KR20180095140A - α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ - Google Patents
α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ Download PDFInfo
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- KR20180095140A KR20180095140A KR1020187023820A KR20187023820A KR20180095140A KR 20180095140 A KR20180095140 A KR 20180095140A KR 1020187023820 A KR1020187023820 A KR 1020187023820A KR 20187023820 A KR20187023820 A KR 20187023820A KR 20180095140 A KR20180095140 A KR 20180095140A
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- sialylation
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- rfsh
- recombinant fsh
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C12Y204/99006—N-Acetyllactosaminide alpha-2,3-sialyltransferase (2.4.99.6)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
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- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4542408P | 2008-04-16 | 2008-04-16 | |
| US61/045,424 | 2008-04-16 | ||
| EP08251528 | 2008-04-25 | ||
| EP08251528.9 | 2008-04-25 | ||
| PCT/GB2009/000978 WO2009127826A1 (en) | 2008-04-16 | 2009-04-16 | Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020177026920A Division KR20170110741A (ko) | 2008-04-16 | 2009-04-16 | α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197022294A Division KR102108377B1 (ko) | 2008-04-16 | 2009-04-16 | α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20180095140A true KR20180095140A (ko) | 2018-08-24 |
Family
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Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187023820A Ceased KR20180095140A (ko) | 2008-04-16 | 2009-04-16 | α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ |
| KR1020177026920A Ceased KR20170110741A (ko) | 2008-04-16 | 2009-04-16 | α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ |
| KR1020107025581A Active KR101622944B1 (ko) | 2008-04-16 | 2009-04-16 | α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ |
| KR1020197022294A Active KR102108377B1 (ko) | 2008-04-16 | 2009-04-16 | α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ |
| KR1020167012148A Ceased KR20160056960A (ko) | 2008-04-16 | 2009-04-16 | α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
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| KR1020177026920A Ceased KR20170110741A (ko) | 2008-04-16 | 2009-04-16 | α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ |
| KR1020107025581A Active KR101622944B1 (ko) | 2008-04-16 | 2009-04-16 | α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ |
| KR1020197022294A Active KR102108377B1 (ko) | 2008-04-16 | 2009-04-16 | α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ |
| KR1020167012148A Ceased KR20160056960A (ko) | 2008-04-16 | 2009-04-16 | α2,3- 및 α2,6-시알화를 포함하는 재조합 ＦＳＨ |
Country Status (29)
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| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| TWI532495B (zh) | 2009-10-05 | 2016-05-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| EP2417982A1 (en) | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| WO2012016576A1 (en) * | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| DK2621517T4 (da) | 2010-09-29 | 2023-11-20 | Ferring Bv | Sammensætning til anvendelse i behandlingen af infertilitet |
| JP5918697B2 (ja) | 2010-10-15 | 2016-05-18 | Ｊｃｒファーマ株式会社 | 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法 |
| ES2693273T3 (es) * | 2011-03-31 | 2018-12-10 | Ferring B.V. | Preparación farmacéutica |
| WO2012168680A1 (en) | 2011-06-06 | 2012-12-13 | Ferring B.V. | Pharmaceutical preparation comprising recombinant fsh |
| JO3092B1 (ar) * | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
| AU2012340501A1 (en) * | 2011-12-19 | 2013-07-11 | Grifols, S.A. | Compositions, methods, and kits for preparing sialylated recombinant proteins |
| US9657310B2 (en) * | 2012-04-27 | 2017-05-23 | Jcr Pharmaceuticals Co., Ltd. | Expression vector |
| EP2824176A1 (en) * | 2013-07-11 | 2015-01-14 | Siamed'xpress | Methods for producing sialylated therapeutic proteins |
| JP6652334B2 (ja) | 2014-05-31 | 2020-02-19 | Ｊｃｒファーマ株式会社 | ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地 |
| JP2018500934A (ja) * | 2014-12-22 | 2018-01-18 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｍｐ依存性シアリダーゼ活性 |
| HUE054300T2 (hu) | 2015-04-17 | 2021-08-30 | Ferring Bv | FSH-t tartalmazó, meddõség kezelésére szolgáló készítmény |
| WO2016207353A1 (en) | 2015-06-26 | 2016-12-29 | Ferring B.V. | Methods of purification and/or viral inactivation |
| EP3205719A1 (en) * | 2016-02-15 | 2017-08-16 | CEVEC Pharmaceuticals GmbH | Cell lines for producing recombinant glycoproteins with di-antennary n-glycans, methods using the same, and recombinant glycoproteins |
| GB201603280D0 (en) | 2016-02-24 | 2016-04-13 | Ferring Bv | Stable liquid gonadotropin formulation |
| EP3382014A1 (en) | 2017-03-29 | 2018-10-03 | CEVEC Pharmaceuticals GmbH | Recombinant glycoproteins with reduced antennary fucosylation |
| EP3441471A1 (en) | 2017-08-08 | 2019-02-13 | CEVEC Pharmaceuticals GmbH | Use of constitutively active variants of growth factor receptors as selection makers for the generation of stable producer cell lines |
| DK3973982T3 (da) | 2017-09-01 | 2024-09-23 | Ferring Bv | Sammensætning til kontrolleret ovariestimulation |
| HUE071268T2 (hu) | 2018-04-30 | 2025-08-28 | Ferring Bv | Készítmény szabályozott petefészek-stimuláláshoz |
| TWI846743B (zh) | 2018-10-17 | 2024-07-01 | 荷蘭商菲林公司 | 用於控制性卵巢刺激之組成物及方法 |
| WO2021081670A1 (en) * | 2019-11-01 | 2021-05-06 | The University Of British Columbia | Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins |
| TW202237173A (zh) | 2020-12-09 | 2022-10-01 | 荷蘭商菲林公司 | 用於受控的卵巢刺激之組成物及方法 |
| AU2022451605A1 (en) | 2022-04-01 | 2024-09-26 | Ferring B.V. | Mixed protocol for treatment of infertility |
| CA3255772A1 (en) | 2022-05-26 | 2023-11-30 | Ferring B.V. | Compositions and methods of treating infertility in men |
| KR20250033230A (ko) | 2022-07-08 | 2025-03-07 | 훼링 비.브이. | 자궁내 인공수정(iui)을 위한 조성물 및 방법 |
| AR133300A1 (es) | 2023-07-20 | 2025-09-17 | Ferring Bv | Micropartículas cargadas con fármaco de liberación prolongada |
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| US5541083A (en) | 1989-10-24 | 1996-07-30 | The Regents Of The University Of California | Method for producing secretable glycosyltransferases and other golgi processing enzymes |
| IL122614A0 (en) | 1995-06-15 | 1998-08-16 | Introgene Bv | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| JP3559652B2 (ja) * | 1996-06-25 | 2004-09-02 | グローリー工業株式会社 | 売上精算システムの管理装置 |
| IL122732A0 (en) * | 1997-01-15 | 1998-08-16 | Akzo Nobel Nv | Liquid gonadotropin-containing formulation its preparation and a device containing same |
| ATE263841T1 (de) | 1997-01-16 | 2004-04-15 | Neose Technologies Inc | Praktische in vitro sialylierung von rekombinanten glykpproteinen |
| JPH1111665A (ja) | 1997-06-28 | 1999-01-19 | Shibuya Kogyo Co Ltd | 無菌エア搬送コンベヤ装置 |
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| CA2372714A1 (en) | 1999-05-07 | 2000-11-16 | Stephen Franks | The use of luteinizing hormone in the induction of pauci-or unifolliculogenesis |
| JP2002011665A (ja) | 2000-06-28 | 2002-01-15 | Sintokogio Ltd | ショットブラスト装置モニタシステム |
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| ES2381104T3 (es) | 2001-10-29 | 2012-05-23 | Crucell Holland B.V. | Métodos y medios para producir proteínas con modificaciones postraduccionales predeterminadas |
| CN100547069C (zh) | 2001-12-07 | 2009-10-07 | 克鲁塞尔荷兰公司 | 病毒、病毒分离物和疫苗的生产 |
| US20040248784A1 (en) | 2003-06-03 | 2004-12-09 | Marco Filicori | Unitary combinations of FSH and hCG |
| EP1694351A2 (en) * | 2003-12-03 | 2006-08-30 | Neose Technologies, Inc. | Glycopegylated follicle stimulating hormone |
| ATE476666T1 (de) | 2004-02-04 | 2010-08-15 | Centre Nat Rech Scient | Verfahren zur identifizierung von glykoformspezifischen antikörpern |
| CN1926242B (zh) * | 2004-02-13 | 2013-01-16 | 格莱克托普有限公司 | 高活性糖蛋白加工条件及其有效生产方法 |
| TWI488640B (zh) | 2008-04-16 | 2015-06-21 | Ferring Int Ct Sa | 藥學製劑 |
| TWI532495B (zh) | 2009-10-05 | 2016-05-11 | 菲瑞茵國際中心股份有限公司 | 藥學製劑 |
| EP2417982A1 (en) | 2010-07-30 | 2012-02-15 | Ferring B.V. | Stabilization of gonadotropins |
| US8790322B2 (en) | 2010-08-03 | 2014-07-29 | King Saud University | Stoma coat |
| WO2012016576A1 (en) * | 2010-08-04 | 2012-02-09 | Glycotope Gmbh | Improved recombinant human follicle-stimulating hormone |
| DK2621517T4 (da) | 2010-09-29 | 2023-11-20 | Ferring Bv | Sammensætning til anvendelse i behandlingen af infertilitet |
| ES2693273T3 (es) | 2011-03-31 | 2018-12-10 | Ferring B.V. | Preparación farmacéutica |
| WO2012168680A1 (en) | 2011-06-06 | 2012-12-13 | Ferring B.V. | Pharmaceutical preparation comprising recombinant fsh |
| JO3092B1 (ar) | 2011-08-08 | 2017-03-15 | Ferring Bv | مركب لتحفيز مسيطر عليه للمبيض |
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