ATE550356T1 - Chimäre t-zellen-rezeptoren sowie entsprechende materialien und verwendungsverfahren - Google Patents

Chimäre t-zellen-rezeptoren sowie entsprechende materialien und verwendungsverfahren

Info

Publication number
ATE550356T1
ATE550356T1 AT07797329T AT07797329T ATE550356T1 AT E550356 T1 ATE550356 T1 AT E550356T1 AT 07797329 T AT07797329 T AT 07797329T AT 07797329 T AT07797329 T AT 07797329T AT E550356 T1 ATE550356 T1 AT E550356T1
Authority
AT
Austria
Prior art keywords
methods
tcr
chimeric
host
tcrs
Prior art date
Application number
AT07797329T
Other languages
English (en)
Inventor
Richard A Morgan
Cyrille J Cohen
Steven A Rosenberg
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38668547&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE550356(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of ATE550356T1 publication Critical patent/ATE550356T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT07797329T 2006-05-03 2007-05-03 Chimäre t-zellen-rezeptoren sowie entsprechende materialien und verwendungsverfahren ATE550356T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79685306P 2006-05-03 2006-05-03
PCT/US2007/068113 WO2007131092A2 (en) 2006-05-03 2007-05-03 Chimeric t cell receptors and related materials and methods of use

Publications (1)

Publication Number Publication Date
ATE550356T1 true ATE550356T1 (de) 2012-04-15

Family

ID=38668547

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07797329T ATE550356T1 (de) 2006-05-03 2007-05-03 Chimäre t-zellen-rezeptoren sowie entsprechende materialien und verwendungsverfahren

Country Status (9)

Country Link
US (2) US20090304657A1 (de)
EP (1) EP2016102B1 (de)
AT (1) ATE550356T1 (de)
AU (1) AU2007248019B2 (de)
CA (1) CA2651174A1 (de)
DK (1) DK2016102T3 (de)
ES (1) ES2382777T3 (de)
PT (1) PT2016102E (de)
WO (1) WO2007131092A2 (de)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10112851C1 (de) 2001-03-16 2002-10-10 Gsf Forschungszentrum Umwelt Semi-allogene Antitumor-Vakzine mit HLA-haplo-identischen Antigen-präsentierenden Zellen
WO2006036445A2 (en) 2004-09-24 2006-04-06 Trustees Of Dartmouth College Chimeric nk receptor and methods for treating cancer
DE102006041455B4 (de) * 2006-09-04 2011-07-28 Johannes-Gutenberg-Universität Mainz, 55122 Verfahren zur Herstellung einer einen stabilisierten funktionellen humanen Einzelketten-Antigen-erkennenden-TCR (scTCR) exprimierenden Zelllinie, damit hergestellt Zelllinie, stabilisierter TAA-spezifischer scTCR, deren Verwendungen und diese enthaltende pharmazeutische Zusammmensetzungen
US8088379B2 (en) * 2006-09-26 2012-01-03 The United States Of America As Represented By The Department Of Health And Human Services Modified T cell receptors and related materials and methods
US9809797B2 (en) * 2007-10-03 2017-11-07 National Institutes Of Health (Nih) U.S. Dept. Of Health And Human Services (Dhhs) Division Of Extramural Inventions And Technology Enhanced generation of cytotoxic T-lymphocytes by IL-21 mediated FOXP3 suppression
WO2010012829A1 (en) * 2008-07-31 2010-02-04 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Her2/neu specific t cell receptors
EP2186825A1 (de) * 2008-11-13 2010-05-19 Max-Delbrück-Centrum für Molekulare Medizin (MDC) Vom Menschen abgeleitete T-Zellen-Rezeptoren
US8697854B2 (en) 2008-11-24 2014-04-15 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt Gmbh High affinity T cell receptor and use thereof
WO2010075417A1 (en) * 2008-12-23 2010-07-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Survivin specific t cell receptor for treating cancer
US8785601B2 (en) 2009-01-28 2014-07-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T cell receptors and related materials and methods of use
AU2010241864B2 (en) 2009-04-30 2014-02-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inducible interleukin-12
GB0911566D0 (en) 2009-07-03 2009-08-12 Immunocore Ltd T cell receptors
GB0917094D0 (en) * 2009-09-29 2009-11-11 Ucl Biomedica Plc T-cell receptor
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
US9181527B2 (en) 2009-10-29 2015-11-10 The Trustees Of Dartmouth College T cell receptor-deficient T cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
CN103124740B (zh) 2010-09-21 2015-09-02 美国卫生和人力服务部 抗-ssx-2t细胞受体和相关材料及使用方法
WO2013033626A2 (en) 2011-08-31 2013-03-07 Trustees Of Dartmouth College Nkp30 receptor targeted therapeutics
DK3424947T3 (da) * 2011-10-28 2021-02-22 Regeneron Pharma Genmodificerede t-celle-receptor-mus
CN104395344B (zh) 2012-05-07 2019-08-13 达特茅斯大学理事会 抗b7-h6抗体、融合蛋白及其使用方法
ES2835200T3 (es) 2012-05-22 2021-06-22 Us Health Uso médico de células que comprenden receptores de células T anti-NY-ESO-1
NZ741124A (en) * 2012-07-27 2019-11-29 Univ Illinois Engineering t-cell receptors
US10316289B2 (en) 2012-09-06 2019-06-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing T memory stem cell populations
JP6475166B2 (ja) 2012-12-14 2019-02-27 バイオエヌテク アールエヌエー ファーマシュティカルズ ジーエムビーエイチ 新規ｍｈｃ非依存性腫瘍関連抗原
US9486475B2 (en) 2013-02-08 2016-11-08 Amgen Research (Munich) Gmbh PPS for the prevention of potential adverse effects caused by CD3 specific binding domains
JO3529B1 (ar) 2013-02-08 2020-07-05 Amgen Res Munich Gmbh مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد
JP2016507066A (ja) 2013-02-08 2016-03-07 インスティテュート フォー ミエローマ アンド ボーン キャンサー リサーチ 多発性骨髄腫、慢性リンパ球性白血病、およびｂ細胞非ホジキンリンパ腫の改善された診断方法、予後予測方法、およびモニタリング方法
JP6444321B2 (ja) 2013-02-22 2018-12-26 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ヒト化主要組織適合性遺伝子複合体を発現するマウス
EP2971045B1 (de) * 2013-03-13 2019-06-19 Health Research, Inc. Zusammensetzungen und verfahren zur verwendung rekombinanter t-zellen-rezeptoren zur direkten erkennung von tumorantigenen
HK1218232A1 (zh) 2013-03-21 2017-02-10 桑格摩生物科学股份有限公司 使用工程化鋅指蛋白核酸酶靶向斷裂t細胞受體基因
ES2973064T3 (es) * 2013-07-15 2024-06-18 Us Health Receptores de células T frente al virus del papiloma humano 16 E6
GB201313377D0 (en) 2013-07-26 2013-09-11 Adaptimmune Ltd T cell receptors
EP3083674B1 (de) * 2013-12-19 2018-10-03 Friedrich-Alexander-Universität Erlangen-Nürnberg Grippenspezifischer t-zellenrezeptor und seine verwendung bei der erkennung, prävention und/oder behandlung von grippe
WO2015160928A2 (en) * 2014-04-15 2015-10-22 University Of Virginia Patent Foundation Isolated t cell receptors and methods of use therefor
EP4609876A3 (de) * 2014-05-29 2026-01-21 The United States of America, as represented by the Secretary, Department of Health and Human Services T-zell-rezeptoren gegen menschliches papillomavirus 16 e7
EP3531133B1 (de) 2014-05-30 2023-08-23 Amgen Research (Munich) GmbH Risikostratifizierung von patienten mit akuter lymphatischer b-vorläufer-leukämie
JP6879910B2 (ja) 2014-10-31 2021-06-02 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Ｃａｒｔ細胞における遺伝子発現の改変およびその使用
SI3223850T1 (sl) * 2014-11-26 2020-09-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-mutiran kras T-celični receptorji
US11259510B2 (en) 2015-04-06 2022-03-01 Regeneron Pharmaceuticals, Inc. Humanized T cell mediated immune responses in non-human animals
EP3303591B1 (de) 2015-06-01 2019-04-03 Medigene Immunotherapies GmbH T-zell-rezeptor-bibliothek
JP2018517711A (ja) * 2015-06-01 2018-07-05 メディジーン イミュノテラピーズ ゲーエムベーハー 細胞表面タンパク質に対する抗体を作製する方法
KR101794304B1 (ko) * 2015-09-01 2017-11-06 가톨릭대학교 산학협력단 Ｅｂｖ 항원 특이 ｔ―세포 수용체 및 이의 용도
US20190119350A1 (en) * 2015-09-09 2019-04-25 Immune Design Corp. Ny-eso-1 specific tcrs and methods of use thereof
WO2017070042A1 (en) 2015-10-20 2017-04-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing t cell populations using akt inhibitors
SG11201802895QA (en) 2015-10-23 2018-05-30 Eureka Therapeutics Inc Antibody/t-cell receptor chimeric constructs and uses thereof
CN106632660B (zh) * 2015-11-04 2021-01-29 广东香雪精准医疗技术有限公司 识别ny-eso-1抗原短肽的tcr
TWI772282B (zh) 2015-12-23 2022-08-01 德商梅迪基因免疫治療公司 樹突細胞組成物
EP3402515B8 (de) 2016-01-12 2021-12-08 Oncotracker, Inc. Verbesserte verfahren zur überwachung des immunstatus einer person
CA3021898A1 (en) 2016-04-26 2017-11-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-kk-lc-1 t cell receptors
HRP20250113T1 (hr) 2016-06-02 2025-03-28 Immunocore Limited Režim doziranja za gp100-specifični tcr - anti-cd3 scfv fuzijski protein
US20190359678A1 (en) * 2017-02-09 2019-11-28 The Regents Of The University Of California Chimeric t cell antigen receptors and methods of use thereof
JP7538601B2 (ja) 2017-04-26 2024-08-22 ユーリカ セラピューティックス， インコーポレイテッド キメラ活性化受容体及びキメラ刺激受容体を発現する細胞並びにその使用
US11041011B2 (en) 2017-05-12 2021-06-22 Augusta University Research Institute, Inc. Human alpha fetoprotein-specific murine T cell receptors and uses thereof
EP3639028B1 (de) 2017-06-13 2025-10-15 Onco Tracker, Inc. Verfahren zur diagnose, prognose und überwachung von brustkrebs
US20200230221A1 (en) 2017-09-19 2020-07-23 Massachusetts Institute Of Technology Compositions for chimeric antigen receptor t cell therapy and uses thereof
JP2020535832A (ja) * 2017-10-05 2020-12-10 アメリカ合衆国 マウス定常領域を伴うｔｃｒを発現する細胞を選択的に増幅するための方法
WO2019069125A1 (en) 2017-10-06 2019-04-11 Oslo Universitetssykehus Hf CHIMERIC ANTIGEN RECEPTORS
US20200316122A1 (en) 2017-10-11 2020-10-08 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Methods of producing t cell populations using p38 mapk inhibitors
KR20190076297A (ko) 2017-12-22 2019-07-02 (주)메디톡스 Mart-1 특이적 t 세포 수용체 및 이의 용도
ES3052818T3 (en) 2018-02-09 2026-01-14 Us Health Tethered interleukin-15 and interleukin-21
JP7721436B2 (ja) 2018-04-12 2025-08-12 ウモジャ バイオファーマ インコーポレイテッド ウイルスベクター及びパッケージング細胞株
CN112236447B (zh) * 2018-04-19 2023-10-20 得克萨斯州大学系统董事会 具有mage-b2特异性的t细胞受体及其用途
WO2019237035A1 (en) 2018-06-08 2019-12-12 Intellia Therapeutics, Inc. Compositions and methods for immunooncology
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
AU2019302603A1 (en) * 2018-07-13 2021-01-14 Nanjing Legend Biotech Co., Ltd. Co-receptor systems for treating infectious diseases
CN110818802B (zh) * 2018-08-08 2022-02-08 华夏英泰（北京）生物技术有限公司 一种嵌合t细胞受体star及其应用
IL320642A (en) 2018-11-01 2025-07-01 Gracell Biotechnologies Shanghai Co Ltd Preparations and methods for engineering T cells
EP3884058A1 (de) 2018-11-21 2021-09-29 Umoja Biopharma, Inc. Multicistronischer vektor zum oberflächen-engineering von lentiviralen teilchen
KR20200068263A (ko) 2018-12-05 2020-06-15 (주)메디톡스 Ny-eso-1 특이적 t 세포 수용체 및 이의 용도
EP3897637A1 (de) 2018-12-20 2021-10-27 Novartis AG Dosierungsschema und pharmazeutische kombination mit 3-(1-oxoisoindolin-2-yl)piperidin-2,6-dion-derivaten
BR112021015783A2 (pt) 2019-02-15 2021-10-05 Novartis Ag Derivados de 3-(1-oxo-5-(piperidin-4-il)isoindolin-2-il)piperidina-2,6-diona e usos dos mesmos
WO2020165834A1 (en) 2019-02-15 2020-08-20 Novartis Ag Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
US20220193137A1 (en) * 2019-04-04 2022-06-23 Umc Utrecht Holding B.V. Modified immune receptor constructs
JP2022538974A (ja) 2019-06-26 2022-09-07 マサチューセッツ インスチテュート オブ テクノロジー 免疫調節融合タンパク質－金属水酸化物錯体およびその方法
WO2021061648A1 (en) 2019-09-23 2021-04-01 Massachusetts Institute Of Technology Methods and compositions for stimulation of endogenous t cell responses
JP2023507190A (ja) 2019-12-20 2023-02-21 ノバルティス アーゲー 増殖性疾患を治療するための抗ＴＧＦβ抗体及びチェックポイント阻害薬の使用
EP4117716A2 (de) 2020-03-10 2023-01-18 Massachusetts Institute of Technology Verfahren zur erzeugung manipulierter gedächtnisähnlicher nk-zellen und zusammensetzungen davon
WO2021221782A1 (en) 2020-05-01 2021-11-04 Massachusetts Institute Of Technology Chimeric antigen receptor-targeting ligands and uses thereof
WO2021221783A1 (en) 2020-05-01 2021-11-04 Massachusetts Institute Of Technology Methods for identifying chimeric antigen receptor-targeting ligands and uses thereof
EP4168007A1 (de) 2020-06-23 2023-04-26 Novartis AG Dosierschema mit 3-(1-oxoisoindolin-2-yl)piperidin-2,6-dion-derivaten
WO2022029573A1 (en) 2020-08-03 2022-02-10 Novartis Ag Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CN116583537A (zh) 2020-09-08 2023-08-11 美国卫生和人力服务部 与对过继细胞疗法的应答相关的t细胞表型
US20240018210A1 (en) 2020-11-13 2024-01-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Enhanced antigen reactivity of immune cells expressing a mutant non-signaling cd3 zeta chain
JP2024512702A (ja) 2021-03-31 2024-03-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｔｃｒβレパートリーの改善された多様性を伴うヒト化細胞免疫系の構成要素を含む、遺伝的に改変されたマウス
TW202304979A (zh) 2021-04-07 2023-02-01 瑞士商諾華公司 抗ＴＧＦβ抗體及其他治療劑用於治療增殖性疾病之用途
KR20240034234A (ko) 2021-07-14 2024-03-13 2세븐티 바이오, 인코포레이티드 항체로부터의 결합 도메인에 융합된 조작된 t 세포 수용체
WO2023002204A1 (en) * 2021-07-21 2023-01-26 Enara Bio Limited T-cell receptor
WO2023081715A1 (en) 2021-11-03 2023-05-11 Viracta Therapeutics, Inc. Combination of car t-cell therapy with btk inhibitors and methods of use thereof
JP2025501259A (ja) 2021-12-31 2025-01-17 アメリカ合衆国 がんに対する組合せ免疫療法としてのワクチン接種を伴うｔ細胞療法
WO2023131053A1 (zh) * 2022-01-05 2023-07-13 苏州系统医学研究所 一种t细胞受体及其制备方法和用途
AU2023251117A1 (en) 2022-04-08 2024-11-21 Regeneron Pharmaceuticals, Inc. Multipartite receptor and signaling complexes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407221B1 (en) * 1990-12-14 2002-06-18 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
WO1992010591A1 (en) * 1990-12-14 1992-06-25 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
WO2000056267A2 (en) * 1999-03-19 2000-09-28 Waldemar Priebe Methods and compositions for the manufacture of c-3' and c-4' anthracycline antibiotics
GB0304068D0 (en) * 2003-02-22 2003-03-26 Avidex Ltd Substances

Also Published As

Publication number Publication date
EP2016102B1 (de) 2012-03-21
AU2007248019A1 (en) 2007-11-15
AU2007248019B2 (en) 2012-10-11
PT2016102E (pt) 2012-05-15
WO2007131092A2 (en) 2007-11-15
ES2382777T3 (es) 2012-06-13
EP2016102A2 (de) 2009-01-21
US20090304657A1 (en) 2009-12-10
WO2007131092A3 (en) 2008-04-03
CA2651174A1 (en) 2007-11-15
DK2016102T3 (da) 2012-07-02
US20130116167A1 (en) 2013-05-09

Similar Documents

Publication Publication Date Title
ATE550356T1 (de) Chimäre t-zellen-rezeptoren sowie entsprechende materialien und verwendungsverfahren
Kane Thermodynamics of multivalent interactions: influence of the linker
PH12013502421A1 (en) Bcma (cd269/tnfrsf17) -binding proteins
MX2009006892A (es) Uso de agonistas del receptor de peptido similar al glucagon de tipo 1 de accion prolongada para mejorar la sensibilidad a la insulina y los perfiles de lipidos.
NZ592973A (en) Compositions and methods of using angiopoietin-like 4 protein
EP1994157A4 (de) Rekombinante menschliche epo-fc-fusionsproteine mit längerer halbwertzeit und erhöhter erythropoetischer aktivität in vivo
AR064639A1 (es) Gen de bacillus thuringiensis con actividad contra lepidopteros
AR079114A1 (es) Proteinas de enlace de antigenos anti-orai1 y usos de las mismas
DK1639013T3 (da) Pan-kir2dl-nk-receptor-antistoffer og anvendelse heraf til diagnosticering og terapi
EP2352523A4 (de) Verbesserte anti-cd19-antikörper
EP2641911A3 (de) Zusammensetzungen und Verfahren zur Neuprogrammierung von Zellen ohne genetische Modifikation
MX2009000659A (es) Composiciones de polipeptidos de retrovirus endogeno humano y metodo para su uso.
IN2012DN03368A (de)
ATE471336T1 (de) Das biomolekültransduktionsmotiv mph-1-btm und dessen verwendung
Chaturvedi et al. The P-loop region of Schlafen 3 acts within the cytosol to induce differentiation of human Caco-2 intestinal epithelial cells
BRPI0514124B8 (pt) anticorpos monoclonais específicos para il-4 humana, seu uso, composição farmacêutica que os comprende e polinucleotídeos
WO2004045544A8 (en) Autocrine growth factor receptor antibodies and methods
WO2005111204A3 (en) Porcine forssman synthetase cdna and polypeptide
Yuan et al. Nidirana chapaensis (Bourret, 1937), one additional anuran species for the amphibian fauna of China
WO2008109127A3 (en) New tumor mouse models using lentiviral vectors
Moral‐Sanz et al. The structural conformation of the tachykinin domain drives the anti‐tumoural activity of an octopus peptide in melanoma BRAFV600E
ATE473235T1 (de) Das biomolekültransduktionsmotiv sim-2-btm und dessen verwendung
BR112013022557A2 (pt) ligantes de peptídeo composições de polipeptídeo e métodos para uso dos mesmos
BRPI0515893B8 (pt) peptídeos da proteína humana de estresse térmico, composição farmacêutica, e, uso do peptídeo e da composição farmacêutica.
EP1807518A4 (de) Rekombinantes alpha-fetoprotein, verfahren und mittel zur herstellung davon, zusammensetzungen auf basis davon und verwendung davon