JPS6463394A - Novel chimera polypeptide - Google Patents
Novel chimera polypeptideInfo
- Publication number
- JPS6463394A JPS6463394A JP22175887A JP22175887A JPS6463394A JP S6463394 A JPS6463394 A JP S6463394A JP 22175887 A JP22175887 A JP 22175887A JP 22175887 A JP22175887 A JP 22175887A JP S6463394 A JPS6463394 A JP S6463394A
- Authority
- JP
- Japan
- Prior art keywords
- immunoglobulin
- cell
- chimera polypeptide
- variable region
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
PURPOSE:To produce the above-mentioned chimera polypeptide, by synthesize a recombinant wherein DNA coding chimera polypeptide containing variable region of mammal immunoglobulin and constant region of mammal T cell receptor are integrated. CONSTITUTION:A chimera polypeptide consisting of a variable region or immunoglobulin of mammal animal is produced in T cell by a recombinant technique. In the chimera polypeptide, variable region of mammal animal immunoglobulin is heavy chain variable region of mouse T15 immunoglobulin or light chain variable region of mouse S107 immunoglobulin and constant region of mammal animal T cell receptor comes preferably from chain constant region of mouse T cell. Antitumor activity is provided to a cell by integrating the chimera polypeptide into the T cell.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22175887A JPS6463394A (en) | 1987-09-04 | 1987-09-04 | Novel chimera polypeptide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22175887A JPS6463394A (en) | 1987-09-04 | 1987-09-04 | Novel chimera polypeptide |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6463394A true JPS6463394A (en) | 1989-03-09 |
Family
ID=16771745
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP22175887A Pending JPS6463394A (en) | 1987-09-04 | 1987-09-04 | Novel chimera polypeptide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6463394A (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0385909A2 (en) * | 1989-03-03 | 1990-09-05 | MicroGeneSys, Inc. | A kit or composition for the prevention or treatment of HIV-1 infections |
WO1996003883A1 (en) * | 1994-08-02 | 1996-02-15 | The General Hospital Corporation | Cells bearing cd4 decoy receptors and related molecules and methods |
US5843728A (en) * | 1991-03-07 | 1998-12-01 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
US5851828A (en) * | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
US5906936A (en) * | 1988-05-04 | 1999-05-25 | Yeda Research And Development Co. Ltd. | Endowing lymphocytes with antibody specificity |
US5912170A (en) * | 1991-03-07 | 1999-06-15 | The General Hospital Corporation | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
US6004811A (en) * | 1991-03-07 | 1999-12-21 | The Massachussetts General Hospital | Redirection of cellular immunity by protein tyrosine kinase chimeras |
US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
JP2017529841A (en) * | 2014-09-19 | 2017-10-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Chimeric antigen receptor |
-
1987
- 1987-09-04 JP JP22175887A patent/JPS6463394A/en active Pending
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5906936A (en) * | 1988-05-04 | 1999-05-25 | Yeda Research And Development Co. Ltd. | Endowing lymphocytes with antibody specificity |
EP0385909A2 (en) * | 1989-03-03 | 1990-09-05 | MicroGeneSys, Inc. | A kit or composition for the prevention or treatment of HIV-1 infections |
US5843728A (en) * | 1991-03-07 | 1998-12-01 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
US5851828A (en) * | 1991-03-07 | 1998-12-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
US5912170A (en) * | 1991-03-07 | 1999-06-15 | The General Hospital Corporation | Redirection of cellular immunity by protein-tyrosine kinase chimeras |
US6004811A (en) * | 1991-03-07 | 1999-12-21 | The Massachussetts General Hospital | Redirection of cellular immunity by protein tyrosine kinase chimeras |
US7049136B2 (en) | 1991-03-07 | 2006-05-23 | The General Hospital Corporation | Redirection of cellular immunity by receptor chimeras |
US7094599B2 (en) | 1991-03-07 | 2006-08-22 | The General Hospital Corporation | Targeted cytolysis of HIV-infected cells by chimeric CD4 receptor-bearing cells |
US7320787B2 (en) | 1991-03-07 | 2008-01-22 | The General Hospital Corporation | Redirection of cellular immunity by protein tyrosine kinase chimeras |
WO1996003883A1 (en) * | 1994-08-02 | 1996-02-15 | The General Hospital Corporation | Cells bearing cd4 decoy receptors and related molecules and methods |
JP2017529841A (en) * | 2014-09-19 | 2017-10-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Chimeric antigen receptor |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL93118A0 (en) | Expression vectors,cells transformed thereby and their use in the production of chimeric monoclonal antibodies | |
EP0309548A4 (en) | Human tissue factor related dna segments, polypeptides and antibodies | |
EP0274394A3 (en) | Chimeric antibody with specificity to human b cell surface antigen | |
EP0575546A4 (en) | Prad1 cyclin and its cdna | |
AU4128089A (en) | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same | |
IL88175A0 (en) | Human immunoglobulins produced by recombinant dna techniques | |
ES2124209T3 (en) | REAGENT IMPROVED MONOCLONAL ANTIBODIES WITH CAQUECTINE. | |
ES498343A0 (en) | A METHOD OF PRODUCING A POLYPEPTIDE THAT EXHIBITS IMMUNOLOGICAL OR BIOLOGICAL ACTIVITY FROM THE INTERFERON OF HUMAN LEUKOCYTES. | |
PH22461A (en) | Preparation of functional human urokinase protein | |
IL80678A0 (en) | Mammalian interleukin-4 | |
EP0293443A4 (en) | Construction of synthetic dna and its use in large polypeptide synthesis. | |
AU2525284A (en) | Human nerve growth factor by recombinant technology | |
IL70414A (en) | Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors | |
AU639226B2 (en) | Recombinant protein receptor | |
JPS6463394A (en) | Novel chimera polypeptide | |
DE3855504T2 (en) | Recombinant production of A chain polypeptides from PDGF | |
EP0860446A4 (en) | Type cc chemokine-like protein | |
JPS574231A (en) | Catalyst, manufacture of said catalyst and manufacture of light hydrocarbon using said catalyst | |
GB2168355B (en) | Novel lymphokine, monoclonal antibody specific to the lymphokine, and their production and uses | |
EP0153961A4 (en) | Recombinant materials and methods for producing human connective tissue-activating peptide-iii and analogs thereof. | |
IL91649A0 (en) | Hybrid monoclonal antibodies,their production and use | |
ATE103973T1 (en) | GAMMA-ATRIAL NATRIURETIC POLYPEPTIDE RECOGNIZING MONOCLONAL ANTIBODIES, SUCH ANTIBODIES-PRODUCING HYBRIDOMES AND THEIR PREPARATION AND USE. | |
EP0343132A3 (en) | Methods and systems for producing hiv antigens | |
EP0460674A3 (en) | Recombinant dna and process for the production of chimaeric antibodies | |
ZA897023B (en) | Hybrid monoclonal antibodies,their production and use |