 A JP 7521213A JP 52121395 A JP52121395 A JP 52121395A JP H09512421 A JPH09512421 A JP H09512421A
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- cells
- cell
- receptor
- hiv
- fragment
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.哺乳類に、有効量の治療用細胞を投与することを含む、哺乳類におけるHIV感 染細胞に対する細胞免疫反応を行う方法において、該治療用細胞が、(a)HIV感 染細胞を特異的に認識し、結合することができるが、HIV感染を媒介することが ないCD4断片を含む細胞外部分、および(b)レセプター結合HIV感染細胞を破壊 するようなシグナルを、該治療細胞に与えることができる細胞内部分、を含む膜 結合型のタンパク質性キメラレセプターを発現するものである方法。 2.CD4断片が1〜394番目のアミノ酸または1〜200番目のアミノ酸を含む、請求の 範囲1の方法。 3.CD4断片が、図26に示したCD7膜貫通ドメインにより、または図25に示したヒト IgG1分子のヒンジ、CH2、およびCH3ドメインにより、細胞内部分から分離されて いる、請求の範囲1の方法。 4.CD4断片が、少なくとも48オングストローム、または少なくとも72オングスト ローム、治療用細胞膜から分離されている、請求の範囲1の方法。 5.細胞内部分が、T細胞レセプタータンパク質、B細胞レセプタータンパク質、ま たはFcレセプタータンパク質のシグナル伝達部分である、請求の範囲1の方法。 6.T細胞レセプタータンパク質がζである、請求の範囲5の方法。 7.治療用細胞が、(a)Tリンパ球、(b)細胞毒性Tリンパ球、(c)ナチュラル キラー細胞、(d)好中球、(e)顆粒球、(f)マクロファージ、(g)肥満細胞 、(h)ヒーラ細胞、および(i)胚性未分化細胞(ES)からなる群より選ばれる 、請求の範囲1の方法。 8.レセプターが、CD7膜貫通部分、CD5膜貫通部分、またはCD34膜貫通部分を含む 、請求の範囲1の方法。 9.CD4断片が、一つまたは複数のタンパク質性アルファヘリックスにより、治療 用細胞の細胞膜から分離されている、請求の範囲1の方法。 10.(a)HIV感染細胞を特異的に認識し、結合することができるが、HIV感染を媒 介することがないCD4断片を含む細胞外部分、および(b)レセプター結合HIV感 染細胞を破壊するようなシグナルを、治療用細胞に与えることができる細胞内部 分、を含むタンパク質性の膜結合型キメラレセプターを発現する細胞。 11.CD4断片が1〜394番目のアミノ酸または1〜200番目のアミノ酸を含む、請求の 範囲10の細胞。 12.CD4断片が、図26に示したCD7膜貫通ドメインにより、または図25に示したヒ トIgG1分子のヒンジ、CH2、およびCH3ドメインにより、細胞内部から分離されて いる、請求の範囲10の細胞。 13.CD4断片が、少なくとも48オングストローム、または少なくとも72オングスト ローム、治療用細胞の細胞膜から分離されている、請求の範囲10の細胞。 14.細胞内部分が、T細胞レセプタータンパク質、B細胞レセプタータンパク質、 またはFcレセプタータンパク質のシグナル伝達部分である、請求の範囲10の細胞 。 15.T細胞レセプタータンパク質がζである、請求の範囲14の細胞。 16.レセプターが、CD7膜貫通部分、CD5膜貫通部分、またはCD34膜貫通部分を含 む、請求の範囲10の細胞。 17.CD4断片が、一つまたは複数のタンパク質性アルファヘリックスにより、治療 用細胞の細胞膜から分離されている、請求の範囲10の細胞。 18.請求の範囲10のキメラレセプターをコードするDNA。 19.請求の範囲18のキメラレセプターDNAを含むベクター。
Applications Claiming Priority (5)
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US19539594A | 1994-02-14 | 1994-02-14 | |
US08/195,395 | 1994-02-14 | ||
US08/284,391 US5851828A (en) | 1991-03-07 | 1994-08-02 | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
US08/284,391 | 1994-08-02 | ||
PCT/US1995/000454 WO1995021528A1 (en) | 1994-02-14 | 1995-01-12 | Targeted cytolysis of hiv-infected cells by chimeric cd4 receptor-bearing cells |
Publications (2)
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JPH09512421A true JPH09512421A (ja) | 1997-12-16 |
JP3832850B2 JP3832850B2 (ja) | 2006-10-11 |
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JP52121395A Expired - Lifetime JP3832850B2 (ja) | 1994-02-14 | 1995-01-12 | キメラcd4レセプターを有する細胞によるhiv感染細胞を標的とする細胞傷害 |
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US (3) | US5851828A (ja) |
EP (1) | EP0750457B1 (ja) |
JP (1) | JP3832850B2 (ja) |
KR (1) | KR100289253B1 (ja) |
CN (1) | CN1318576C (ja) |
AT (1) | ATE308888T1 (ja) |
AU (1) | AU690204B2 (ja) |
BR (1) | BR9506783A (ja) |
CA (1) | CA2182890C (ja) |
CZ (1) | CZ293969B6 (ja) |
DE (1) | DE69534589T2 (ja) |
DK (1) | DK0750457T3 (ja) |
ES (1) | ES2249766T3 (ja) |
FI (1) | FI120264B (ja) |
HU (1) | HU220100B (ja) |
IL (1) | IL112390A (ja) |
NO (1) | NO319378B1 (ja) |
NZ (1) | NZ279123A (ja) |
PL (1) | PL180066B1 (ja) |
UA (1) | UA42760C2 (ja) |
WO (1) | WO1995021528A1 (ja) |
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