KR880009027A - 비-천연 데메틸아베르멕틴 및 이의 제조방법 - Google Patents

비-천연 데메틸아베르멕틴 및 이의 제조방법 Download PDF

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KR880009027A
KR880009027A KR1019880000506A KR880000506A KR880009027A KR 880009027 A KR880009027 A KR 880009027A KR 1019880000506 A KR1019880000506 A KR 1019880000506A KR 880000506 A KR880000506 A KR 880000506A KR 880009027 A KR880009027 A KR 880009027A
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compound
hydrogen
methyl
group
double bond
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KR1019880000506A
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KR910002225B1 (ko
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윌리엄 하프너 에드먼드
스코트 홀덤 켈빈
에드워드 리 쉬-젠
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원본미기재
화이자 인코퍼레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Abstract

내용 없음.

Description

비-천연 데메틸아베르멕틴 및 이의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 일반식 (I)의 화합물.
    상기식에서, 22 내지 23번 위치에서의 점선은 임의의 이중결합을 나타내고 ; R1은 H 또는 OH이고 이중결합은 부재하거나 ; 또는 이중결합이 존재하고 R1은 부재하며 ; R은 알파-측쇄 C3-C8알킬, 알케닐, 알키닐, 알콕시알킬 또는 알킬티오알킬 그룹 ; 알킬 그룹이 알파-측쇄 C2-C5알킬 그룹인 C5-C8사이클로알킬알킬 그룹 메틸렌 또는 1개 이상의 C1-C4알킬 그룹 또는 할로원자에 ; 의하여 임의로 치환될 수 있는 C3-C4사이클로알킬 또는 C5-C8사이클로알케닐 그룹 ; 또는 포화되거나 완전히 또는 부분적으로 불포화될 수 있고 1개 이상의 C1-C4알킬 그룹 또는 할로원자에 의하여 임의로 치환될 수 있는 산소 또는 황을 함유하는 3 내지 6원 헤테로사이클 환이나 ; 단, R이 알킬일 경우, 이는 이소프로필 또는 2급-부틸은 아니며 ; R2는 다음 일반식의 디사카라이드기이고[여기에서, R4및 R5각각은 수소 또는 메틸이나, 단, R4및 R5중 적어도 하나는 수소이다] ; R3는 수소 또는 메틸이다.
  2. 제1항에 있어서, R이 사이클로알킬인 화합물.
  3. 제2항에 있어서, R이 사이클로헥실이고, R1이 OH인 화합물.
  4. 제3항에 있어서, R3이 수소이고, R4및 R5각각이 수소인 화합물.
  5. 제3항에 있어서, R3이 메틸이고, R4및 R5각각이 수소인 화합물.
  6. 제2항에 있어서, R이 사이클로펜틸이고, R1이 OH이며, R4및 R5중 1개가 수소이고, R3이 메틸인 화합물.
  7. 제1항에 있어서, R이 포화 또는 불포화될 수 있는 산소 또는 황을 함유하는 3 내지 6원 헤테로사이클환인 화합물.
  8. 제7항에 있어서, R이 3-티에닐이고, R1이 OH이며, R3이 메틸이고, R4및 R5각각이 수소인 화합물.
  9. 제7항에 있어서, R이 3-푸릴이고, R이 OH이며, R3이 수소이고, R4및 R5각각이 수소인 화합물.
  10. 제1항에 있어서, R이 1-메틸티오에틸이고, 이중결합이 22 내지 23번 위치에 존재하며, R3이 메틸이고, R4및 R5각각이 수소인 화합물.
  11. 제1항의 화합물을 불활성 희석제 또는 담체와 함께 함유하는 사람 및 동물에 있어서의 기생충 감염을 치료 및 예방하기 위한 조성물.
  12. 제11항에 있어서, 액체 물약 또는 경구용 또는 주사용 제형의 형태인 조성물.
  13. 제11항에 있어서, 동물 사료 또는 동물 먹이에 첨가하기 위한 에비혼합물 또는 첨가물의 형태인 조성물.
  14. 제1항에 따른 화합물의 구충적 양으로 기생충 감염 또는 침투의 원인성 유기체와 접촉시키거나 상기 유기체가 존재하는 곳에 살포함을 포함하는 기생충 감염 또는 침투의 방제방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880000506A 1987-01-23 1988-01-23 비-천연 데메틸아베르멕틴 및 이의 제조방법 KR910002225B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US651287A 1987-01-23 1987-01-23
US6,512 1987-01-23
US006512 1987-01-23

Publications (2)

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KR880009027A true KR880009027A (ko) 1988-09-13
KR910002225B1 KR910002225B1 (ko) 1991-04-08

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KR1019880000470A KR900004419B1 (ko) 1987-01-23 1988-01-22 B 아베르멕틴의 제조방법 및 이를 위한 배양물
KR1019880000506A KR910002225B1 (ko) 1987-01-23 1988-01-23 비-천연 데메틸아베르멕틴 및 이의 제조방법

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KR100415395B1 (ko) * 2000-08-02 2004-01-16 한국생명공학연구원 에버멕틴 ｂｃ-5-ｏ-메칠트랜스퍼라제의 유전자가 파괴된 스트렙토마이세스 에버미티리스 변이균주 및 그의 제조 방법
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MA21160A1 (fr) 1988-10-01
IL85165A (en) 1992-07-15
IE880160L (en) 1988-07-23
DE3884973D1 (de) 1993-11-25
AU595673B2 (en) 1990-04-05
IE880161L (en) 1988-07-23
FI880280A (fi) 1988-07-24
JPS63291576A (ja) 1988-11-29
EP0276131A2 (en) 1988-07-27
NZ223271A (en) 1991-12-23
ZA88447B (en) 1989-08-30
BR8800271A (pt) 1988-09-06
FI90088C (fi) 1993-12-27
DE3884973T2 (de) 1994-02-17
AU603416B2 (en) 1990-11-15
CN88100649A (zh) 1988-10-26
IE61066B1 (en) 1994-09-21
HUT47644A (en) 1989-03-28
DE3879975T2 (de) 1993-07-15
SK279351B6 (sk) 1998-10-07
PT86583A (en) 1988-02-01
IL85165A0 (en) 1988-07-31
FI880281A0 (fi) 1988-01-22
CZ279782B6 (cs) 1995-06-14
DK29088A (da) 1988-07-24
DE3879975D1 (de) 1993-05-13
JPH0681757B2 (ja) 1994-10-19
PL156764B1 (pl) 1992-04-30
DK29088D0 (da) 1988-01-22
YU11988A (en) 1989-08-31
KR900004419B1 (ko) 1990-06-25
DK175720B1 (da) 2005-02-07
FI90091B (fi) 1993-09-15
AU1074288A (en) 1988-07-28
HUT47978A (en) 1989-04-28
JPH0817693B2 (ja) 1996-02-28
IL85118A0 (en) 1988-06-30
IL85118A (en) 1993-01-31
FI880281A (fi) 1988-07-24
DD290214A5 (de) 1991-05-23
ZA88449B (en) 1989-08-30
BG51051A3 (en) 1993-01-15
EP0276103A3 (en) 1989-11-08
CN1056883C (zh) 2000-09-27
IE61483B1 (en) 1994-11-02
EP0276103A2 (en) 1988-07-27
EP0276103B1 (en) 1993-10-20
EG18797A (en) 1994-06-30
YU47878B (sh) 1996-05-20
GR3007586T3 (ko) 1993-08-31
DK28988D0 (da) 1988-01-22
ATE87927T1 (de) 1993-04-15
KR910002225B1 (ko) 1991-04-08
AR241798A1 (es) 1992-12-30
DK28988A (da) 1988-07-24
MY103514A (en) 1993-07-31
IN167980B (ko) 1991-01-19
PT86584A (en) 1988-02-01
AU631298B2 (en) 1992-11-19
EP0276131A3 (en) 1989-10-25
ES2059498T3 (es) 1994-11-16
PT86584B (pt) 1991-12-31
PL156763B1 (pl) 1992-04-30
PT86583B (pt) 1991-12-31
AU1069688A (en) 1988-07-28
EP0276131B1 (en) 1993-04-07
RU1806198C (ru) 1993-03-30
CZ40788A3 (en) 1994-12-15
HU201973B (en) 1991-01-28
SK40788A3 (en) 1998-10-07
AU7111091A (en) 1991-08-08
FI880280A0 (fi) 1988-01-22
ES2053719T3 (es) 1994-08-01
PL270238A1 (en) 1989-06-26
FI90088B (fi) 1993-09-15
NZ223272A (en) 1989-12-21
JPS63270684A (ja) 1988-11-08
KR880009122A (ko) 1988-09-14
ZA88448B (en) 1989-08-30
FI90091C (fi) 1993-12-27
DD267512A5 (de) 1989-05-03
PL270239A1 (en) 1989-06-26
ATE96174T1 (de) 1993-11-15
HU200487B (en) 1990-06-28

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