KR20210003814A - IL-15/IL-15Rα Fc-융합 단백질 및 TIM-3 항원 결합 도메인을 함유하는 TIM-3 표적화 이종이량체 융합 단백질 - Google Patents

IL-15/IL-15Rα Fc-융합 단백질 및 TIM-3 항원 결합 도메인을 함유하는 TIM-3 표적화 이종이량체 융합 단백질 Download PDF

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KR20210003814A
KR20210003814A KR1020207033041A KR20207033041A KR20210003814A KR 20210003814 A KR20210003814 A KR 20210003814A KR 1020207033041 A KR1020207033041 A KR 1020207033041A KR 20207033041 A KR20207033041 A KR 20207033041A KR 20210003814 A KR20210003814 A KR 20210003814A
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매튜 버넷
존 데스자라이스
루마나 래쉬드
라자트 바르마
크리스틴 본존
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젠코어 인코포레이티드
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

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KR1020207033041A 2018-04-18 2019-04-18 IL-15/IL-15Rα Fc-융합 단백질 및 TIM-3 항원 결합 도메인을 함유하는 TIM-3 표적화 이종이량체 융합 단백질 Ceased KR20210003814A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862659626P 2018-04-18 2018-04-18
US62/659,626 2018-04-18
US201862783110P 2018-12-20 2018-12-20
US62/783,110 2018-12-20
PCT/US2019/028192 WO2019204655A1 (en) 2018-04-18 2019-04-18 Tim-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and tim-3 antigen binding domains

Publications (1)

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KR20210003814A true KR20210003814A (ko) 2021-01-12

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KR1020207033041A Ceased KR20210003814A (ko) 2018-04-18 2019-04-18 IL-15/IL-15Rα Fc-융합 단백질 및 TIM-3 항원 결합 도메인을 함유하는 TIM-3 표적화 이종이량체 융합 단백질

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US (2) US11505595B2 (https=)
EP (1) EP3781598A1 (https=)
JP (1) JP2021520829A (https=)
KR (1) KR20210003814A (https=)
CN (1) CN112437777A (https=)
AU (1) AU2019256529A1 (https=)
CA (1) CA3097741A1 (https=)
IL (1) IL278089A (https=)
WO (1) WO2019204655A1 (https=)

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JP7010854B2 (ja) * 2016-06-14 2022-01-26 ゼンコア インコーポレイテッド 二重特異性チェックポイント阻害剤抗体
MY203000A (en) * 2016-10-14 2024-06-01 Xencor Inc Il15/il15r� heterodimeric fc-fusion proteins
WO2019006472A1 (en) 2017-06-30 2019-01-03 Xencor, Inc. TARGETED HETETRODIMERIC FUSION PROTEINS CONTAINING IL-15 / IL-15RA AND ANTIGEN-BINDING DOMAINS
MA52289A (fr) 2018-04-18 2021-02-24 Xencor Inc Protéines de fusion fc hétérodimères il-15/il-15ra et leurs utilisations
WO2019204646A1 (en) 2018-04-18 2019-10-24 Xencor, Inc. Lag-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and lag-3 antigen binding domains
CN113438961A (zh) 2018-12-20 2021-09-24 Xencor股份有限公司 含有IL-15/IL-15Rα和NKG2D抗原结合结构域的靶向异二聚体Fc融合蛋白
TW202128757A (zh) 2019-10-11 2021-08-01 美商建南德克公司 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白
WO2021092719A1 (zh) * 2019-11-11 2021-05-20 王盛典 一种靶向抗原特异性t细胞诱导其向记忆干性细胞分化的融合蛋白
CN113135996A (zh) * 2019-12-09 2021-07-20 启愈生物技术(上海)有限公司 一种双特异抗体及其应用
WO2021231976A1 (en) 2020-05-14 2021-11-18 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
US20240067727A1 (en) * 2020-12-17 2024-02-29 Ose Immunotherapeutics Bifunctional anti-pd1/il-7 molecules
WO2022140701A1 (en) * 2020-12-24 2022-06-30 Xencor, Inc. Icos targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and icos antigen binding domains
CN113321736B (zh) * 2020-12-30 2024-01-09 苏州复融生物技术有限公司 一种长效化白介素15融合蛋白及其制备方法和应用
CN112961239B (zh) * 2021-02-24 2021-09-10 北京昭衍生物技术有限公司 Tim抑制剂及其应用
CN112979809B (zh) * 2021-02-24 2021-11-09 北京昭衍生物技术有限公司 一种与抗原tim-3结合的靶向分子
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CN116217735A (zh) * 2022-08-03 2023-06-06 深圳市先康达生命科学有限公司 一种自分泌IL-15与anti-TIM3结合的融合蛋白及其应用
CN115807020A (zh) * 2022-09-23 2023-03-17 卡瑞济(北京)生命科技有限公司 白介素15受体α装甲CAR-T细胞在降低白介素15诱导的细胞毒性中的用途
CN120289652B (zh) * 2025-04-16 2026-02-13 广东拓普灵生物医药科技有限公司 一种nk细胞的制备方法及其在肿瘤免疫治疗中的应用
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CN113438961A (zh) 2018-12-20 2021-09-24 Xencor股份有限公司 含有IL-15/IL-15Rα和NKG2D抗原结合结构域的靶向异二聚体Fc融合蛋白

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AU2019256529A1 (en) 2020-11-26
WO2019204655A9 (en) 2019-11-14
US20230331813A1 (en) 2023-10-19
CA3097741A1 (en) 2019-10-24
US20190359684A1 (en) 2019-11-28
US11505595B2 (en) 2022-11-22

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