IL85165A - Streptomyces mutant strains lacking branched-chain 2-oxo acid dehydrogenase activity and avermectin b o-methyl-transferase activity and their use for production of b avermectins - Google Patents

Streptomyces mutant strains lacking branched-chain 2-oxo acid dehydrogenase activity and avermectin b o-methyl-transferase activity and their use for production of b avermectins

Info

Publication number
IL85165A
IL85165A IL85165A IL8516588A IL85165A IL 85165 A IL85165 A IL 85165A IL 85165 A IL85165 A IL 85165A IL 8516588 A IL8516588 A IL 8516588A IL 85165 A IL85165 A IL 85165A
Authority
IL
Israel
Prior art keywords
avermectins
avermectin
activity
methyl
chain
Prior art date
Application number
IL85165A
Other languages
English (en)
Other versions
IL85165A0 (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL85165A0 publication Critical patent/IL85165A0/xx
Publication of IL85165A publication Critical patent/IL85165A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Fodder In General (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Steroid Compounds (AREA)
IL85165A 1987-01-23 1988-01-21 Streptomyces mutant strains lacking branched-chain 2-oxo acid dehydrogenase activity and avermectin b o-methyl-transferase activity and their use for production of b avermectins IL85165A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US651287A 1987-01-23 1987-01-23

Publications (2)

Publication Number Publication Date
IL85165A0 IL85165A0 (en) 1988-07-31
IL85165A true IL85165A (en) 1992-07-15

Family

ID=21721247

Family Applications (2)

Application Number Title Priority Date Filing Date
IL85118A IL85118A (en) 1987-01-23 1988-01-18 Non-natural 3) and/or 3*-demethylavermectins, antiparasitic compositions containing them and methods of combating parasites with them
IL85165A IL85165A (en) 1987-01-23 1988-01-21 Streptomyces mutant strains lacking branched-chain 2-oxo acid dehydrogenase activity and avermectin b o-methyl-transferase activity and their use for production of b avermectins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL85118A IL85118A (en) 1987-01-23 1988-01-18 Non-natural 3) and/or 3*-demethylavermectins, antiparasitic compositions containing them and methods of combating parasites with them

Country Status (30)

Country Link
EP (2) EP0276103B1 (xx)
JP (2) JPH0681757B2 (xx)
KR (2) KR900004419B1 (xx)
CN (1) CN1056883C (xx)
AR (1) AR241798A1 (xx)
AT (2) ATE96174T1 (xx)
AU (2) AU595673B2 (xx)
BG (1) BG51051A3 (xx)
BR (1) BR8800271A (xx)
CZ (1) CZ279782B6 (xx)
DD (2) DD290214A5 (xx)
DE (2) DE3884973T2 (xx)
DK (2) DK28988A (xx)
EG (1) EG18797A (xx)
ES (2) ES2059498T3 (xx)
FI (2) FI90091C (xx)
GR (1) GR3007586T3 (xx)
HU (2) HU201973B (xx)
IE (2) IE61066B1 (xx)
IL (2) IL85118A (xx)
IN (1) IN167980B (xx)
MA (1) MA21160A1 (xx)
MY (1) MY103514A (xx)
NZ (2) NZ223271A (xx)
PL (2) PL156763B1 (xx)
PT (2) PT86583B (xx)
RU (1) RU1806198C (xx)
SK (1) SK279351B6 (xx)
YU (1) YU47878B (xx)
ZA (3) ZA88448B (xx)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
US4874749A (en) * 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
EP0313297B1 (en) * 1987-10-23 1993-05-19 Pfizer Inc. Process for production of avermectin aglycones and cultures therefor
GB8807280D0 (en) * 1988-03-26 1988-04-27 Pfizer Ltd Antiparasitic agents
GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8813760D0 (en) * 1988-06-10 1988-07-13 American Cyanamid Co Chemical process
GB8815967D0 (en) * 1988-07-05 1988-08-10 Pfizer Ltd Antiparasitic agents
NZ231772A (en) * 1988-12-23 1992-11-25 Merck & Co Inc Avermectin derivatives, preparation and parasiticidal compositions thereof
NZ231773A (en) * 1988-12-23 1992-09-25 Merck & Co Inc Avermectin derivatives, preparation and parasiticidal pharmaceutical compositions thereof
US5015630A (en) * 1989-01-19 1991-05-14 Merck & Co., Inc. 5-oxime avermectin derivatives
US4897383A (en) * 1989-02-13 1990-01-30 Merck & Co., Inc. Avermectin derivatives
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
US5030622A (en) * 1989-06-02 1991-07-09 Merck & Co., Inc. Avermectin derivatives
US5057499A (en) * 1989-06-02 1991-10-15 Merck & Co. Inc. Avermectin derivatives
US5023241A (en) * 1989-07-31 1991-06-11 Merck & Co., Inc. Avermectin derivatives
US5830875A (en) * 1989-10-30 1998-11-03 Merck & Co., Inc. 24-and 25-substituted avermectin and milbemycin derivatives
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
US5169839A (en) * 1990-05-11 1992-12-08 Merck & Co., Inc. Derivatives of 3'- and 3"-o-desmethyl avermectin compounds, compositions and methods of treating melmintic and parasitic infections
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
US5240915A (en) * 1991-10-15 1993-08-31 Merck & Co., Inc. Avermectin derivatives
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
US5292647A (en) * 1992-11-30 1994-03-08 Eli Lilly And Company Strain of streptomyces for producing avermectins and processes therewith
CN1038330C (zh) * 1993-07-05 1998-05-13 塞泰克斯公司 阿弗麦菌素的生产与分离
EP0711349B1 (en) * 1993-07-30 2003-09-03 Pfizer Inc. Genes encoding branched-chain alpha-ketoacid dehydrogenase complex from streptomyces avermitilis
JP2761296B2 (ja) * 1993-10-05 1998-06-04 フアイザー・インコーポレイテツド ドラメクチンの製造方法および駆虫性中間体
FI942725A (fi) * 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
US5701591A (en) * 1995-04-07 1997-12-23 Telecommunications Equipment Corporation Multi-function interactive communications system with circularly/elliptically polarized signal transmission and reception
CN1297485A (zh) * 1998-02-13 2001-05-30 辉瑞产品公司 介导除虫菌素b2:b1比例的除虫链霉菌基因
IL147563A0 (en) * 1999-08-12 2002-08-14 Pfizer Prod Inc Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
KR100415395B1 (ko) * 2000-08-02 2004-01-16 한국생명공학연구원 에버멕틴 ｂｃ-5-ｏ-메칠트랜스퍼라제의 유전자가 파괴된 스트렙토마이세스 에버미티리스 변이균주 및 그의 제조 방법
ES2373629T3 (es) 2002-02-12 2012-02-07 Pfizer Products Inc. Gen de streptomyces avemitilis que dirige la proporción de avermectinas b2:b1.
WO2023203038A1 (en) 2022-04-19 2023-10-26 Syngenta Crop Protection Ag Insect, acarina and nematode pest control

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
NZ188459A (en) * 1977-10-03 1982-09-07 Merck & Co Inc Derivatives of c-076 compounds and pesticidal compositions
US4429042A (en) 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
GB8606120D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process

Also Published As

Publication number Publication date
DK29088A (da) 1988-07-24
ZA88449B (en) 1989-08-30
MY103514A (en) 1993-07-31
DE3884973T2 (de) 1994-02-17
FI90091C (fi) 1993-12-27
JPH0817693B2 (ja) 1996-02-28
EG18797A (en) 1994-06-30
PT86583B (pt) 1991-12-31
YU11988A (en) 1989-08-31
DD267512A5 (de) 1989-05-03
FI90088C (fi) 1993-12-27
FI880280A0 (fi) 1988-01-22
HUT47644A (en) 1989-03-28
PL270239A1 (en) 1989-06-26
DE3884973D1 (de) 1993-11-25
ES2059498T3 (es) 1994-11-16
SK40788A3 (en) 1998-10-07
AU603416B2 (en) 1990-11-15
EP0276103A3 (en) 1989-11-08
AU1074288A (en) 1988-07-28
DE3879975D1 (de) 1993-05-13
IE880160L (en) 1988-07-23
DD290214A5 (de) 1991-05-23
JPS63270684A (ja) 1988-11-08
EP0276131A3 (en) 1989-10-25
IE880161L (en) 1988-07-23
AU595673B2 (en) 1990-04-05
ZA88447B (en) 1989-08-30
ATE87927T1 (de) 1993-04-15
EP0276103B1 (en) 1993-10-20
DE3879975T2 (de) 1993-07-15
AU7111091A (en) 1991-08-08
MA21160A1 (fr) 1988-10-01
IL85118A0 (en) 1988-06-30
BR8800271A (pt) 1988-09-06
DK175720B1 (da) 2005-02-07
HUT47978A (en) 1989-04-28
YU47878B (sh) 1996-05-20
CN1056883C (zh) 2000-09-27
PT86583A (en) 1988-02-01
FI90091B (fi) 1993-09-15
IL85118A (en) 1993-01-31
JPH0681757B2 (ja) 1994-10-19
EP0276131A2 (en) 1988-07-27
BG51051A3 (en) 1993-01-15
EP0276103A2 (en) 1988-07-27
SK279351B6 (sk) 1998-10-07
PT86584B (pt) 1991-12-31
IE61066B1 (en) 1994-09-21
HU200487B (en) 1990-06-28
CN88100649A (zh) 1988-10-26
KR910002225B1 (ko) 1991-04-08
RU1806198C (ru) 1993-03-30
PL270238A1 (en) 1989-06-26
CZ40788A3 (en) 1994-12-15
EP0276131B1 (en) 1993-04-07
ZA88448B (en) 1989-08-30
ATE96174T1 (de) 1993-11-15
FI880281A (fi) 1988-07-24
IN167980B (xx) 1991-01-19
CZ279782B6 (cs) 1995-06-14
IL85165A0 (en) 1988-07-31
KR900004419B1 (ko) 1990-06-25
GR3007586T3 (xx) 1993-08-31
PT86584A (en) 1988-02-01
FI880280A (fi) 1988-07-24
DK28988A (da) 1988-07-24
HU201973B (en) 1991-01-28
PL156763B1 (pl) 1992-04-30
JPS63291576A (ja) 1988-11-29
AR241798A1 (es) 1992-12-30
FI90088B (fi) 1993-09-15
NZ223271A (en) 1991-12-23
PL156764B1 (pl) 1992-04-30
KR880009122A (ko) 1988-09-14
NZ223272A (en) 1989-12-21
IE61483B1 (en) 1994-11-02
FI880281A0 (fi) 1988-01-22
DK28988D0 (da) 1988-01-22
AU631298B2 (en) 1992-11-19
DK29088D0 (da) 1988-01-22
ES2053719T3 (es) 1994-08-01
KR880009027A (ko) 1988-09-13
AU1069688A (en) 1988-07-28

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